AU609109B2 - New ribofuranuronic acid derivatives - Google Patents

New ribofuranuronic acid derivatives Download PDF

Info

Publication number
AU609109B2
AU609109B2 AU14151/88A AU1415188A AU609109B2 AU 609109 B2 AU609109 B2 AU 609109B2 AU 14151/88 A AU14151/88 A AU 14151/88A AU 1415188 A AU1415188 A AU 1415188A AU 609109 B2 AU609109 B2 AU 609109B2
Authority
AU
Australia
Prior art keywords
alkyl
desoxy
substituted
group
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU14151/88A
Other languages
English (en)
Other versions
AU1415188A (en
Inventor
Fulvio Gadient
Arnold Vogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of AU1415188A publication Critical patent/AU1415188A/en
Application granted granted Critical
Publication of AU609109B2 publication Critical patent/AU609109B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU14151/88A 1987-04-06 1988-04-05 New ribofuranuronic acid derivatives Ceased AU609109B2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE3711563 1987-04-06
DE3711562 1987-04-06
DE3711564 1987-04-06
DE3711561 1987-04-06
DE3711564 1987-04-06
DE3711562 1987-04-06
DE3711563 1987-04-06
DE3711561 1987-04-06

Publications (2)

Publication Number Publication Date
AU1415188A AU1415188A (en) 1988-10-06
AU609109B2 true AU609109B2 (en) 1991-04-26

Family

ID=27433888

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14151/88A Ceased AU609109B2 (en) 1987-04-06 1988-04-05 New ribofuranuronic acid derivatives

Country Status (22)

Country Link
JP (1) JPS63258892A (fr)
KR (1) KR880012629A (fr)
AT (1) AT393507B (fr)
AU (1) AU609109B2 (fr)
BE (1) BE1002151A5 (fr)
CA (1) CA1326017C (fr)
CH (1) CH676121A5 (fr)
DK (1) DK183488A (fr)
ES (1) ES2007177A6 (fr)
FI (1) FI87463C (fr)
FR (1) FR2613367A1 (fr)
GB (1) GB2203149B (fr)
HU (1) HU201955B (fr)
IL (1) IL85969A (fr)
IT (1) IT1219892B (fr)
LU (1) LU87181A1 (fr)
MY (1) MY102323A (fr)
NL (1) NL8800862A (fr)
NZ (1) NZ224131A (fr)
PH (1) PH25424A (fr)
PT (1) PT87153B (fr)
SE (1) SE8801236L (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755594A (en) * 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
US4954504A (en) * 1986-11-14 1990-09-04 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US5063233A (en) * 1986-11-14 1991-11-05 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
NL8702926A (nl) * 1986-12-15 1988-07-01 Sandoz Ag Nieuwe furanuronzuurderivaten en werkwijzen voor het bereiden en toepassen van deze derivaten.
US4968697A (en) * 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
EP0277917A3 (fr) * 1987-02-04 1990-03-28 Ciba-Geigy Ag Certains dérivés d'adénosine-5'-carboxamide
US5140015A (en) * 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
USRE36494E (en) * 1990-02-20 2000-01-11 Discovery Therapeutics, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
EA200001224A1 (ru) 1998-06-23 2001-08-27 Глаксо Груп Лимитед Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
AR023463A1 (es) 1999-04-16 2002-09-04 Schering Corp Uso de compuestos de azetidinona
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
BRPI0515506A (pt) * 2004-09-20 2008-07-29 Inotek Pharmaceuticals Corp derivados de purina e métodos de uso dos mesmos
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4167565A (en) * 1976-11-08 1979-09-11 Abbott Laboratories Adenosine-5'-carboxamides and method of use
AU1123388A (en) * 1987-02-04 1988-08-18 Ciba-Geigy Ag Certain adenosine 5'-carboxamide derivatives
AU601247B2 (en) * 1986-12-15 1990-09-06 Sandoz Ltd. New furanuronic acid derivatives, process for their production and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH606084A5 (en) * 1975-02-18 1978-10-13 Hoffmann La Roche (Di) nitrates of adenosine -5'-carboxylic acid derivs
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4167565A (en) * 1976-11-08 1979-09-11 Abbott Laboratories Adenosine-5'-carboxamides and method of use
AU601247B2 (en) * 1986-12-15 1990-09-06 Sandoz Ltd. New furanuronic acid derivatives, process for their production and their use
AU1123388A (en) * 1987-02-04 1988-08-18 Ciba-Geigy Ag Certain adenosine 5'-carboxamide derivatives

Also Published As

Publication number Publication date
MY102323A (en) 1992-05-28
IT1219892B (it) 1990-05-24
CA1326017C (fr) 1994-01-11
FI87463C (fi) 1993-01-11
PT87153B (pt) 1992-07-31
DK183488D0 (da) 1988-04-05
PT87153A (pt) 1988-05-01
ES2007177A6 (es) 1989-06-01
KR880012629A (ko) 1988-11-28
FI881571A0 (fi) 1988-04-05
CH676121A5 (fr) 1990-12-14
FI87463B (fi) 1992-09-30
DK183488A (da) 1988-10-07
HUT48902A (en) 1989-07-28
LU87181A1 (fr) 1988-11-17
HU201955B (en) 1991-01-28
AU1415188A (en) 1988-10-06
SE8801236A0 (sv) 1988-10-17
AT393507B (de) 1991-11-11
GB8807750D0 (en) 1988-05-05
ATA87388A (de) 1991-04-15
JPS63258892A (ja) 1988-10-26
IL85969A (en) 1992-03-29
FR2613367A1 (fr) 1988-10-07
SE8801236D0 (sv) 1988-04-05
SE8801236L (sv) 1988-10-17
IL85969A0 (en) 1988-09-30
PH25424A (fr) 1991-07-01
FI881571L (fi) 1988-10-07
BE1002151A5 (fr) 1990-08-07
GB2203149A (en) 1988-10-12
IT8847794A0 (it) 1988-03-30
GB2203149B (en) 1991-02-13
NL8800862A (nl) 1988-11-01
NZ224131A (en) 1991-12-23

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