BG100040A - Индолови производни като 5-нт1а и/или 5-нт2 лиганди - Google Patents
Индолови производни като 5-нт1а и/или 5-нт2 лиганди Download PDFInfo
- Publication number
- BG100040A BG100040A BG100040A BG10004095A BG100040A BG 100040 A BG100040 A BG 100040A BG 100040 A BG100040 A BG 100040A BG 10004095 A BG10004095 A BG 10004095A BG 100040 A BG100040 A BG 100040A
- Authority
- BG
- Bulgaria
- Prior art keywords
- ylmethyl
- indole
- compound
- methoxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI930699A IT1271352B (it) | 1993-04-08 | 1993-04-08 | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
| PCT/EP1994/001016 WO1994024125A1 (en) | 1993-04-08 | 1994-03-31 | Indole derivatives as 5-ht1a and/or 5-ht2 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG100040A true BG100040A (bg) | 1996-03-29 |
Family
ID=11365694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG100040A BG100040A (bg) | 1993-04-08 | 1995-10-02 | Индолови производни като 5-нт1а и/или 5-нт2 лиганди |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5834493A (de) |
| EP (1) | EP0694033A1 (de) |
| JP (1) | JPH08508738A (de) |
| CN (1) | CN1124960A (de) |
| AU (1) | AU684276B2 (de) |
| BG (1) | BG100040A (de) |
| BR (1) | BR9406206A (de) |
| CA (1) | CA2160020A1 (de) |
| CZ (1) | CZ283398B6 (de) |
| FI (1) | FI954734L (de) |
| HU (1) | HUT74090A (de) |
| IL (1) | IL109234A (de) |
| IT (1) | IT1271352B (de) |
| NO (1) | NO953967L (de) |
| NZ (1) | NZ265055A (de) |
| PL (1) | PL310995A1 (de) |
| SG (1) | SG50507A1 (de) |
| SK (1) | SK119795A3 (de) |
| WO (1) | WO1994024125A1 (de) |
| ZA (1) | ZA942383B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9420521D0 (en) * | 1994-10-12 | 1994-11-30 | Smithkline Beecham Plc | Novel compounds |
| SK285410B6 (sk) * | 1997-05-09 | 2007-01-04 | H. Lundbeck A/S | Spôsob výroby sertindolu a medziproduktov |
| CA2317439A1 (en) | 1998-01-14 | 1999-07-22 | Wayne J. Brouillette | Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme |
| US6673827B1 (en) | 1999-06-29 | 2004-01-06 | The Uab Research Foundation | Methods of treating fungal infections with inhibitors of NAD synthetase enzyme |
| US6861448B2 (en) * | 1998-01-14 | 2005-03-01 | Virtual Drug Development, Inc. | NAD synthetase inhibitors and uses thereof |
| US6133287A (en) * | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
| AU3386299A (en) * | 1998-04-08 | 1999-10-25 | American Home Products Corporation | N-aryloxyethylamine derivatives for the treatment of depression |
| CN1307576A (zh) * | 1998-04-29 | 2001-08-08 | 美国家用产品公司 | 5－羟色胺能药物 |
| FR2799463B1 (fr) * | 1999-10-12 | 2004-04-16 | Adir | Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent |
| DE19951360A1 (de) * | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| ATE327232T1 (de) * | 2000-12-22 | 2006-06-15 | Wyeth Corp | Heterozyklylalkylindole oder -azaindole als 5- hydroxytryptamine-6 liganden |
| US7135479B2 (en) | 2002-09-12 | 2006-11-14 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans |
| CA2796756A1 (en) * | 2010-04-22 | 2011-10-27 | Intra-Cellular Therapies, Inc. | Substituted pyrido(3',4':4,5)pyrrolo(1,2,3-de)quinoxalines for the treatment of central nervous system disorders |
| KR20140146192A (ko) | 2012-04-14 | 2014-12-24 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| US9708322B2 (en) | 2013-03-15 | 2017-07-18 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity |
| KR102373288B1 (ko) | 2013-12-03 | 2022-03-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| CA2944755A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2017023894A1 (en) * | 2015-08-03 | 2017-02-09 | Raze Therapeutics, Inc. | Mthfd2 inhibitors and uses thereof |
| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| DK3407889T3 (da) | 2016-03-25 | 2021-08-09 | Intra Cellular Therapies Inc | Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| EP3525763B1 (de) | 2016-10-12 | 2025-03-05 | Intra-Cellular Therapies, Inc. | Amorphe feste dispersionen |
| EP3562484B1 (de) | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalinderivate zur behandlung von erkrankungen des zns |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| RU2767410C2 (ru) | 2017-03-24 | 2022-03-17 | Интра-Селлулар Терапиз, Инк. | Новые композиции и способы |
| WO2019023062A1 (en) | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | ORGANIC COMPOUNDS |
| EP3658144B1 (de) | 2017-07-26 | 2022-01-26 | Intra-Cellular Therapies, Inc. | Pyridopyrroloquinoxalinverbindungen, deren zusammensetzungen und verwendungen in therapie |
| CN112040940A (zh) | 2018-03-23 | 2020-12-04 | 细胞内治疗公司 | 有机化合物 |
| EP3801527B1 (de) | 2018-06-08 | 2025-02-19 | Intra-Cellular Therapies, Inc. | Anellierte gamma-carboline zur akutbehandlung von angst oder depression |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| BR112021003655A2 (pt) | 2018-08-31 | 2021-05-18 | Intra-Cellular Therapies, Inc. | métodos novos |
| WO2020047408A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
| WO2021007245A1 (en) | 2019-07-07 | 2021-01-14 | Intra-Cellular Therapies, Inc. | Novel methods |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0429341A3 (en) * | 1989-11-20 | 1991-11-13 | Rhone-Poulenc Sante | Heterocyclic derivatives, their preparation and pharmaceuticals containing them |
| PL170330B1 (pl) * | 1990-10-15 | 1996-11-29 | Pfizer | Sposób wytwarzania nowych pochodnych indolu PL PL PL PL PL PL |
| JP3140155B2 (ja) * | 1992-03-09 | 2001-03-05 | 杏林製薬株式会社 | Ｎ，ｎ’−ジ置換アミド誘導体 |
| CA2092112A1 (en) * | 1992-03-23 | 1993-09-24 | Nobuyoshi Iwata | Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use |
-
1993
- 1993-04-08 IT ITMI930699A patent/IT1271352B/it active IP Right Grant
-
1994
- 1994-03-31 JP JP6522684A patent/JPH08508738A/ja active Pending
- 1994-03-31 CA CA002160020A patent/CA2160020A1/en not_active Abandoned
- 1994-03-31 PL PL94310995A patent/PL310995A1/xx unknown
- 1994-03-31 SG SG1996002949A patent/SG50507A1/en unknown
- 1994-03-31 US US08/530,354 patent/US5834493A/en not_active Expired - Fee Related
- 1994-03-31 CN CN94192345A patent/CN1124960A/zh active Pending
- 1994-03-31 AU AU65382/94A patent/AU684276B2/en not_active Ceased
- 1994-03-31 NZ NZ265055A patent/NZ265055A/en unknown
- 1994-03-31 FI FI954734A patent/FI954734L/fi unknown
- 1994-03-31 SK SK1197-95A patent/SK119795A3/sk unknown
- 1994-03-31 BR BR9406206A patent/BR9406206A/pt not_active Application Discontinuation
- 1994-03-31 WO PCT/EP1994/001016 patent/WO1994024125A1/en not_active Ceased
- 1994-03-31 HU HU9502913A patent/HUT74090A/hu unknown
- 1994-03-31 EP EP94913101A patent/EP0694033A1/de not_active Withdrawn
- 1994-03-31 CZ CZ952602A patent/CZ283398B6/cs unknown
- 1994-04-06 IL IL109234A patent/IL109234A/en not_active IP Right Cessation
- 1994-04-07 ZA ZA942383A patent/ZA942383B/xx unknown
-
1995
- 1995-10-02 BG BG100040A patent/BG100040A/bg unknown
- 1995-10-05 NO NO953967A patent/NO953967L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO953967D0 (no) | 1995-10-05 |
| IT1271352B (it) | 1997-05-27 |
| EP0694033A1 (de) | 1996-01-31 |
| BR9406206A (pt) | 1996-02-06 |
| FI954734A0 (fi) | 1995-10-05 |
| FI954734A7 (fi) | 1995-10-05 |
| CZ260295A3 (en) | 1996-01-17 |
| FI954734L (fi) | 1995-10-05 |
| PL310995A1 (en) | 1996-01-22 |
| CZ283398B6 (cs) | 1998-04-15 |
| IL109234A0 (en) | 1994-07-31 |
| CA2160020A1 (en) | 1994-10-27 |
| SK119795A3 (en) | 1996-04-03 |
| SG50507A1 (en) | 1998-07-20 |
| HUT74090A (en) | 1996-11-28 |
| US5834493A (en) | 1998-11-10 |
| IL109234A (en) | 1998-04-05 |
| JPH08508738A (ja) | 1996-09-17 |
| NO953967L (no) | 1995-12-05 |
| HU9502913D0 (en) | 1995-11-28 |
| ITMI930699A1 (it) | 1994-10-08 |
| ITMI930699A0 (it) | 1993-04-08 |
| CN1124960A (zh) | 1996-06-19 |
| NZ265055A (en) | 1996-09-25 |
| AU6538294A (en) | 1994-11-08 |
| AU684276B2 (en) | 1997-12-11 |
| ZA942383B (en) | 1995-10-09 |
| WO1994024125A1 (en) | 1994-10-27 |
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