BE902750A - Nouveaux derives de ganglioside. - Google Patents

Nouveaux derives de ganglioside.

Info

Publication number
BE902750A
BE902750A BE1/11279A BE1011279A BE902750A BE 902750 A BE902750 A BE 902750A BE 1/11279 A BE1/11279 A BE 1/11279A BE 1011279 A BE1011279 A BE 1011279A BE 902750 A BE902750 A BE 902750A
Authority
BE
Belgium
Prior art keywords
ganglioside derivatives
nerve
new ganglioside
derivatives
new
Prior art date
Application number
BE1/11279A
Other languages
English (en)
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of BE902750A publication Critical patent/BE902750A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Nouveaux dérivés de gangliosides fonctionnels comprenant des dérivés ester, amide et peracylés de gangliosides, leur méthode de préparation, des compositions pharmaceutiques les comprenant et leur utilisation dans la thérapeutique des pathologies du système nerveux périphérique et notamment dans la stimulation des phénomères de bougeonement de la cellule nerveuse, et dans l'activation des enzymes de membrane impliqués dans la conduction des stimulus nerveux.
BE1/11279A 1984-07-03 1985-06-27 Nouveaux derives de ganglioside. BE902750A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48492/84A IT1199116B (it) 1984-07-03 1984-07-03 Derivati di gangliosidi

Publications (1)

Publication Number Publication Date
BE902750A true BE902750A (fr) 1985-12-30

Family

ID=11266890

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/11279A BE902750A (fr) 1984-07-03 1985-06-27 Nouveaux derives de ganglioside.

Country Status (31)

Country Link
US (2) US4713374A (fr)
EP (1) EP0167449B1 (fr)
JP (1) JPS6163691A (fr)
KR (1) KR880001232B1 (fr)
CN (2) CN1021574C (fr)
AR (1) AR242219A1 (fr)
AT (1) ATE58739T1 (fr)
AU (1) AU578706B2 (fr)
BE (1) BE902750A (fr)
CA (1) CA1263954A (fr)
CH (1) CH670645A5 (fr)
DE (1) DE3580710D1 (fr)
DK (2) DK289885A (fr)
ES (3) ES8706711A1 (fr)
FI (1) FI84074C (fr)
FR (1) FR2567131B1 (fr)
GR (1) GR851573B (fr)
HU (2) HU199860B (fr)
IE (1) IE59376B1 (fr)
IL (1) IL75640A0 (fr)
IN (1) IN164786B (fr)
IT (1) IT1199116B (fr)
LU (1) LU85972A1 (fr)
MX (1) MX163384B (fr)
NO (1) NO164545C (fr)
NZ (1) NZ212540A (fr)
PH (1) PH27021A (fr)
PL (2) PL151289B1 (fr)
PT (1) PT80724B (fr)
YU (1) YU46603B (fr)
ZA (1) ZA854807B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
IT1177863B (it) * 1984-07-03 1987-08-26 Fidia Farmaceutici Una miscela gangliosidica come agente terapeutico capare di eliminare il dolore nele neuropatie periferiche
AU582758B2 (en) * 1984-06-28 1989-04-13 Mect Corporation Sialic acid derivatives, galactose derivatives and method for producing the same
JPS6168418A (ja) * 1984-09-11 1986-04-08 Kanto Ishi Pharma Co Ltd 去痰薬
US4769362A (en) * 1985-10-01 1988-09-06 Trustees Of Boston University Increased vascular perfusion following administration of lipids
FR2598434B1 (fr) * 1986-05-12 1988-09-16 Pf Medicament Nouveaux immunomodulateurs obtenus par hemisynthese a partir d'un polysaccharide bacterien isole d'une souche mutante non capsulee de klebsiella pneumoniae
EP0508493A1 (fr) * 1986-08-06 1992-10-14 Mect Corporation Dérivés de gangliosides et leur procédé de préparation
JPS6368526A (ja) * 1986-09-11 1988-03-28 Mect Corp シアリルグリセライドからなる神経障害疾患治療剤
NZ222192A (en) * 1986-10-20 1991-03-26 Kanto Ishi Pharma Co Ltd Glycolipid containing n-glycolylneuraminic acid, and preparation thereof
FR2614306B1 (fr) * 1987-04-22 1989-07-28 Pf Medicament Nouveau derive de d.25, procede de preparation, utilisation a titre d'agent immunostimulant et compositions pharmaceutiques le contenant.
JP2517293B2 (ja) * 1987-06-25 1996-07-24 メクト株式会社 細胞、組織修復剤
IT1212041B (it) * 1987-11-02 1989-11-08 Fidia Farmaceutici Gangliosidi esteri interni come agenti terapeutici capaci di eliminare il dolore nelle neuropatie periferiche
US5169636A (en) * 1988-03-17 1992-12-08 Nippon Fine Chemical Co., Ltd. Liposomes
IT1224513B (it) * 1988-07-19 1990-10-04 Fidia Farmaceutici Uso terapeutico del derivato estere isopropilico del monosialogangliosi de in patologie ad interessamento nervoso con componente infiammatoria
DE3840044A1 (de) * 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US6407072B1 (en) * 1988-12-02 2002-06-18 Fidia S.P.A. Lysoganglioside derivatives
IT1232175B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Analoghi semisintetici di gangliosidi
IT1232176B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Derivati di-lisogangliosidi
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
IN172427B (fr) * 1989-11-14 1993-07-24 Fidia Spa
DK238190D0 (da) * 1990-10-03 1990-10-03 Lundbeck & Co As H Depotderivater
IT1251540B (it) * 1991-05-31 1995-05-17 Fidia Spa Uso di un derivato gangliosidico.
WO1993002686A1 (fr) * 1991-07-31 1993-02-18 The Regents Of The University Of California Gangliosides comprenant des fractions de ceramides a effet immunosuppresseur
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi
AU674293B2 (en) * 1991-11-11 1996-12-19 Hans Goran Magnusson Ganglioside analogs
IT1254706B (it) 1991-12-23 1995-10-09 Fidia Spa Uso terapeutico del ganglioside gm1 nel trattamento del danno al midollo spinale
DE4204907A1 (de) * 1992-02-14 1993-08-19 Reutter Werner Neuartige glykokonjugate mit n-substituierten neuraminsaeuren als mittel zur stimulierung des immunsystems
IT1254280B (it) * 1992-03-13 1995-09-14 Fidia Spa Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson
AU7831594A (en) * 1993-09-09 1995-03-27 Duke University A method of promoting cellular function
US5567684A (en) * 1994-09-14 1996-10-22 The Regents Of The University Of California Synthetic ganglioside derivatives
IT1302530B1 (it) * 1998-12-16 2000-09-05 Fidia Spa In Amministrazione S Processo di preparazione del ganglioside gm3 e dei suoi lisoderivati apartire dal ganglioside gm1.
AU2002330968B2 (en) 2001-08-17 2007-03-22 Neose Technologies, Inc. Chemo-enzymatic synthesis of sialylated oligosaccharides
AU2002326805B2 (en) 2001-08-29 2009-01-22 Seneb Biosciences, Inc. Novel synthetic ganglioside derivatives and compositions thereof
WO2004080960A2 (fr) 2003-03-06 2004-09-23 Neose Technologies Inc. Procedes et compositions pour la synthese enzymatique de gangliosides
JP2007003173A (ja) * 2005-05-26 2007-01-11 Matsushita Electric Ind Co Ltd 冷蔵庫
US7943750B2 (en) 2007-06-18 2011-05-17 Laboratoire Medidom S.A. Process for obtaining pure monosialoganglioside GM1 for medical use
WO2009006613A1 (fr) 2007-07-03 2009-01-08 Children's Hospital & Research Center At Oakland Dérivés d'acide polysialique, procédés de production, et utilisations pour améliorer la production et le ciblage d'antigènes de cancers
WO2009006620A1 (fr) 2007-07-03 2009-01-08 Children's Hospital & Research Center At Oakland Dérivés d'acide oligosialique, procédés de fabrication et utilisations immunologiques
AU2008272854B2 (en) * 2007-07-03 2014-03-13 Children's Hospital & Research Center At Oakland Inhibitors of polysialic acid de-N-acetylase and methods for using the same
WO2010111530A1 (fr) 2009-03-25 2010-09-30 Seneb Biosciences, Inc. Glycolipides en tant que traitement de maladies
BR112012004689A2 (pt) 2009-09-01 2019-09-24 Lz Therapeutics Inc métodos para extração e purificação de gangliosídeos.
US9556467B2 (en) 2012-01-20 2017-01-31 Garnet Bio Therapeutics, Inc. Methods of ganglioside production
EP2968378A4 (fr) * 2013-03-15 2016-08-31 Garnet Biotherapeutics Inc Compositions de ganglioside

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098995A (en) * 1976-07-12 1978-07-04 American Cyanamid Company Polygalactosido-sucrose poly(h-)sulfate salts
FR2478104B1 (fr) * 1980-03-17 1986-08-08 Merieux Inst Nouveaux derives de gangliosides, leur preparation et leur application
US4435389A (en) * 1980-07-07 1984-03-06 Kabushiki Kaisha Yakult Honsha Composition for promoting growth of bifidobacteria
DE3071815D1 (en) * 1980-08-05 1986-12-11 Debat Lab Use of glycosylglucanes in the treatment of infections of the large intestines
US4476119A (en) * 1981-08-04 1984-10-09 Fidia S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
US4469795A (en) * 1981-08-26 1984-09-04 Edward Ginns Radioassay for monosialoglycosphingolipid (GM1) ganglioside concentration
NL8104293A (nl) * 1981-09-17 1983-04-18 Ihc Holland Nv Werkwijze voor het opzuigen van grond of slib met een sleepzuiger alsmede sleepzuiger voor het toepassen van de werkwijze.
CH658458A5 (fr) * 1981-12-17 1986-11-14 Lucchini Lab Sa Procede pour l'obtention du lacto-n-norhexaosyl ceramide.
EP0146810A3 (fr) * 1983-12-05 1987-05-13 Solco Basel AG Procédé de préparation de dérivés de la sphingosine
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi

Also Published As

Publication number Publication date
IN164786B (fr) 1989-06-03
PT80724B (pt) 1987-08-19
ES8801925A1 (es) 1988-03-16
YU107285A (en) 1988-08-31
NO164545C (no) 1990-10-17
KR860000310A (ko) 1986-01-27
NO164545B (no) 1990-07-09
ES552826A0 (es) 1988-04-01
DK78592A (da) 1992-06-12
PL261619A1 (en) 1988-02-04
FI84074B (fi) 1991-06-28
KR880001232B1 (ko) 1988-07-12
PL151829B1 (en) 1990-10-31
PL254207A1 (en) 1987-02-09
DK289885A (da) 1986-01-04
EP0167449A3 (en) 1987-10-21
JPS6163691A (ja) 1986-04-01
CN1021574C (zh) 1993-07-14
ZA854807B (en) 1987-09-30
PL151289B1 (en) 1990-08-31
IE59376B1 (en) 1994-02-23
IT1199116B (it) 1988-12-30
FI852515L (fi) 1986-01-04
DE3580710D1 (de) 1991-01-10
NZ212540A (en) 1989-01-27
CN85104937A (zh) 1987-01-07
HUT38652A (en) 1986-06-30
IE851608L (en) 1986-01-03
DK78592D0 (da) 1992-06-12
PH27021A (en) 1993-02-01
MX163384B (es) 1992-05-07
ES8706711A1 (es) 1987-07-01
DK289885D0 (da) 1985-06-26
AU4420885A (en) 1986-01-02
FI852515A0 (fi) 1985-06-26
US4849413A (en) 1989-07-18
IT8448492A0 (it) 1984-07-03
CH670645A5 (fr) 1989-06-30
PT80724A (en) 1985-07-01
YU46603B (sh) 1994-01-20
FI84074C (fi) 1991-10-10
FR2567131A1 (fr) 1986-01-10
US4713374A (en) 1987-12-15
EP0167449A2 (fr) 1986-01-08
LU85972A1 (fr) 1986-01-22
HU199860B (en) 1990-03-28
IL75640A0 (en) 1985-10-31
EP0167449B1 (fr) 1990-11-28
ES557807A0 (es) 1988-03-16
IT8448492A1 (it) 1986-01-03
AR242219A1 (es) 1993-03-31
AU578706B2 (en) 1988-11-03
CA1263954A (fr) 1989-12-19
CN1021333C (zh) 1993-06-23
CN1055741A (zh) 1991-10-30
ES8802055A1 (es) 1988-04-01
NO852565L (no) 1986-01-06
ATE58739T1 (de) 1990-12-15
ES544574A0 (es) 1987-07-01
GR851573B (fr) 1985-11-25
FR2567131B1 (fr) 1991-06-07

Similar Documents

Publication Publication Date Title
BE902750A (fr) Nouveaux derives de ganglioside.
ROMANUL et al. Enzymatic changes in denervated muscle: I. Histochemical studies
YU47886B (sh) Postupak za dobijanje novih sojeva s. avermitilis
DE69615561D1 (de) Polyether-blockcopolymer micellare zusammensetzungen zur zielgerichteten verabreichung biologischer stoffe
ATE122885T1 (de) Mittel zur behandlung von herzerkrankungen.
UA19808A (uk) Спосіб одержаhhя феhілалкіламіhів або солей цих сполук
FR2707882B1 (fr) Nouveaux kits thérapeutiques anti-médiateurs protéiques, procédé de préparation et compositions pharmaceutiques les renfermant.
FR2359127A1 (fr) Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation
FR2644788B1 (fr) Nouveaux steroides 3-ceto comportant une chaine en 17 amino-substituee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
RU94045825A (ru) Применение материала, полученного из mycobacterium vaccae для производства терапевтического средства для лечения психических заболеваний, способ лечения психических заболеваний, продукт, содержащий антигенный и/или иммунорегуляторный материал, фармацевтическое средство
Smith Jr et al. Effects of pharmacological agents on the physiological responses of hair discs
KUDO et al. Alteration of extracellular K+-activity induced by amino acids in the frog spinal cord
DE3750235D1 (de) Behandlung von autoimmunen Krankheiten mit Immunoverstärkungssubstanzen.
Schwartz et al. Metabolism of acetylcholine in the nervous system of Aplysia californica. I. Source of choline and its uptake by intact nervous tissue.
Tecce et al. Chlorpromazine effects on brain activity (contingent negative variation) and reaction time in normal women
FR2553409B1 (fr) Nouveaux benzenesulfonyl-lactames, leur procede de preparation et leur application comme substance active de compositions pharmaceutiques
FR2585709B1 (fr) Nouveaux derives peptidiques a structure lactonique ou cycloamidique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
OA07684A (fr) Nouveaux acides flavone-carboxylique-4, leur méthode de préparation et leur application thérapeutique.
BG44709A3 (bg) Метод за получаване на 9-хлор-1,5-бензотиазепинови производни
Suzuki et al. Laminar stimulation for direct cortical responses from intact and chronically isolated cortex
FR2582835B1 (fr) Derives de la quinoleine, leur procede de preparation et compositions pharmaceutiques les contenant
FR2619220B1 (fr) Antigenes specifiques de leishmania et leur procede de preparation, profils antigeniques contenant ces antigenes et leur application au diagnostic des leishmanioses viscerales.
FR2603040B1 (fr) Proteine, sequence d'adn, poxvirus, cellules et leur procede de culture, ainsi que les compositions pharmaceutiques les contenant, utiles dans la prevention de la schistosomose
FR2622194B1 (fr) Nouveaux derives de la 19-nor progesterone, leur procede d'obtention et les compositions pharmaceutiques en contenant
Ornitz et al. The recovery cycle of the averaged auditory evoked response during sleep in autistic children

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FIDIA S.P.A.

Effective date: 20000630