BE891048A - Dihydro-4', 5' antibiotique ax-127b-1, n-des-beta-lysyl-2' dihydro-4', 5' antibiotique ax-127b-1, leurs derives n-acyl-4 et n-alkyl-4 et leurs sels acceptables en pharmacie, utiles comme intermediaires pour la preparation des derives 0-demethyl-3 correspondants de l'antibiotique ax-127b-1 et comme medicaments antibiotiques - Google Patents

Dihydro-4', 5' antibiotique ax-127b-1, n-des-beta-lysyl-2' dihydro-4', 5' antibiotique ax-127b-1, leurs derives n-acyl-4 et n-alkyl-4 et leurs sels acceptables en pharmacie, utiles comme intermediaires pour la preparation des derives 0-demethyl-3 correspondants de l'antibiotique ax-127b-1 et comme medicaments antibiotiques

Info

Publication number
BE891048A
BE891048A BE0/206485A BE206485A BE891048A BE 891048 A BE891048 A BE 891048A BE 0/206485 A BE0/206485 A BE 0/206485A BE 206485 A BE206485 A BE 206485A BE 891048 A BE891048 A BE 891048A
Authority
BE
Belgium
Prior art keywords
antibiotic
dihydro
derivatives
demethyl
lysyl
Prior art date
Application number
BE0/206485A
Other languages
English (en)
Inventor
P Kurath
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BE891048A publication Critical patent/BE891048A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BE0/206485A 1980-11-10 1981-11-09 Dihydro-4', 5' antibiotique ax-127b-1, n-des-beta-lysyl-2' dihydro-4', 5' antibiotique ax-127b-1, leurs derives n-acyl-4 et n-alkyl-4 et leurs sels acceptables en pharmacie, utiles comme intermediaires pour la preparation des derives 0-demethyl-3 correspondants de l'antibiotique ax-127b-1 et comme medicaments antibiotiques BE891048A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/205,815 US4338309A (en) 1980-11-10 1980-11-10 4',5'-Dihydro-antibiotic AX-127B-1; 2'-N-des-β-lysyl-4',5'-dihydro-antibiotic AX-127B-1; and 4-N-derivatives thereof

Publications (1)

Publication Number Publication Date
BE891048A true BE891048A (fr) 1982-05-10

Family

ID=22763749

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/206485A BE891048A (fr) 1980-11-10 1981-11-09 Dihydro-4', 5' antibiotique ax-127b-1, n-des-beta-lysyl-2' dihydro-4', 5' antibiotique ax-127b-1, leurs derives n-acyl-4 et n-alkyl-4 et leurs sels acceptables en pharmacie, utiles comme intermediaires pour la preparation des derives 0-demethyl-3 correspondants de l'antibiotique ax-127b-1 et comme medicaments antibiotiques

Country Status (2)

Country Link
US (1) US4338309A (fr)
BE (1) BE891048A (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091032A (en) * 1976-09-23 1978-05-23 Abbott Laboratories 4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A
GR66054B (fr) * 1976-10-28 1981-01-14 Abbott Lab
US4187299A (en) * 1977-12-21 1980-02-05 Abbott Laboratories Fortimicin E
JPS6041679B2 (ja) * 1978-03-03 1985-09-18 協和醗酵工業株式会社 新抗生物質ホ−テイマイシンｋｇ↓１，ｋｇ↓２およびｋｇ↓３ならびにそれらの製造法
US4283529A (en) * 1980-03-03 1981-08-11 Abbott Laboratories 3-O-Demethyl derivatives of Sannamycin C and antibiotic AX-127B-1

Also Published As

Publication number Publication date
US4338309A (en) 1982-07-06

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