BE1001938A4 - Nouveau procede de preparation des polynucleotides produits ainsi obtenus et preparations pharmaceutiques en contenant. - Google Patents

Nouveau procede de preparation des polynucleotides produits ainsi obtenus et preparations pharmaceutiques en contenant. Download PDF

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Publication number
BE1001938A4
BE1001938A4 BE8801243A BE8801243A BE1001938A4 BE 1001938 A4 BE1001938 A4 BE 1001938A4 BE 8801243 A BE8801243 A BE 8801243A BE 8801243 A BE8801243 A BE 8801243A BE 1001938 A4 BE1001938 A4 BE 1001938A4
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BE
Belgium
Prior art keywords
preparation
preparations containing
same
pharmaceutical preparations
novel process
Prior art date
Application number
BE8801243A
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English (en)
Inventor
De Lassauniere Pierre Chabrier
Acaye Soudhir Colote
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application granted granted Critical
Publication of BE1001938A4 publication Critical patent/BE1001938A4/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un procédé de préparation de polymères de nucléotides dans lequel un lysat d'une culture de souche bactérienne est filtré successivement à travers trois colonnes (résine échangeuse d'ions, résine hydrophobique et tamis moléculaire), ce grâce à quoi on obtient une solution de polynucléotide-phosphorylase substantiellement pure. Une polymérisation ultérieure par cet agent permet d'obtenir des produits non toxiques et non pyrogènes. L'invention concerne également les produits obtenus selon ce procédé et les préparations thérapeutiques en contenant.
BE8801243A 1987-11-02 1988-10-28 Nouveau procede de preparation des polynucleotides produits ainsi obtenus et preparations pharmaceutiques en contenant. BE1001938A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878725606A GB8725606D0 (en) 1987-11-02 1987-11-02 Preparation polynucleotides

Publications (1)

Publication Number Publication Date
BE1001938A4 true BE1001938A4 (fr) 1990-04-17

Family

ID=10626275

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8801243A BE1001938A4 (fr) 1987-11-02 1988-10-28 Nouveau procede de preparation des polynucleotides produits ainsi obtenus et preparations pharmaceutiques en contenant.

Country Status (29)

Country Link
US (1) US4927755A (fr)
JP (1) JPH0712316B2 (fr)
KR (1) KR0134624B1 (fr)
AR (1) AR244342A1 (fr)
AT (1) AT396251B (fr)
AU (1) AU610792B2 (fr)
BE (1) BE1001938A4 (fr)
CA (1) CA1339911C (fr)
CH (1) CH676248A5 (fr)
DE (1) DE3837203A1 (fr)
DK (1) DK607388A (fr)
ES (1) ES2009099A6 (fr)
FI (1) FI95135C (fr)
FR (2) FR2622586B1 (fr)
GB (2) GB8725606D0 (fr)
GR (1) GR1000715B (fr)
HK (1) HK47692A (fr)
IE (1) IE61610B1 (fr)
IT (1) IT1227447B (fr)
MY (1) MY103445A (fr)
NL (1) NL194949C (fr)
NO (1) NO172902C (fr)
NZ (1) NZ226643A (fr)
OA (1) OA10206A (fr)
PT (1) PT88903B (fr)
SE (1) SE503401C2 (fr)
SG (1) SG40792G (fr)
TN (1) TNSN88113A1 (fr)
ZA (1) ZA888180B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9108085D0 (en) * 1991-04-16 1991-06-05 Scras Complexes of polyadenylic acid with polyuridylic acid
AR013269A1 (es) * 1997-08-04 2000-12-13 Scras Producto que contiene por lo menos un rna de doble filamento combinado con por lo menos un agente anti-viral, para la utilizacion terapeutica en eltratamiento de una enfermedad viral, en especial de la hepatitis viral
EP2258712A3 (fr) * 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Compositions et procédés permettant d'initier ou d'ameliorer les réponses des cellules T limitées par le complexe majeur d 'histocompatibilité de classe I ou II et un anticorps au moyen de motifs d'ARN non codants immunomodulateurs
EP1582584A4 (fr) * 2002-12-26 2006-05-31 Nippon Shinyaku Co Ltd Procede de production de pnpase
KR20060129340A (ko) * 2003-12-30 2006-12-15 시그마-알드리치컴퍼니 효소 소화에 의한 핵산의 신속한 제조
AU2009239655B2 (en) 2008-04-25 2014-05-22 Innate Pharma Improved TLR3 agonist compositions
WO2012092540A1 (fr) * 2010-12-30 2012-07-05 Ibis Biosciences, Inc. Procédés de synthèse d'acide polyadénylique
MX2022009001A (es) * 2020-01-24 2022-10-27 Aim Immunotech Inc Arn bicatenario terapéutico y métodos para producirlo.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2252350A1 (en) * 1973-11-22 1975-06-20 Choay Sa Polynucleotide phosphorylase - extraction from E coli, fixation on sepharose, and use in preparing polynucleotides
SU601287A1 (ru) * 1976-05-12 1978-04-05 Предприятие П/Я М-5043 Способ получени полирибонуклеотидов
US4379843A (en) * 1981-01-26 1983-04-12 Peter Cashion Immobilization of polynucleotides and polypeptides with tritylated polysaccharides

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU6012A1 (ru) * 1927-04-04 1928-07-31 Л.С. Кравцов Горизонтальный вод ной двигатель с поворотными лопаст ми
JPS4940954B1 (fr) * 1970-02-16 1974-11-06
DE2056081A1 (en) * 1970-11-14 1972-06-22 Pabst Brewing Company, Milwaukee, Wis. (V.StA.) Poly nucleotides prepn
IL37076A (en) * 1971-06-16 1974-05-16 Littauer U A method for stepwise synthesis of oligoribonucleotides of defined sequence using 2'(3')-o-acyl-nucleoside diphosphates and polynucleotide phosphorylase
JPS524633B2 (fr) * 1972-07-21 1977-02-05
GB1435571A (en) * 1973-04-02 1976-05-12 Searle & Co Polynucleotides
DE2319495C2 (de) * 1973-04-17 1985-01-10 Yeda Research And Development Co., Ltd., Rehovot Verfahren zum selektiven, reversiblen Binden von Biomolekülen an ein Adsorbens in einer chromatographischen Säule
JPS50107187A (fr) * 1974-02-08 1975-08-23
US4006059A (en) * 1974-07-29 1977-02-01 Purdue Research Foundation Hydrophobic noncovalent binding of proteins to support materials
US4000098A (en) * 1974-08-16 1976-12-28 Palo Alto Medical Research Foundation Separation of proteins by hydrophobic adsorption
US4075195A (en) * 1976-08-31 1978-02-21 Kraft, Inc. Debittered protein product and method for manufacture
SU619508A1 (ru) * 1976-12-07 1978-08-15 Предприятие П/Я Г-4740 Способ получени полинуклеотидов, обладающих полирибонуклеотидфосфорилазной активностью
JPS5922518B2 (ja) * 1977-03-09 1984-05-26 三菱化学株式会社 ポリグアニル酸の製造方法
JPS5618597A (en) * 1979-07-23 1981-02-21 Mitsubishi Chem Ind Ltd Production of oligonucleotide
US4617376A (en) * 1985-07-01 1986-10-14 Eli Lilly And Company Process for recovering glucagon from pancreas glands
US4771128A (en) * 1986-10-10 1988-09-13 Cetus Corporation Method of purifying toxin conjugates using hydrophobic interaction chromatography

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2252350A1 (en) * 1973-11-22 1975-06-20 Choay Sa Polynucleotide phosphorylase - extraction from E coli, fixation on sepharose, and use in preparing polynucleotides
SU601287A1 (ru) * 1976-05-12 1978-04-05 Предприятие П/Я М-5043 Способ получени полирибонуклеотидов
US4379843A (en) * 1981-01-26 1983-04-12 Peter Cashion Immobilization of polynucleotides and polypeptides with tritylated polysaccharides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 77, no. 9, 28 août 1972, page 351, résumé no. 60085f, Columbus, Ohio, US; & JP-A-72 16 796 (TAKEDA CHEMICAL INDUSTRIES LTD) 17-05-1972 *
CHEMICAL ABSTRACTS, vol. 85, 1976, page 210, résumé no. 74047x, Columbus, Ohio, US; J.C. SMITH et al.: "Purification of polynucleotide phosphorylase by affinity chromatography and some properties of the purified enzymes", & NUCLEIC ACIDS RES. 1974, 1(12), 1763-73 *
JOURNAL OF BIOLOGICAL RESPONSE MODIFIERS, vol. 4, 1985, pages 129-133, Raven Press, New York, US; J.P. DUCRET et al.: "A phase I clinical tolerance study of polyadenylic-polyuridylic acid in cancer patients" *
SOVIET INVENTIONS ILLUSTRATED, no. 15303B/08, semaine B08, 4 avril 1979; & SU-A-601 287 (D.E. GRAVITE) 15-03-1978 *
THE JOURNAL OF IMMUNOLOGY, vol. 106, no. 5, mai 1971, pages 1191-1200, The Williams & Wilkins Co., US; J.R. SCHMIDTKE et al.: "Regulation of the immune system by synthetic polynucleotides" *

Also Published As

Publication number Publication date
HK47692A (en) 1992-07-10
GR1000715B (el) 1992-11-23
AU610792B2 (en) 1991-05-23
PT88903B (pt) 1993-02-26
JPH01148196A (ja) 1989-06-09
NL8802617A (nl) 1989-06-01
JPH0712316B2 (ja) 1995-02-15
NO884865L (no) 1989-05-03
GB2211847A (en) 1989-07-12
NL194949B (nl) 2003-04-01
SG40792G (en) 1992-06-12
FI95135C (fi) 1995-12-27
ATA267788A (de) 1992-11-15
AT396251B (de) 1993-07-26
MY103445A (en) 1993-06-30
FI885045L (fi) 1989-05-03
IT1227447B (it) 1991-04-11
IE883290L (en) 1989-05-02
SE503401C2 (sv) 1996-06-10
OA10206A (fr) 1997-01-16
KR0134624B1 (ko) 1998-04-20
GB8725606D0 (en) 1987-12-09
ES2009099A6 (es) 1989-08-16
ZA888180B (en) 1989-07-26
FI885045A0 (fi) 1988-11-02
FR2622451A1 (fr) 1989-05-05
US4927755A (en) 1990-05-22
NO172902B (no) 1993-06-14
IT8822471A0 (it) 1988-10-31
FI95135B (fi) 1995-09-15
CH676248A5 (fr) 1990-12-28
NL194949C (nl) 2003-08-04
FR2622586B1 (fr) 1992-02-21
PT88903A (pt) 1988-11-01
KR890008163A (ko) 1989-07-10
FR2622451B1 (fr) 1992-02-21
IE61610B1 (en) 1994-11-16
NO884865D0 (no) 1988-11-01
DK607388A (da) 1989-05-03
SE8803930D0 (sv) 1988-10-31
AU2442988A (en) 1989-05-04
DE3837203A1 (de) 1989-05-11
DK607388D0 (da) 1988-11-01
AR244342A1 (es) 1993-10-29
TNSN88113A1 (fr) 1990-07-10
GB2211847B (en) 1992-01-22
NZ226643A (en) 1990-11-27
SE8803930L (sv) 1989-05-03
GB8825399D0 (en) 1988-11-30
FR2622586A1 (fr) 1989-05-05
DE3837203C2 (fr) 1991-08-08
CA1339911C (fr) 1998-06-16
NO172902C (no) 1993-09-22

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Effective date: 20041031

RE Patent lapsed

Effective date: 20041031