BE891050A - N-des-beta-lysyl-2' antibiotique ax-127b-1, ses derives de type n-acyl-4 et n-alkyl-4 et leurs sels acceptables en pharmacie utiles comme intermediaires pour la preparation du 0-demethyl-3 antibiotique ax-127b-1 et de ses derives et/ou comme medicaments antibacteriens a spectre large - Google Patents

N-des-beta-lysyl-2' antibiotique ax-127b-1, ses derives de type n-acyl-4 et n-alkyl-4 et leurs sels acceptables en pharmacie utiles comme intermediaires pour la preparation du 0-demethyl-3 antibiotique ax-127b-1 et de ses derives et/ou comme medicaments antibacteriens a spectre large

Info

Publication number
BE891050A
BE891050A BE0/206487A BE206487A BE891050A BE 891050 A BE891050 A BE 891050A BE 0/206487 A BE0/206487 A BE 0/206487A BE 206487 A BE206487 A BE 206487A BE 891050 A BE891050 A BE 891050A
Authority
BE
Belgium
Prior art keywords
antibiotic
derivatives
demethyl
lysyl
intermediates
Prior art date
Application number
BE0/206487A
Other languages
English (en)
Inventor
P Kurath
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BE891050A publication Critical patent/BE891050A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BE0/206487A 1980-11-10 1981-11-09 N-des-beta-lysyl-2' antibiotique ax-127b-1, ses derives de type n-acyl-4 et n-alkyl-4 et leurs sels acceptables en pharmacie utiles comme intermediaires pour la preparation du 0-demethyl-3 antibiotique ax-127b-1 et de ses derives et/ou comme medicaments antibacteriens a spectre large BE891050A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/205,813 US4338307A (en) 1980-11-10 1980-11-10 2'-N-Des-β-lysyl antibiotic AX-127B-1 and 4-N-acyl and alkyl derivatives thereof

Publications (1)

Publication Number Publication Date
BE891050A true BE891050A (fr) 1982-05-10

Family

ID=22763737

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/206487A BE891050A (fr) 1980-11-10 1981-11-09 N-des-beta-lysyl-2' antibiotique ax-127b-1, ses derives de type n-acyl-4 et n-alkyl-4 et leurs sels acceptables en pharmacie utiles comme intermediaires pour la preparation du 0-demethyl-3 antibiotique ax-127b-1 et de ses derives et/ou comme medicaments antibacteriens a spectre large

Country Status (2)

Country Link
US (1) US4338307A (fr)
BE (1) BE891050A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE265847T1 (de) * 1997-07-29 2004-05-15 Upjohn Co Selbstemulgierbare formulierung enthaltend lipophile verbindungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091032A (en) * 1976-09-23 1978-05-23 Abbott Laboratories 4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A
US4187299A (en) * 1977-12-21 1980-02-05 Abbott Laboratories Fortimicin E
JPS6041679B2 (ja) * 1978-03-03 1985-09-18 協和醗酵工業株式会社 新抗生物質ホ−テイマイシンｋｇ↓１，ｋｇ↓２およびｋｇ↓３ならびにそれらの製造法
US4283529A (en) * 1980-03-03 1981-08-11 Abbott Laboratories 3-O-Demethyl derivatives of Sannamycin C and antibiotic AX-127B-1

Also Published As

Publication number Publication date
US4338307A (en) 1982-07-06

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