LU80483A1 - Procede ameliore de synthese d'oligonucleotides par la voie"triester" - Google Patents

Procede ameliore de synthese d'oligonucleotides par la voie"triester"

Info

Publication number
LU80483A1
LU80483A1 LU80483A LU80483A LU80483A1 LU 80483 A1 LU80483 A1 LU 80483A1 LU 80483 A LU80483 A LU 80483A LU 80483 A LU80483 A LU 80483A LU 80483 A1 LU80483 A1 LU 80483A1
Authority
LU
Luxembourg
Prior art keywords
triester
oligonucleotides
route
synthesis
improved process
Prior art date
Application number
LU80483A
Other languages
English (en)
Inventor
K Itakura
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of LU80483A1 publication Critical patent/LU80483A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LU80483A 1977-11-08 1978-11-08 Procede ameliore de synthese d'oligonucleotides par la voie"triester" LU80483A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84960877A 1977-11-08 1977-11-08

Publications (1)

Publication Number Publication Date
LU80483A1 true LU80483A1 (fr) 1979-03-22

Family

ID=25306107

Family Applications (1)

Application Number Title Priority Date Filing Date
LU80483A LU80483A1 (fr) 1977-11-08 1978-11-08 Procede ameliore de synthese d'oligonucleotides par la voie"triester"

Country Status (22)

Country Link
EP (1) EP0002322A3 (fr)
JP (1) JPS5473787A (fr)
AU (1) AU4136078A (fr)
BE (1) BE871781A (fr)
BR (1) BR7807288A (fr)
DD (1) DD141836A5 (fr)
DE (1) DE2848054A1 (fr)
DK (1) DK493678A (fr)
ES (1) ES474850A1 (fr)
FI (1) FI783364A7 (fr)
FR (1) FR2407939A1 (fr)
GB (1) GB2007670A (fr)
IL (1) IL55893A0 (fr)
LU (1) LU80483A1 (fr)
NL (1) NL7811043A (fr)
NO (1) NO783721L (fr)
OA (1) OA06003A (fr)
PL (1) PL210786A1 (fr)
PT (1) PT68754A (fr)
SE (1) SE7811459L (fr)
ZA (1) ZA786303B (fr)
ZM (1) ZM9478A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527165B2 (en) * 1977-02-08 1983-02-17 Genentech Inc. Method and means for microbial polypeptide expression; synthetic DNA and process therefor
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4474947A (en) * 1982-04-08 1984-10-02 Biosearch Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes
JPS61152695A (ja) * 1984-12-26 1986-07-11 Nippon Shinyaku Co Ltd 長鎖ｄｎａの合成法
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
CA2879066C (fr) 2012-07-13 2019-08-13 Shin Nippon Biomedical Laboratories, Ltd. Adjuvant d'acide nucleique chiral
PL2872485T3 (pl) 2012-07-13 2021-05-31 Wave Life Sciences Ltd. Asymetryczna grupa pomocnicza
KR102213609B1 (ko) 2012-07-13 2021-02-08 웨이브 라이프 사이언시스 리미티드 키랄 제어
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
BR112016016400A2 (pt) 2014-01-16 2017-10-03 Wave Life Sciences Ltd Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos

Also Published As

Publication number Publication date
EP0002322A2 (fr) 1979-06-13
OA06003A (fr) 1981-06-30
ZM9478A1 (en) 1980-03-21
NL7811043A (nl) 1979-05-10
PT68754A (en) 1978-12-01
FI783364A7 (fi) 1979-05-09
EP0002322A3 (fr) 1979-06-27
BE871781A (fr) 1979-05-07
AU4136078A (en) 1979-05-17
BR7807288A (pt) 1979-06-12
JPS5473787A (en) 1979-06-13
GB2007670A (en) 1979-05-23
DK493678A (da) 1979-07-12
SE7811459L (sv) 1979-05-09
ES474850A1 (es) 1979-12-01
NO783721L (no) 1979-05-09
ZA786303B (en) 1979-10-31
DE2848054A1 (de) 1979-05-10
PL210786A1 (pl) 1979-07-16
IL55893A0 (en) 1979-01-31
DD141836A5 (de) 1980-05-21
FR2407939A1 (fr) 1979-06-01

Similar Documents

Publication Publication Date Title
FR2645533B1 (fr) Procede de synthese de sulfonylimidures
LU79926A1 (fr) Procede de preparation d'amides derives du trimethoxy-3,4,5 benzene
PT68573A (fr) Procede de preparation des derivatifs d'imidazole.
BE871781A (fr) Procede ameliore de synthese d'oligonucleotides par la voie "triester"
BE865317A (fr) Procede de synthese d'une matiere inorganique
RO82276A (fr) Procede de synthese du chloroformiates alpha-chlorures
FR2335507A1 (fr) Procede de production d'intermediaires de synthese de dibenzo(b,d)pyranes
FR2336412A1 (fr) Procede nouveau de synthese de la 3', 4'-didesoxykanamycine b''
BE877243A (fr) Procede de preparation de l'o-methallyloxyphenol par monoetherification selective de la pyrocatechine
BE857706R (fr) Procede de preparation continue d'aldehydes par hydroformylation
BE869395A (fr) Procede de production de nouveaux derives d'anthracycline
RO77321A (fr) Procede pour la preparation des derives de 3(2-hydroxy-4-substitu-p(enyle)-cycloalcanones
FR2385788B1 (fr) Procede de deparaffinage catalytique d'hydrocarbures
RO81685A (fr) Procede de preparation des derives d'antraquinonsulfonamides
BE863268R (fr) Procede de preparation continue d'aldehydes par hydroformylation
BE863267R (fr) Procede de preparation continue d'aldehydes par hydroformylation
FR2408661B1 (fr) Procede de production d'aciers resulfures
RO79264A (fr) Procede pour la preparation des derives de oleandomicine
FR2470141B1 (fr) Nouveau procede de synthese de copolycondensats sequences polyetheresteramide
BE881078A (fr) Nouveau procede de synthese de la vindesine
BE879537A (fr) Procede de synthese de ceto-acides ou ceto-esters
FR2593506B1 (fr) Procede de synthese de diorganomonothiophosphinates
PT69327A (fr) Procede d'isomerisation des derives de la vinyl-3 piperidine
FR2393495B1 (fr) Procede de synthese d'images isolees
BE854486A (fr) Procede de preparation d'un derive d'acetonitrile et derive obtenu par ce procede