AU584321B2 - 17 ```(N-t-butylcarbamoyl)-4-aza-5```-androst-1-en-3-one - Google Patents

17 ```(N-t-butylcarbamoyl)-4-aza-5```-androst-1-en-3-one

Info

Publication number
AU584321B2
AU584321B2 AU39167/85A AU3916785A AU584321B2 AU 584321 B2 AU584321 B2 AU 584321B2 AU 39167/85 A AU39167/85 A AU 39167/85A AU 3916785 A AU3916785 A AU 3916785A AU 584321 B2 AU584321 B2 AU 584321B2
Authority
AU
Australia
Prior art keywords
androst
butylcarbamoyl
aza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU39167/85A
Other languages
English (en)
Other versions
AU3916785A (en
Inventor
Gary H. Rasmusson
Glenn F. Reynolds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27078980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU584321(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU3916785A publication Critical patent/AU3916785A/en
Application granted granted Critical
Publication of AU584321B2 publication Critical patent/AU584321B2/en
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU39167/85A 1984-02-27 1985-02-26 17 ```(N-t-butylcarbamoyl)-4-aza-5```-androst-1-en-3-one Expired AU584321B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58406284A 1984-02-27 1984-02-27
US58406184A 1984-02-27 1984-02-27
US584061 1984-02-27
US584062 1984-02-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU33135/89A Division AU626293B2 (en) 1984-02-27 1989-04-18 17beta-n-monosubstituted carbamoyl or 17beta-acyl-4-aza- 5alpha-androst-1-en-3-ones as 5alpha reductase inhibitors

Publications (2)

Publication Number Publication Date
AU3916785A AU3916785A (en) 1985-09-05
AU584321B2 true AU584321B2 (en) 1989-05-25

Family

ID=27078980

Family Applications (4)

Application Number Title Priority Date Filing Date
AU39167/85A Expired AU584321B2 (en) 1984-02-27 1985-02-26 17 ```(N-t-butylcarbamoyl)-4-aza-5```-androst-1-en-3-one
AU33135/89A Expired AU626293B2 (en) 1984-02-27 1989-04-18 17beta-n-monosubstituted carbamoyl or 17beta-acyl-4-aza- 5alpha-androst-1-en-3-ones as 5alpha reductase inhibitors
AU70835/91A Abandoned AU7083591A (en) 1984-02-27 1991-02-06 A 17beta-(cyclohexylcarbonyl)-4-aza-5alpha-androst-1-en-3-one, process for its preparation and method of inhibiting testosterone-5alpha reductase
AU27481/92A Ceased AU651741B2 (en) 1984-02-27 1992-10-30 22-Methyl-4-aza-21-nor-5alpha-chol-1-en-3,20-dione and 4,22-dimethyl-4-aza-21-nor-5alpha-chol-1-en-3,20-dione as 5alpha-reductase inhibitors

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU33135/89A Expired AU626293B2 (en) 1984-02-27 1989-04-18 17beta-n-monosubstituted carbamoyl or 17beta-acyl-4-aza- 5alpha-androst-1-en-3-ones as 5alpha reductase inhibitors
AU70835/91A Abandoned AU7083591A (en) 1984-02-27 1991-02-06 A 17beta-(cyclohexylcarbonyl)-4-aza-5alpha-androst-1-en-3-one, process for its preparation and method of inhibiting testosterone-5alpha reductase
AU27481/92A Ceased AU651741B2 (en) 1984-02-27 1992-10-30 22-Methyl-4-aza-21-nor-5alpha-chol-1-en-3,20-dione and 4,22-dimethyl-4-aza-21-nor-5alpha-chol-1-en-3,20-dione as 5alpha-reductase inhibitors

Country Status (16)

Country Link
EP (1) EP0155096B1 (2)
JP (1) JPH0193600A (2)
KR (1) KR900001206B1 (2)
AU (4) AU584321B2 (2)
CA (1) CA1314541C (2)
CY (1) CY1553A (2)
DE (2) DE3573429D1 (2)
DK (1) DK166704B1 (2)
ES (1) ES8702430A1 (2)
GR (1) GR850483B (2)
HK (1) HK63090A (2)
IE (2) IE922862L (2)
IL (1) IL74365A (2)
NL (1) NL930005I2 (2)
NZ (1) NZ211145A (2)
PT (1) PT80010B (2)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU608560B2 (en) * 1987-01-28 1991-04-11 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
AU608860B2 (en) * 1987-06-29 1991-04-18 Merck & Co., Inc. Dehydrogenation process and intermediates
AU640279B2 (en) * 1990-10-29 1993-08-19 Sankyo Company Limited Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use
AU658774B2 (en) * 1992-11-19 1995-04-27 Merck Sharp & Dohme Corp. New finasteride processes

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151429A (en) * 1984-02-27 1992-09-29 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α reductase inhibitors
US5138063A (en) * 1984-02-27 1992-08-11 Merck & Co., Inc. 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
US5049562A (en) * 1984-02-27 1991-09-17 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US5120742A (en) * 1984-02-27 1992-06-09 Merck & Co., Inc. 17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors
US5571817A (en) * 1984-02-27 1996-11-05 Merck & Co., Inc. Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
JPS62201896A (ja) * 1986-02-28 1987-09-05 Shiseido Co Ltd 多毛症治療剤
ATE78827T1 (de) * 1986-11-20 1992-08-15 Merck & Co Inc Topisches arzneimittel enthaltend 17-beta-methoxy-carbonyl-4-methyl-4-aza-5-alpha androst-1-en-3- one.
US4845104A (en) * 1986-11-20 1989-07-04 Merck & Co., Inc. Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones
DE3888378T2 (de) * 1987-04-03 1994-09-29 Merck & Co Inc Behandlung von Prostatacarcinoma mit 17-beta-n-monosubstituierten-Carbamoyl-4-aza-5-alpha-Androst-1-en-3-onen.
EP0285382B1 (en) * 1987-04-03 1994-04-13 Merck & Co. Inc. Treatment of androgenic alopecia with 17beta-n-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-en-3-ones
US5116983A (en) * 1988-04-18 1992-05-26 Merck & Co., Inc. Dehydrogenation process intermediates
US5084574A (en) * 1988-04-18 1992-01-28 Merck & Co., Inc. Dehydrogenation process
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
CA2023157A1 (en) * 1989-08-21 1991-02-22 Gary H. Rasmusson 17 beta-acyl-4-aza-5 alpha-androst-1-ene-3-ones as 5 alpha-reductase inhibitors
US5021575A (en) * 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
EP0462662A3 (en) * 1990-06-20 1992-08-19 Merck & Co. Inc. 17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
US5151430A (en) * 1990-06-20 1992-09-29 Merck & Co., Inc. Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5098908A (en) * 1990-06-20 1992-03-24 Merck & Co., Inc. 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5061802A (en) * 1990-06-20 1991-10-29 Merck & Co. Inc. 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
EP0462664A3 (en) * 1990-06-20 1992-11-25 Merck & Co. Inc. Specific 17beta-thiobenzoyl-4-aza-5alpha-androst-1-en-3-ones as antiandrogenic agents
US5162332A (en) * 1990-06-20 1992-11-10 Merck & Co., Inc. Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
EP0462665A3 (en) * 1990-06-20 1993-06-30 Merck & Co. Inc. Selected 17beta-polyaroyl-4-aza-5alpha-androst-1-en-3-ones as steroidal reductase inhibitors
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
US5120847A (en) * 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5091534A (en) * 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5061803A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Process for making 17-beta alkanoyl 3-oxo-4-aza-5-α-androst-1-enes
CA2050824A1 (en) * 1990-09-24 1992-03-25 John M. Williams Process for making 3-oxo-4-aza-androst-1-ene 17-.beta.-ketones
US5061801A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Intermediate for making 3-oxo-4-aza-androst-1-ene 17β-ketones
IL101243A (en) * 1991-03-20 1999-12-22 Merck & Co Inc Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
GB9115676D0 (en) * 1991-07-19 1991-09-04 Erba Carlo Spa Process for the preparation of 17 beta substituted-4-aza-5 alpha-androstan-3-one derivatives
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
EP0547687A1 (en) * 1991-12-18 1993-06-23 Merck & Co. Inc. 17B-N-Substituted adamantyl/norbonanyl carbamoyl-4-aza-5a-and-rost-1-en-3-ones and androstan-3 ones
ATE165368T1 (de) * 1991-12-20 1998-05-15 Glaxo Wellcome Inc Inhibitoren von testosteron-5-alpha reductase.
EP0725074A3 (en) * 1992-04-20 1996-11-20 Sankyo Co Intermediate compounds for the preparation of androst-3,5-diene-3-carboxy derivatives
US5698720A (en) * 1992-04-20 1997-12-16 Sankyo Company, Limited Steroid derivatives
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones
CZ283894A3 (en) * 1992-05-20 1995-09-13 Merck & Co Inc 7beta-substituted 4-aza-5alpha-cholestanones, their use for the preparation of pharmaceutical preparations and pharmaceutical compositions containing thereof
DE69326008T2 (de) * 1992-05-20 2000-03-02 Merck & Co., Inc. 17-amino-substituierte 4-azasteroide als 5-alpha-reductase inhibitoren
AU674145B2 (en) * 1992-05-20 1996-12-12 Merck & Co., Inc. New 17-ester, amide, and ketone derivatives of 3-oxo-4-azasteroids as 5a-reductase inhibitors
US5710275A (en) * 1992-05-20 1998-01-20 Merck & Co., Inc. 7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors
CA2135173A1 (en) * 1992-05-20 1993-11-25 Bruce E. Witzel Ester derivatives of 4-aza-steroids
EP0641204B1 (en) * 1992-05-20 2000-08-16 Merck & Co. Inc. 17-ethers and thioethers of 4-aza-steroids
ATE195129T1 (de) * 1992-05-20 2000-08-15 Merck & Co Inc 4-azasteroide als 5-alpha-reduktase
WO1993023039A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. Substituted 4-aza-5a-androstan-ones as 5a-reductase inhibitors
JPH07506575A (ja) * 1992-05-21 1995-07-20 アンドルシェルシュ・インコーポレイテッド テストステロン５α−レダクターゼ活性の阻害剤
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
US5278159A (en) * 1992-10-06 1994-01-11 Merck & Co., Inc. Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
US5359071A (en) * 1993-03-12 1994-10-25 Merck & Co., Inc. 15-substituted 4-azasteroids
US5621104A (en) * 1993-03-24 1997-04-15 Merck & Co., Inc. Substituted 3-phenanthridinone derivatives as 5-alpha-reductase inhibitors
EP0705272B1 (en) * 1993-06-24 2002-03-27 Richter Gedeon Vegyeszeti Gyar R.T. Novel process for preparing 17 beta-substituted 4-azaandrostane derivatives
DE69405760T2 (de) * 1993-06-28 1998-04-09 Merck & Co Inc 4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren
US5438061A (en) * 1993-07-16 1995-08-01 Merck & Co., Inc. 7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5547957A (en) 1993-10-15 1996-08-20 Merck & Co., Inc. Method of treating androgenic alopecia with 5-α reductase inhibitors
TW382595B (en) * 1993-10-15 2000-02-21 Merck & Co Inc Pharmaceutical composition for use in arresting and reversing androgenic alopecia
HUT74613A (en) * 1993-10-21 1997-01-28 Merck & Co Inc 16-substituted-4-aza-androstane derivatives as 5-alpha-reductase isozyme 1 inhibitors and pharmaceutical compositions containing the same
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
GB0026876D0 (en) * 2000-11-03 2000-12-20 Glaxo Group Ltd Process
WO2003020311A1 (fr) * 2001-08-28 2003-03-13 Fujisawa Pharmaceutical Co., Ltd. Remedes contre les maladies de la peau
DE60313603T2 (de) 2002-04-24 2008-01-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische kombination zur behandlung von benigner prostatahyperplasie oder zur langzeitvorbeugung von akuter harnzurückhaltung
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds
CN1314241C (zh) * 2002-09-27 2007-05-02 华为技术有限公司 在城域网相同虚容器映射通道内传送不同用户数据的方法
KR100508019B1 (ko) 2003-07-19 2005-08-17 한미약품 주식회사 고순도 1-안드로스텐 유도체의 제조 방법
WO2006058781A2 (en) * 2004-12-03 2006-06-08 Proteosys Ag Finasteride, dutasteride and related compounds for preventing/treating neurologically-associated disorders
EP2050436A1 (en) 2007-12-21 2009-04-22 Siegfried Generics International AG Pharmaceutical composition containing dutasteride
CN104292293B (zh) * 2014-09-17 2016-04-06 广东众生药业股份有限公司 一种度他雄胺杂质i的制备方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
EP0200859A1 (en) * 1985-03-07 1986-11-12 FARMITALIA CARLO ERBA S.p.A. Steroidal 5-alpha-reductase inhibitors, processes for their preparation and pharmaceutical compositions containing them

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US3285918A (en) * 1962-04-18 1966-11-15 Norman J Doorenbos 1', 4', 5', 6'-tetrahydropyrimidino[a-4, 3]-4-aza-5-cholestene
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
KR830000085B1 (ko) * 1978-04-13 1983-02-08 제임스 에프. 너우톤 5α-환원효소 억제제로서 유용한 4-아자-17-치환-5α-안드로스탄-3-온류의 제조방법
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
EP0200859A1 (en) * 1985-03-07 1986-11-12 FARMITALIA CARLO ERBA S.p.A. Steroidal 5-alpha-reductase inhibitors, processes for their preparation and pharmaceutical compositions containing them

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU608560B2 (en) * 1987-01-28 1991-04-11 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
AU608860B2 (en) * 1987-06-29 1991-04-18 Merck & Co., Inc. Dehydrogenation process and intermediates
AU640279B2 (en) * 1990-10-29 1993-08-19 Sankyo Company Limited Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use
AU658774B2 (en) * 1992-11-19 1995-04-27 Merck Sharp & Dohme Corp. New finasteride processes

Also Published As

Publication number Publication date
EP0155096A2 (en) 1985-09-18
EP0155096B1 (en) 1989-10-04
IE58058B1 (en) 1993-06-16
GR850483B (2) 1985-06-26
NL930005I1 (nl) 1993-04-01
NZ211145A (en) 1988-10-28
JPH0193600A (ja) 1989-04-12
DE3573429D1 (en) 1989-11-09
AU7083591A (en) 1991-07-11
AU2748192A (en) 1993-03-18
ES8702430A1 (es) 1987-01-01
DE3584172D1 (de) 1991-10-24
DK166704B1 (da) 1993-06-28
AU3916785A (en) 1985-09-05
ES540705A0 (es) 1987-01-01
IL74365A0 (en) 1985-05-31
DK85985D0 (da) 1985-02-26
HK63090A (en) 1990-08-17
IE922862L (en) 1985-08-27
KR900001206B1 (ko) 1990-02-28
PT80010B (pt) 1987-09-18
AU651741B2 (en) 1994-07-28
PT80010A (en) 1985-03-01
IL74365A (en) 1990-07-26
EP0155096A3 (en) 1986-07-02
NL930005I2 (nl) 1993-09-16
DK85985A (da) 1985-10-22
AU626293B2 (en) 1992-07-30
KR850006185A (ko) 1985-10-02
IE850476L (en) 1985-08-27
AU3313589A (en) 1989-08-10
CA1314541C (en) 1993-03-16
JPH0541638B2 (2) 1993-06-24
CY1553A (en) 1991-03-22

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