BE871781A - Procede ameliore de synthese d'oligonucleotides par la voie "triester" - Google Patents

Procede ameliore de synthese d'oligonucleotides par la voie "triester"

Info

Publication number: BE871781A
Authority: BE; Belgium
Prior art keywords: triester; oligonucleotides; route; synthesis; improved process
Prior art date: 1977-11-08

Application number

BE1009120A

Other languages

English (en)

Inventor

K Itakura

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-11-08

Filing date

1978-11-06

Publication date

1979-05-07

1978-11-06 Application filed by Genentech Inc filed Critical Genentech Inc

1979-05-07 Publication of BE871781A publication Critical patent/BE871781A/fr

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
150000005691 triesters Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BE1009120A 1977-11-08 1978-11-06 Procede ameliore de synthese d'oligonucleotides par la voie "triester" BE871781A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US84960877A	1977-11-08	1977-11-08

Publications (1)

Publication Number	Publication Date
BE871781A true BE871781A (fr)	1979-05-07

Family

ID=25306107

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE1009120A BE871781A (fr)	1977-11-08	1978-11-06	Procede ameliore de synthese d'oligonucleotides par la voie "triester"

Country Status (22)

Country	Link
EP (1)	EP0002322A3 (fr)
JP (1)	JPS5473787A (fr)
AU (1)	AU4136078A (fr)
BE (1)	BE871781A (fr)
BR (1)	BR7807288A (fr)
DD (1)	DD141836A5 (fr)
DE (1)	DE2848054A1 (fr)
DK (1)	DK493678A (fr)
ES (1)	ES474850A1 (fr)
FI (1)	FI783364A7 (fr)
FR (1)	FR2407939A1 (fr)
GB (1)	GB2007670A (fr)
IL (1)	IL55893A0 (fr)
LU (1)	LU80483A1 (fr)
NL (1)	NL7811043A (fr)
NO (1)	NO783721L (fr)
OA (1)	OA06003A (fr)
PL (1)	PL210786A1 (fr)
PT (1)	PT68754A (fr)
SE (1)	SE7811459L (fr)
ZA (1)	ZA786303B (fr)
ZM (1)	ZM9478A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RO80052B (ro) *	1977-11-08	1985-03-30	Genetech	Procedeu pentru prepararea unui vehicul recombinat de clonare pentru transformarea unei gazde bacteriene pentru a deveni generator de polipeptida heterologa
US4342832A (en) *	1979-07-05	1982-08-03	Genentech, Inc.	Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4474947A (en) *	1982-04-08	1984-10-02	Biosearch	Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes
JPS61152695A (ja) *	1984-12-26	1986-07-11	Nippon Shinyaku Co Ltd	長鎖ｄｎａの合成法
SG171914A1 (en)	2008-12-02	2011-07-28	Chiralgen Ltd	Method for the synthesis of phosphorus atom modified nucleic acids
EP2451461A4 (fr)	2009-07-06	2013-05-29	Ontorii Inc	Nouveaux précurseurs d'acide nucléique et leurs méthodes d'utilisation
DK2620428T3 (da)	2010-09-24	2019-07-01	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
US9605019B2 (en)	2011-07-19	2017-03-28	Wave Life Sciences Ltd.	Methods for the synthesis of functionalized nucleic acids
CN112007045B (zh)	2012-07-13	2026-01-06	波涛生命科学有限公司	手性控制
JP6246121B2 (ja)	2012-07-13	2017-12-13	株式会社新日本科学	キラル核酸アジュバント
DK2872485T3 (da)	2012-07-13	2021-03-08	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
WO2015108048A1 (fr)	2014-01-15	2015-07-23	株式会社新日本科学	Adjuvant d'acide nucléique chiral ayant un effet antitumoral et agent antitumoral
US10322173B2 (en)	2014-01-15	2019-06-18	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
EP3095461A4 (fr)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Adjuvant d'acide nucléique chiral possédant une activité d'induction d'immunité, et activateur d'induction d'immunité
KR102423317B1 (ko)	2014-01-16	2022-07-22	웨이브 라이프 사이언시스 리미티드	키랄 디자인

1978
- 1978-09-06 BR BR7807288A patent/BR7807288A/pt unknown
- 1978-11-06 NL NL7811043A patent/NL7811043A/xx not_active Application Discontinuation
- 1978-11-06 JP JP13721478A patent/JPS5473787A/ja active Pending
- 1978-11-06 GB GB7843445A patent/GB2007670A/en not_active Withdrawn
- 1978-11-06 DK DK493678A patent/DK493678A/da unknown
- 1978-11-06 AU AU41360/78A patent/AU4136078A/en active Pending
- 1978-11-06 NO NO783721A patent/NO783721L/no unknown
- 1978-11-06 DE DE19782848054 patent/DE2848054A1/de not_active Withdrawn
- 1978-11-06 SE SE7811459A patent/SE7811459L/xx unknown
- 1978-11-06 EP EP78300595A patent/EP0002322A3/fr not_active Withdrawn
- 1978-11-06 ES ES474850A patent/ES474850A1/es not_active Expired
- 1978-11-06 FI FI783364A patent/FI783364A7/fi unknown
- 1978-11-06 IL IL55893A patent/IL55893A0/xx unknown
- 1978-11-06 BE BE1009120A patent/BE871781A/fr unknown
- 1978-11-06 FR FR7831349A patent/FR2407939A1/fr not_active Withdrawn
- 1978-11-07 DD DD78208919A patent/DD141836A5/de unknown
- 1978-11-07 PT PT68754A patent/PT68754A/pt unknown
- 1978-11-08 ZM ZM94/78A patent/ZM9478A1/xx unknown
- 1978-11-08 ZA ZA00786303A patent/ZA786303B/xx unknown
- 1978-11-08 OA OA56653A patent/OA06003A/fr unknown
- 1978-11-08 LU LU80483A patent/LU80483A1/fr unknown
- 1978-11-08 PL PL21078678A patent/PL210786A1/xx unknown

Also Published As

Publication number	Publication date
EP0002322A3 (fr)	1979-06-27
DE2848054A1 (de)	1979-05-10
LU80483A1 (fr)	1979-03-22
NL7811043A (nl)	1979-05-10
JPS5473787A (en)	1979-06-13
BR7807288A (pt)	1979-06-12
IL55893A0 (en)	1979-01-31
PT68754A (en)	1978-12-01
NO783721L (no)	1979-05-09
SE7811459L (sv)	1979-05-09
FI783364A7 (fi)	1979-05-09
OA06003A (fr)	1981-06-30
PL210786A1 (pl)	1979-07-16
ZA786303B (en)	1979-10-31
AU4136078A (en)	1979-05-17
GB2007670A (en)	1979-05-23
EP0002322A2 (fr)	1979-06-13
ES474850A1 (es)	1979-12-01
DD141836A5 (de)	1980-05-21
ZM9478A1 (en)	1980-03-21
FR2407939A1 (fr)	1979-06-01
DK493678A (da)	1979-07-12

Publication	Publication Date	Title
BE886750A (fr)	1981-04-16	Procede de synthese de l'ether fluoromethyl-hexafluor-iso-propylique
FR2645533B1 (fr)	1991-07-12	Procede de synthese de sulfonylimidures
LU79926A1 (fr)	1979-04-09	Procede de preparation d'amides derives du trimethoxy-3,4,5 benzene
PT68573A (fr)	1978-10-01	Procede de preparation des derivatifs d'imidazole.
LU80483A1 (fr)	1979-03-22	Procede ameliore de synthese d'oligonucleotides par la voie"triester"
BE842200A (fr)	1976-09-16	Procede de synthese de composes de la serie des vinblastine-vincristine
BE865317A (fr)	1978-07-17	Procede de synthese d'une matiere inorganique
RO82276A (fr)	1984-01-14	Procede de synthese du chloroformiates alpha-chlorures
FR2335507A1 (fr)	1977-07-15	Procede de production d'intermediaires de synthese de dibenzo(b,d)pyranes
BE877243A (fr)	1979-12-27	Procede de preparation de l'o-methallyloxyphenol par monoetherification selective de la pyrocatechine
BE857706R (fr)	1978-02-13	Procede de preparation continue d'aldehydes par hydroformylation
BE869395A (fr)	1978-11-16	Procede de production de nouveaux derives d'anthracycline
RO77321A (fr)	1981-08-17	Procede pour la preparation des derives de 3(2-hydroxy-4-substitu-p(enyle)-cycloalcanones
FR2385788B1 (fr)	1985-07-12	Procede de deparaffinage catalytique d'hydrocarbures
RO81685A (fr)	1983-04-29	Procede de preparation des derives d'antraquinonsulfonamides
BE863268R (fr)	1978-07-24	Procede de preparation continue d'aldehydes par hydroformylation
BE863267R (fr)	1978-07-24	Procede de preparation continue d'aldehydes par hydroformylation
FR2408661B1 (fr)	1985-09-13	Procede de production d'aciers resulfures
RO79264A (fr)	1982-06-25	Procede pour la preparation des derives de oleandomicine
FR2470141B1 (fr)	1985-05-31	Nouveau procede de synthese de copolycondensats sequences polyetheresteramide
BE881078A (fr)	1980-07-10	Nouveau procede de synthese de la vindesine
BE879537A (fr)	1980-02-15	Procede de synthese de ceto-acides ou ceto-esters
BE865429A (fr)	1978-09-29	Procede de production d'alcane-polyols
FR2593506B1 (fr)	1992-07-31	Procede de synthese de diorganomonothiophosphinates
PT69327A (fr)	1979-04-01	Procede d'isomerisation des derives de la vinyl-3 piperidine