DK0956033T3 - Totalsyntese af amino-Hip-analogen af didemnin A - Google Patents

Totalsyntese af amino-Hip-analogen af didemnin A

Info

Publication number: DK0956033T3
Authority: DK; Denmark
Prior art keywords: didemnin; amino; total synthesis; hip analog; hip
Prior art date: 1996-10-24

Application number

DK97946294T

Other languages

English (en)

Inventor

Kenneth L Rinehart

J Katauskas Alexandra

Alexandra J Sanborn

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-24

Filing date

1997-10-24

Publication date

2003-10-06

1997-10-24 Application filed by Univ Illinois filed Critical Univ Illinois

2003-10-06 Application granted granted Critical

2003-10-06 Publication of DK0956033T3 publication Critical patent/DK0956033T3/da

Links

XQZOGOCTPKFYKC-VSZULPIASA-N (2r)-n-[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]-4-methyl-2-(m Chemical compound C([C@H]1C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)NC)C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N1C)C(C)C)O)[C@@H](C)CC)C1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-VSZULPIASA-N 0.000 title abstract 3
108010061297 didemnins Proteins 0.000 title abstract 3
XQZOGOCTPKFYKC-UHFFFAOYSA-N epididemnin A1 Natural products CN1C(=O)C2CCCN2C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(C(C)C)OC(=O)CC(O)C(C(C)CC)NC(=O)C(NC(=O)C(CC(C)C)NC)C(C)OC(=O)C1CC1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-UHFFFAOYSA-N 0.000 title abstract 3
238000006257 total synthesis reaction Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Transplantation (AREA)
Virology (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Catalysts (AREA)

DK97946294T 1996-10-24 1997-10-24 Totalsyntese af amino-Hip-analogen af didemnin A DK0956033T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2910996P	1996-10-24	1996-10-24
PCT/US1997/019211 WO1998017302A1 (en)	1996-10-24	1997-10-24	Total synthesis of the amino hip analogue of didemnin a

Publications (1)

Publication Number	Publication Date
DK0956033T3 true DK0956033T3 (da)	2003-10-06

Family

ID=21847275

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97946294T DK0956033T3 (da)	1996-10-24	1997-10-24	Totalsyntese af amino-Hip-analogen af didemnin A

Country Status (11)

Country	Link
US (1)	US6380156B1 (da)
EP (1)	EP0956033B1 (da)
JP (1)	JP2001504814A (da)
AT (1)	ATE245435T1 (da)
AU (1)	AU726146B2 (da)
CA (1)	CA2269878A1 (da)
DE (1)	DE69723728T2 (da)
DK (1)	DK0956033T3 (da)
ES (1)	ES2202644T3 (da)
PT (1)	PT956033E (da)
WO (1)	WO1998017302A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
ES2272462T3 (es)	2000-04-07	2007-05-01	The Trustees Of The University Of Pennsylvania	Analogos de tamadarina y didemnina y procedimiento de fabricacion y uso.
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
GB0103750D0 (en) *	2001-02-15	2001-04-04	Pharma Mar Sa	Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
UA76718C2 (uk) *	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
GB0016148D0 (en) *	2000-06-30	2000-08-23	Pharma Mar Sa	Synthetic methods for aplidine and new antitiumoral derivatives
BR0114604A (pt)	2000-10-12	2003-10-14	Pharma Mar Sa	Tratamento de cnceres
KR20060002778A (ko)	2003-03-12	2006-01-09	파르마 마르, 에스.에이.	개선된 항종양 치료
JP4584245B2 (ja)	2003-03-12	2010-11-17	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	多発性骨髄腫治療用のアプリジン
AU2004224418A1 (en)	2003-03-21	2004-10-07	Madeleine M. Joullie	Tamandarin analogs and fragments thereof and methods of making and using
DE102004051024A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Heterocyclyl-substituierte Nonadepsipeptide
DE102004051023A1 (de) *	2004-10-20	2006-05-04	Bayer Healthcare Ag	Desoxo-Nonadepsipeptide
DE102004051025A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Substituierte Nonadepsipeptide
DE102004053410A1 (de) *	2004-11-05	2006-05-11	Bayer Healthcare Ag	Cyclische Nonadepsipeptidamide
DE102006003443A1 (de) *	2006-01-25	2007-07-26	Aicuris Gmbh & Co. Kg	Asparagin-10-substituierte Nonadepsipeptide
HUE028055T2 (en)	2006-02-28	2016-11-28	Pharma Mar Sa	Improved treatment of myeloma multiplex
DE102006018250A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Verfahren zum Herstellen von cyclischen Depsipeptiden
DE102006018080A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Lysobactinamide
LT3615544T (lt)	2017-04-27	2023-05-10	Pharma Mar S.A.	Priešnavikiniai junginiai
EP3636656A4 (en)	2017-06-09	2021-04-14	Chugai Seiyaku Kabushiki Kaisha	METHOD OF SYNTHESIS OF PEPTIDE WITH N-SUBSTITUTED AMINO ACID
CN119143631A (zh) *	2018-11-30	2024-12-17	中外制药株式会社	用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法

1997
- 1997-10-24 JP JP51964998A patent/JP2001504814A/ja not_active Ceased
- 1997-10-24 US US09/284,905 patent/US6380156B1/en not_active Expired - Fee Related
- 1997-10-24 CA CA002269878A patent/CA2269878A1/en not_active Abandoned
- 1997-10-24 DK DK97946294T patent/DK0956033T3/da active
- 1997-10-24 ES ES97946294T patent/ES2202644T3/es not_active Expired - Lifetime
- 1997-10-24 AU AU51495/98A patent/AU726146B2/en not_active Ceased
- 1997-10-24 EP EP97946294A patent/EP0956033B1/en not_active Expired - Lifetime
- 1997-10-24 AT AT97946294T patent/ATE245435T1/de not_active IP Right Cessation
- 1997-10-24 PT PT97946294T patent/PT956033E/pt unknown
- 1997-10-24 WO PCT/US1997/019211 patent/WO1998017302A1/en not_active Ceased
- 1997-10-24 DE DE69723728T patent/DE69723728T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69723728T2 (de)	2004-06-03
EP0956033A1 (en)	1999-11-17
ATE245435T1 (de)	2003-08-15
EP0956033B1 (en)	2003-07-23
WO1998017302A1 (en)	1998-04-30
DE69723728D1 (de)	2003-08-28
ES2202644T3 (es)	2004-04-01
AU5149598A (en)	1998-05-15
PT956033E (pt)	2003-10-31
AU726146B2 (en)	2000-11-02
JP2001504814A (ja)	2001-04-10
US6380156B1 (en)	2002-04-30
EP0956033A4 (en)	2000-06-21
CA2269878A1 (en)	1998-04-30

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