ES474850A1 - Mejoras introducidas en un procedimiento para la sintesis depolinucleotidos - Google Patents
Mejoras introducidas en un procedimiento para la sintesis depolinucleotidosInfo
- Publication number
- ES474850A1 ES474850A1 ES474850A ES474850A ES474850A1 ES 474850 A1 ES474850 A1 ES 474850A1 ES 474850 A ES474850 A ES 474850A ES 474850 A ES474850 A ES 474850A ES 474850 A1 ES474850 A1 ES 474850A1
- Authority
- ES
- Spain
- Prior art keywords
- moiety
- coupling reaction
- synthesis
- procedure
- nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Mejoras introducidas en un procedimiento para la síntesis de polinucleótidos de secuencia definida que comprende las siguientes etapas sucesivas: a) someter a reacción de copulación, como primer resto, un nucleótido que tiene un grupo diéster de 3''-fosfato enmascarado con, como segundo resto, un nucleósido o nucleótido que tiene un grupo 5''-hidroxilo libre disponibles, realizándose la reacción de copulación en presencia de un agente de copulación; b) opcionalmente, separar cualquier grupo protector presente en el compuesto procedente de la etapa anterior; c) si se desea, separar el dinucleótido procedente de la etapa b) de la mezcla de reacción y d) opcionalmente, repetir el proceso cuantas veces sea necesario para conseguir una cadena de polinucleótido tan larga como se desee. Cuya mejora comprende emplear un primer resto en un exceso molar considerable con relación al segundo resto y donde el segundo resto sustancialmente se consume completamente en la reacción de copulación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84960877A | 1977-11-08 | 1977-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES474850A1 true ES474850A1 (es) | 1979-12-01 |
Family
ID=25306107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES474850A Expired ES474850A1 (es) | 1977-11-08 | 1978-11-06 | Mejoras introducidas en un procedimiento para la sintesis depolinucleotidos |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0002322A3 (es) |
| JP (1) | JPS5473787A (es) |
| AU (1) | AU4136078A (es) |
| BE (1) | BE871781A (es) |
| BR (1) | BR7807288A (es) |
| DD (1) | DD141836A5 (es) |
| DE (1) | DE2848054A1 (es) |
| DK (1) | DK493678A (es) |
| ES (1) | ES474850A1 (es) |
| FI (1) | FI783364A7 (es) |
| FR (1) | FR2407939A1 (es) |
| GB (1) | GB2007670A (es) |
| IL (1) | IL55893A0 (es) |
| LU (1) | LU80483A1 (es) |
| NL (1) | NL7811043A (es) |
| NO (1) | NO783721L (es) |
| OA (1) | OA06003A (es) |
| PL (1) | PL210786A1 (es) |
| PT (1) | PT68754A (es) |
| SE (1) | SE7811459L (es) |
| ZA (1) | ZA786303B (es) |
| ZM (1) | ZM9478A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU527165B2 (en) * | 1977-02-08 | 1983-02-17 | Genentech Inc. | Method and means for microbial polypeptide expression; synthetic DNA and process therefor |
| US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| US4474947A (en) * | 1982-04-08 | 1984-10-02 | Biosearch | Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes |
| JPS61152695A (ja) * | 1984-12-26 | 1986-07-11 | Nippon Shinyaku Co Ltd | 長鎖ｄｎａの合成法 |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| CA2879066C (en) | 2012-07-13 | 2019-08-13 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
-
1978
- 1978-09-06 BR BR7807288A patent/BR7807288A/pt unknown
- 1978-11-06 DK DK493678A patent/DK493678A/da unknown
- 1978-11-06 AU AU41360/78A patent/AU4136078A/en active Pending
- 1978-11-06 JP JP13721478A patent/JPS5473787A/ja active Pending
- 1978-11-06 BE BE1009120A patent/BE871781A/xx unknown
- 1978-11-06 EP EP78300595A patent/EP0002322A3/en not_active Withdrawn
- 1978-11-06 NL NL7811043A patent/NL7811043A/xx not_active Application Discontinuation
- 1978-11-06 FI FI783364A patent/FI783364A7/fi unknown
- 1978-11-06 ES ES474850A patent/ES474850A1/es not_active Expired
- 1978-11-06 FR FR7831349A patent/FR2407939A1/fr not_active Withdrawn
- 1978-11-06 SE SE7811459A patent/SE7811459L/xx unknown
- 1978-11-06 GB GB7843445A patent/GB2007670A/en not_active Withdrawn
- 1978-11-06 IL IL55893A patent/IL55893A0/xx unknown
- 1978-11-06 DE DE19782848054 patent/DE2848054A1/de not_active Withdrawn
- 1978-11-06 NO NO783721A patent/NO783721L/no unknown
- 1978-11-07 PT PT68754A patent/PT68754A/pt unknown
- 1978-11-07 DD DD78208919A patent/DD141836A5/de unknown
- 1978-11-08 OA OA56653A patent/OA06003A/xx unknown
- 1978-11-08 ZA ZA00786303A patent/ZA786303B/xx unknown
- 1978-11-08 LU LU80483A patent/LU80483A1/xx unknown
- 1978-11-08 PL PL21078678A patent/PL210786A1/xx unknown
- 1978-11-08 ZM ZM94/78A patent/ZM9478A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0002322A2 (en) | 1979-06-13 |
| OA06003A (fr) | 1981-06-30 |
| ZM9478A1 (en) | 1980-03-21 |
| NL7811043A (nl) | 1979-05-10 |
| PT68754A (en) | 1978-12-01 |
| FI783364A7 (fi) | 1979-05-09 |
| LU80483A1 (fr) | 1979-03-22 |
| EP0002322A3 (en) | 1979-06-27 |
| BE871781A (fr) | 1979-05-07 |
| AU4136078A (en) | 1979-05-17 |
| BR7807288A (pt) | 1979-06-12 |
| JPS5473787A (en) | 1979-06-13 |
| GB2007670A (en) | 1979-05-23 |
| DK493678A (da) | 1979-07-12 |
| SE7811459L (sv) | 1979-05-09 |
| NO783721L (no) | 1979-05-09 |
| ZA786303B (en) | 1979-10-31 |
| DE2848054A1 (de) | 1979-05-10 |
| PL210786A1 (pl) | 1979-07-16 |
| IL55893A0 (en) | 1979-01-31 |
| DD141836A5 (de) | 1980-05-21 |
| FR2407939A1 (fr) | 1979-06-01 |
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