AU733091B2 - Isoxazole derivatives - Google Patents

Isoxazole derivatives Download PDF

Info

Publication number
AU733091B2
AU733091B2 AU61934/98A AU6193498A AU733091B2 AU 733091 B2 AU733091 B2 AU 733091B2 AU 61934/98 A AU61934/98 A AU 61934/98A AU 6193498 A AU6193498 A AU 6193498A AU 733091 B2 AU733091 B2 AU 733091B2
Authority
AU
Australia
Prior art keywords
group
substituted
ethyl
unsubstituted
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU61934/98A
Other languages
English (en)
Other versions
AU6193498A (en
Inventor
Masashi Nakatsuka
Fumio Nishikaku
Shinichiro Okada
Yoshihide Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Publication of AU6193498A publication Critical patent/AU6193498A/en
Application granted granted Critical
Publication of AU733091B2 publication Critical patent/AU733091B2/en
Assigned to DAINIPPON SUMITOMO PHARMA CO., LTD. reassignment DAINIPPON SUMITOMO PHARMA CO., LTD. Alteration of Name(s) in Register under S187 Assignors: SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
AU61934/98A 1997-04-21 1998-04-17 Isoxazole derivatives Ceased AU733091B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11887197 1997-04-21
JP9-118871 1997-04-21
JP9-367154 1997-12-24
JP36715497 1997-12-24

Publications (2)

Publication Number Publication Date
AU6193498A AU6193498A (en) 1998-10-22
AU733091B2 true AU733091B2 (en) 2001-05-03

Family

ID=26456721

Family Applications (1)

Application Number Title Priority Date Filing Date
AU61934/98A Ceased AU733091B2 (en) 1997-04-21 1998-04-17 Isoxazole derivatives

Country Status (14)

Country Link
EP (1) EP0979226B1 (de)
KR (1) KR100512087B1 (de)
CN (1) CN1138764C (de)
AT (1) ATE309228T1 (de)
AU (1) AU733091B2 (de)
CA (1) CA2235298C (de)
DE (1) DE69832270T2 (de)
DK (1) DK0979226T3 (de)
ES (1) ES2248894T3 (de)
ID (1) ID22897A (de)
NZ (1) NZ330244A (de)
RU (1) RU2196770C2 (de)
TW (1) TW442476B (de)
WO (1) WO1998047880A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202095C (zh) * 1999-07-15 2005-05-18 住友制药株式会社 杂芳环化合物
WO2001047895A1 (en) * 1999-12-28 2001-07-05 Sumitomo Pharmaceuticals Company, Limited Novel compounds having five-membered hetero-aromatic rings
GB0010183D0 (en) * 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
WO2002092094A1 (en) 2001-03-27 2002-11-21 Sumitomo Pharmaceuticals Co., Ltd. Crystalline isoxazole derivative and medical preparation thereof
WO2003068239A1 (en) * 2002-02-12 2003-08-21 Sumitomo Pharmaceuticals Co., Ltd. Novel drugs for external use
US7618632B2 (en) * 2003-05-23 2009-11-17 Wyeth Method of treating or ameliorating an immune cell associated pathology using GITR ligand antibodies
ITMI20040019A1 (it) * 2004-01-12 2004-04-12 Univ Bari Derivati isossazolici e loro impiego come inibitori della ciclossigenasi
DE102004008141A1 (de) * 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
CA2589808A1 (en) * 2004-11-02 2006-05-11 Dainippon Sumitomo Pharma Co., Ltd. Combination drug for treating autoimmune disease
US7989450B2 (en) 2008-01-11 2011-08-02 Universita' Degli Studi Di Bari Functionalized diarylisoxazoles inhibitors of ciclooxygenase
JP5969505B2 (ja) * 2011-01-28 2016-08-17 ４エスツェー ディスカバリー ゲゼルシャフト ミット ベシュレンクテル ハフツング 自己免疫性炎症の治療のためのＩＬ１７及びＩＦＮ−γ阻害
DE102014201651A1 (de) * 2014-01-30 2015-07-30 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Isoxazolderivate zur Verwendung bei der Behandlung und/oder Prophylaxe von Herzerkrankungen
CN111269149B (zh) * 2020-04-08 2022-04-15 南京优氟医药科技有限公司 一种5-(3,3-二甲基胍基)-2-氧代戊酸的生产工艺
CN114478350B (zh) * 2022-01-25 2023-08-11 苏州大学 一种c3-烷基化吲哚的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2068418A1 (en) * 1969-10-27 1971-08-27 Innothera Lab Sa 2-substd-5-amino isoxazole derivs
US3720685A (en) * 1970-07-15 1973-03-13 Squibb & Sons Inc 3-amino-5-benzyl-1,2,4-oxadiazoles
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
DE2341507A1 (de) * 1973-08-16 1975-02-27 Thomae Gmbh Dr K Neue biphenylderivate und verfahren zur herstellung
JPS54144347A (en) * 1978-05-02 1979-11-10 Nikken Kagaku Kk 3-(2-fluoro-4-biphenylyl)-2-butanone
HU180567B (en) * 1980-03-19 1983-03-28 Egyt Gyogyszervegyeszeti Gyar Method for producing derivatives of isooxazole
US4399075A (en) * 1981-06-25 1983-08-16 Asahi Chemical Company, Limited Process for producing chlorinated phenoxytoluene derivatives
JPS58150576A (ja) * 1982-03-03 1983-09-07 Sumitomo Chem Co Ltd 新規な１，２，４−オキサジアゾ−ル誘導体
US4680300A (en) * 1985-01-10 1987-07-14 Syntex (U.S.A.) Inc. Anti-inflammatory guanidines
US4914112A (en) * 1986-06-03 1990-04-03 Sumitomo Pharmaceuticals Company, Limited Aminoazole derivatives and their production and use
ES2061556T3 (es) * 1987-05-26 1994-12-16 Sumitomo Chemical Co Derivados amida y su produccion y fungicidas agricolas que los contienen.
JP2719742B2 (ja) * 1991-04-30 1998-02-25 株式会社大塚製薬工場 フェニルチアゾール誘導体
US5514643A (en) * 1993-08-16 1996-05-07 Lucky Ltd. 2-aminothiazolecarboxamide derivatives, processes for preparing the same and use thereof for controlling phytopathogenic organisms

Also Published As

Publication number Publication date
TW442476B (en) 2001-06-23
DE69832270T2 (de) 2006-07-13
CA2235298A1 (en) 1998-10-21
ATE309228T1 (de) 2005-11-15
DE69832270D1 (de) 2005-12-15
KR100512087B1 (ko) 2005-09-05
ES2248894T3 (es) 2006-03-16
ID22897A (id) 1999-12-16
CN1252794A (zh) 2000-05-10
CN1138764C (zh) 2004-02-18
RU2196770C2 (ru) 2003-01-20
CA2235298C (en) 2008-05-13
NZ330244A (en) 2000-01-28
DK0979226T3 (da) 2006-03-06
AU6193498A (en) 1998-10-22
EP0979226A1 (de) 2000-02-16
WO1998047880A1 (en) 1998-10-29
KR20010006501A (ko) 2001-01-26
EP0979226B1 (de) 2005-11-09

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FGA Letters patent sealed or granted (standard patent)