BE1002696A3 - Derives de dioxazocine, leur procede de preparation et compositions pharmaceutiques les contenant. - Google Patents

Derives de dioxazocine, leur procede de preparation et compositions pharmaceutiques les contenant. Download PDF

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Publication number
BE1002696A3
BE1002696A3 BE8801449A BE8801449A BE1002696A3 BE 1002696 A3 BE1002696 A3 BE 1002696A3 BE 8801449 A BE8801449 A BE 8801449A BE 8801449 A BE8801449 A BE 8801449A BE 1002696 A3 BE1002696 A3 BE 1002696A3
Authority
BE
Belgium
Prior art keywords
preparation
derivatives
pharmaceutical compositions
compositions containing
dioxazocin
Prior art date
Application number
BE8801449A
Other languages
English (en)
Inventor
Laszlo Rozsa
Lujza Petocz
Kiszelly Eniko Sziri
Marton Fekete
Hegedues Maria Szecsey
Gabor Gigler
Istvan Gacsalyi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of BE1002696A3 publication Critical patent/BE1002696A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/01—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having one nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Dérivés de dioxazocine, leur préparation et des compositions les contenant, ces dérivés étant représentés par la formule (fig. 1) dans laquelle R1 représente un atome d'hydrogène ou un groupe alkyle ayant 1 à 4 atomes de carbone, R2 représente un groupe alkyle de 1 à 4 atomes de carbone, et n est égal à 0 ou 1, et leurs sels d'addition acides acceptables du point de vue pharmaceutique formés avec un acide inorganique ou organique. On décrit deux réactions différentes pour préparer ces composés. Ils peuvent être formulés en compositions pharmaceutiques de façon habituelle et ils présentent des activités touchant le système nerveux central.
BE8801449A 1987-12-31 1988-12-30 Derives de dioxazocine, leur procede de preparation et compositions pharmaceutiques les contenant. BE1002696A3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU876170A HU201318B (en) 1987-12-31 1987-12-31 Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same

Publications (1)

Publication Number Publication Date
BE1002696A3 true BE1002696A3 (fr) 1991-05-07

Family

ID=10971300

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8801449A BE1002696A3 (fr) 1987-12-31 1988-12-30 Derives de dioxazocine, leur procede de preparation et compositions pharmaceutiques les contenant.

Country Status (22)

Country Link
US (1) US4965259A (fr)
JP (1) JPH01213273A (fr)
KR (1) KR890009896A (fr)
CN (1) CN1034926A (fr)
AU (1) AU610678B2 (fr)
BE (1) BE1002696A3 (fr)
CH (1) CH677669A5 (fr)
CS (1) CS272247B2 (fr)
DE (1) DE3844394A1 (fr)
DK (1) DK733688A (fr)
ES (1) ES2010855A6 (fr)
FI (1) FI886065A7 (fr)
FR (1) FR2625503A1 (fr)
GB (1) GB2213480B (fr)
GR (1) GR1000098B (fr)
HU (1) HU201318B (fr)
IT (1) IT1227920B (fr)
NL (1) NL8803218A (fr)
PL (1) PL154357B1 (fr)
SE (1) SE8804696L (fr)
SU (1) SU1641190A3 (fr)
YU (1) YU240088A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198194B (en) * 1986-12-30 1989-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of new derivatives of dioxazocin and medical compositions containing them
ES2058761T3 (es) * 1989-10-20 1994-11-01 Akzo Nv Proceso para la preparacion de derivados de dibenzodioxazecina y dibenzodioxaazacicloundecina.
PL186708B1 (pl) * 1995-09-19 2004-02-27 Novo Nordisk As Nowe związki heterocykliczne, sposób ich wytwarzania, kompozycje je zawierające oraz ich stosowaniedo wytwarzania leków

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2001980A (en) * 1977-08-02 1979-02-14 Egyt Gyogyszervegyeszeti Gyar Dioxazocine derivatives their preparation and compositions containing them

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL108827C (fr) * 1956-04-09
US3258459A (en) * 1962-08-30 1966-06-28 Squibb & Sons Inc Method for the preparation of n-monosubstituted-secondary aminoalkyl derivatives of polycyclic compounds
US3803143A (en) * 1969-09-08 1974-04-09 Eisai Co Ltd 6-amino alkylene 6,7-dihydro-5h-dibenzo (b,g),(1,5)thiazocines
GB1464431A (en) * 1974-03-25 1977-02-16 Roche Products Ltd Indolobenzazepine derivatives and a process for the manufacture thereof
HU195491B (en) * 1985-12-20 1988-05-30 Egyt Gyogyszervegyeszeti Gyar Process for production of optically active 2-chlor-12-/3-/dimethil-amin/-2-methil-prophil/-12h-dibenzol /d,g/ /1,3,6/-diaxazocine and medical compositions containing such compounds
HU198194B (en) * 1986-12-30 1989-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of new derivatives of dioxazocin and medical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2001980A (en) * 1977-08-02 1979-02-14 Egyt Gyogyszervegyeszeti Gyar Dioxazocine derivatives their preparation and compositions containing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ARZNEIMITTEL-FORSCHUNG, vol. 26, no. 6, June 1976, pages 1036-1039, Aulendorf, DE; W. HAEFELY et al.: "Interaction of psychotropic agents with central neurotransmitters as revealed by their effects on PGO waves in the cat" *

Also Published As

Publication number Publication date
IT1227920B (it) 1991-05-14
HUT50144A (en) 1989-12-28
GB2213480A (en) 1989-08-16
GR1000098B (el) 1991-03-15
AU2763788A (en) 1989-07-06
CS910288A2 (en) 1990-03-14
GB8830416D0 (en) 1989-03-01
SE8804696D0 (sv) 1988-12-29
ES2010855A6 (es) 1989-12-01
DK733688A (da) 1989-07-01
FI886065A7 (fi) 1989-07-01
FR2625503A1 (fr) 1989-07-07
NL8803218A (nl) 1989-07-17
CH677669A5 (fr) 1991-06-14
AU610678B2 (en) 1991-05-23
YU240088A (en) 1990-02-28
PL154357B1 (en) 1991-08-30
US4965259A (en) 1990-10-23
GB2213480B (en) 1991-06-26
DK733688D0 (da) 1988-12-30
DE3844394A1 (de) 1989-07-13
CN1034926A (zh) 1989-08-23
HU201318B (en) 1990-10-28
JPH01213273A (ja) 1989-08-28
PL276891A1 (en) 1989-12-27
SU1641190A3 (ru) 1991-04-07
KR890009896A (ko) 1989-08-04
IT8823183A0 (it) 1988-12-30
SE8804696L (sv) 1989-07-01
CS272247B2 (en) 1991-01-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: EGIS GYOGYSZERGYAR

Effective date: 19921231