BG102525A - Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine - Google Patents

Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine

Info

Publication number: BG102525A
Authority: BG; Bulgaria
Prior art keywords: alkyl; compound; formulawhere; trifluoromethyl; alkoxy
Prior art date: 1995-12-15

Application number

BG102525A

Other languages

Bulgarian (bg)

English (en)

Inventor

Keith DEVRIES

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-15

Filing date

1998-06-09

Publication date

1999-05-31

1998-06-09 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

1999-05-31 Publication of BG102525A publication Critical patent/BG102525A/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 6
238000000034 method Methods 0.000 title abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

BG102525A 1995-12-15 1998-06-09 Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine BG102525A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US875395P	1995-12-15	1995-12-15
PCT/IB1996/001076 WO1997022584A1 (en)	1995-12-15	1996-10-11	Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine

Publications (1)

Publication Number	Publication Date
BG102525A true BG102525A (en)	1999-05-31

Family

ID=21733469

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102525A BG102525A (en)	1995-12-15	1998-06-09	Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine

Country Status (33)

Country	Link
EP (1)	EP0883607A1 (pl)
JP (1)	JP3066083B2 (pl)
KR (1)	KR20000064387A (pl)
AP (1)	AP708A (pl)
AR (1)	AR004368A1 (pl)
AU (1)	AU716462B2 (pl)
BG (1)	BG102525A (pl)
BR (1)	BR9612018A (pl)
CA (1)	CA2237647A1 (pl)
CO (1)	CO4750831A1 (pl)
CZ (1)	CZ180898A3 (pl)
DZ (1)	DZ2141A1 (pl)
GT (1)	GT199600092A (pl)
HN (1)	HN1996000065A (pl)
HR (1)	HRP960592A2 (pl)
HU (1)	HUP9904275A3 (pl)
IL (3)	IL136421A0 (pl)
IS (1)	IS4752A (pl)
MA (1)	MA24032A1 (pl)
NO (1)	NO982712L (pl)
NZ (1)	NZ318843A (pl)
OA (1)	OA10694A (pl)
PE (1)	PE25698A1 (pl)
PL (1)	PL197306B1 (pl)
RO (1)	RO121382B1 (pl)
RU (1)	RU2160731C2 (pl)
SK (1)	SK75498A3 (pl)
TN (1)	TNSN96153A1 (pl)
TW (1)	TW414787B (pl)
UY (1)	UY24401A1 (pl)
WO (1)	WO1997022584A1 (pl)
YU (1)	YU49486B (pl)
ZA (1)	ZA9610533B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1047674B1 (en)	1998-01-16	2005-03-30	Eisai Co., Ltd.	Process for production of donepezil derivatives
IL125809A (en) *	1998-08-17	2005-08-31	Finetech Lab Ltd	Process and intermediates for production of donepezil and related compounds
US7148354B2 (en) *	2002-07-24	2006-12-12	Dr. Reddy's Laboratories Limited	Process for preparation of donepezil
IL150982A (en)	2002-07-30	2007-02-11	Ori Lerman	Process for making Donafzil
IL151253A0 (en) *	2002-08-14	2003-04-10	Finetech Lab Ltd	Process for production of highly pure donepezil hydrochloride
US6649765B1 (en)	2003-02-12	2003-11-18	Usv Limited, Bsd Marg.	Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
US6953856B2 (en)	2003-02-12	2005-10-11	Usv, Limited	Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
EP1608371A1 (en) *	2003-03-21	2005-12-28	Ranbaxy Laboratories, Ltd.	Process for the preparation of donepezil and derivatives thereof
WO2004099142A1 (en) *	2003-05-05	2004-11-18	Ranbaxy Laboratories Limited	Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs
US7446203B2 (en)	2003-07-01	2008-11-04	Hetero Drugs Limited	Preparation of intermediates for acetycholinesterase inhibitors
CN1280273C (zh)	2003-11-05	2006-10-18	天津和美生物技术有限公司	合成多奈哌齐及其衍生物的方法
AU2005288521A1 (en)	2004-09-29	2006-04-06	Chemagis Ltd.	Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
CN100436416C (zh) *	2005-07-29	2008-11-26	西南合成制药股份有限公司	盐酸多奈哌齐合成工艺
GB0515803D0 (en)	2005-07-30	2005-09-07	Pliva Hrvatska D O O	Intermediate compounds
AR057910A1 (es)	2005-11-18	2007-12-26	Synthon Bv	Proceso para preparar donepezilo
NZ569532A (en)	2006-01-04	2010-11-26	Cipla Ltd	Process and intermediate for preparation of donepezil
RU2478619C2 (ru) *	2006-12-11	2013-04-10	Ривайва Фармасьютикалс, Инк.	Композиции, синтез и способы применения ингибиторов холинэстеразы на основе инданона
WO2013078608A1 (en)	2011-11-29	2013-06-06	Ziqiang Gu	Donepezil pamoate and methods of making and using the same
CA2921308A1 (en)	2013-08-16	2015-02-19	Universiteit Maastricht	Treatment of cognitive impairment with pde4 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI95572C (fi) *	1987-06-22	1996-02-26	Eisai Co Ltd	Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2642069B1 (fr) *	1989-01-20	1991-04-12	Rhone Poulenc Sante	Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
DE4439822A1 (de) *	1994-11-08	1996-08-29	Bayer Ag	Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

1996
- 1996-10-11 PL PL327512A patent/PL197306B1/pl not_active IP Right Cessation
- 1996-10-11 RO RO98-01070A patent/RO121382B1/ro unknown
- 1996-10-11 IL IL13642196A patent/IL136421A0/xx unknown
- 1996-10-11 NZ NZ318843A patent/NZ318843A/xx unknown
- 1996-10-11 SK SK754-98A patent/SK75498A3/sk unknown
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/hu unknown
- 1996-10-11 IL IL12445296A patent/IL124452A0/xx unknown
- 1996-10-11 JP JP9522607A patent/JP3066083B2/ja not_active Expired - Lifetime
- 1996-10-11 BR BR9612018A patent/BR9612018A/pt not_active Application Discontinuation
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/cs unknown
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-11 EP EP96931937A patent/EP0883607A1/en not_active Withdrawn
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/en not_active Ceased
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/ru not_active IP Right Cessation
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/ko not_active Ceased
- 1996-10-11 IL IL13642096A patent/IL136420A0/xx unknown
- 1996-10-11 CA CA002237647A patent/CA2237647A1/en not_active Abandoned
- 1996-10-14 TW TW085112515A patent/TW414787B/zh not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/es unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/es unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/es not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/es unknown
- 1996-12-11 YU YU66096A patent/YU49486B/sh unknown
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/fr unknown
- 1996-12-11 MA MA24424A patent/MA24032A1/fr unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/fr active
- 1996-12-12 CO CO96065334A patent/CO4750831A1/es unknown
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-12 UY UY24401A patent/UY24401A1/es not_active IP Right Cessation
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/xx not_active Application Discontinuation
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/xx unknown
1998
- 1998-05-22 IS IS4752A patent/IS4752A/is unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/xx unknown
- 1998-06-12 NO NO982712A patent/NO982712L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP9904275A3 (en)	2001-05-28
EP0883607A1 (en)	1998-12-16
BR9612018A (pt)	1999-02-17
JP3066083B2 (ja)	2000-07-17
CZ180898A3 (cs)	1999-05-12
IL136420A0 (en)	2001-06-14
IL124452A0 (en)	1998-12-06
MX9804820A (es)	1998-10-31
UY24401A1 (es)	1997-06-09
HN1996000065A (es)	1997-06-26
KR20000064387A (ko)	2000-11-06
CA2237647A1 (en)	1997-06-26
HRP960592A2 (en)	1998-06-30
JPH11500756A (ja)	1999-01-19
NO982712D0 (no)	1998-06-12
PL327512A1 (en)	1998-12-21
SK75498A3 (en)	1999-08-06
AR004368A1 (es)	1998-11-04
MA24032A1 (fr)	1997-07-01
IL136421A0 (en)	2001-06-14
WO1997022584A1 (en)	1997-06-26
AP708A (en)	1998-12-04
YU49486B (sh)	2006-08-17
TNSN96153A1 (fr)	2005-03-15
TW414787B (en)	2000-12-11
RU2160731C2 (ru)	2000-12-20
AP9600892A0 (en)	1997-01-31
AU7092596A (en)	1997-07-14
CO4750831A1 (es)	1999-03-31
YU66096A (en)	1999-11-22
IS4752A (is)	1998-05-22
AU716462B2 (en)	2000-02-24
PE25698A1 (es)	1998-05-21
OA10694A (en)	2001-05-04
PL197306B1 (pl)	2008-03-31
ZA9610533B (en)	1998-06-15
RO121382B1 (ro)	2007-04-30
DZ2141A1 (fr)	2002-07-23
NZ318843A (en)	2000-01-28
HUP9904275A2 (hu)	2000-05-28
GT199600092A (es)	1998-05-12
NO982712L (no)	1998-06-12

Publication	Publication Date	Title
AU649418B2 (en)	1994-05-26	Benzimidazole derivatives, their production and use
NZ318843A (en)	2000-01-28	Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine
NZ511739A (en)	2002-11-26	New esters derived from substituted phenyl-cyclohexyl compounds
NO994582L (no)	1995-12-12	Fremgangsmåte for fremstilling av piperidinderivater
BG105457A (en)	2001-12-29	Method for the preparation of citalopram
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