PE25698A1 - Procedimientos e intermedios para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina - Google Patents

Procedimientos e intermedios para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina

Info

Publication number: PE25698A1
Authority: PE; Peru
Prior art keywords: compound; react; iii; alkyl; bencil
Prior art date: 1995-12-15

Application number

PE1996000883A

Other languages

English (en)

Spanish (es)

Inventor

Keith M Devries

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-15

Filing date

1996-12-09

Publication date

1998-05-21

1996-12-09 Application filed by Pfizer filed Critical Pfizer

1998-05-21 Publication of PE25698A1 publication Critical patent/PE25698A1/es

Links

238000000034 method Methods 0.000 title abstract 2
PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
-1 BENZYL HALIDE Chemical class 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
235000011149 sulphuric acid Nutrition 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

PE1996000883A 1995-12-15 1996-12-09 Procedimientos e intermedios para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina PE25698A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US875395P	1995-12-15	1995-12-15

Publications (1)

Publication Number	Publication Date
PE25698A1 true PE25698A1 (es)	1998-05-21

Family

ID=21733469

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE1996000883A PE25698A1 (es)	1995-12-15	1996-12-09	Procedimientos e intermedios para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina

Country Status (33)

Country	Link
EP (1)	EP0883607A1 (pl)
JP (1)	JP3066083B2 (pl)
KR (1)	KR20000064387A (pl)
AP (1)	AP708A (pl)
AR (1)	AR004368A1 (pl)
AU (1)	AU716462B2 (pl)
BG (1)	BG102525A (pl)
BR (1)	BR9612018A (pl)
CA (1)	CA2237647A1 (pl)
CO (1)	CO4750831A1 (pl)
CZ (1)	CZ180898A3 (pl)
DZ (1)	DZ2141A1 (pl)
GT (1)	GT199600092A (pl)
HN (1)	HN1996000065A (pl)
HR (1)	HRP960592A2 (pl)
HU (1)	HUP9904275A3 (pl)
IL (3)	IL136421A0 (pl)
IS (1)	IS4752A (pl)
MA (1)	MA24032A1 (pl)
NO (1)	NO982712L (pl)
NZ (1)	NZ318843A (pl)
OA (1)	OA10694A (pl)
PE (1)	PE25698A1 (pl)
PL (1)	PL197306B1 (pl)
RO (1)	RO121382B1 (pl)
RU (1)	RU2160731C2 (pl)
SK (1)	SK75498A3 (pl)
TN (1)	TNSN96153A1 (pl)
TW (1)	TW414787B (pl)
UY (1)	UY24401A1 (pl)
WO (1)	WO1997022584A1 (pl)
YU (1)	YU49486B (pl)
ZA (1)	ZA9610533B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1047674B1 (en)	1998-01-16	2005-03-30	Eisai Co., Ltd.	Process for production of donepezil derivatives
IL125809A (en) *	1998-08-17	2005-08-31	Finetech Lab Ltd	Process and intermediates for production of donepezil and related compounds
US7148354B2 (en) *	2002-07-24	2006-12-12	Dr. Reddy's Laboratories Limited	Process for preparation of donepezil
IL150982A (en)	2002-07-30	2007-02-11	Ori Lerman	Process for making Donafzil
IL151253A0 (en) *	2002-08-14	2003-04-10	Finetech Lab Ltd	Process for production of highly pure donepezil hydrochloride
US6649765B1 (en)	2003-02-12	2003-11-18	Usv Limited, Bsd Marg.	Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
US6953856B2 (en)	2003-02-12	2005-10-11	Usv, Limited	Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
EP1608371A1 (en) *	2003-03-21	2005-12-28	Ranbaxy Laboratories, Ltd.	Process for the preparation of donepezil and derivatives thereof
WO2004099142A1 (en) *	2003-05-05	2004-11-18	Ranbaxy Laboratories Limited	Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs
US7446203B2 (en)	2003-07-01	2008-11-04	Hetero Drugs Limited	Preparation of intermediates for acetycholinesterase inhibitors
CN1280273C (zh)	2003-11-05	2006-10-18	天津和美生物技术有限公司	合成多奈哌齐及其衍生物的方法
AU2005288521A1 (en)	2004-09-29	2006-04-06	Chemagis Ltd.	Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
CN100436416C (zh) *	2005-07-29	2008-11-26	西南合成制药股份有限公司	盐酸多奈哌齐合成工艺
GB0515803D0 (en)	2005-07-30	2005-09-07	Pliva Hrvatska D O O	Intermediate compounds
AR057910A1 (es)	2005-11-18	2007-12-26	Synthon Bv	Proceso para preparar donepezilo
NZ569532A (en)	2006-01-04	2010-11-26	Cipla Ltd	Process and intermediate for preparation of donepezil
RU2478619C2 (ru) *	2006-12-11	2013-04-10	Ривайва Фармасьютикалс, Инк.	Композиции, синтез и способы применения ингибиторов холинэстеразы на основе инданона
WO2013078608A1 (en)	2011-11-29	2013-06-06	Ziqiang Gu	Donepezil pamoate and methods of making and using the same
CA2921308A1 (en)	2013-08-16	2015-02-19	Universiteit Maastricht	Treatment of cognitive impairment with pde4 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI95572C (fi) *	1987-06-22	1996-02-26	Eisai Co Ltd	Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2642069B1 (fr) *	1989-01-20	1991-04-12	Rhone Poulenc Sante	Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
DE4439822A1 (de) *	1994-11-08	1996-08-29	Bayer Ag	Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

1996
- 1996-10-11 PL PL327512A patent/PL197306B1/pl not_active IP Right Cessation
- 1996-10-11 RO RO98-01070A patent/RO121382B1/ro unknown
- 1996-10-11 IL IL13642196A patent/IL136421A0/xx unknown
- 1996-10-11 NZ NZ318843A patent/NZ318843A/xx unknown
- 1996-10-11 SK SK754-98A patent/SK75498A3/sk unknown
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/hu unknown
- 1996-10-11 IL IL12445296A patent/IL124452A0/xx unknown
- 1996-10-11 JP JP9522607A patent/JP3066083B2/ja not_active Expired - Lifetime
- 1996-10-11 BR BR9612018A patent/BR9612018A/pt not_active Application Discontinuation
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/cs unknown
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-11 EP EP96931937A patent/EP0883607A1/en not_active Withdrawn
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/en not_active Ceased
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/ru not_active IP Right Cessation
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/ko not_active Ceased
- 1996-10-11 IL IL13642096A patent/IL136420A0/xx unknown
- 1996-10-11 CA CA002237647A patent/CA2237647A1/en not_active Abandoned
- 1996-10-14 TW TW085112515A patent/TW414787B/zh not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/es unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/es unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/es not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/es unknown
- 1996-12-11 YU YU66096A patent/YU49486B/sh unknown
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/fr unknown
- 1996-12-11 MA MA24424A patent/MA24032A1/fr unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/fr active
- 1996-12-12 CO CO96065334A patent/CO4750831A1/es unknown
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-12 UY UY24401A patent/UY24401A1/es not_active IP Right Cessation
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/xx not_active Application Discontinuation
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/xx unknown
1998
- 1998-05-22 IS IS4752A patent/IS4752A/is unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/xx unknown
- 1998-06-12 NO NO982712A patent/NO982712L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP9904275A3 (en)	2001-05-28
EP0883607A1 (en)	1998-12-16
BR9612018A (pt)	1999-02-17
JP3066083B2 (ja)	2000-07-17
CZ180898A3 (cs)	1999-05-12
IL136420A0 (en)	2001-06-14
IL124452A0 (en)	1998-12-06
MX9804820A (es)	1998-10-31
UY24401A1 (es)	1997-06-09
HN1996000065A (es)	1997-06-26
KR20000064387A (ko)	2000-11-06
CA2237647A1 (en)	1997-06-26
HRP960592A2 (en)	1998-06-30
JPH11500756A (ja)	1999-01-19
NO982712D0 (no)	1998-06-12
PL327512A1 (en)	1998-12-21
SK75498A3 (en)	1999-08-06
AR004368A1 (es)	1998-11-04
MA24032A1 (fr)	1997-07-01
IL136421A0 (en)	2001-06-14
WO1997022584A1 (en)	1997-06-26
AP708A (en)	1998-12-04
YU49486B (sh)	2006-08-17
TNSN96153A1 (fr)	2005-03-15
TW414787B (en)	2000-12-11
RU2160731C2 (ru)	2000-12-20
AP9600892A0 (en)	1997-01-31
AU7092596A (en)	1997-07-14
CO4750831A1 (es)	1999-03-31
YU66096A (en)	1999-11-22
IS4752A (is)	1998-05-22
AU716462B2 (en)	2000-02-24
OA10694A (en)	2001-05-04
BG102525A (en)	1999-05-31
PL197306B1 (pl)	2008-03-31
ZA9610533B (en)	1998-06-15
RO121382B1 (ro)	2007-04-30
DZ2141A1 (fr)	2002-07-23
NZ318843A (en)	2000-01-28
HUP9904275A2 (hu)	2000-05-28
GT199600092A (es)	1998-05-12
NO982712L (no)	1998-06-12

Legal Events

Date	Code	Title	Description
2000-04-28	FG	Grant, registration
2009-07-30	FD	Application declared void or lapsed

Publication	Publication Date	Title
ES8106723A1 (es)	1981-08-01	Un metodo para la preparacion de derivados de ftalimidina
ES8303293A1 (es)	1983-03-01	"procedimiento de preparar derivados carboxamidicos".
ES2013067A6 (es)	1990-04-16	Un procedimiento para producir un derivado de piperazina.
Fort et al.	2012	Synthesis of fluorinated tricyclic scaffolds by intramolecular [2+ 2] photocycloaddition reactions
CO4950563A1 (es)	2000-09-01	Nuevos compuestos
DK0707851T3 (da)	2002-04-22	Benzopyran-phenol derivater til anvendelse som antibakterielle, antivirale og sårhelende midler
ES8506616A1 (es)	1985-08-01	Un procedimiento para la preparacion de carboxamidas
FR2447904A1 (fr)	1980-08-29	Nouveau derive d'alcool benzylique, son procede de production et composition pharmaceutique le contenant
GT199600092A (es)	1998-05-12	Procedimientos e intermedios para preparar 1-bencil-4-(5,6-dimetoxi-1-indanon)-2-il)metilpiperidina.
Oliver et al.	1991	Pentacyclo [5.4. 0.02, 6.03, 10.05, 9] undecylamines. Synthesis and pharmacology
MX173360B (es)	1994-02-23	Procedimiento para la produccion de fenil-4,5,6,7-tetrahidro-2h-isoindol-1,3-dionas 2-substituidas
ATE59943T1 (de)	1991-02-15	Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung.
PT88301A (pt)	1989-06-30	Processo para a preparacao de derivados de oxima de 1,2,5,6-tetraidropiridina e de composicoes farmaceuticas que os contem
ES8105997A1 (es)	1981-07-01	Un procedimiento para la preparacion de fenil-quinolicidinas
RU94046012A (ru)	1996-09-20	Способ стереоспецифического гидролиза производных пиперидиндиона, продукт гидролиза и способ получения пароксетина
ATE1625T1 (de)	1982-10-15	Isoxazolylcarbonsaeureanilide, ihre herstellung, diese enthaltende fungizide mittel und verfahren zur bekaempfung von pilzen.
ATE119869T1 (de)	1995-04-15	Verfahren zur herstellung von 9,9-bis-(4- hydroxyphenyl-)fluoren.
ES8300332A1 (es)	1982-11-01	Un procedimiento para la preparacion de nuevos derivados de imidazoquinazolinas
ES2085923T3 (es)	1996-06-16	Procedimiento para la preparacion de poliamidas aromaticas con elevada estabilidad frente a la hidrolisis.
ES2108364T3 (es)	1997-12-16	Composiciones azeotropicas que comprenden agua y un hidrofluorocarburo, procedimiento de eliminacion de agua de una solucion por destilacion azeotropica y procedimiento de produccion de un hidrofluoroalcano.
IT1222526B (it)	1990-09-05	Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
AR003328A1 (es)	1998-07-08	Proceso para la preparacion de nitro-sustituido-difenileteres, utiles como herbicidas o como intermediarios en la sintesis de herbicidas
UY24945A1 (es)	1998-09-28	Proceso para preparar haluros de acido o-(3-amino-2-hidroxi- propil)-hidroximico
ES8607224A1 (es)	1986-05-16	Un procedimiento para preparar esteres de acidos (alquilsulfonil)-metanosulfonicos
ES8300681A1 (es)	1982-11-01	Procedimiento para preparar amidas.