BG103417A - Condensed pyrimidine bicyclic derivatives - Google Patents
Condensed pyrimidine bicyclic derivativesInfo
- Publication number
- BG103417A BG103417A BG103417A BG10341799A BG103417A BG 103417 A BG103417 A BG 103417A BG 103417 A BG103417 A BG 103417A BG 10341799 A BG10341799 A BG 10341799A BG 103417 A BG103417 A BG 103417A
- Authority
- BG
- Bulgaria
- Prior art keywords
- bicyclic derivatives
- condensed pyrimidine
- pyrimidine bicyclic
- compounds
- relates
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3186296P | 1996-11-27 | 1996-11-27 | |
| US4184697P | 1997-04-09 | 1997-04-09 | |
| PCT/IB1997/001393 WO1998023613A1 (en) | 1996-11-27 | 1997-11-05 | Fused bicyclic pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG103417A true BG103417A (en) | 2000-06-30 |
Family
ID=26707706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103417A BG103417A (en) | 1996-11-27 | 1999-05-20 | Condensed pyrimidine bicyclic derivatives |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6413971B1 (is) |
| EP (1) | EP0946554A1 (is) |
| JP (1) | JP2000505109A (is) |
| KR (1) | KR20000057228A (is) |
| CN (1) | CN1237177A (is) |
| AP (1) | AP9701146A0 (is) |
| AR (1) | AR010740A1 (is) |
| AU (1) | AU4718997A (is) |
| BG (1) | BG103417A (is) |
| BR (1) | BR9713552A (is) |
| CA (1) | CA2272705C (is) |
| CO (1) | CO4650037A1 (is) |
| HN (1) | HN1997000146A (is) |
| HR (1) | HRP970641A2 (is) |
| ID (1) | ID18958A (is) |
| IL (1) | IL129825A0 (is) |
| IS (1) | IS5041A (is) |
| MA (1) | MA26452A1 (is) |
| NO (1) | NO992524L (is) |
| OA (1) | OA11051A (is) |
| PA (1) | PA8442001A1 (is) |
| PE (1) | PE17299A1 (is) |
| TN (1) | TNSN97192A1 (is) |
| WO (1) | WO1998023613A1 (is) |
Families Citing this family (101)
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| AU1441497A (en) * | 1996-01-23 | 1997-08-20 | Novartis Ag | Pyrrolopyrimidines and processes for their preparation |
| DE69720965T2 (de) | 1996-02-13 | 2004-02-05 | Astrazeneca Ab | Chinazolinderivate und deren verwendung als vegf hemmer |
| NZ331191A (en) | 1996-03-05 | 2000-03-27 | Zeneca Ltd | 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof |
| GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
| HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| WO1998013350A1 (en) | 1996-09-25 | 1998-04-02 | Zeneca Limited | Qinoline derivatives inhibiting the effect of growth factors such as vegf |
| ZA986729B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| ES2289791T3 (es) | 1997-08-22 | 2008-02-01 | Astrazeneca Ab | Derivados de oxindolilquinazolina como inhibidores de la angiogenesis. |
| SK286640B6 (sk) * | 1998-06-19 | 2009-03-05 | Pfizer Products Inc. | Pyrol [2,3-d] pyrimidínová zlúčenina, jej použitie na výrobu liečiva, farmaceutická kompozícia s jej obsahom, použitie jej kombinácie s ďalšími činidlami a súpravy s jej obsahom na výrobu liečiva |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| CA2387351C (en) | 1999-10-19 | 2009-09-08 | Merck & Co., Inc. | Indole derivatives as tyrosine kinase inhibitors |
| US6794393B1 (en) | 1999-10-19 | 2004-09-21 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| KR100881105B1 (ko) | 1999-11-05 | 2009-02-02 | 아스트라제네카 아베 | Vegf 억제제로서의 퀴나졸린 유도체 |
| DE60037345T2 (de) | 1999-12-10 | 2008-11-13 | Pfizer Products Inc., Groton | Pyrrolo(2,3-d)pyrimidin-Verbindungen |
| CO5271715A1 (es) | 1999-12-21 | 2003-04-30 | Sugen Inc | 7-aza-indolin-2-onas sustituidas en 4 y su uso como inhibidores de proteiuna quinasa |
| US6420382B2 (en) | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
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| ES2267748T3 (es) | 2000-04-07 | 2007-03-16 | Astrazeneca Ab | Compuestos de quinazolina. |
| US6608053B2 (en) | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| BR0111377A (pt) | 2000-06-06 | 2003-06-03 | Pfizer Prod Inc | Derivados de tiofeno úteis como agentes anticancerìgenos |
| ATE423120T1 (de) | 2000-06-26 | 2009-03-15 | Pfizer Prod Inc | Pyrroloä2,3-düpyrimidin verbindungen als immunosuppressive wirkstoffe |
| ATE303998T1 (de) | 2000-10-17 | 2005-09-15 | Merck & Co Inc | Oral aktive salze mit tyrosinkinaseaktivität |
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| NZ539901A (en) | 2002-11-26 | 2007-09-28 | Pfizer Prod Inc | Method of treatment of transplant rejection |
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| WO2006130673A1 (en) * | 2005-05-31 | 2006-12-07 | Janssen Pharmaceutica, N.V. | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders |
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| KR20150098605A (ko) | 2012-12-21 | 2015-08-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 퀴놀린 유도체의 비정질 형태 및 그의 제조방법 |
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| PT3524595T (pt) | 2014-08-28 | 2022-09-19 | Eisai R&D Man Co Ltd | Derivado de quinolina altamente puro e método para produção do mesmo |
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| KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
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| DE59500788D1 (de) * | 1994-05-03 | 1997-11-20 | Ciba Geigy Ag | Pyrrolopyrimidinderivate mit antiproliferativer Wirkung |
| JPH089637A (ja) * | 1994-06-20 | 1996-01-12 | Shindengen Electric Mfg Co Ltd | Fetによる出力スイッチの駆動回路 |
| CA2214086C (en) * | 1995-04-03 | 2008-07-29 | Novartis Ag | Pyrazole derivatives and processes for the preparation thereof |
| US5804685A (en) * | 1995-06-07 | 1998-09-08 | Neurogen Corporation | Deazapurine derivatives: a new class of CRF1 specific ligands |
| US5644057A (en) * | 1995-05-12 | 1997-07-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
| JPH08329674A (ja) * | 1995-06-02 | 1996-12-13 | Hitachi Ltd | 半導体装置 |
| JP3290666B2 (ja) | 1995-06-07 | 2002-06-10 | ファイザー・インコーポレーテッド | 複素環式の縮合環ピリミジン誘導体 |
| SI9620103A (sl) * | 1995-07-06 | 1998-10-31 | Novartis Ag | Pirolopirimidini in postopki za njihovo pripravo |
| PT944629E (pt) * | 1996-11-26 | 2002-12-31 | American Cyanamid Co | Derivados de biaril-piridoquinazolinona como agentes anti-cancerosos |
-
1997
- 1997-11-05 WO PCT/IB1997/001393 patent/WO1998023613A1/en not_active Ceased
- 1997-11-05 CA CA002272705A patent/CA2272705C/en not_active Expired - Fee Related
- 1997-11-05 EP EP97909525A patent/EP0946554A1/en not_active Ceased
- 1997-11-05 CN CN97199662A patent/CN1237177A/zh active Pending
- 1997-11-05 US US09/308,602 patent/US6413971B1/en not_active Expired - Fee Related
- 1997-11-05 KR KR1019990704587A patent/KR20000057228A/ko not_active Ceased
- 1997-11-05 BR BR9713552-6A patent/BR9713552A/pt unknown
- 1997-11-05 AU AU47189/97A patent/AU4718997A/en not_active Abandoned
- 1997-11-05 IL IL12982597A patent/IL129825A0/xx unknown
- 1997-11-05 JP JP10524465A patent/JP2000505109A/ja active Pending
- 1997-11-07 HN HN1997000146A patent/HN1997000146A/es unknown
- 1997-11-20 PE PE1997001057A patent/PE17299A1/es not_active Application Discontinuation
- 1997-11-20 AP APAP/P/1997/001146A patent/AP9701146A0/en unknown
- 1997-11-25 AR ARP970105506A patent/AR010740A1/es unknown
- 1997-11-25 CO CO97068959A patent/CO4650037A1/es unknown
- 1997-11-26 PA PA19978442001A patent/PA8442001A1/es unknown
- 1997-11-26 TN TNTNSN97192A patent/TNSN97192A1/fr unknown
- 1997-11-26 ID IDP973768A patent/ID18958A/id unknown
- 1997-11-26 HR HR60/041,846A patent/HRP970641A2/hr not_active Application Discontinuation
- 1997-11-26 MA MA24878A patent/MA26452A1/fr unknown
-
1999
- 1999-04-30 IS IS5041A patent/IS5041A/is unknown
- 1999-05-20 BG BG103417A patent/BG103417A/xx unknown
- 1999-05-24 OA OA9900107A patent/OA11051A/en unknown
- 1999-05-26 NO NO992524A patent/NO992524L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HN1997000146A (es) | 1998-02-26 |
| OA11051A (en) | 2003-03-07 |
| JP2000505109A (ja) | 2000-04-25 |
| ID18958A (id) | 1998-05-28 |
| NO992524D0 (no) | 1999-05-26 |
| HRP970641A2 (en) | 1998-10-31 |
| CN1237177A (zh) | 1999-12-01 |
| AP9701146A0 (en) | 1998-01-31 |
| CO4650037A1 (es) | 1998-09-03 |
| BR9713552A (pt) | 2000-01-25 |
| WO1998023613A1 (en) | 1998-06-04 |
| IS5041A (is) | 1999-04-30 |
| AR010740A1 (es) | 2000-07-12 |
| NO992524L (no) | 1999-05-26 |
| US6413971B1 (en) | 2002-07-02 |
| EP0946554A1 (en) | 1999-10-06 |
| CA2272705C (en) | 2003-03-18 |
| IL129825A0 (en) | 2000-02-29 |
| TNSN97192A1 (fr) | 2005-03-15 |
| CA2272705A1 (en) | 1998-06-04 |
| US20020045630A1 (en) | 2002-04-18 |
| KR20000057228A (ko) | 2000-09-15 |
| AU4718997A (en) | 1998-06-22 |
| MA26452A1 (fr) | 2004-12-20 |
| PA8442001A1 (es) | 2000-05-24 |
| PE17299A1 (es) | 1999-02-19 |
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