BE1003009A5 - Nouvelles compositions pharmaceutiques a base de cyclosporines. - Google Patents

Nouvelles compositions pharmaceutiques a base de cyclosporines. Download PDF

Info

Publication number
BE1003009A5
BE1003009A5 BE9000133A BE9000133A BE1003009A5 BE 1003009 A5 BE1003009 A5 BE 1003009A5 BE 9000133 A BE9000133 A BE 9000133A BE 9000133 A BE9000133 A BE 9000133A BE 1003009 A5 BE1003009 A5 BE 1003009A5
Authority
BE
Belgium
Prior art keywords
pharmaceutical compositions
cyclosporins
compositions based
novel pharmaceutical
cyclosporine
Prior art date
Application number
BE9000133A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898902901A external-priority patent/GB8902901D0/en
Priority claimed from GB898902898A external-priority patent/GB8902898D0/en
Priority claimed from GB898903147A external-priority patent/GB8903147D0/en
Priority claimed from GB898903663A external-priority patent/GB8903663D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1003009A5 publication Critical patent/BE1003009A5/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention a pour objet de nouvelles compositions pharmaceutiques comprenant (a) une cyclosporine comme substance active, (b) un monoester d'un acide gras avec un saccharide et (c) un diluant ou véhicule.
BE9000133A 1989-02-09 1990-02-05 Nouvelles compositions pharmaceutiques a base de cyclosporines. BE1003009A5 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898902901A GB8902901D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB898902898A GB8902898D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB898903147A GB8903147D0 (en) 1989-02-13 1989-02-13 Improvements in or relating to organic compounds
GB898903663A GB8903663D0 (en) 1989-02-17 1989-02-17 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
BE1003009A5 true BE1003009A5 (fr) 1991-10-22

Family

ID=27450262

Family Applications (1)

Application Number Title Priority Date Filing Date
BE9000133A BE1003009A5 (fr) 1989-02-09 1990-02-05 Nouvelles compositions pharmaceutiques a base de cyclosporines.

Country Status (25)

Country Link
JP (3) JP3484190B2 (fr)
KR (1) KR0170769B1 (fr)
AT (1) AT404552B (fr)
AU (1) AU630413B2 (fr)
BE (1) BE1003009A5 (fr)
CA (1) CA2009533C (fr)
CH (1) CH679277A5 (fr)
CY (1) CY1903A (fr)
DE (1) DE4003844B4 (fr)
DK (1) DK176209B1 (fr)
ES (1) ES2021942A6 (fr)
FI (1) FI97524C (fr)
FR (1) FR2642650B1 (fr)
GB (1) GB2230440B (fr)
HK (1) HK37296A (fr)
HU (1) HU213394B (fr)
IT (1) IT1240758B (fr)
LU (1) LU87675A1 (fr)
MY (1) MY107377A (fr)
NL (1) NL195028C (fr)
NO (1) NO301576B1 (fr)
NZ (1) NZ232401A (fr)
PH (1) PH30917A (fr)
PT (1) PT93079B (fr)
SE (1) SE511398C2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
MX9201782A (es) † 1991-04-19 1992-10-01 Sandoz Ag Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
US5759566A (en) * 1992-07-28 1998-06-02 Poli Industria Chimica Spa Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
DK0589843T3 (da) 1992-09-25 2002-04-02 Novartis Ag Cyclosporinholdige farmaceutiske præparater
DE4412201A1 (de) * 1993-04-20 1994-11-10 Rentschler Arzneimittel Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
ATE218878T1 (de) * 1993-04-20 2002-06-15 Novartis Erfind Verwalt Gmbh Neue pharmazeutische zubereitungen zur oralen verabreichung enthaltend cyclosporin
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
ES2177652T3 (es) 1994-11-03 2002-12-16 Novartis Ag Nuevas formas de preparacion de ciclosporina para la aplicacion oral con composicion simple y alta biodisponibilidad, y procedimiento para su obtencion.
US5679566A (en) * 1995-01-20 1997-10-21 University Of Massachusetts Medical Center Yeast NMD2 gene
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
AU762247B2 (en) * 1997-01-30 2003-06-19 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
KR20050084502A (ko) * 1997-01-30 2005-08-26 노파르티스 아게 오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
KR100966245B1 (ko) * 1997-03-12 2010-06-28 아보트 러보러터리즈 사이클로스포린 투여용 친수성 2원 시스템
NZ328751A (en) * 1997-09-16 1999-01-28 Bernard Charles Sherman Solid medicament containing an anionic surfactant and cyclosporin
US6447806B1 (en) 1999-02-25 2002-09-10 Novartis Ag Pharmaceutical compositions comprised of stabilized peptide particles
EP2116228A1 (fr) 2001-10-19 2009-11-11 Isotechnika Inc. Nouveaux préconcentrés de microémulsion analogue de cyclosporine
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
JP4521554B2 (ja) * 2004-03-31 2010-08-11 マイラン製薬株式会社 シクロスポリン製剤
US8333989B2 (en) * 2005-10-26 2012-12-18 Banner Pharmacaps, Inc. Hydrophilic vehicle-based dual controlled release matrix system
AU2007230716B2 (en) 2006-03-28 2012-05-03 Javelin Pharmaceuticals, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
US7495024B2 (en) 2006-08-07 2009-02-24 Via Pharmaceuticals, Inc. Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102008059201A1 (de) * 2008-11-27 2010-06-02 GÖPFERICH, Achim, Prof. Dr. In situ präzipitierende Arzneistofflösungen
KR102146704B1 (ko) 2018-04-13 2020-08-21 가천대학교 산학협력단 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체
KR20240070705A (ko) * 2021-10-13 2024-05-21 추가이 세이야쿠 가부시키가이샤 펩타이드 화합물 및 계면활성제를 포함하는 조성물
KR20250002095A (ko) * 2022-05-02 2025-01-07 추가이 세이야쿠 가부시키가이샤 계면활성제와 병용하기 위한 펩타이드 화합물을 포함하는 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2015339A (en) * 1978-03-07 1979-09-12 Sandoz Ltd Compositions comprising mono-cyclic peptides
EP0230332A1 (fr) * 1986-01-13 1987-07-29 N.V. Sanico Composition pharmaceutique à effet prolongé du composé actif et procédé de préparation
FR2620336A1 (fr) * 1987-09-15 1989-03-17 Sandoz Sa Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments
FR2636534A1 (fr) * 1988-09-16 1990-03-23 Sandoz Sa Compositions pharmaceutiques a base de cyclosporines

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤
GB8602372D0 (en) * 1986-01-31 1986-03-05 Sandoz Ltd Organic compounds
CA1290249C (fr) * 1986-04-09 1991-10-08 Cetus Corporation TRAITEMENT A BASE D'INTERLEUKINE-2 ET (OU) D'INTERFERON .beta. ET FACTEUR DE NECROSE TUMORALE
EP0267615A3 (fr) * 1986-11-13 1989-05-03 Sloan-Kettering Institute For Cancer Research Compositions et méthodes pour le traitement du cancer utilisant d'une part un anticorps monoclonal contre le ganglioside GD3 et d'autre part l'IL-2
ES2059558T3 (es) * 1987-06-17 1994-11-16 Sandoz Ag Ciclosporins y su uso como productos farmaceuticos.
JP2536876B2 (ja) * 1987-07-31 1996-09-25 寛治 高田 シクロスポリンの溶解性粉末状製剤
US5756450A (en) * 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
DE3830494B4 (de) * 1987-09-15 2006-05-18 Novartis Ag Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
JP2792862B2 (ja) * 1988-07-30 1998-09-03 寛治 高田 経口腸溶製剤
JPH1038029A (ja) * 1996-07-26 1998-02-13 Ebara Corp 制振機能付き円板状構造物
JPH10280435A (ja) * 1997-04-03 1998-10-20 Sekisui Chem Co Ltd 地下室の構築方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2015339A (en) * 1978-03-07 1979-09-12 Sandoz Ltd Compositions comprising mono-cyclic peptides
EP0230332A1 (fr) * 1986-01-13 1987-07-29 N.V. Sanico Composition pharmaceutique à effet prolongé du composé actif et procédé de préparation
FR2620336A1 (fr) * 1987-09-15 1989-03-17 Sandoz Sa Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments
FR2636534A1 (fr) * 1988-09-16 1990-03-23 Sandoz Sa Compositions pharmaceutiques a base de cyclosporines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 85, 1976, page 282, résumé no. 37149m, Columbus, Ohio, US; S. JANICKI et al.: "Effect of sucrose monoesters on the physical properties of tablets containing moprobamate", & FARM. POL. 1976, 32(2), 113-16 *
PHARMACEUTICAL RESEARCH, vol. 6, no. 11, novembre 1989, pages 958-960, Plenum Publishing Corp.; L. HAHN et al.: "Solid surfactant solutions of active ingredients in sugar esters" *

Also Published As

Publication number Publication date
CA2009533C (fr) 2002-11-12
MY107377A (en) 1995-11-30
IT9047609A0 (it) 1990-02-08
JP2006001947A (ja) 2006-01-05
SE9000441D0 (sv) 1990-02-07
DE4003844A1 (de) 1990-08-16
HU213394B (en) 1997-06-30
NO900577L (no) 1990-08-10
NO900577D0 (no) 1990-02-07
PT93079A (pt) 1990-08-31
IT1240758B (it) 1993-12-17
JP4073641B2 (ja) 2008-04-09
SE511398C2 (sv) 1999-09-20
SE9000441L (sv) 1991-08-08
FR2642650B1 (fr) 1994-12-09
JPH02235817A (ja) 1990-09-18
AU4925290A (en) 1990-08-16
AU630413B2 (en) 1992-10-29
JP3484190B2 (ja) 2004-01-06
FI97524B (fi) 1996-09-30
GB9002504D0 (en) 1990-04-04
PH30917A (en) 1997-12-23
FI97524C (fi) 1997-01-10
FI900604A0 (fi) 1990-02-07
ES2021942A6 (es) 1991-11-16
LU87675A1 (fr) 1991-10-08
CY1903A (en) 1996-11-22
GB2230440B (en) 1993-05-19
JP2001302538A (ja) 2001-10-31
CA2009533A1 (fr) 1990-08-09
FR2642650A1 (fr) 1990-08-10
DK32790A (da) 1990-08-10
KR900012625A (ko) 1990-09-01
NO301576B1 (no) 1997-11-17
DE4003844B4 (de) 2007-09-20
NL195028C (nl) 2003-12-02
AT404552B (de) 1998-12-28
ATA27290A (de) 1998-05-15
KR0170769B1 (ko) 1999-02-01
IT9047609A1 (it) 1991-08-08
GB2230440A (en) 1990-10-24
NL9000299A (nl) 1990-09-03
DK176209B1 (da) 2007-02-05
NL195028B (nl) 2003-08-01
HU900701D0 (en) 1990-04-28
HK37296A (en) 1996-03-15
DK32790D0 (da) 1990-02-07
CH679277A5 (fr) 1992-01-31
PT93079B (pt) 1996-04-30
NZ232401A (en) 1992-10-28

Similar Documents

Publication Publication Date Title
EP1449921A3 (fr) Nouveaux polypeptides biologiquement actifs, leur préparation et composition pharmaceutique les contenant
CA2039491A1 (fr) Compositions stables devant etre administrees par voie parenterale, et methode de fabrication
FR2719479B1 (fr) Formulation stable lyophilisée comprenant une protéine: kit de dosage.
CA2063886A1 (fr) Proteines conjuguees au polyethylene
SE9000441D0 (sv) Novel cyclosporin galenic forms
BE901737A (fr) Composition pharmaceutique pour le traitement de l'ischemie myocardique aigue.
HK86593A (en) Pharmaceutical compositions containing cyclosporins
DK524187D0 (da) Aminosyrechelaterede midler til udlevering til specifikke biologiske vaevssteder
FR2601259B1 (fr) Nouvelles compositions tensio-actives a base d'esters phosphoriques leur procede de preparation et leur application a la formulation de matieres actives.
FR2378027A1 (fr) Acide, ester ou amide alkyl-lactone hetero-substitue, leur obtention et leur application a la preparation de lactone-oxazolines
EP0695171A1 (fr) Lyospheres contenant de la gonadotrophine
ATE138099T1 (de) Nicht glycosierte proteine, analoge des menschlichen interleukin-3
EP0173664A3 (fr) Dérivés de benzimidazole biologiquement actifs et leur procédé de préparation
FR2446634A1 (fr) Composition a base d'hydrolysat de lactalbumine pour le traitement et les soins de la peau
FR2362618A1 (fr) Composition de shampooing liquide a base d'ester monoalcoylique d'acide phosphorique
BE1002504A3 (fr) Preparation medicamenteuse a base de derives d'esters d'hecogenine et leur utilisation pour le traitement de l'hyperplasie prostatique benigne.
TNSN97173A1 (fr) Analogues peptidiques de la lh-rh, leurs utilisations et les compositions pharmaceutiques en contenant.
EP0373613A3 (fr) Monopersulfate de l'acide pyridine-3-percarboxylique
IT8619288A0 (it) Formulazioni farmaceutiche iniettabili di principi attivi adattivita' anestetica generale.
MY104813A (en) Pharmaceutical compositions of tebufelone
FR2605223B1 (fr) Compositions therapeutiques stables a base d' huile vegetale hydrophobe et son procede de preparation
ATE204286T1 (de) Modifizierte alpha-d-glcp-(1,2)-alpha-d-glcp-(1, 3)-alpha-d-glcp-analoge
MY128778A (en) Storage-stable, water-dilutable formulations of herbicidally active compounds
EP0348664A3 (fr) Compositions pharmaceutiques contenant des monoacétoacétines pour le traitement des tumeurs
FR2643637B1 (fr) Complexe d'ion calcium avec au moins un acide gras insature, agent biomediateur comprenant un tel complexe, composition pharmaceutique l'incorporant et extraits de plantes ou d'organes d'animaux en contenant

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20100205