AU609390B2 - Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs - Google Patents

Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs

Info

Publication number
AU609390B2
AU609390B2 AU71609/87A AU7160987A AU609390B2 AU 609390 B2 AU609390 B2 AU 609390B2 AU 71609/87 A AU71609/87 A AU 71609/87A AU 7160987 A AU7160987 A AU 7160987A AU 609390 B2 AU609390 B2 AU 609390B2
Authority
AU
Australia
Prior art keywords
cyclodextrinclathrates
medicinal drugs
carbacycline derivatives
carbacycline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU71609/87A
Other languages
English (en)
Other versions
AU7160987A (en
Inventor
Helmut Dahl
Werner Skuballa
Claus-Steffen Sturzebecher
Karl-Heinz Thierauch
Helmut Vorbruggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU7160987A publication Critical patent/AU7160987A/en
Application granted granted Critical
Publication of AU609390B2 publication Critical patent/AU609390B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nanotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU71609/87A 1986-03-07 1987-03-09 Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs Expired AU609390B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3608088A DE3608088C2 (de) 1986-03-07 1986-03-07 Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
DE3608088 1986-03-07

Publications (2)

Publication Number Publication Date
AU7160987A AU7160987A (en) 1987-09-28
AU609390B2 true AU609390B2 (en) 1991-05-02

Family

ID=6296073

Family Applications (2)

Application Number Title Priority Date Filing Date
AU69886/87A Abandoned AU6988687A (en) 1986-03-07 1987-03-09 Cyclodextrin clathrate and its use as a medicinal agent
AU71609/87A Expired AU609390B2 (en) 1986-03-07 1987-03-09 Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU69886/87A Abandoned AU6988687A (en) 1986-03-07 1987-03-09 Cyclodextrin clathrate and its use as a medicinal agent

Country Status (22)

Country Link
US (1) US4886788A (de)
EP (1) EP0259468B1 (de)
JP (2) JPH07107020B2 (de)
AT (1) AT397084B (de)
AU (2) AU6988687A (de)
CA (1) CA1309087C (de)
CH (1) CH672313A5 (de)
CS (1) CS270558B2 (de)
DD (1) DD258942A5 (de)
DE (3) DE3608088C2 (de)
ES (1) ES2004543A6 (de)
FI (1) FI92388C (de)
GB (2) GB2189783A (de)
GR (1) GR870363B (de)
HU (1) HU198906B (de)
IE (1) IE59760B1 (de)
IL (1) IL81802A (de)
NO (1) NO173440C (de)
NZ (1) NZ219508A (de)
SU (1) SU1632371A3 (de)
WO (1) WO1987005294A1 (de)
ZA (1) ZA871663B (de)

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US4663316A (en) * 1985-06-28 1987-05-05 Warner-Lambert Company Antibiotic clathrates and pharmaceutical compositions thereof
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
DE3740838A1 (de) * 1987-11-27 1989-06-08 Schering Ag Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
EP0410652B1 (de) * 1989-07-27 1995-05-17 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Verwendung von 15-Keto-Prostansäure-Derivaten zur Herstellung eines Medikaments für die Verbesserung der Ausscheidung des Kaliumions
DE3933523A1 (de) * 1989-10-05 1991-04-11 Schering Ag Antimetastatisch wirkende mittel
DE4010355A1 (de) * 1990-03-28 1991-10-02 Schering Ag Bicyclo(3.3.0)octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE4104606C1 (de) * 1991-02-12 1992-10-15 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
US5221735A (en) * 1991-02-25 1993-06-22 Hoffmann-La Roche Inc. Cyclodextrin-polyene inclusion complexes
DE4135193C1 (de) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
US6103403A (en) * 1997-05-15 2000-08-15 University Of Kentucky Research Foundation Intellectual Property Development Clathrate structure for electronic and electro-optic applications
DE19808634A1 (de) 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
DE19828881A1 (de) * 1998-06-22 1999-12-23 Schering Ag Oxidationsinhibitor bei Prostan-Derivaten
DE10225551A1 (de) * 2002-06-06 2003-12-24 Schering Ag Verwendung von oral verfügbaren Prostacyclinderivaten für die Herstellung eines Arzneimittels zur Behandlung von Krankheiten, die mit Knochenmarködemen assoziiert sind
MY145694A (en) * 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
WO2007079078A1 (en) 2005-12-29 2007-07-12 Bayer Schering Pharma Aktiengesellschaft Diamine derivatives as inhibitors of leukotriene a4 hydrolase
JPWO2008018592A1 (ja) * 2006-08-11 2010-01-07 大正製薬株式会社 プロスタグランジン誘導体含有外用剤
JP2010506853A (ja) * 2006-10-12 2010-03-04 ゼノン・ファーマシューティカルズ・インコーポレイテッド 疼痛などのナトリウムチャネル媒介性の疾患の処置のための、スピロ（［３，２−フロ］ピリジン−３，３’−インドール）−２’（１’ｈ）−オン誘導体および関連化合物
AR063280A1 (es) 2006-10-12 2009-01-21 Xenon Pharmaceuticals Inc Uso de compuestos de espiro-oxindol como agentes terapeuticos
CN105218565A (zh) 2008-10-17 2016-01-06 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
CA2741024A1 (en) 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
MX2012004373A (es) * 2009-10-14 2012-06-28 Xenon Pharmaceuticals Inc Metodos sinteticos para compuestos espiro-oxoindol.
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
CA2788440A1 (en) 2010-02-26 2011-09-01 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
EA201491854A1 (ru) 2012-04-12 2015-03-31 Ксенон Фармасьютикалз Инк. Асимметрический синтез соединений спирооксиндола, полезных в качестве терапевтических средств
MX2015011677A (es) 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
US10100060B2 (en) 2016-06-16 2018-10-16 Xenon Pharmaceuticals Inc. Asymmetric synthesis of funapide
AU2017371348B2 (en) 2016-12-09 2022-02-03 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
CA3045887A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
AU2017371353B2 (en) 2016-12-09 2022-02-03 Celltaxis, Llc Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase
HU231212B1 (hu) * 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására
RU2741848C1 (ru) * 2019-03-16 2021-01-29 Иванова Мария Ивановна Способ получения клатратных комплексов летучих веществ
JP7671358B2 (ja) * 2021-09-13 2025-05-01 富士フイルム株式会社 ビシクロアルカン化合物の包摂体の製造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56150039A (en) * 1980-04-22 1981-11-20 Sankyo Co Ltd Clathrate compound of prostacycline derivative
AU6988687A (en) * 1986-03-07 1987-09-10 Schering Aktiengesellschaft Cyclodextrin clathrate and its use as a medicinal agent

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JPS503362B1 (de) * 1970-06-10 1975-02-04
AU476695B2 (en) * 1974-01-15 1975-07-17 Ono Pharmaceutical Co. Ltd Clathrate prostaglandins and compositions containing same
HU179141B (de) * 1977-09-23 1982-08-28
IT1113341B (it) * 1978-03-31 1986-01-20 Ono Pharmaceutical Co Analoghi della 6,9-metano-pgi2
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
DE2950027A1 (de) * 1979-12-10 1981-06-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE3126924A1 (de) * 1981-07-03 1983-01-20 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
JPS5818357A (ja) * 1981-07-28 1983-02-02 Ono Pharmaceut Co Ltd ６，９−メタノ−ｐｇｉ↓２及び６，９−メタノ−ｐｇｉ↓２類似化合物の安定化組成物及びその製造方法
JPS58116423A (ja) * 1981-12-28 1983-07-11 Sumitomo Chem Co Ltd メタノプロスタサイクリン製剤組成物
JPS58192821A (ja) * 1982-04-30 1983-11-10 Dainippon Pharmaceut Co Ltd 脳神経細胞の酸素欠乏性疾患の治療剤
US4517202A (en) * 1982-05-28 1985-05-14 May & Baker Limited Prostaglandin analogues
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
DE3306123A1 (de) * 1983-02-18 1984-09-06 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2547818B1 (fr) * 1983-05-24 1986-09-05 May & Baker Ltd Nouveaux analogues de prostaglandines, leur preparation, les compositions pharmaceutiques qui les contiennent et les intermediaires-cles pour les preparer
DE3405181A1 (de) * 1984-02-10 1985-08-22 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0171992B1 (de) * 1984-08-09 1990-06-06 Mitsubishi Kasei Corporation Arzneimittel die Prostaglandin I2 enthalten
JPS6144819A (ja) * 1984-08-09 1986-03-04 Sagami Chem Res Center プロスタグランジンｉ２類縁化合物を含有する循環改善作用を有する薬剤
US4757087A (en) * 1985-03-19 1988-07-12 Sankyo Company Limited Carbacyclin derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56150039A (en) * 1980-04-22 1981-11-20 Sankyo Co Ltd Clathrate compound of prostacycline derivative
AU6988687A (en) * 1986-03-07 1987-09-10 Schering Aktiengesellschaft Cyclodextrin clathrate and its use as a medicinal agent

Also Published As

Publication number Publication date
NO874632D0 (no) 1987-11-06
JP2634787B2 (ja) 1997-07-30
JPH07107020B2 (ja) 1995-11-15
HU198906B (en) 1989-12-28
GB8704982D0 (en) 1987-04-08
CH672313A5 (de) 1989-11-15
FI92388C (fi) 1994-11-10
FI874406A7 (fi) 1987-10-07
JPH08193046A (ja) 1996-07-30
NO173440C (no) 1993-12-15
AU6988687A (en) 1987-09-10
FI874406A0 (fi) 1987-10-07
SU1632371A3 (ru) 1991-02-28
DE3770085D1 (de) 1991-06-20
EP0259468A1 (de) 1988-03-16
ZA871663B (en) 1987-08-28
AU7160987A (en) 1987-09-28
IE870586L (en) 1987-09-07
US4886788A (en) 1989-12-12
NO874632L (no) 1987-11-06
CA1309087C (en) 1992-10-20
CS151187A2 (en) 1989-11-14
IL81802A0 (en) 1987-10-20
JPS63502665A (ja) 1988-10-06
EP0259468B1 (de) 1991-05-15
DE3608088A1 (de) 1987-09-10
GB2189783A (en) 1987-11-04
HUT45484A (en) 1988-07-28
AT397084B (de) 1994-01-25
WO1987005294A1 (fr) 1987-09-11
IL81802A (en) 1991-07-18
NO173440B (no) 1993-09-06
CS270558B2 (en) 1990-07-12
FI92388B (fi) 1994-07-29
IE59760B1 (en) 1994-03-23
DE3608088C2 (de) 1995-11-16
DD258942A5 (de) 1988-08-10
ES2004543A6 (es) 1989-01-16
ATA900787A (de) 1993-06-15
GR870363B (en) 1987-06-30
GB2199031A (en) 1988-06-29
GB2199031B (en) 1990-01-10
NZ219508A (en) 1990-08-28
DE3790121D2 (en) 1988-03-10
GB8725695D0 (en) 1987-12-09

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