BG102959A - Бензоксазинонови антагонисти на допаминов d долу 4 рецептор - Google Patents
Бензоксазинонови антагонисти на допаминов d долу 4 рецепторInfo
- Publication number
- BG102959A BG102959A BG102959A BG10295998A BG102959A BG 102959 A BG102959 A BG 102959A BG 102959 A BG102959 A BG 102959A BG 10295998 A BG10295998 A BG 10295998A BG 102959 A BG102959 A BG 102959A
- Authority
- BG
- Bulgaria
- Prior art keywords
- domamine
- benzooxazinon
- antagonists
- receptor
- alkyl
- Prior art date
Links
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical compound C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 sulphonamido Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретението се отнася до съединения с формула Iили II, в които R1 и R2 означават поотделно водород или С1-С6 алкил, Х е N или СН и R3 е фенил, нафтил, хетероарил, заместен фенил, заместен нафтил или заместен хетероарил, като всеки заместител е избран поотделно от халоген, С1-С6 алкокси, С1-С6 алкил, -CN, -CF3 или сулфонамидо. Изобретението се отнася и до техни фармацевтично приемливи соли, естери, амиди и пролекарства.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1838396P | 1996-05-29 | 1996-05-29 | |
| US4020897P | 1997-03-06 | 1997-03-06 | |
| PCT/US1997/008524 WO1997045419A1 (en) | 1996-05-29 | 1997-05-20 | Benzoxazinone dopamine d4 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG102959A true BG102959A (bg) | 1999-08-31 |
| BG64049B1 BG64049B1 (bg) | 2003-11-28 |
Family
ID=26691052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102959A BG64049B1 (bg) | 1996-05-29 | 1998-11-26 | Бензоксазинонови антагонисти на допаминов d долу 4 рецептор |
Country Status (36)
| Country | Link |
|---|---|
| EP (1) | EP0906294B1 (bg) |
| JP (1) | JP2000511534A (bg) |
| KR (1) | KR20000016151A (bg) |
| CN (1) | CN1074764C (bg) |
| AR (1) | AR008372A1 (bg) |
| AT (1) | ATE231846T1 (bg) |
| AU (1) | AU731104B2 (bg) |
| BG (1) | BG64049B1 (bg) |
| BR (1) | BR9709630A (bg) |
| CA (1) | CA2253406A1 (bg) |
| CO (1) | CO4940505A1 (bg) |
| CZ (1) | CZ384698A3 (bg) |
| DE (1) | DE69718786T2 (bg) |
| DK (1) | DK0906294T3 (bg) |
| EA (1) | EA001486B1 (bg) |
| EE (1) | EE03686B1 (bg) |
| ES (1) | ES2191180T3 (bg) |
| GE (1) | GEP20012389B (bg) |
| HN (1) | HN1997000075A (bg) |
| HR (1) | HRP970301B1 (bg) |
| HU (1) | HUP9903758A3 (bg) |
| ID (1) | ID17266A (bg) |
| IL (1) | IL126895A (bg) |
| NO (1) | NO312296B1 (bg) |
| NZ (1) | NZ332737A (bg) |
| PA (1) | PA8431101A1 (bg) |
| PE (1) | PE69398A1 (bg) |
| PL (1) | PL330195A1 (bg) |
| PT (1) | PT906294E (bg) |
| RO (1) | RO120845B1 (bg) |
| SI (1) | SI0906294T1 (bg) |
| SK (1) | SK282703B6 (bg) |
| SV (1) | SV1997000047A (bg) |
| TW (1) | TW542833B (bg) |
| UY (1) | UY24569A1 (bg) |
| WO (1) | WO1997045419A1 (bg) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177422B1 (en) | 1996-05-29 | 2001-01-23 | Warner-Lambert Company | Benzoxazinone dopamine D4 receptor antagonists |
| GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| EP1089990A1 (en) * | 1998-06-30 | 2001-04-11 | Neurogen Corporation | 1-(benzothiazol-2-yl)-4-(1-phenylmethyl)piperazines: dopamine receptor subtype specific ligands |
| US6177566B1 (en) | 1998-06-30 | 2001-01-23 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands |
| CA2336089A1 (en) * | 1998-06-30 | 2000-01-06 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands |
| US6291463B1 (en) | 1998-06-30 | 2001-09-18 | Neurogen Corporation | 1-(Benzothiazol-2-yl)-4-(1-phenylmethyl) piperazines: dopamine receptor subtype specific ligands |
| DE19844291A1 (de) | 1998-09-18 | 2000-03-23 | Schering Ag | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| CN1478092A (zh) * | 2000-10-26 | 2004-02-25 | ʷ | 苯并噁嗪酮衍生物及其制备和应用 |
| GB0203804D0 (en) | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
| GB0209244D0 (en) * | 2002-04-23 | 2002-06-05 | Glaxo Group Ltd | Compounds |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| ES2232292B1 (es) * | 2003-07-30 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
| CN100455573C (zh) * | 2005-11-11 | 2009-01-28 | 华东理工大学 | 一种制备1,4-苯并噁唑嗪-3-酮化合物的微波合成方法 |
| KR200482995Y1 (ko) | 2015-08-19 | 2017-03-23 | 이현진 | 물 공급부를 구비하는 얼음 트레이 |
| AU2022261029A1 (en) * | 2021-04-23 | 2023-10-19 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Heterocyclic derivative inhibitor and preparation method therefor and application thereof |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| CN119487027A (zh) * | 2022-04-28 | 2025-02-18 | 宁波新湾科技发展有限公司 | 作为parp1抑制剂的化合物 |
| CN117903159A (zh) * | 2022-12-30 | 2024-04-19 | 成都硕德药业有限公司 | 一种内酰胺类衍生物、其制备方法及用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4613598A (en) * | 1984-03-13 | 1986-09-23 | Mitsubishi Chemical Industries Limited | Piperazine derivatives and their acid addition salts |
| EP0233728A1 (en) * | 1986-02-11 | 1987-08-26 | Takeda Chemical Industries, Ltd. | 1,4-Benzoxazine derivatives their production and use |
| EP0654023B1 (en) * | 1992-08-06 | 1998-09-16 | Smithkline Beecham Plc | 5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor antagonists |
-
1997
- 1997-05-20 KR KR1019980709719A patent/KR20000016151A/ko not_active Ceased
- 1997-05-20 SI SI9730482T patent/SI0906294T1/xx unknown
- 1997-05-20 CA CA002253406A patent/CA2253406A1/en not_active Abandoned
- 1997-05-20 GE GEAP19974623A patent/GEP20012389B/en unknown
- 1997-05-20 EP EP97925651A patent/EP0906294B1/en not_active Expired - Lifetime
- 1997-05-20 DK DK97925651T patent/DK0906294T3/da active
- 1997-05-20 EE EE9800417A patent/EE03686B1/xx not_active IP Right Cessation
- 1997-05-20 CN CN97195015A patent/CN1074764C/zh not_active Expired - Fee Related
- 1997-05-20 ES ES97925651T patent/ES2191180T3/es not_active Expired - Lifetime
- 1997-05-20 JP JP09542647A patent/JP2000511534A/ja not_active Ceased
- 1997-05-20 AU AU30727/97A patent/AU731104B2/en not_active Ceased
- 1997-05-20 SK SK1627-98A patent/SK282703B6/sk unknown
- 1997-05-20 NZ NZ332737A patent/NZ332737A/en unknown
- 1997-05-20 AT AT97925651T patent/ATE231846T1/de not_active IP Right Cessation
- 1997-05-20 BR BR9709630A patent/BR9709630A/pt not_active Application Discontinuation
- 1997-05-20 HU HU9903758A patent/HUP9903758A3/hu unknown
- 1997-05-20 EA EA199800987A patent/EA001486B1/ru not_active IP Right Cessation
- 1997-05-20 WO PCT/US1997/008524 patent/WO1997045419A1/en not_active Ceased
- 1997-05-20 PT PT97925651T patent/PT906294E/pt unknown
- 1997-05-20 IL IL12689597A patent/IL126895A/en not_active IP Right Cessation
- 1997-05-20 RO RO98-01622A patent/RO120845B1/ro unknown
- 1997-05-20 DE DE69718786T patent/DE69718786T2/de not_active Expired - Fee Related
- 1997-05-20 CZ CZ983846A patent/CZ384698A3/cs unknown
- 1997-05-20 PL PL97330195A patent/PL330195A1/xx unknown
- 1997-05-22 HN HN1997000075A patent/HN1997000075A/es unknown
- 1997-05-27 AR ARP970102249A patent/AR008372A1/es unknown
- 1997-05-28 PE PE1997000432A patent/PE69398A1/es not_active Application Discontinuation
- 1997-05-28 CO CO97029474A patent/CO4940505A1/es unknown
- 1997-05-28 SV SV1997000047A patent/SV1997000047A/es not_active Application Discontinuation
- 1997-05-28 UY UY24569A patent/UY24569A1/es not_active Application Discontinuation
- 1997-05-28 TW TW086107221A patent/TW542833B/zh active
- 1997-05-28 PA PA19978431101A patent/PA8431101A1/es unknown
- 1997-05-28 ID IDP971778A patent/ID17266A/id unknown
- 1997-05-29 HR HR970301A patent/HRP970301B1/xx not_active IP Right Cessation
-
1998
- 1998-11-26 BG BG102959A patent/BG64049B1/bg unknown
- 1998-11-27 NO NO19985531A patent/NO312296B1/no not_active IP Right Cessation
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