BE904796A - Nouveaux derives du morphinane et de la morphine, leur preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant. - Google Patents

Nouveaux derives du morphinane et de la morphine, leur preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant.

Info

Publication number
BE904796A
BE904796A BE1/011493A BE1011493A BE904796A BE 904796 A BE904796 A BE 904796A BE 1/011493 A BE1/011493 A BE 1/011493A BE 1011493 A BE1011493 A BE 1011493A BE 904796 A BE904796 A BE 904796A
Authority
BE
Belgium
Prior art keywords
morphinane
medicaments
novel
preparation
application
Prior art date
Application number
BE1/011493A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE904796A publication Critical patent/BE904796A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Composés de formule ci-dessous, dans laquelle X et Y signifient l'hydrogène ou forment ensemble un groupe -O- et R1, R2, R3, R4 et R5 représentent des restes organiques variés. Ces composés peuvent etre utilisés comme médicaments.
BE1/011493A 1985-05-23 1986-05-21 Nouveaux derives du morphinane et de la morphine, leur preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant. BE904796A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3518525 1985-05-23

Publications (1)

Publication Number Publication Date
BE904796A true BE904796A (fr) 1986-11-21

Family

ID=6271435

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/011493A BE904796A (fr) 1985-05-23 1986-05-21 Nouveaux derives du morphinane et de la morphine, leur preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant.

Country Status (18)

Country Link
JP (1) JPS61271275A (fr)
AU (1) AU594954B2 (fr)
BE (1) BE904796A (fr)
DK (1) DK240386A (fr)
ES (1) ES8802318A1 (fr)
FI (1) FI862124L (fr)
FR (1) FR2582309B1 (fr)
GB (1) GB2175898B (fr)
GR (1) GR861318B (fr)
HU (1) HU196376B (fr)
IL (1) IL78872A0 (fr)
IT (1) IT1203791B (fr)
LU (1) LU86435A1 (fr)
NL (1) NL8601188A (fr)
NZ (1) NZ216250A (fr)
PH (1) PH23341A (fr)
SE (1) SE8602308L (fr)
ZA (1) ZA863873B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857533A (en) * 1988-12-15 1989-08-15 Baker Cummins Pharmaceuticals, Inc. Method of treatment for autoimmune diseases
US4863928A (en) * 1989-01-04 1989-09-05 Baker Cummins Pharmaceuticals, Inc. Method of treatment for arthritic and inflammatory diseases
US4923875A (en) * 1989-07-10 1990-05-08 Baker Cummins Pharmaceuticals, Inc. Method for treatment of mast cell-mediated dermatologic disorders
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
US5057322A (en) * 1990-08-10 1991-10-15 Baker Cummins Dermatologicals, Inc. Method of treating mast cell disease
ES2121988T3 (es) * 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.
KR100341950B1 (ko) * 1993-07-19 2002-11-29 도레이 가부시끼가이샤 뇌세포보호제
AU686203B2 (en) * 1993-07-23 1998-02-05 Toray Industries, Inc. Morphinan derivative and medicinal use
KR19990077125A (ko) * 1996-01-10 1999-10-25 파올로 비지, 엔리꼬 카쭐라니 헤테로고리-축합 모르핀 유도체 (ⅱ)
NZ331001A (en) * 1996-11-25 2000-05-26 Toray Industries Use of an opiate K receptor agonist as an antipruritic
AU6117298A (en) * 1997-07-25 1999-02-16 Toray Industries, Inc. Hyponatremia remedies
JP5438250B2 (ja) 2002-05-17 2014-03-12 ジェンケン バイオサイエンスィズ，インコーポレイテッド オピオイド及びオピオイド様の化合物並びにそれらの使用
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
JP4957489B2 (ja) * 2002-10-09 2012-06-20 東レ株式会社 含窒素環状置換基を有するモルヒナン誘導体またはその薬理学的に許容される酸付加塩を含有する医薬
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8354534B2 (en) * 2008-02-14 2013-01-15 Alkermes, Inc. Selective opioid compounds
TWI513697B (zh) * 2012-12-14 2015-12-21 Purdue Pharma Lp 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
WO2014091297A1 (fr) * 2012-12-14 2014-06-19 Purdue Pharma L.P. Morphinanes spirocycliques et leur utilisation
AR096851A1 (es) * 2013-07-11 2016-02-03 H Lundbeck As Sales que no forman hidratos ni solvatos de nalmefeno
EP3154972A4 (fr) * 2014-06-13 2017-11-22 Purdue Pharma L.P. Dérivés d'azamophinan et leur utilisation

Also Published As

Publication number Publication date
FI862124A0 (fi) 1986-05-21
LU86435A1 (fr) 1986-12-05
GB2175898B (en) 1989-07-05
SE8602308L (sv) 1986-11-24
FR2582309A1 (fr) 1986-11-28
PH23341A (en) 1989-07-14
GB8612159D0 (en) 1986-06-25
NZ216250A (en) 1990-04-26
DK240386A (da) 1986-11-24
IL78872A0 (en) 1986-09-30
SE8602308D0 (sv) 1986-05-21
FR2582309B1 (fr) 1989-08-18
GB2175898A (en) 1986-12-10
DK240386D0 (da) 1986-05-22
FI862124A7 (fi) 1986-11-24
IT8648050A0 (it) 1986-05-23
JPS61271275A (ja) 1986-12-01
AU5763786A (en) 1986-11-27
HUT41737A (en) 1987-05-28
NL8601188A (nl) 1986-12-16
HU196376B (en) 1988-11-28
IT1203791B (it) 1989-02-23
AU594954B2 (en) 1990-03-22
ZA863873B (en) 1988-01-27
ES8802318A1 (es) 1988-05-01
FI862124L (fi) 1986-11-24
GR861318B (en) 1986-09-19
ES555200A0 (es) 1988-05-01

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SANDOZ S.A.

Effective date: 19900531