LU80483A1 - Procede ameliore de synthese d'oligonucleotides par la voie"triester" - Google Patents

Procede ameliore de synthese d'oligonucleotides par la voie"triester"

Info

Publication number
LU80483A1
LU80483A1 LU80483A LU80483A LU80483A1 LU 80483 A1 LU80483 A1 LU 80483A1 LU 80483 A LU80483 A LU 80483A LU 80483 A LU80483 A LU 80483A LU 80483 A1 LU80483 A1 LU 80483A1
Authority
LU
Luxembourg
Prior art keywords
triester
oligonucleotides
route
synthesis
improved process
Prior art date
Application number
LU80483A
Other languages
English (en)
Inventor
K Itakura
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of LU80483A1 publication Critical patent/LU80483A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LU80483A 1977-11-08 1978-11-08 Procede ameliore de synthese d'oligonucleotides par la voie"triester" LU80483A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84960877A 1977-11-08 1977-11-08

Publications (1)

Publication Number Publication Date
LU80483A1 true LU80483A1 (fr) 1979-03-22

Family

ID=25306107

Family Applications (1)

Application Number Title Priority Date Filing Date
LU80483A LU80483A1 (fr) 1977-11-08 1978-11-08 Procede ameliore de synthese d'oligonucleotides par la voie"triester"

Country Status (22)

Country Link
EP (1) EP0002322A3 (fr)
JP (1) JPS5473787A (fr)
AU (1) AU4136078A (fr)
BE (1) BE871781A (fr)
BR (1) BR7807288A (fr)
DD (1) DD141836A5 (fr)
DE (1) DE2848054A1 (fr)
DK (1) DK493678A (fr)
ES (1) ES474850A1 (fr)
FI (1) FI783364A7 (fr)
FR (1) FR2407939A1 (fr)
GB (1) GB2007670A (fr)
IL (1) IL55893A0 (fr)
LU (1) LU80483A1 (fr)
NL (1) NL7811043A (fr)
NO (1) NO783721L (fr)
OA (1) OA06003A (fr)
PL (1) PL210786A1 (fr)
PT (1) PT68754A (fr)
SE (1) SE7811459L (fr)
ZA (1) ZA786303B (fr)
ZM (1) ZM9478A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO80052B (ro) * 1977-11-08 1985-03-30 Genetech Procedeu pentru prepararea unui vehicul recombinat de clonare pentru transformarea unei gazde bacteriene pentru a deveni generator de polipeptida heterologa
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4474947A (en) * 1982-04-08 1984-10-02 Biosearch Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes
JPS61152695A (ja) * 1984-12-26 1986-07-11 Nippon Shinyaku Co Ltd 長鎖ｄｎａの合成法
US9394333B2 (en) 2008-12-02 2016-07-19 Wave Life Sciences Japan Method for the synthesis of phosphorus atom modified nucleic acids
MX342945B (es) 2009-07-06 2016-10-18 Ontorii Inc * Profármacos de ácido nucleico novedosos y métodos de uso de los mismos.
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
SG11201500243WA (en) 2012-07-13 2015-04-29 Shin Nippon Biomedical Lab Ltd Chiral nucleic acid adjuvant
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
KR20240148947A (ko) 2012-07-13 2024-10-11 웨이브 라이프 사이언시스 리미티드 키랄 제어
WO2015108048A1 (fr) 2014-01-15 2015-07-23 株式会社新日本科学 Adjuvant d'acide nucléique chiral ayant un effet antitumoral et agent antitumoral
WO2015108047A1 (fr) 2014-01-15 2015-07-23 株式会社新日本科学 Adjuvant d'acide nucléique chiral possédant une activité d'induction d'immunité, et activateur d'induction d'immunité
EP3095460A4 (fr) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Adjuvant d'acide nucléique chiral ayant une activité anti-allergique, et agent anti-allergique
ES2917473T3 (es) 2014-01-16 2022-07-08 Wave Life Sciences Ltd Diseño quiral

Also Published As

Publication number Publication date
ES474850A1 (es) 1979-12-01
BR7807288A (pt) 1979-06-12
PT68754A (en) 1978-12-01
FI783364A7 (fi) 1979-05-09
GB2007670A (en) 1979-05-23
OA06003A (fr) 1981-06-30
NO783721L (no) 1979-05-09
NL7811043A (nl) 1979-05-10
EP0002322A3 (fr) 1979-06-27
FR2407939A1 (fr) 1979-06-01
DD141836A5 (de) 1980-05-21
PL210786A1 (pl) 1979-07-16
ZM9478A1 (en) 1980-03-21
BE871781A (fr) 1979-05-07
AU4136078A (en) 1979-05-17
EP0002322A2 (fr) 1979-06-13
DE2848054A1 (de) 1979-05-10
DK493678A (da) 1979-07-12
SE7811459L (sv) 1979-05-09
IL55893A0 (en) 1979-01-31
JPS5473787A (en) 1979-06-13
ZA786303B (en) 1979-10-31

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