OA10694A - Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine. - Google Patents

Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine. Download PDF

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Publication number
OA10694A
OA10694A OA9800076A OA9800076A OA10694A OA 10694 A OA10694 A OA 10694A OA 9800076 A OA9800076 A OA 9800076A OA 9800076 A OA9800076 A OA 9800076A OA 10694 A OA10694 A OA 10694A
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OA
OAPI
Prior art keywords
compound
alkyl
formula
process according
halo
Prior art date
Application number
OA9800076A
Other languages
English (en)
Inventor
Keith M Devries
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of OA10694A publication Critical patent/OA10694A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA9800076A 1995-12-15 1998-06-05 Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine. OA10694A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US875395P 1995-12-15 1995-12-15

Publications (1)

Publication Number Publication Date
OA10694A true OA10694A (en) 2001-05-04

Family

ID=21733469

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9800076A OA10694A (en) 1995-12-15 1998-06-05 Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine.

Country Status (33)

Country Link
EP (1) EP0883607A1 (pl)
JP (1) JP3066083B2 (pl)
KR (1) KR20000064387A (pl)
AP (1) AP708A (pl)
AR (1) AR004368A1 (pl)
AU (1) AU716462B2 (pl)
BG (1) BG102525A (pl)
BR (1) BR9612018A (pl)
CA (1) CA2237647A1 (pl)
CO (1) CO4750831A1 (pl)
CZ (1) CZ180898A3 (pl)
DZ (1) DZ2141A1 (pl)
GT (1) GT199600092A (pl)
HN (1) HN1996000065A (pl)
HR (1) HRP960592A2 (pl)
HU (1) HUP9904275A3 (pl)
IL (3) IL136421A0 (pl)
IS (1) IS4752A (pl)
MA (1) MA24032A1 (pl)
NO (1) NO982712L (pl)
NZ (1) NZ318843A (pl)
OA (1) OA10694A (pl)
PE (1) PE25698A1 (pl)
PL (1) PL197306B1 (pl)
RO (1) RO121382B1 (pl)
RU (1) RU2160731C2 (pl)
SK (1) SK75498A3 (pl)
TN (1) TNSN96153A1 (pl)
TW (1) TW414787B (pl)
UY (1) UY24401A1 (pl)
WO (1) WO1997022584A1 (pl)
YU (1) YU49486B (pl)
ZA (1) ZA9610533B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1047674B1 (en) 1998-01-16 2005-03-30 Eisai Co., Ltd. Process for production of donepezil derivatives
IL125809A (en) * 1998-08-17 2005-08-31 Finetech Lab Ltd Process and intermediates for production of donepezil and related compounds
US7148354B2 (en) * 2002-07-24 2006-12-12 Dr. Reddy's Laboratories Limited Process for preparation of donepezil
IL150982A (en) 2002-07-30 2007-02-11 Ori Lerman Process for making Donafzil
IL151253A0 (en) * 2002-08-14 2003-04-10 Finetech Lab Ltd Process for production of highly pure donepezil hydrochloride
US6649765B1 (en) 2003-02-12 2003-11-18 Usv Limited, Bsd Marg. Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
US6953856B2 (en) 2003-02-12 2005-10-11 Usv, Limited Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
EP1608371A1 (en) * 2003-03-21 2005-12-28 Ranbaxy Laboratories, Ltd. Process for the preparation of donepezil and derivatives thereof
WO2004099142A1 (en) * 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs
US7446203B2 (en) 2003-07-01 2008-11-04 Hetero Drugs Limited Preparation of intermediates for acetycholinesterase inhibitors
CN1280273C (zh) 2003-11-05 2006-10-18 天津和美生物技术有限公司 合成多奈哌齐及其衍生物的方法
AU2005288521A1 (en) 2004-09-29 2006-04-06 Chemagis Ltd. Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
CN100436416C (zh) * 2005-07-29 2008-11-26 西南合成制药股份有限公司 盐酸多奈哌齐合成工艺
GB0515803D0 (en) 2005-07-30 2005-09-07 Pliva Hrvatska D O O Intermediate compounds
AR057910A1 (es) 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar donepezilo
NZ569532A (en) 2006-01-04 2010-11-26 Cipla Ltd Process and intermediate for preparation of donepezil
RU2478619C2 (ru) * 2006-12-11 2013-04-10 Ривайва Фармасьютикалс, Инк. Композиции, синтез и способы применения ингибиторов холинэстеразы на основе инданона
WO2013078608A1 (en) 2011-11-29 2013-06-06 Ziqiang Gu Donepezil pamoate and methods of making and using the same
CA2921308A1 (en) 2013-08-16 2015-02-19 Universiteit Maastricht Treatment of cognitive impairment with pde4 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2642069B1 (fr) * 1989-01-20 1991-04-12 Rhone Poulenc Sante Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
DE4439822A1 (de) * 1994-11-08 1996-08-29 Bayer Ag Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

Also Published As

Publication number Publication date
HUP9904275A3 (en) 2001-05-28
EP0883607A1 (en) 1998-12-16
BR9612018A (pt) 1999-02-17
JP3066083B2 (ja) 2000-07-17
CZ180898A3 (cs) 1999-05-12
IL136420A0 (en) 2001-06-14
IL124452A0 (en) 1998-12-06
MX9804820A (es) 1998-10-31
UY24401A1 (es) 1997-06-09
HN1996000065A (es) 1997-06-26
KR20000064387A (ko) 2000-11-06
CA2237647A1 (en) 1997-06-26
HRP960592A2 (en) 1998-06-30
JPH11500756A (ja) 1999-01-19
NO982712D0 (no) 1998-06-12
PL327512A1 (en) 1998-12-21
SK75498A3 (en) 1999-08-06
AR004368A1 (es) 1998-11-04
MA24032A1 (fr) 1997-07-01
IL136421A0 (en) 2001-06-14
WO1997022584A1 (en) 1997-06-26
AP708A (en) 1998-12-04
YU49486B (sh) 2006-08-17
TNSN96153A1 (fr) 2005-03-15
TW414787B (en) 2000-12-11
RU2160731C2 (ru) 2000-12-20
AP9600892A0 (en) 1997-01-31
AU7092596A (en) 1997-07-14
CO4750831A1 (es) 1999-03-31
YU66096A (en) 1999-11-22
IS4752A (is) 1998-05-22
AU716462B2 (en) 2000-02-24
PE25698A1 (es) 1998-05-21
BG102525A (en) 1999-05-31
PL197306B1 (pl) 2008-03-31
ZA9610533B (en) 1998-06-15
RO121382B1 (ro) 2007-04-30
DZ2141A1 (fr) 2002-07-23
NZ318843A (en) 2000-01-28
HUP9904275A2 (hu) 2000-05-28
GT199600092A (es) 1998-05-12
NO982712L (no) 1998-06-12

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