BG102229A - Endothelium receptor antagonists - Google Patents

Endothelium receptor antagonists

Info

Publication number: BG102229A
Authority: BG; Bulgaria
Prior art keywords: receptor antagonists; endothelium receptor; endothelium; antagonistsand; andtriazoles
Prior art date: 1995-08-02

Application number

BG102229A

Other languages

Bulgarian (bg)

English (en)

Inventor

Juan Luengo

John Elliott

Original Assignee

Smithkline Beecham Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-02

Filing date

1998-02-02

Publication date

1998-09-30

1998-02-02 Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation

1998-09-30 Publication of BG102229A publication Critical patent/BG102229A/xx

Links

210000003038 endothelium Anatomy 0.000 title abstract 2
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003233 pyrroles Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

BG102229A 1995-08-02 1998-02-02 Endothelium receptor antagonists BG102229A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US179295P	1995-08-02	1995-08-02
US1098296P	1996-02-01	1996-02-01
PCT/US1996/012581 WO1997004772A1 (en)	1995-08-02	1996-08-02	Endothelin receptor antagonists

Publications (1)

Publication Number	Publication Date
BG102229A true BG102229A (en)	1998-09-30

Family

ID=26669471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102229A BG102229A (en)	1995-08-02	1998-02-02	Endothelium receptor antagonists

Country Status (25)

Country	Link
US (5)	US5969151A (cs)
EP (2)	EP0843551B1 (cs)
JP (2)	JP2001517195A (cs)
KR (1)	KR19990036032A (cs)
CN (1)	CN1196680A (cs)
AP (1)	AP9801182A0 (cs)
AT (1)	ATE341324T1 (cs)
AU (2)	AU717172B2 (cs)
BG (1)	BG102229A (cs)
BR (1)	BR9609914A (cs)
CA (2)	CA2228293A1 (cs)
CZ (1)	CZ30498A3 (cs)
DE (2)	DE69619116T2 (cs)
EA (1)	EA000952B1 (cs)
ES (2)	ES2171697T3 (cs)
HU (1)	HU220776B1 (cs)
MX (1)	MX9800975A (cs)
NO (1)	NO980422L (cs)
NZ (1)	NZ315846A (cs)
OA (1)	OA10755A (cs)
PL (1)	PL184272B1 (cs)
RO (1)	RO115802B1 (cs)
SK (1)	SK282584B6 (cs)
TR (1)	TR199800152T1 (cs)
WO (2)	WO1997004772A1 (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR017426A1 (es) *	1997-12-08	2001-09-05	Smithkline Beecham Corp	Sal de monoargininilo del acido (e)-3-[1-n-butil-5-[2-(2-carboxifenil)metoxi-4-clorofenil]-1h-pirazol-4-il]-2-[(5-metoxi-2,3-dihidrobenzofuran-6-il)metil]-prop-2-enoico, composicion farmaceutica que la contiene, su uso para la manufactura de un medicamento y procedimiento para su preparacion
DE10155076A1 (de) *	2001-11-09	2003-05-22	Merck Patent Gmbh	Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
US7087630B2 (en) *	2002-06-27	2006-08-08	Nitromed, Inc.	Cyclooxygenase 2 selective inhibitors, compositions and methods of use
WO2006075955A1 (en) *	2005-01-13	2006-07-20	Astrazeneca Ab	Pyrazolyl acylsulfonamide derivatives as endothelin converting enzyme inhibitors and useful in the treatment of chronic obstructive pulmonary disease
US7521435B2 (en) *	2005-02-18	2009-04-21	Pharma Diagnostics, N.V.	Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
US8012038B1 (en)	2008-12-11	2011-09-06	Taylor Made Golf Company, Inc.	Golf club head
US10086240B1 (en)	2015-08-14	2018-10-02	Taylor Made Golf Company, Inc.	Golf club head
EP3380970B1 (en)	2015-11-24	2023-01-04	Sanford Burnham Prebys Medical Discovery Institute	Novel azole derivatives as apelin receptor agonist
US10773135B1 (en)	2019-08-28	2020-09-15	Taylor Made Golf Company, Inc.	Golf club head

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1937241A1 (de) *	1968-08-02	1970-02-19	Sumitomo Chemical Co	3,5-Dioxopyrazolidinderivate und Verfahren zu ihrer Herstellung
JPH01211582A (ja) *	1988-02-16	1989-08-24	Tanabe Seiyaku Co Ltd	ベンゾジオキソール誘導体
EP0403158A3 (en) *	1989-06-14	1991-12-18	Smithkline Beecham Corporation	Imidazolyl-alkenoic acids
JP3214856B2 (ja) *	1990-12-14	2001-10-02	スミスクライン・ビーチャム・コーポレイション	イミダゾリル−アルケン酸
FR2682379B1 (fr) *	1991-10-09	1994-02-11	Rhone Poulenc Agrochimie	Nouveaux phenylpyrazoles fongicides.
WO1994022830A1 (en) *	1993-03-31	1994-10-13	Smithkline Beecham Corporation	Chemical compounds
AU675870B2 (en) *	1993-08-18	1997-02-20	Msd K.K.	Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
IL111613A0 (en) *	1993-11-12	1995-01-24	Rhone Poulenc Rorer Ltd	Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them
DE69526738T2 (de) *	1994-09-02	2003-02-06	Smithkline Beecham Corp., Philadelphia	Endothelin-rezeptor-antagonisten

1996
- 1996-08-02 MX MX9800975A patent/MX9800975A/es not_active IP Right Cessation
- 1996-08-02 AT AT96928036T patent/ATE341324T1/de not_active IP Right Cessation
- 1996-08-02 WO PCT/US1996/012581 patent/WO1997004772A1/en not_active Ceased
- 1996-08-02 BR BR9609914A patent/BR9609914A/pt not_active Application Discontinuation
- 1996-08-02 EP EP96926243A patent/EP0843551B1/en not_active Expired - Lifetime
- 1996-08-02 CA CA002228293A patent/CA2228293A1/en not_active Abandoned
- 1996-08-02 SK SK113-98A patent/SK282584B6/sk unknown
- 1996-08-02 RO RO98-00135A patent/RO115802B1/ro unknown
- 1996-08-02 AP APAP/P/1998/001182A patent/AP9801182A0/en unknown
- 1996-08-02 JP JP50788797A patent/JP2001517195A/ja not_active Ceased
- 1996-08-02 NZ NZ315846A patent/NZ315846A/xx unknown
- 1996-08-02 EA EA199800185A patent/EA000952B1/ru not_active IP Right Cessation
- 1996-08-02 ES ES96926243T patent/ES2171697T3/es not_active Expired - Lifetime
- 1996-08-02 KR KR1019980700697A patent/KR19990036032A/ko not_active Ceased
- 1996-08-02 CZ CZ98304A patent/CZ30498A3/cs unknown
- 1996-08-02 CN CN96197111A patent/CN1196680A/zh active Pending
- 1996-08-02 JP JP9507907A patent/JPH11511133A/ja not_active Ceased
- 1996-08-02 WO PCT/US1996/012661 patent/WO1997004773A1/en not_active Ceased
- 1996-08-02 DE DE69619116T patent/DE69619116T2/de not_active Expired - Fee Related
- 1996-08-02 ES ES96928036T patent/ES2273350T3/es not_active Expired - Lifetime
- 1996-08-02 HU HU9902817A patent/HU220776B1/hu not_active IP Right Cessation
- 1996-08-02 AU AU67645/96A patent/AU717172B2/en not_active Ceased
- 1996-08-02 PL PL96324745A patent/PL184272B1/pl not_active IP Right Cessation
- 1996-08-02 TR TR1998/00152T patent/TR199800152T1/xx unknown
- 1996-08-02 CA CA002228296A patent/CA2228296A1/en not_active Abandoned
- 1996-08-02 AU AU66463/96A patent/AU6646396A/en not_active Abandoned
- 1996-08-02 DE DE69636597T patent/DE69636597T2/de not_active Expired - Fee Related
- 1996-08-02 EP EP96928036A patent/EP0841925B1/en not_active Expired - Lifetime
1998
- 1998-01-28 OA OA9800014A patent/OA10755A/en unknown
- 1998-01-30 NO NO980422A patent/NO980422L/no not_active Application Discontinuation
- 1998-02-02 BG BG102229A patent/BG102229A/xx unknown
- 1998-07-23 US US09/121,545 patent/US5969151A/en not_active Expired - Fee Related
1999
- 1999-01-08 US US09/227,361 patent/US5958968A/en not_active Expired - Fee Related
- 1999-06-29 US US09/342,989 patent/US6096897A/en not_active Expired - Fee Related
- 1999-12-14 US US09/460,487 patent/US6353116B1/en not_active Expired - Fee Related
2001
- 2001-11-30 US US10/021,461 patent/US6482956B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU717172B2 (en)	2000-03-16
KR19990036032A (ko)	1999-05-25
EP0843551A4 (en)	1998-08-12
DE69619116T2 (de)	2002-09-19
JP2001517195A (ja)	2001-10-02
AU6646396A (en)	1997-02-26
TR199800152T1 (xx)	1998-05-21
EP0843551A1 (en)	1998-05-27
AP9801182A0 (en)	1998-01-31
DE69636597D1 (de)	2006-11-16
US20020072614A1 (en)	2002-06-13
PL324745A1 (en)	1998-06-08
MX9800975A (es)	1998-04-30
US6096897A (en)	2000-08-01
PL184272B1 (pl)	2002-09-30
US6353116B1 (en)	2002-03-05
DE69636597T2 (de)	2007-08-16
NO980422L (no)	1998-03-24
CA2228293A1 (en)	1997-02-13
HUP9902817A3 (en)	2001-03-28
EP0843551B1 (en)	2002-02-06
ATE341324T1 (de)	2006-10-15
BR9609914A (pt)	1999-07-06
OA10755A (en)	2002-12-13
NO980422D0 (no)	1998-01-30
EP0841925A4 (en)	2001-10-17
HUP9902817A2 (hu)	1999-12-28
SK282584B6 (sk)	2002-10-08
AU6764596A (en)	1997-02-26
EP0841925A1 (en)	1998-05-20
NZ315846A (en)	1999-01-28
CA2228296A1 (en)	1997-02-13
EA000952B1 (ru)	2000-08-28
US6482956B2 (en)	2002-11-19
JPH11511133A (ja)	1999-09-28
EA199800185A1 (ru)	1998-10-29
EP0841925B1 (en)	2006-10-04
RO115802B1 (ro)	2000-06-30
ES2273350T3 (es)	2007-05-01
HU220776B1 (hu)	2002-05-28
CN1196680A (zh)	1998-10-21
DE69619116D1 (de)	2002-03-21
US5958968A (en)	1999-09-28
WO1997004773A1 (en)	1997-02-13
ES2171697T3 (es)	2002-09-16
WO1997004772A1 (en)	1997-02-13
CZ30498A3 (cs)	1998-07-15
US5969151A (en)	1999-10-19
SK11398A3 (en)	1998-07-08

Publication	Publication Date	Title
UA34428C2 (uk)	2001-03-15	Заміщені фенілімідазолідини, спосіб їх одержання, фармацевтична композиція, проміжні сполуки
MXPA02009773A (es)	2003-06-17	Derivados de indolin-2-ona y su uso como ligandos de receptores de ocitocina.
IL114599A0 (en)	1995-11-27	Substituted pyrimidine compounds their preparation and pharmaceutical compositions containing them
UA66750C2 (en)	2004-06-15	Substituted 1-phenylpirazole 3-carboxamides, a method for the preparation thereof and intermediary compounds, pharmaceutical composition having affinity to neurotensin receptors
MY117274A (en)	2004-06-30	Polycyclic amine compounds and their enantiomers,their method of preparation and pharmaceutical compositions in which they are present.
IL117091A (en)	2000-07-26	Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation threreof
MY116027A (en)	2003-10-31	New use
TW229208B (cs)	1994-09-01
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BG104916A (en)	2001-06-29	Calcilytic compounds
WO1992014696A3 (en)	1993-02-18	SUBSTITUTED α-AMINOALDEHYDES AND DERIVATIVES
NO944781D0 (no)	1994-12-09	2,5-diokso-2,5-dihydro-1H-benz(b)azepiner som NMDA-reseptor-antagonister
HUP0301228A3 (en)	2005-08-29	3-azabicyclo(3.1.0)hexane derivatives having opioid receptor affinity, process for their preparation and pharmaceutical compositions containing them
HUP0001165A3 (en)	2002-02-28	Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists, pharmaceutical compositions containing them and process for producing them
MY120683A (en)	2005-11-30	New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
WO1999006388A8 (en)	2000-06-15	Pharmaceutical compounds isolated from aristolochia taliscana
BG102229A (en)	1998-09-30	Endothelium receptor antagonists
HUP0202433A3 (en)	2003-06-30	Substituted pyrrolidin-2,3,4-trion-3-oxime derivatives useful as nmda-receptor antagonists, process for producing them and pharmaceutical compositions containing them
MX9708394A (es)	1998-02-28	Composicion farmaceutica que contiene clorhidrato de tiagabina y el proceso para su preparacion.
MY120550A (en)	2005-11-30	Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, processes for preparing them and their use as pharmaceutical compositions.
IL128500A (en)	2003-06-24	SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA[b] BENZOFURANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PL352104A1 (en)	2003-07-28	Oral composition containing perlite
BG101849A (en)	1998-04-30	Bicyclic tachyquinine antagonists, their preparation and use in pharmaceutical compositions
YU48200A (sh)	2003-02-28	Farmaceutski preparati
EP0778833A4 (en)	1998-12-16	ENDOTHELIN RECEPTOR ANTAGONISTS