BE903778A - Derives d'indoles. - Google Patents

Derives d'indoles.

Info

Publication number
BE903778A
BE903778A BE0/215954A BE215954A BE903778A BE 903778 A BE903778 A BE 903778A BE 0/215954 A BE0/215954 A BE 0/215954A BE 215954 A BE215954 A BE 215954A BE 903778 A BE903778 A BE 903778A
Authority
BE
Belgium
Prior art keywords
alkyl
alkenyl
optionally substituted
phenyl
chain
Prior art date
Application number
BE0/215954A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848430626A external-priority patent/GB8430626D0/en
Priority claimed from GB848430625A external-priority patent/GB8430625D0/en
Priority claimed from GB848430624A external-priority patent/GB8430624D0/en
Priority claimed from GB848430773A external-priority patent/GB8430773D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE903778A publication Critical patent/BE903778A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Des dérivés d'indoles qui répondent à la formule (I) : dans laquelle R1 = H, alkyle ou alcényle ; R2 = H, alkyle alcényle, cycloalkyle, phényle ou phénylalkyle, le noyau phényle étant facultativement substitué par halogène, alkyle, alcoxy, hydroxyle ou par un groupe -NRaRb ou -CONRaRb dans lequel Ra, Rb sont H, Alkyle, alcényle ou avec un atome d'azote ; R3 et R4 sont H, alkyle ou propényle ou forment ensemble un radical aralkylidène ; Alk = chaine alkyle en C2-3 facultativement substituée par un ou deux radicaux alkyle ; et A1 représente une chaine alcényle en C2-5' et leurs sels et solvates. Les composés ont une activité vasoconstrictrice et sont utiles contre la douleur provenant de la dilatation du système vasculaire cranien en particulier de la migraine.
BE0/215954A 1984-12-04 1985-12-03 Derives d'indoles. BE903778A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB848430626A GB8430626D0 (en) 1984-12-04 1984-12-04 Chemical compounds
GB848430625A GB8430625D0 (en) 1984-12-04 1984-12-04 Production of chemical compounds
GB848430624A GB8430624D0 (en) 1984-12-04 1984-12-04 Chemical compounds
GB848430773A GB8430773D0 (en) 1984-12-05 1984-12-05 Chemical compounds

Publications (1)

Publication Number Publication Date
BE903778A true BE903778A (fr) 1986-06-03

Family

ID=27449610

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215954A BE903778A (fr) 1984-12-04 1985-12-03 Derives d'indoles.

Country Status (10)

Country Link
US (1) US4785016A (fr)
AU (1) AU584142B2 (fr)
BE (1) BE903778A (fr)
CH (1) CH667647A5 (fr)
DE (1) DE3542698A1 (fr)
FR (1) FR2574077A1 (fr)
GB (1) GB2168973B (fr)
IT (1) IT1181741B (fr)
NL (1) NL8503337A (fr)
SE (1) SE8505715L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
IL87437A0 (en) * 1987-08-13 1989-01-31 Glaxo Group Ltd Indole derivatives,their preparation and pharmaceutical compositions containing them
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
SI9111010B (sl) * 1990-06-07 2005-02-28 Astrazeneca Ab 3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti
AT394895B (de) * 1990-07-05 1992-07-10 Steyr Daimler Puch Ag Fluessigkeitsreibungskupplung
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
GB9207396D0 (en) * 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
ES2059236B1 (es) * 1992-06-18 1995-06-16 Imidex S A Procedimiento para la sintesis de la 3-(2-dimetilamino) etil)-n-metil-1h-indol-5-metanosulfonamida.
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
DE19963178A1 (de) * 1999-12-27 2001-07-05 Gruenenthal Gmbh Substituierte Indol-Mannichbasen
US10736878B2 (en) 2012-01-06 2020-08-11 Tina Pfadenhauer Treatment of organophosphate exposure with triptans

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof

Also Published As

Publication number Publication date
GB2168973B (en) 1988-02-03
CH667647A5 (fr) 1988-10-31
US4785016A (en) 1988-11-15
GB2168973A (en) 1986-07-02
AU584142B2 (en) 1989-05-18
IT1181741B (it) 1987-09-30
DE3542698A1 (de) 1986-06-05
IT8548869A0 (it) 1985-12-03
AU5070585A (en) 1986-06-12
FR2574077A1 (fr) 1986-06-06
GB8529799D0 (en) 1986-01-08
NL8503337A (nl) 1986-07-01
SE8505715L (sv) 1986-06-05
SE8505715D0 (sv) 1985-12-03

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19921231