BE904709A - Antibiotiques du type des macrolides et leur preparation. - Google Patents

Antibiotiques du type des macrolides et leur preparation.

Info

Publication number
BE904709A
BE904709A BE0/216612A BE216612A BE904709A BE 904709 A BE904709 A BE 904709A BE 0/216612 A BE0/216612 A BE 0/216612A BE 216612 A BE216612 A BE 216612A BE 904709 A BE904709 A BE 904709A
Authority
BE
Belgium
Prior art keywords
preparation
type antibiotics
macrolide type
compounds
substituted
Prior art date
Application number
BE0/216612A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858510943A external-priority patent/GB8510943D0/en
Priority claimed from GB858510944A external-priority patent/GB8510944D0/en
Priority claimed from GB858510942A external-priority patent/GB8510942D0/en
Priority claimed from GB868606103A external-priority patent/GB8606103D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE904709A publication Critical patent/BE904709A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Composées de la formule dans laquelle R1 est méthyle, éthyle ou isopropyle;R2 représente H ou OR5 qui est lui-meme hydroxyle ou hydroxyle substitué et R3 est H, ou R2 et R3 représentent un groupe C=C avec l'atome de carbone qui les relie et OR4 a la signification de OR5, avec la condition que lorsque R2 représente OH, OR4 représente OH substitué autre que méthoxy. Ces composés peuvent s'utiliser pour combattre des insectes, des acariens, des nématodes et d'autres organismes nuisibles.
BE0/216612A 1985-04-30 1986-04-30 Antibiotiques du type des macrolides et leur preparation. BE904709A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858510943A GB8510943D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB858510944A GB8510944D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB858510942A GB8510942D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB868606103A GB8606103D0 (en) 1986-03-12 1986-03-12 Chemical compounds

Publications (1)

Publication Number Publication Date
BE904709A true BE904709A (fr) 1986-10-30

Family

ID=27449656

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216612A BE904709A (fr) 1985-04-30 1986-04-30 Antibiotiques du type des macrolides et leur preparation.

Country Status (25)

Country Link
US (1) US4978675A (fr)
JP (1) JPH0819132B2 (fr)
KR (1) KR930011282B1 (fr)
AT (1) AT397095B (fr)
AU (1) AU596586B2 (fr)
BE (1) BE904709A (fr)
CA (1) CA1335368C (fr)
CH (1) CH675124A5 (fr)
DE (1) DE3614549C2 (fr)
DK (1) DK160992C (fr)
ES (4) ES8802229A1 (fr)
FR (1) FR2587344B1 (fr)
GB (1) GB2176182B (fr)
GE (3) GEP19971046B (fr)
HU (1) HU200771B (fr)
IE (1) IE59070B1 (fr)
IL (1) IL78621A (fr)
LU (1) LU86412A1 (fr)
LV (2) LV10777B (fr)
NL (1) NL193420C (fr)
NZ (1) NZ215997A (fr)
PH (1) PH23386A (fr)
PT (1) PT82485B (fr)
RU (1) RU2004545C1 (fr)
SE (1) SE503571C2 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
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CH666690A5 (de) * 1984-09-14 1988-08-15 Glaxo Group Ltd Antibiotisch wirkende verbindungen der makrolidgruppe aus streptomyces-mikroorganismen, ihre herstellung und verwendung.
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
EP0215654B1 (fr) * 1985-09-13 1995-03-15 American Cyanamid Company Antibiotiques du type macrolide et leur préparation
US5185456A (en) * 1986-03-12 1993-02-09 American Cyanamid Company Macrolide compounds
GB8606108D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
US5336789A (en) * 1986-03-12 1994-08-09 American Cyanamid Company Macrolide compounds
BE1003039A4 (fr) * 1986-03-12 1991-11-05 American Cyanamid Co Nouveau compose antibiotique et procedes pour sa preparation.
BR8701119A (pt) * 1986-03-12 1988-01-05 Glaxo Group Ltd Processo para a preparacao de compostos,composicao para o controle de pragas e processo para combater pragas na agricultura
BR8701121A (pt) * 1986-03-12 1988-01-05 Glaxo Group Ltd Processo para a preparacao de um composto e processo para combate a pestes
GB8606123D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
CA1296329C (fr) * 1986-06-06 1992-02-25 Derek R. Sutherland Composes de type macrolide
GB8613790D0 (en) * 1986-06-06 1986-07-09 Glaxo Group Ltd Chemical compounds
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
DE3750495T2 (de) * 1986-07-24 1995-02-23 Beecham Group Plc Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen.
DE3782481T2 (de) * 1986-09-12 1993-05-19 American Cyanamid Co 23-deoxy-derivate von ll-f28249-verbindungen.
EP0260537A1 (fr) * 1986-09-12 1988-03-23 American Cyanamid Company Dérivés 13-déoxy-23-oxo(céto) et 23-imino des composés de 13-déoxy-C-076-aglycone
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
ATE109783T1 (de) * 1986-09-12 1994-08-15 American Cyanamid Co 23-oxo(keto) und 23-imino-derivate von ll-f28249- verbindungen.
US5149832A (en) * 1986-09-12 1992-09-22 American Cyanamid Company Mono and diacyl derivatives of ll-f28249 compounds
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US4956479A (en) * 1987-03-06 1990-09-11 American Cyanamid Company 23-deoxy-27-chloro derivatives of LL-F28249 compounds
US4886829A (en) * 1987-03-06 1989-12-12 American Cyanamid Company 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
US4886830A (en) * 1987-03-06 1989-12-12 American Cyanamid Company Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
EP0285561A3 (fr) * 1987-03-27 1989-10-25 Ciba-Geigy Ag Dérivés de la milbémycine à activité antiparasitaire et insecticide
JPS6431776A (en) * 1987-07-28 1989-02-02 Sankyo Co Novel macrolide compound and production thereof
GB8721375D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721373D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721378D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721376D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
JPH01156981A (ja) * 1987-09-11 1989-06-20 American Cyanamid Co マクロライド化合物の製法
GB8721647D0 (en) * 1987-09-15 1987-10-21 Pfizer Ltd Antiparasitic agents
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
CA1340771C (fr) * 1987-11-09 1999-09-28 Shih-Jen Edward Lee Avermectines ethylees
GB8726384D0 (en) * 1987-11-11 1987-12-16 Coopers Animal Health Veterinary treatment
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
GB8801908D0 (en) * 1988-01-28 1988-02-24 Glaxo Group Ltd Chemical compounds
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
NZ229052A (en) * 1988-05-10 1991-03-26 American Cyanamid Co Milbemycin derivatives, use for combating pests
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
US5428034A (en) * 1988-09-02 1995-06-27 Sankyo Co., Ltd. Milbemycin derivatives, their preparation and their use
EP0393890B1 (fr) * 1989-04-11 1992-08-12 Pfizer Limited Compositions injectables à base de 25-cyclohexyle avermectine B1
US6001822A (en) * 1989-04-11 1999-12-14 Pfizer Inc. Antiparasitic formulations
NZ234802A (en) * 1989-08-14 1992-11-25 Merck & Co Inc Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals
US5055486A (en) * 1989-12-22 1991-10-08 American Cyanamid Company 13-alkyl-23-imino derivative of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents
US4988824A (en) * 1989-09-11 1991-01-29 Maulding Donald R Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US5290804A (en) * 1991-05-01 1994-03-01 Merck & Co., Inc. Anthelmintic milbemycin analogs of novel microorganisms
DE69229318T2 (de) * 1991-09-30 1999-11-18 Merck & Co Inc Hydrierte Rizinusöl-enthaltende injizierbare Formulierungen mit verlängerter Wirkstoffabgabe
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
GB9402916D0 (en) * 1994-02-16 1994-04-06 Pfizer Ltd Antiparasitic agents
GB9408044D0 (en) * 1994-04-22 1994-06-15 Sod Conseils Rech Applic Conversion of ginkgolide c to ginkgolide b
DE19534366C2 (de) * 1995-09-15 2000-08-17 Asta Medica Ag Verfahren zur Herstellung von 2,3,4,6-Tetra-O-benzyl-D-glucopyranose und 2,3,4,6-Tetra-O-allyl-D-glucopyranose
ES2155172T3 (es) * 1995-09-29 2001-05-01 Sankyo Co Derivados milbemicina 5-oxima 13-sustituidos, su preparacion y su uso contra insectos y otras plagas.
CA2211949A1 (fr) * 1997-07-21 1999-01-29 David Farley Johnson Compositions non aqueuses a administrer par voie parenterale
PT1197215E (pt) 2000-10-10 2006-07-31 Wyeth Corp Composicoes antelminticas
NZ552040A (en) * 2006-12-13 2009-04-30 Bomac Research Ltd Veterinary formulation comprising an anthelmintic compound and glyceryl acetate
DE102010064245A1 (de) 2010-12-28 2012-06-28 Bayer Animal Health Gmbh Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen
WO2012028556A1 (fr) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Lactones macrocycliques et leur utilisation et leurs combinaisons avec d'autres substances actives

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Publication number Priority date Publication date Assignee Title
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
US4550160A (en) * 1979-08-13 1985-10-29 Merck & Co., Inc. Processes for the interconversion of C-076 compounds
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4457920A (en) * 1981-09-03 1984-07-03 Merck & Co., Inc. 4a-Substituted avermectin compounds
US4423209A (en) * 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
JPS59108785A (ja) * 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体
JPS60126289A (ja) * 1983-11-14 1985-07-05 Sankyo Co Ltd ミルベマイシン類の５−カ−ボネ−ト誘導体
DE3519834C2 (de) * 1984-06-05 1993-12-16 American Cyanamid Co Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen
CH666690A5 (de) * 1984-09-14 1988-08-15 Glaxo Group Ltd Antibiotisch wirkende verbindungen der makrolidgruppe aus streptomyces-mikroorganismen, ihre herstellung und verwendung.
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina

Also Published As

Publication number Publication date
IE861127L (en) 1986-10-30
CH675124A5 (fr) 1990-08-31
ES557851A0 (es) 1990-05-01
US4978675A (en) 1990-12-18
IL78621A0 (en) 1986-08-31
RU2004545C1 (ru) 1993-12-15
SE503571C2 (sv) 1996-07-08
PT82485A (en) 1986-05-01
ES8802522A1 (es) 1988-07-16
DK160992C (da) 1991-11-11
ES9000023A1 (es) 1990-05-01
IE59070B1 (en) 1993-12-15
SE8601998D0 (sv) 1986-04-29
NL8601103A (nl) 1986-11-17
DK160992B (da) 1991-05-13
ES557517A0 (es) 1988-07-16
PH23386A (en) 1989-07-26
LV10314B (en) 1995-08-20
AT397095B (de) 1994-01-25
JPH0819132B2 (ja) 1996-02-28
GEP19971046B (en) 1997-11-26
DK196586A (da) 1986-10-31
FR2587344B1 (fr) 1991-04-05
ATA115486A (de) 1993-06-15
ES8900093A1 (es) 1988-12-01
NL193420B (nl) 1999-06-01
PT82485B (pt) 1988-03-03
HUT46012A (en) 1988-09-28
IL78621A (en) 1991-06-30
JPS61280496A (ja) 1986-12-11
GB2176182B (en) 1989-02-01
ES8802229A1 (es) 1988-04-16
KR930011282B1 (ko) 1993-11-29
LV10777B (en) 1996-04-20
DE3614549A1 (de) 1987-01-02
GB8610631D0 (en) 1986-06-04
GEP19970833B (en) 1997-02-10
LV10314A (lv) 1994-10-20
AU5676786A (en) 1986-11-06
LV10777A (lv) 1995-08-20
GEP20001917B (en) 2000-01-05
FR2587344A1 (fr) 1987-03-20
AU596586B2 (en) 1990-05-10
SE8601998L (sv) 1986-10-31
KR860008205A (ko) 1986-11-14
HU200771B (en) 1990-08-28
LU86412A1 (fr) 1986-11-05
NZ215997A (en) 1989-06-28
DK196586D0 (da) 1986-04-29
ES554444A0 (es) 1988-04-16
DE3614549C2 (de) 1998-03-12
ES557774A0 (es) 1988-12-01
CA1335368C (fr) 1995-04-25
GB2176182A (en) 1986-12-17
NL193420C (nl) 1999-10-04

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Legal Events

Date Code Title Description
RE Patent lapsed

Effective date: 20030430