BE1003255A5 - Acides (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofurannyl)-acetiques et acides 2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzo-furannyl)-acetiques et leurs esters mucoregulateurs et anti-ischemiques et procede pour les preparer. - Google Patents

Acides (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofurannyl)-acetiques et acides 2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzo-furannyl)-acetiques et leurs esters mucoregulateurs et anti-ischemiques et procede pour les preparer. Download PDF

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Publication number
BE1003255A5
BE1003255A5 BE8900822A BE8900822A BE1003255A5 BE 1003255 A5 BE1003255 A5 BE 1003255A5 BE 8900822 A BE8900822 A BE 8900822A BE 8900822 A BE8900822 A BE 8900822A BE 1003255 A5 BE1003255 A5 BE 1003255A5
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BE
Belgium
Prior art keywords
dihydro
acids
acetics
trimethylbenzofurannyl
acyloxy
Prior art date
Application number
BE8900822A
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English (en)
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Foscama Biomed Chim Farma
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Les acides (RS)-2-(2,3-dihydro-5-hydroxy-4,6,7 triméthylbenzofurannyl) acétiques et acides 2-(2,3-dihydro-5-acyloxy-4,6,7 triméthylbenzofurannyl) acétiques, de même que leurs esters, sont des substances antioxydantes convenant comme agents thérapeutiques pour le traitement de l'emphyzème pulmonaire et des processus inflammatoires des muqueuses de l'appareil respiratoire, de même que pour le traitement des séquelles de l'infarctus cérébral ou cardiaque. Ils sont préférés comme mucolytiques.
BE8900822A 1988-08-01 1989-08-01 Acides (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofurannyl)-acetiques et acides 2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzo-furannyl)-acetiques et leurs esters mucoregulateurs et anti-ischemiques et procede pour les preparer. BE1003255A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821603A IT1229482B (it) 1988-08-01 1988-08-01 Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici.

Publications (1)

Publication Number Publication Date
BE1003255A5 true BE1003255A5 (fr) 1992-02-11

Family

ID=11184201

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900822A BE1003255A5 (fr) 1988-08-01 1989-08-01 Acides (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofurannyl)-acetiques et acides 2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzo-furannyl)-acetiques et leurs esters mucoregulateurs et anti-ischemiques et procede pour les preparer.

Country Status (15)

Country Link
US (2) US4999350A (fr)
JP (1) JPH0278675A (fr)
KR (1) KR0129526B1 (fr)
CN (1) CN1034574C (fr)
BE (1) BE1003255A5 (fr)
CA (1) CA1324134C (fr)
CH (1) CH679583A5 (fr)
DE (1) DE3925496A1 (fr)
ES (1) ES2014188A6 (fr)
FR (1) FR2634766A1 (fr)
GB (1) GB2221463B (fr)
HK (1) HK48693A (fr)
IT (1) IT1229482B (fr)
SE (1) SE469652B (fr)
SG (1) SG26693G (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231341B (it) * 1989-08-18 1991-11-28 Foscama Biomed Chim Farma 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche.
IT1239946B (it) * 1990-03-12 1993-11-27 Biomedica Foscama Industria Chimicofarmaceutica Procedimento per la sintesi degli acidi 5-acilossi e 5-alcossi-2,3-diidro-4,6,7-trimetil-2-(rs)-benzofuranacetici
US5240956A (en) * 1990-11-07 1993-08-31 Cortech, Inc. Ester inhibitors
EP0550292A1 (fr) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Analogues de tocophérol de protection des tissus
AU670433B2 (en) * 1992-04-06 1996-07-18 Merrell Dow Pharmaceuticals Inc. Novel derivatives of 2,3-dihydro-benzofuranols
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
TW393475B (en) * 1992-10-16 2000-06-11 Chugai Pharmaceutical Co Ltd 4-alkoxyl-2,6-di-t-butyl phenol derivatives
IT1289494B1 (it) * 1996-12-20 1998-10-15 Biomedica Foscana Ind Chimico Acidi 5-idrossi- e 5-acilossi-2,3-diidro-4,6,7-trimetil-2- benzofuranaceti e loro esteri per il trattamento e la prevenzione
IT1320131B1 (it) * 2000-12-21 2003-11-18 Foscama Biomed Chim Farma Uso degli acidi 5-idrossi e 5-acilossi-2,3-diidro-4,6,7-trimetil-2-benzofuranacetici e loro esteri come cicatrizzanti delle lesioni

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165810A2 (fr) * 1984-06-20 1985-12-27 Merck Frosst Canada Inc. Dérivés de benzofuranne et de benzothiophène, leur application pour inhiber la biosynthèse de leucotriène aux mammifères et compositions pharmaceutiques contenant ces dérivés
JPS6388173A (ja) * 1986-09-30 1988-04-19 Kuraray Co Ltd ２，３−ジヒドロベンゾフラン誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6065063A (ja) * 1983-09-20 1985-04-13 Matsunaga Kagaku Kogyo Kk 難燃化剤
US4537903A (en) * 1983-10-12 1985-08-27 Merck & Co., Inc. Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents
US4918092A (en) * 1983-12-21 1990-04-17 Merck Frosst Canada, Inc. Leukotriene antagonists
EP0273647B1 (fr) * 1986-12-27 1992-03-11 Takeda Chemical Industries, Ltd. Dérivés de coumaranne, leur préparation et leur utilisation
JP2855340B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 ２―置換クマラン誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165810A2 (fr) * 1984-06-20 1985-12-27 Merck Frosst Canada Inc. Dérivés de benzofuranne et de benzothiophène, leur application pour inhiber la biosynthèse de leucotriène aux mammifères et compositions pharmaceutiques contenant ces dérivés
JPS6388173A (ja) * 1986-09-30 1988-04-19 Kuraray Co Ltd ２，３−ジヒドロベンゾフラン誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 110, no. 9, 27 février 1989, page 630, abrégé no. 75294x, Columbus, Ohio, US; & JP-A-63 088 173 (KURARAY CO., LTD) 19-04-1988 *

Also Published As

Publication number Publication date
DE3925496C2 (fr) 1992-04-30
HK48693A (en) 1993-05-27
CN1034574C (zh) 1997-04-16
GB8917515D0 (en) 1989-09-13
IT8821603A0 (it) 1988-08-01
SE469652B (sv) 1993-08-16
CH679583A5 (fr) 1992-03-13
FR2634766A1 (fr) 1990-02-02
JPH0278675A (ja) 1990-03-19
GB2221463B (en) 1992-03-25
ES2014188A6 (es) 1990-06-16
CA1324134C (fr) 1993-11-09
GB2221463A (en) 1990-02-07
KR0129526B1 (ko) 1998-04-09
SG26693G (en) 1993-05-21
CN1042354A (zh) 1990-05-23
DE3925496A1 (de) 1990-02-22
FR2634766B1 (fr) 1994-08-19
SE8902603L (sv) 1990-02-02
US5041568A (en) 1991-08-20
US4999350A (en) 1991-03-12
SE8902603D0 (sv) 1989-07-26
IT1229482B (it) 1991-09-03
KR900003145A (ko) 1990-03-23

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