BE1003279A5 - Nouveaux composes pharmacologiquement actifs, leurs procedes de preparation et les compositions en contenant. - Google Patents

Nouveaux composes pharmacologiquement actifs, leurs procedes de preparation et les compositions en contenant. Download PDF

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Publication number
BE1003279A5
BE1003279A5 BE8701356A BE8701356A BE1003279A5 BE 1003279 A5 BE1003279 A5 BE 1003279A5 BE 8701356 A BE8701356 A BE 8701356A BE 8701356 A BE8701356 A BE 8701356A BE 1003279 A5 BE1003279 A5 BE 1003279A5
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Belgium
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pharmacologically active
processes
preparation
same
active compounds
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BE8701356A
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Inventor
Reijo Johannes Baeckstroem
Kalevi Evert Heinola
Erkki Juhani Honkanen
Seppo Kalevi Kaakkola
Pekka Juhani Kairisalo
Inge-Britt Yvonne Linden
Pekka Topias Maennistoe
Erkki Aarne Olavi Nissinen
Pentti Pohto
Aino Kyllikki Pippuri
Jarmo Johan Pystynen
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Orion Yhtymae Oy
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Priority claimed from FI864875A external-priority patent/FI864875A0/fi
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
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    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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    • C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
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    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
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    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C07C45/565—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom by reaction with hexamethylene-tetramine
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
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    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
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    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
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    • C07C59/40—Unsaturated compounds
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
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Abstract

Dérivés de pyrocatéchol pharmacologiquement actifs de formule I se trouvant à la figure où R1 et R2 signifient individuellement de l'hydrogène, alcoyle, acyle, etc. ou représentent ensemble un groupe alcoylidène ou cycloalcoylidène, X est un substituant électronégatif (halogène,nitro,etc) et R3 est de l'hydrogène, hydroxyalcoyle, etc, ou présente encore une série d'autres significations.
BE8701356A 1986-11-28 1987-11-27 Nouveaux composes pharmacologiquement actifs, leurs procedes de preparation et les compositions en contenant. BE1003279A5 (fr)

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FI864875A FI864875A0 (fi) 1986-11-28 1986-11-28 Nya farmakologiskt aktiva foereningar, dessa innehaollande kompositioner samt foerfarande och mellanprodukter foer anvaendning vid framstaellning av dessa.
GB878712437A GB8712437D0 (en) 1986-11-28 1987-05-27 Pharmacologically active compounds

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BE1003279A5 true BE1003279A5 (fr) 1992-02-18

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IE873242L (en) 1988-05-28
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HUT45473A (en) 1988-07-28
MA21120A1 (fr) 1988-07-01
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FR2607493B1 (fr) 1994-08-12
CS843988A3 (en) 1992-01-15
JPS63150237A (ja) 1988-06-22
NL300136I1 (nl) 2003-12-01
JP2735834B2 (ja) 1998-04-02
DK623087D0 (da) 1987-11-27
YU47790B (sr) 1996-01-09
LV10236A (lv) 1994-10-20
HU206073B (en) 1992-08-28
IS3290A7 (is) 1988-05-29
SE503434C2 (sv) 1996-06-17
CA1334967C (fr) 1995-03-28
LU87050A1 (fr) 1988-05-03
JPH085781B2 (ja) 1996-01-24
CS276263B6 (en) 1992-05-13
PT86236B (pt) 1990-11-07
PL152642B1 (en) 1991-01-31
CS844088A3 (en) 1992-05-13
LV10236B (en) 1995-06-20
NO171450B (no) 1992-12-07
AU8187987A (en) 1988-06-02
IT1225762B (it) 1990-11-26
GR871817B (en) 1988-03-24
US4963590A (en) 1990-10-16
FR2607493A1 (fr) 1988-06-03
PL269091A1 (en) 1988-12-08
YU213587A (en) 1989-06-30
CS277018B6 (en) 1992-11-18
AU621036B2 (en) 1992-03-05
YU2189A (en) 1989-12-31
CN87108011A (zh) 1988-06-08
AR243491A1 (es) 1993-08-31
GB8727854D0 (en) 1987-12-31
PH26145A (en) 1992-03-18
DK175394B1 (da) 2004-09-20
NZ222729A (en) 1990-04-26
RU2014319C1 (ru) 1994-06-15
IE60320B1 (en) 1994-06-29
CN1040062C (zh) 1998-10-07
NL300136I2 (nl) 2004-02-02
AT401053B (de) 1996-06-25
JPS63170311A (ja) 1988-07-14
YU2289A (en) 1989-12-31
IT8722790A0 (it) 1987-11-27
BG60407B2 (bg) 1995-02-28
DK623087A (da) 1988-05-29
NO171450C (no) 1993-03-17
NL194821B (nl) 2002-12-02
PT86236A (en) 1987-12-01
DE19975025I2 (de) 2000-08-24
DE3740383C2 (de) 1997-09-25
NL8702857A (nl) 1988-06-16
SE8704751L (sv) 1988-05-29
CH685436A5 (de) 1995-07-14
HK75594A (en) 1994-08-12
SE8704751D0 (sv) 1987-11-27
ATA312987A (de) 1995-10-15
IS1753B (is) 2000-07-21
EG18338A (en) 1992-09-30
CA1289078C (fr) 1991-09-17
NO874966L (no) 1988-05-30
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NO874966D0 (no) 1987-11-27
YU48020B (sh) 1996-10-09
MTP1012B (en) 1988-10-18
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