BE853227A - 11alpha-amino, delta 4 ou delta 5 pregnanes et androstanes a groupe disubstitue - Google Patents

11alpha-amino, delta 4 ou delta 5 pregnanes et androstanes a groupe disubstitue

Info

Publication number: BE853227A
Authority: BE; Belgium
Prior art keywords: delta; 11alpha; androstanes; pregnanes; amino
Prior art date: 1976-04-05

Application number

BE176410A

Other languages

English (en)

French (fr)

Original Assignee

Glaxo Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-04-05

Filing date

1977-04-04

Publication date

1977-10-04

1977-04-04 Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd

1977-10-04 Publication of BE853227A publication Critical patent/BE853227A/xx

Links

150000001441 androstanes Chemical class 0.000 title 1
150000003128 pregnanes Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Anesthesiology (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BE176410A 1976-04-05 1977-04-04 11alpha-amino, delta 4 ou delta 5 pregnanes et androstanes a groupe disubstitue BE853227A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB13707/76A GB1581234A (en)	1976-04-05	1976-04-05	11a - amino - 3a - hydroxysteroids

Publications (1)

Publication Number	Publication Date
BE853227A true BE853227A (fr)	1977-10-04

Family

ID=10027931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE176410A BE853227A (fr)	1976-04-05	1977-04-04	11alpha-amino, delta 4 ou delta 5 pregnanes et androstanes a groupe disubstitue

Country Status (19)

Country	Link
JP (1)	JPS52142056A (pl)
AU (1)	AU517206B2 (pl)
BE (1)	BE853227A (pl)
DE (1)	DE2715078A1 (pl)
DK (1)	DK148677A (pl)
ES (1)	ES457507A1 (pl)
FI (1)	FI771046A7 (pl)
FR (2)	FR2347382A1 (pl)
GB (1)	GB1581234A (pl)
IE (1)	IE45276B1 (pl)
IL (1)	IL51816A (pl)
IT (1)	IT1073232B (pl)
LU (1)	LU77064A1 (pl)
NL (1)	NL7703667A (pl)
NO (1)	NO771197L (pl)
NZ (1)	NZ183775A (pl)
PL (1)	PL197186A1 (pl)
SE (1)	SE7703929L (pl)
ZA (1)	ZA772029B (pl)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0059637A1 (en) *	1981-03-02	1982-09-08	Glaxo Group Limited	11Alpha-amino-3 Beta-hydroxy-androstanes
US4352798A (en) *	1980-07-16	1982-10-05	Glaxo Group Limited	11 α-Amino-androstanes
US4353898A (en) *	1980-07-16	1982-10-12	Glaxo Group Limited	11α-Amino-androstanes

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57203100A (en) *	1981-05-29	1982-12-13	Glaxo Group Ltd	11 alpha-amino-androstanes
DE3260539D1 (en) *	1981-05-29	1984-09-13	Glaxo Group Ltd	11-alpha-amino-androstanes
US5232917A (en) *	1987-08-25	1993-08-03	University Of Southern California	Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
CZ300694A3 (en) *	1993-12-02	1996-05-15	Akzo Nobel Nv	Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof
FR2910002B1 (fr) *	2006-12-13	2009-01-30	Sanofi Aventis Sa	Nouveau procede pour l'obtention diastereoselective d'une amine primaire chirale sur un steroide
JP2010037243A (ja) *	2008-08-04	2010-02-18	Mitsubishi Rayon Co Ltd	ノルボルネンラクトンモノマーの製造方法
EP4717314A2 (en)	2011-10-14	2026-04-01	Sage Therapeutics, LLC	3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
SG10201606063RA (en)	2012-01-23	2016-09-29	Sage Therapeutics Inc	Neuroactive steroid formulations and methods of treating cns disorders
RS62761B1 (sr)	2012-08-21	2022-01-31	Sage Therapeutics Inc	Alopregnanolon za lečenje refraktornog epileptičkog statusa
CN117304245A (zh)	2013-04-17	2023-12-29	萨奇治疗股份有限公司	刺激神经活性的19-去甲类固醇及其使用方法
SMT202100509T1 (it)	2013-04-17	2021-11-12	Sage Therapeutics Inc	Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia
WO2014169836A1 (en)	2013-04-17	2014-10-23	Sage Therapeutics, Inc.	19-nor neuroactive steroids and methods of use thereof
US9725481B2 (en)	2013-04-17	2017-08-08	Sage Therapeutics, Inc.	19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
CA2918735C (en) *	2013-07-19	2023-08-01	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
CN105579043B (zh)	2013-08-23	2021-09-14	萨奇治疗股份有限公司	神经活性类固醇、组合物和其用途
US10246482B2 (en)	2014-06-18	2019-04-02	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar)	2014-09-08	2017-06-16	Sage Therapeutics Inc	سترويدات وتركيبات نشطة عصبياً، واستخداماتها
US20170233433A1 (en)	2014-10-16	2017-08-17	Sage Therapeutics, Inc.	Compositions and methods for treating cns disorders
MY190408A (en)	2014-10-16	2022-04-21	Sage Therapeutics Inc	Compositions and methods for treating cns disorders
WO2016082789A1 (en) *	2014-11-27	2016-06-02	Sage Therapeutics, Inc.	Compositions and methods for treating cns disorders
LT3250210T (lt)	2015-01-26	2021-04-12	Sage Therapeutics, Inc.	Kompozicijos ir būdai, skirti gydyti cns sutrikimus
DK3258939T3 (da)	2015-02-20	2022-12-12	Sage Therapeutics Inc	Neuroaktive steroider, sammensætninger og anvendelser heraf
PH12018501923B1 (en)	2016-03-08	2024-06-28	Sage Therapeutics Inc	Neuroactive steroids, compositions, and uses thereof
CA3030420C (en)	2016-07-11	2025-11-18	Sage Therapeutics, Inc.	C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE
WO2018013613A1 (en)	2016-07-11	2018-01-18	Sage Therapeutics, Inc.	C17, c20, and c21 substituted neuroactive steroids and their methods of use
EP3728285B1 (en) *	2017-12-22	2026-04-08	Sage Therapeutics, LLC	Compositions and methods for treating cns disorders
IL312610B2 (en)	2018-12-05	2026-05-01	Sage Therapeutics Llc	Neuroactive steroids and methods of using them
JP7670626B2 (ja)	2019-05-31	2025-04-30	セージセラピューティクス，インコーポレイテッド	神経刺激性ステロイド及びその組成物
BR112021026447A2 (pt) *	2019-06-27	2022-04-12	Sage Therapeutics Inc	Composições e métodos para tratamento de distúrbios de cns
JP7787635B2 (ja)	2019-06-27	2025-12-17	セージセラピューティクス，エルエルシー	Ｃｎｓ障害を治療するための組成物及び方法
CA3143545A1 (en) *	2019-06-27	2020-12-30	Sage Therapeutics, Inc.	Compounds for treating cns disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2982775A (en) *	1957-05-06	1961-05-02	Schering Corp	11-oximino-, amino- and acylaminosteroids

1976
- 1976-04-05 GB GB13707/76A patent/GB1581234A/en not_active Expired
1977
- 1977-04-04 NL NL7703667A patent/NL7703667A/xx not_active Application Discontinuation
- 1977-04-04 FI FI771046A patent/FI771046A7/fi not_active Application Discontinuation
- 1977-04-04 JP JP3768077A patent/JPS52142056A/ja active Pending
- 1977-04-04 DK DK148677A patent/DK148677A/da not_active IP Right Cessation
- 1977-04-04 IT IT48805/77A patent/IT1073232B/it active
- 1977-04-04 ES ES457507A patent/ES457507A1/es not_active Expired
- 1977-04-04 NO NO771197A patent/NO771197L/no unknown
- 1977-04-04 LU LU77064A patent/LU77064A1/xx unknown
- 1977-04-04 NZ NZ183775A patent/NZ183775A/xx unknown
- 1977-04-04 PL PL19718677A patent/PL197186A1/pl unknown
- 1977-04-04 SE SE7703929A patent/SE7703929L/xx unknown
- 1977-04-04 BE BE176410A patent/BE853227A/xx not_active IP Right Cessation
- 1977-04-04 IE IE712/77A patent/IE45276B1/en unknown
- 1977-04-04 IL IL51816A patent/IL51816A/xx unknown
- 1977-04-04 AU AU23942/77A patent/AU517206B2/en not_active Expired
- 1977-04-04 ZA ZA00772029A patent/ZA772029B/xx unknown
- 1977-04-04 DE DE19772715078 patent/DE2715078A1/de not_active Withdrawn
- 1977-04-05 FR FR7710271A patent/FR2347382A1/fr active Granted
1981
- 1981-05-25 FR FR8110329A patent/FR2485020A1/fr not_active Withdrawn

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4352798A (en) *	1980-07-16	1982-10-05	Glaxo Group Limited	11 α-Amino-androstanes
US4353898A (en) *	1980-07-16	1982-10-12	Glaxo Group Limited	11α-Amino-androstanes
EP0059637A1 (en) *	1981-03-02	1982-09-08	Glaxo Group Limited	11Alpha-amino-3 Beta-hydroxy-androstanes

Also Published As

Publication number	Publication date
PL197186A1 (pl)	1979-06-18
ZA772029B (en)	1978-11-29
IE45276B1 (en)	1982-07-28
FR2485020A1 (fr)	1981-12-24
GB1581234A (en)	1980-12-10
NZ183775A (en)	1979-12-11
NO771197L (no)	1977-10-06
JPS52142056A (en)	1977-11-26
NL7703667A (nl)	1977-10-07
DE2715078A1 (de)	1977-10-13
AU517206B2 (en)	1981-07-16
FI771046A7 (pl)	1977-10-06
IT1073232B (it)	1985-04-13
AU2394277A (en)	1978-10-12
FR2347382A1 (fr)	1977-11-04
IL51816A (en)	1981-09-13
DK148677A (da)	1977-10-06
LU77064A1 (pl)	1979-01-18
ES457507A1 (es)	1978-03-16
IE45276L (en)	1977-10-05
FR2347382B1 (pl)	1982-01-08
IL51816A0 (en)	1977-06-30
SE7703929L (sv)	1978-10-27

Legal Events

Date

Code

Title

Description

1984-10-31

RE

Patent lapsed

Owner name: GLAXO LABORATORIES LTD

Effective date: 19840404

Publication	Publication Date	Title
FR2347382A1 (fr)	1977-11-04	11a-amino, d4 ou d5 pregnanes et androstanes a groupe amino disubstitue
BE850108A (fr)	1977-07-05	Pregnanes et androstanes anesthesiques
NL7711591A (nl)	1978-05-22	Luierbevestiging.
FR2321080A1 (fr)	1977-03-11	Vanne d'arret
FI51728C (fi)	1977-03-10	Kiinnike.
NL7701818A (nl)	1977-08-25	Vlinderklep.
NL7612097A (nl)	1978-05-03	Vlinderklep.
NL166887B (nl)	1981-05-15	Luchtband uit elastisch materiaal en ten minste in de schouderzones en de wangen zonder wapening.
DK25177A (da)	1977-07-25	1,2-benzisothiazolinoner-3 samt fremgangsmade til fremstilling deraf
NL7601421A (nl)	1976-08-17	Boutvormig bevestigingsorgaan.
BE880282A (fr)	1980-03-17	4,1-benzoxazepines et 4,1-benzothiazepines
SE7704857L (sv)	1977-10-30	1,3-dihydro-heteroarylspiro(isobensofuran)er
NL7806227A (nl)	1978-12-19	Oxazoline en 1,3,5-trioxanverbindingen.
SE7607683L (sv)	1977-01-08	9-hydroxi-7,8,9,10-tetrahydro-6h-dibenso/b//d/-pyraner och-pyranoner
PL196355A1 (pl)	1978-01-02	Sposob mikrobiologicznego wytwarzania mieszaniny androstadieno-1,4-dionu-3,17 i androsteno-4-dionu-3,17
NL7903973A (nl)	1979-11-27	1,2,4-triazolidinonen-3 en thionen-3.
BE845209A (fr)	1977-02-16	1, 1-dichloro-4-methyl-3-hydroxy-pentene-(1) et sa preparation
NO156435C (no)	1987-09-23	Festeanordning.
SE7505673L (sv)	1975-11-17	Lastuppberande och -metande apparat.
NL7604294A (nl)	1976-10-26	N'-sulfonyl-n"-dihalogeenfenylimidazolidinedion- -derivaten.
NL7710537A (nl)	1978-04-06	Insecticide en ovicide preparaten.
NL7614287A (nl)	1977-06-24	N'-sulfenyl-n''-dihalogeenfenylimidazolidine- dionen.
SU539171A1 (ru)	1976-12-15	Крепежный элемент
FI772434A7 (fi)	1978-03-03	Foerfarande foer framstaellning av 2,3-dikloranisol
DK329976A (da)	1977-01-24	11,12-umettede 9alfa-fluorsteroider samt fremgangsmade til fremstilling deraf

BE853227A - 11alpha-amino, delta 4 ou delta 5 pregnanes et androstanes a groupe disubstitue - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (1)

Publications (1)

Family

ID=10027931

Family Applications (1)

Country Status (19)

Cited By (3)

Families Citing this family (31)

Family Cites Families (1)

Cited By (3)

Also Published As

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