BG102709A - Антиглюкокортикоидно лекарствено средство - Google Patents

Антиглюкокортикоидно лекарствено средство

Info

Publication number
BG102709A
BG102709A BG102709A BG10270998A BG102709A BG 102709 A BG102709 A BG 102709A BG 102709 A BG102709 A BG 102709A BG 10270998 A BG10270998 A BG 10270998A BG 102709 A BG102709 A BG 102709A
Authority
BG
Bulgaria
Prior art keywords
glucocorticoid
lengths
action
chains
medicine
Prior art date
Application number
BG102709A
Other languages
English (en)
Inventor
Original Assignee
Бурлаков Сергей
Генкин Дмитрий
Сурков Кирилл
Тец Виктор
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бурлаков Сергей, Генкин Дмитрий, Сурков Кирилл, Тец Виктор filed Critical Бурлаков Сергей
Publication of BG102709A publication Critical patent/BG102709A/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Securing Of Glass Panes Or The Like (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

(54) АНТИГЛЮКОКОРТИКОИДНО ЛЕКАРСТВЕНО СРЕДСТВО@(57) Средството намира приложение в хуманната и ветеринарна медицина. То представлява антиглю-кокортикоиден лекарствен препарат с нестероидна природа, сниска токсичност и висока ефикасност за регулиранечувствителността на клетките на мле-копитаещите към действието на глюкокортикоид-ните хормони. С цел селективно подтискане действието на глюкокортикоидните хормони върху клетвите на млекопитаещите сеизползва феромон от насекоми с нестероидна природа или негов синтетичен аналог или производно, представляващо дъл-говерижен ненаситен алифатен алкохол, алдехид или естер. Дължината на линейната въглеродна верига на всеки от посочените елементи е в границите от 10 до 21 атома. За увеличаване на терапевтичния ефект се използват два или повече феромона и/или техните синтетични аналози и производни, подбрани съгласно принципа на съществена разлика вхидрофобността, пропорционална на дължините на алифатните въглеводородни вериги. Разликата между дължините на веригите трябва да бъде не по-малка от пет.
BG102709A 1996-01-31 1998-08-20 Антиглюкокортикоидно лекарствено средство BG102709A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU96101194/14A RU2125446C1 (ru) 1996-01-31 1996-01-31 Антиглюкокортикоидное лекарственное средство
PCT/RU1996/000028 WO1997027845A1 (en) 1996-01-31 1996-02-01 Antiglucocorticoid drug

Publications (1)

Publication Number Publication Date
BG102709A true BG102709A (bg) 1999-06-30

Family

ID=20175968

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102709A BG102709A (bg) 1996-01-31 1998-08-20 Антиглюкокортикоидно лекарствено средство

Country Status (24)

Country Link
US (1) US5965623A (bg)
EP (1) EP0896819A4 (bg)
JP (1) JPH11504946A (bg)
KR (1) KR100347862B1 (bg)
CN (1) CN1213964A (bg)
AU (1) AU710479B2 (bg)
BG (1) BG102709A (bg)
BR (1) BR9612470A (bg)
CA (1) CA2244985A1 (bg)
CZ (1) CZ160598A3 (bg)
EE (1) EE9800209A (bg)
GE (1) GEP20001955B (bg)
HU (1) HUP9900504A2 (bg)
LT (1) LT4441B (bg)
LV (1) LV12177B (bg)
MD (1) MD1430B1 (bg)
MX (1) MX9806182A (bg)
NO (1) NO983508L (bg)
PL (1) PL187564B1 (bg)
RU (1) RU2125446C1 (bg)
SI (1) SI9620053A (bg)
SK (1) SK65598A3 (bg)
UA (1) UA48212C2 (bg)
WO (1) WO1997027845A1 (bg)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1929401A (en) * 1999-12-01 2001-06-12 Alydar Pharmaceuticals Ltd. Method for screening non-peptide, non-steroid inverterbrate pheromones, compositions containing the same and use of the compositions to treat diseases, conditions, and symptoms thereof
US6548706B2 (en) * 1999-12-23 2003-04-15 Aerojet Fine Chemicals Llc Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
US6806293B1 (en) 2001-03-12 2004-10-19 Darley Pharmaceuticals Ltd Use of pheromone compounds having MAP kinase modulating activity
AU2001243556A1 (en) * 2001-03-12 2002-09-24 Alydar Pharmaceuticals, Inc. Screening non-peptide, non-steroid invertebrate pheromone compounds for mitogen-activated protein kinase modulating activity
RU2211213C2 (ru) * 2001-05-16 2003-08-27 Закрытое Акционерное Общество "Асгл - Исследовательские Лаборатории" Лекарственное средство, обладающее противоязвенным, кардиопротективным и противошоковым действием
US20040018959A1 (en) * 2002-05-02 2004-01-29 Randall S. Hickle System and methods of lipid removal from the body
RU2222326C1 (ru) * 2002-10-09 2004-01-27 Российский онкологический научный центр им. Н.Н.Блохина РАМН Способ лечения саркомы юинга
US6752649B2 (en) * 2002-11-07 2004-06-22 Xentris, Llc Illuminated indicia power supply apparatus and method of manufacture
DE10335845B4 (de) * 2003-05-09 2006-08-31 Müller, Martina, Dr.med. Pheromone als Antikrebsmittel
KR100556335B1 (ko) * 2004-02-05 2006-03-03 정만길 6알-(3,6-디데옥시-엘-아라비노-헥소피라노실옥시)헵타노익산, 그 제조방법 및 그를 포함하는 장기휴면 유발효과
WO2010017177A1 (en) * 2008-08-06 2010-02-11 The Trustees Of The University Of Pennsylvania Ultrasonically induced release from polymer vesicles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US161926A (en) 1875-04-13 Improvement in ink-wells
US2900756A (en) * 1958-12-09 1959-08-25 Jacobson Martin Attractants for the gypsy moth
EP0149847A3 (en) * 1983-12-26 1989-11-08 Eisai Co., Ltd. Therapeutic and preventive agent containing dolichol
JPH0759504B2 (ja) * 1986-01-23 1995-06-28 エーザイ株式会社 ポリプレニルアルコ−ル含有注射剤
US5019569A (en) * 1986-11-03 1991-05-28 Ortho Pharmaceutical Corporation Reversal of glucocorticoid-induced skin atrophy
US4740627A (en) * 1987-05-21 1988-04-26 Phillips Petroleum Company Synthesis of E,Z-11-tetradecen-1-al
ATE80313T1 (de) 1988-02-29 1992-09-15 Pfizer Mittel zur erhoehung des transdermalen penetrationsflusses.
US5190978A (en) * 1989-09-29 1993-03-02 Dai-Ichi Kogyo Seiyaku Co. Ltd. Carcinostatic compositions and methods
FR2718354B1 (fr) * 1994-04-08 1996-05-03 Roussel Uclaf Application des composés antiglucocorticoïde pour la préparation de médicaments destinés à la prévention ou au traitement des manifestations liées au syndrome de sevrage des narcotiques et les compositions les renfermant.

Also Published As

Publication number Publication date
RU2125446C1 (ru) 1999-01-27
HUP9900504A2 (en) 1999-09-28
EE9800209A (et) 1998-12-15
AU4636396A (en) 1997-08-22
WO1997027845A1 (en) 1997-08-07
NO983508D0 (no) 1998-07-30
KR19990076946A (ko) 1999-10-25
LV12177A (lv) 1998-12-20
LV12177B (lv) 1999-06-20
EP0896819A1 (en) 1999-02-17
MX9806182A (es) 1998-10-31
LT98054A (en) 1998-10-26
CZ160598A3 (cs) 1998-08-12
LT4441B (lt) 1999-01-25
SK65598A3 (en) 1998-09-09
CN1213964A (zh) 1999-04-14
PL187564B1 (pl) 2004-08-31
EP0896819A4 (en) 2001-11-07
UA48212C2 (uk) 2002-08-15
CA2244985A1 (en) 1997-08-07
GEP20001955B (en) 2000-03-05
JPH11504946A (ja) 1999-05-11
SI9620053A (sl) 1998-04-30
PL322596A1 (en) 1998-02-02
AU710479B2 (en) 1999-09-23
US5965623A (en) 1999-10-12
KR100347862B1 (ko) 2003-01-24
MD1430B1 (ro) 2000-03-31
NO983508L (no) 1998-07-30
BR9612470A (pt) 1999-07-13

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