BE562073A - - Google Patents

Info

Publication number: BE562073A
Authority: BE; Belgium
Prior art keywords: sep; tetracycline; process according; chlorination; inhibitor
Prior art date: 1956-11-02

Application number

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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1956-11-02

Publication of BE562073A publication Critical patent/BE562073A/fr

Links

229960002180 tetracycline Drugs 0.000 claims description 27
229930101283 tetracycline Natural products 0.000 claims description 27
239000004098 Tetracycline Substances 0.000 claims description 26
235000019364 tetracycline Nutrition 0.000 claims description 26
150000003522 tetracyclines Chemical class 0.000 claims description 26
238000000855 fermentation Methods 0.000 claims description 25
230000004151 fermentation Effects 0.000 claims description 25
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 22
CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 19
CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 19
239000003112 inhibitor Substances 0.000 claims description 19
238000005660 chlorination reaction Methods 0.000 claims description 16
244000005700 microbiome Species 0.000 claims description 14
238000000034 method Methods 0.000 claims description 12
238000002360 preparation method Methods 0.000 claims description 7
-1 benzyl N-acetyl-dithiocarbazate Chemical group 0.000 claims description 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
239000000126 substance Substances 0.000 claims description 5
241000187747 Streptomyces Species 0.000 claims description 4
125000000217 alkyl group Chemical group 0.000 claims description 4
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
239000000463 material Substances 0.000 claims description 3
239000002609 medium Substances 0.000 claims 2
125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims 1
HLKIEZNVCBRNSO-UHFFFAOYSA-N NN(C=O)C(SCC1=CC=CC=C1)=S Chemical group NN(C=O)C(SCC1=CC=CC=C1)=S HLKIEZNVCBRNSO-UHFFFAOYSA-N 0.000 claims 1
238000010564 aerobic fermentation Methods 0.000 claims 1
150000001412 amines Chemical class 0.000 claims 1
239000012736 aqueous medium Substances 0.000 claims 1
239000007864 aqueous solution Substances 0.000 claims 1
239000012990 dithiocarbamate Substances 0.000 claims 1
230000015572 biosynthetic process Effects 0.000 description 9
235000015097 nutrients Nutrition 0.000 description 8
240000008042 Zea mays Species 0.000 description 6
235000002017 Zea mays subsp mays Nutrition 0.000 description 6
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
150000001805 chlorine compounds Chemical class 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
235000005822 corn Nutrition 0.000 description 4
238000002803 maceration Methods 0.000 description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
241000894007 species Species 0.000 description 4
238000003786 synthesis reaction Methods 0.000 description 4
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 3
241000186984 Kitasatospora aureofaciens Species 0.000 description 3
230000008901 benefit Effects 0.000 description 3
230000003115 biocidal effect Effects 0.000 description 3
239000000470 constituent Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
102000016736 Cyclin Human genes 0.000 description 2
108050006400 Cyclin Proteins 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 description 2
241000282320 Panthera leo Species 0.000 description 2
241001637516 Polygonia c-album Species 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 2
235000019270 ammonium chloride Nutrition 0.000 description 2
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
229910052921 ammonium sulfate Inorganic materials 0.000 description 2
235000011130 ammonium sulphate Nutrition 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
235000010216 calcium carbonate Nutrition 0.000 description 2
230000007423 decrease Effects 0.000 description 2
235000013312 flour Nutrition 0.000 description 2
239000002054 inoculum Substances 0.000 description 2
239000003456 ion exchange resin Substances 0.000 description 2
229920003303 ion-exchange polymer Polymers 0.000 description 2
235000009973 maize Nutrition 0.000 description 2
239000002994 raw material Substances 0.000 description 2
238000011084 recovery Methods 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
229940072172 tetracycline antibiotic Drugs 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
235000017060 Arachis glabrata Nutrition 0.000 description 1
244000105624 Arachis hypogaea Species 0.000 description 1
235000010777 Arachis hypogaea Nutrition 0.000 description 1
235000018262 Arachis monticola Nutrition 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
239000004099 Chlortetracycline Substances 0.000 description 1
241000581364 Clinitrachus argentatus Species 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
235000019733 Fish meal Nutrition 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
229910021607 Silver chloride Inorganic materials 0.000 description 1
235000019764 Soybean Meal Nutrition 0.000 description 1
101100073357 Streptomyces halstedii sch2 gene Proteins 0.000 description 1
241000811234 Streptomyces sayamaensis Species 0.000 description 1
241000231756 Streptomyces viridifaciens Species 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
238000005273 aeration Methods 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
239000001166 ammonium sulphate Substances 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
235000013877 carbamide Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
229960004475 chlortetracycline Drugs 0.000 description 1
235000019365 chlortetracycline Nutrition 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
229910017052 cobalt Inorganic materials 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
OAEGRYMCJYIXQT-UHFFFAOYSA-N dithiooxamide Chemical compound NC(=S)C(N)=S OAEGRYMCJYIXQT-UHFFFAOYSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000004467 fishmeal Substances 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000001727 glucose Nutrition 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
RWSOTUBLDIXVET-UHFFFAOYSA-M hydrosulfide Chemical compound [SH-] RWSOTUBLDIXVET-UHFFFAOYSA-M 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000010699 lard oil Substances 0.000 description 1
238000011031 large-scale manufacturing process Methods 0.000 description 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000000203 mixture Substances 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
230000000877 morphologic effect Effects 0.000 description 1
235000020232 peanut Nutrition 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
230000007096 poisonous effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000009877 rendering Methods 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
239000004455 soybean meal Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
238000010408 sweeping Methods 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BE562073D 1956-11-02 BE562073A (2)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US1232321XA	1956-11-02	1956-11-02

Publications (1)

Publication Number	Publication Date
BE562073A true BE562073A (2)

Family

ID=22407459

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE562073D BE562073A (2)	1956-11-02

Country Status (1)

Country	Link
BE (1)	BE562073A (2)

0
- BE BE562073D patent/BE562073A/fr unknown

Publication	Publication Date	Title
DE2161164A1 (de)	1972-09-21	Verfahren zur mikrobiologischen Her stellung von Protein sowie Verwendung des Verfahrensproduktes
BE533886A (2)
CA1074242A (en)	1980-03-25	Process for the production of polysaccharides by fermentation
US3963574A (en)	1976-06-15	Process for producing 2-keto-L-gulonic acid
US3019173A (en)	1962-01-30	Method for preparing tetracycline
US4505821A (en)	1985-03-19	Method of treating waste liquors containing phenolics and formaldehyde
BE562074A (2)
US3591455A (en)	1971-07-06	Continuous microbial process
BE555259A (2)
CA1052308A (fr)	1979-04-10	Substance anticoccidienne 30.504 rp de streptomyces gallinarius
FI77893C (fi)	1989-05-10	Foerfarande foer framstaellning av indanylderivat.
FR2459288A1 (fr)	1981-01-09	Procede de preparation de la mildiomycine par un micro-organisme du genre streptoverticillium, dans une culture contenant un compose n-methyle
DE1960524C3 (de)	1974-07-11	Fermentatives Verfahren zur Herstellung von L-3,4-Dihydroxyphenylalanin
DE3048824C2 (de)	1985-04-25	Mikrobielle Polyamin-Oxidase AT-1
FR2496691A1 (fr)	1982-06-25	Procede de production d'un melange de nocardicines a et b, par culture d'une souche de microtetraspora caesia sp. nov.
FR2557455A1 (fr)	1985-07-05	Antibiotique nouveau 81-484 antitumeur et sa production
EP0694615B1 (fr)	2002-09-18	Méthode de préparation de gamma-nonalactones sous forme naturelle
EP0325534B1 (fr)	1991-05-02	Procédé de synthèse de mononitrates de glycéryle par bioconversion de la nitroglycérine
EP0266258B1 (fr)	1993-04-28	Procédé de préparation d'acide lactique
CH645921A5 (fr)	1984-10-31	Procede de production d'acide 2,5-dicetogluconique.
CH650797A5 (fr)	1985-08-15	Procede microbiologique de production de narasine.
US2949407A (en)	1960-08-16	Method for preparing tetracycline iii
US2949406A (en)	1960-08-16	Method for preparing tetracycline ii
US4835287A (en)	1989-05-30	Antibiotic substance
JPH037587A (ja)	1991-01-14	Ｌ―リンゴ酸の製造方法