BG101209A - Хиполипидемични 1,4-бензотиазепин-1,1-диоксиди - Google Patents

Хиполипидемични 1,4-бензотиазепин-1,1-диоксиди

Info

Publication number
BG101209A
BG101209A BG101209A BG10120997A BG101209A BG 101209 A BG101209 A BG 101209A BG 101209 A BG101209 A BG 101209A BG 10120997 A BG10120997 A BG 10120997A BG 101209 A BG101209 A BG 101209A
Authority
BG
Bulgaria
Prior art keywords
hypolypidemic
benzothiazepine
dioxides
new
hiperlipidemic
Prior art date
Application number
BG101209A
Other languages
English (en)
Other versions
BG62048B1 (bg
Inventor
Lawrence Brieaddy
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of BG101209A publication Critical patent/BG101209A/bg
Publication of BG62048B1 publication Critical patent/BG62048B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

Изобретението се отнася до нови хиполипидемични бензотиазепиндиоксиди с формуладо метод и нови междинни продукти за получаването им, до фармацевтичнисъстави, които ги съдържат, и до приложението им в медицината, по-специално при профилактика и лечението на хиперлипидемични състояния като атеросклероза.
BG101209A 1994-08-10 1997-02-07 Хиполипидемични 1,4-бензотиазепин-1,1-диоксиди BG62048B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28852794A 1994-08-10 1994-08-10
PCT/GB1995/001884 WO1996005188A1 (en) 1994-08-10 1995-08-09 Hypolipidemic 1,4-benzothiazepine-1,1-dioxides

Publications (2)

Publication Number Publication Date
BG101209A true BG101209A (bg) 1997-08-29
BG62048B1 BG62048B1 (bg) 1999-01-29

Family

ID=23107516

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101209A BG62048B1 (bg) 1994-08-10 1997-02-07 Хиполипидемични 1,4-бензотиазепин-1,1-диоксиди

Country Status (30)

Country Link
US (1) US5910494A (bg)
EP (2) EP0775126B1 (bg)
JP (1) JP2935756B2 (bg)
KR (1) KR100354288B1 (bg)
CN (1) CN1059673C (bg)
AP (1) AP720A (bg)
AT (1) ATE226946T1 (bg)
AU (1) AU696073B2 (bg)
BG (1) BG62048B1 (bg)
BR (1) BR9508586A (bg)
CA (1) CA2197099A1 (bg)
CZ (1) CZ37397A3 (bg)
DE (1) DE69528704T2 (bg)
DK (1) DK0775126T3 (bg)
EE (1) EE9700028A (bg)
ES (1) ES2185711T3 (bg)
FI (1) FI970531A0 (bg)
HU (1) HUT77129A (bg)
IL (1) IL114877A (bg)
IS (1) IS4418A (bg)
MX (1) MX9700890A (bg)
NO (1) NO308131B1 (bg)
NZ (1) NZ290911A (bg)
OA (1) OA10597A (bg)
PL (1) PL184512B1 (bg)
PT (1) PT775126E (bg)
RU (1) RU2156245C2 (bg)
SK (1) SK17797A3 (bg)
WO (1) WO1996005188A1 (bg)
ZA (1) ZA956647B (bg)

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ES2155136T3 (es) * 1994-09-13 2001-05-01 Monsanto Co Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato.
GB9423172D0 (en) * 1994-11-17 1995-01-04 Wellcom Foundation The Limited Hypolipidemic benzothiazepines

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ES2185711T3 (es) 2003-05-01
NO970585D0 (no) 1997-02-07
WO1996005188A1 (en) 1996-02-22
AU4426096A (en) 1996-03-07
FI970531L (fi) 1997-02-07
DK0775126T3 (da) 2003-03-03
RU2156245C2 (ru) 2000-09-20
CN1161035A (zh) 1997-10-01
EP1203769A1 (en) 2002-05-08
CA2197099A1 (en) 1996-02-22
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MX9700890A (es) 1997-04-30
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FI970531A0 (fi) 1997-02-07
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