BE2014C034I2 - Derivatives of 3-(2-oxo- 1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems - Google Patents

Derivatives of 3-(2-oxo- 1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems

Info

Publication number: BE2014C034I2
Authority: BE; Belgium
Prior art keywords: hydrogen; compounds; ocor; coor; salts
Prior art date: 1998-06-15

Application number

BE2014C034C

Other languages

English (en)

Original Assignee

Basilea Pharmaceutica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-15

Filing date

2014-05-15

Publication date

2018-08-24

2014-05-15 Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag

2018-08-24 Publication of BE2014C034I2 publication Critical patent/BE2014C034I2/fr

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
150000001875 compounds Chemical class 0.000 abstract 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
150000003839 salts Chemical class 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
150000004677 hydrates Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BE2014C034C 1998-06-15 2014-05-15 Derivatives of 3-(2-oxo- 1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems BE2014C034I2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP98110888		1998-06-15
EP98117099		1998-09-10
EP99927894A EP1087980B1 (fr)	1998-06-15	1999-06-07	Derives de 3-(2-oxo- 1,3']bipyrrolidinyl-3-ylidenemethyl)-cephemes
PCT/EP1999/003907 WO1999065920A1 (fr)	1998-06-15	1999-06-07	Derives de 3-(2-oxo-[1,3']bipyrrolidinyl-3-ylidenemethyl)-cephemes

Publications (1)

Publication Number	Publication Date
BE2014C034I2 true BE2014C034I2 (en)	2018-08-24

Family

ID=26149347

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE2014C034C BE2014C034I2 (en)	1998-06-15	2014-05-15	Derivatives of 3-(2-oxo- 1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems

Country Status (28)

Country	Link
EP (1)	EP1087980B1 (fr)
JP (1)	JP3872955B2 (fr)
KR (1)	KR100411915B1 (fr)
CN (1)	CN1136222C (fr)
AR (1)	AR018675A1 (fr)
AT (1)	ATE231871T1 (fr)
AU (1)	AU754732B2 (fr)
BE (1)	BE2014C034I2 (fr)
BR (2)	BRPI9911178B8 (fr)
CA (1)	CA2334568C (fr)
CO (1)	CO5080758A1 (fr)
DE (1)	DE69905162T2 (fr)
DK (1)	DK1087980T3 (fr)
ES (1)	ES2190222T3 (fr)
FR (1)	FR14C0044I2 (fr)
GT (1)	GT199900084A (fr)
HU (1)	HUP0105426A3 (fr)
ID (1)	ID27686A (fr)
IL (1)	IL139872A0 (fr)
LU (1)	LU92564I2 (fr)
MA (1)	MA26650A1 (fr)
NO (1)	NO20006350D0 (fr)
PA (1)	PA8475701A1 (fr)
PE (1)	PE20000645A1 (fr)
PL (1)	PL344994A1 (fr)
SV (1)	SV1999000075A (fr)
TN (1)	TNSN99114A1 (fr)
WO (1)	WO1999065920A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6267100A (en) *	1999-07-07	2001-01-30	F. Hoffmann-La Roche Ag	Vinylpyrrolidinone derivatives with substituted thiazole ring
DE60123513T2 (de)	2000-04-19	2007-05-10	Basilea Pharmaceutica Ag	Verfahren zur Herstellung von D-Asparaginderivaten
US6504025B2 (en) *	2000-05-24	2003-01-07	Basilea Pharmaceutica Ag	Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
JP5230934B2 (ja) *	2003-03-27	2013-07-10	バジリアファルマスーチカアーゲー	結晶形態のセファロスポリン
EP1656930A1 (fr) *	2004-11-10	2006-05-17	Basilea Pharmaceutica AG	Formulation lyophilisée stabilisée pour des dérivés des céphalosporines
AR071318A1 (es)	2008-04-15	2010-06-09	Basilea Pharmaceutica Ag	Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010072672A1 (fr)	2008-12-24	2010-07-01	Basilea Pharmaceutica Ag	Nouveaux polymorphes cristallins du ceftobiprole
ES2565952T3 (es) *	2009-05-25	2016-04-07	Sandoz Ag	Método para la producción de ceftobiprol medocaril
BR112012028678A2 (pt)	2010-05-10	2015-09-15	Basilea Pharmaceutica Internat Ltd	processo de oxidação para preparar derivados de 3-formil-cefem

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69737382T2 (de) *	1996-11-06	2007-10-31	Basilea Pharmaceutica Ag	Vinylpyrrolidinon-Cephalosporin-Derivate
TW415949B (en) *	1996-12-19	2000-12-21	Hoffmann La Roche	Vinyl pyrrolidine cephalosporin derivatives with basic substituents

1999
- 1999-06-07 AT AT99927894T patent/ATE231871T1/de active
- 1999-06-07 IL IL13987299A patent/IL139872A0/xx unknown
- 1999-06-07 BR BRPI9911178A patent/BRPI9911178B8/pt not_active IP Right Cessation
- 1999-06-07 JP JP2000554745A patent/JP3872955B2/ja not_active Expired - Lifetime
- 1999-06-07 DK DK99927894T patent/DK1087980T3/da active
- 1999-06-07 ID IDW20002565A patent/ID27686A/id unknown
- 1999-06-07 KR KR10-2000-7014203A patent/KR100411915B1/ko not_active Expired - Lifetime
- 1999-06-07 ES ES99927894T patent/ES2190222T3/es not_active Expired - Lifetime
- 1999-06-07 EP EP99927894A patent/EP1087980B1/fr not_active Expired - Lifetime
- 1999-06-07 CA CA002334568A patent/CA2334568C/fr not_active Expired - Lifetime
- 1999-06-07 DE DE69905162T patent/DE69905162T2/de not_active Expired - Lifetime
- 1999-06-07 AU AU45081/99A patent/AU754732B2/en not_active Expired
- 1999-06-07 CN CNB998073474A patent/CN1136222C/zh not_active Expired - Lifetime
- 1999-06-07 BR BRPI9911178A patent/BRPI9911178C1/pt unknown
- 1999-06-07 PL PL99344994A patent/PL344994A1/xx unknown
- 1999-06-07 HU HU0105426A patent/HUP0105426A3/hu unknown
- 1999-06-07 WO PCT/EP1999/003907 patent/WO1999065920A1/fr not_active Ceased
- 1999-06-11 PE PE1999000521A patent/PE20000645A1/es not_active Application Discontinuation
- 1999-06-11 AR ARP990102825A patent/AR018675A1/es active IP Right Grant
- 1999-06-11 CO CO99036886A patent/CO5080758A1/es unknown
- 1999-06-14 GT GT199900084A patent/GT199900084A/es unknown
- 1999-06-14 PA PA19998475701A patent/PA8475701A1/es unknown
- 1999-06-15 MA MA25625A patent/MA26650A1/fr unknown
- 1999-06-15 TN TNTNSN99114A patent/TNSN99114A1/fr unknown
- 1999-06-15 SV SV1999000075A patent/SV1999000075A/es not_active Application Discontinuation
2000
- 2000-12-13 NO NO20006350A patent/NO20006350D0/no not_active Application Discontinuation
2014
- 2014-05-15 BE BE2014C034C patent/BE2014C034I2/fr unknown
- 2014-06-11 FR FR14C0044C patent/FR14C0044I2/fr active Active
- 2014-10-01 LU LU92564C patent/LU92564I2/fr unknown

Also Published As

Publication number	Publication date
AU4508199A (en)	2000-01-05
ES2190222T3 (es)	2003-07-16
CO5080758A1 (es)	2001-09-25
AU754732B2 (en)	2002-11-21
KR100411915B1 (ko)	2003-12-18
LU92564I2 (fr)	2014-12-01
DK1087980T3 (da)	2003-05-26
MA26650A1 (fr)	2004-12-20
JP2002518401A (ja)	2002-06-25
EP1087980A1 (fr)	2001-04-04
DE69905162T2 (de)	2003-12-24
HUP0105426A3 (en)	2002-12-28
AR018675A1 (es)	2001-11-28
BRPI9911178C1 (pt)	2021-05-25
KR20010052866A (ko)	2001-06-25
HUP0105426A2 (hu)	2002-05-29
CA2334568A1 (fr)	1999-12-23
CA2334568C (fr)	2009-02-24
BR9911178B1 (pt)	2013-10-29
CN1305484A (zh)	2001-07-25
NO20006350L (no)	2000-12-13
BRPI9911178B8 (pt)	2017-03-07
ATE231871T1 (de)	2003-02-15
TNSN99114A1 (fr)	2005-11-10
IL139872A0 (en)	2002-02-10
JP3872955B2 (ja)	2007-01-24
SV1999000075A (es)	2000-05-02
GT199900084A (es)	2000-12-05
FR14C0044I2 (fr)	2015-02-20
DE69905162D1 (de)	2003-03-06
CN1136222C (zh)	2004-01-28
NO20006350D0 (no)	2000-12-13
PE20000645A1 (es)	2000-07-26
PL344994A1 (en)	2001-11-19
FR14C0044I1 (fr)	2014-07-18
PA8475701A1 (es)	2000-09-29
EP1087980B1 (fr)	2003-01-29
BR9911178A (pt)	2001-03-13
ID27686A (id)	2001-04-19
WO1999065920A1 (fr)	1999-12-23

Publication	Publication Date	Title
AU3461697A (en)	1998-02-10	Heterocyclic compounds, their production and use
PT848004E (pt)	2003-07-31	Derivados pirrolidina tendo actividade inibidora da fosfolipase a2
ES539446A0 (es)	1986-06-01	Un procedimiento para preparar un derivado de dihidropiridazinona
DK0956033T3 (da)	2003-10-06	Totalsyntese af amino-Hip-analogen af didemnin A
CA2334568A1 (fr)	1999-12-23	Derives de 3-(2-oxo-[1,3']bipyrrolidinyl-3-ylidenemethyl)-cephemes
AU6220300A (en)	2001-02-19	Benzofurylpiperazine serotonin agonists
EP1026162A4 (fr)	2001-01-17	Agent anti-rhumatismal
WO2000051589A3 (fr)	2001-07-12	Composes inhibiteurs d'atpase-(h+) de type vacuolaire, compositions et uitlisations associees
PL344696A1 (en)	2001-11-19	Hyperforin derivatives, the use thereof and formulations containing them
CA2261271A1 (fr)	1997-09-18	Derives de dihydrodibenzo(b,e)oxazepine, et compositions medicamenteuses les comportant
CA2049655A1 (fr)	1992-03-18	Composition pharmaceutique pour inhiber l'aggregation des plaquettes
AU7094796A (en)	1997-04-17	Sesquiterpene derivatives having antiviral activity
KR970042503A (ko)	1997-07-24	약제학적 화합물
EP0201349A3 (fr)	1987-10-21	Dérivés de tétrazole
KR960014780B1 (en)	1996-10-19	Dental plaque inhibitor composition and its preparation
EP0049999A3 (fr)	1982-06-23	Composés cycliques, leur préparation et leur utilisation
MX9601953A (es)	1997-08-30	Nuevo compesto derivados de 5h-tiazolo [3,2-a] pirimidin-5-ona.
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HK62292A (en)	1992-08-28	Prophylactic and curing composition for arteriosclerosis
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CA2016300A1 (fr)	1991-11-08	Analogue de la prostaglandine i
JPS54126732A (en)	1979-10-02	Antidepressant containing 2-(3-aminopropoxy)diphenyl ether or its derivative