BG103685A - Хиноксалиндиони - Google Patents

Хиноксалиндиони Download PDF

Info

Publication number: BG103685A
Authority: BG; Bulgaria
Prior art keywords: formula; compound; pharmaceutically acceptable; acceptable salt; solvate
Prior art date: 1997-02-27

Application number

BG103685A

Other languages

Bulgarian (bg)

English (en)

Inventor

Alan Stobie

Elisabeth GAUTIER

David Waite

Robert CROOK

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-27

Filing date

1999-08-24

Publication date

2000-06-30

1997-02-27 Priority claimed from PCT/EP1997/000995 external-priority patent/WO1997032873A1/en

1997-07-25 Priority claimed from GBGB9715783.8A external-priority patent/GB9715783D0/en

1999-08-24 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2000-06-30 Publication of BG103685A publication Critical patent/BG103685A/bg

Links

150000001875 compounds Chemical class 0.000 claims abstract description 96
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238000002360 preparation method Methods 0.000 claims abstract description 17
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VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 21
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims description 12
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239000002253 acid Substances 0.000 claims description 12
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201000010099 disease Diseases 0.000 claims description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
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SEPKUNXLGWMPHL-UHFFFAOYSA-N quinoxaline-2,3-dione Chemical compound C1=CC=CC2=NC(=O)C(=O)N=C21 SEPKUNXLGWMPHL-UHFFFAOYSA-N 0.000 claims description 5
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URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
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235000019345 sodium thiosulphate Nutrition 0.000 description 1
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CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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GZNAASVAJNXPPW-UHFFFAOYSA-M tin(4+) chloride dihydrate Chemical compound O.O.[Cl-].[Sn+4] GZNAASVAJNXPPW-UHFFFAOYSA-M 0.000 description 1
FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Substances O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 description 1
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PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Luminescent Compositions (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BG103685A 1997-02-27 1999-08-24 Хиноксалиндиони BG103685A (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/EP1997/000995 WO1997032873A1 (en)	1996-03-09	1997-02-27	Quinoxalinediones
GBGB9715783.8A GB9715783D0 (en)	1997-02-27	1997-07-25	Quinoxalinediones
PCT/EP1998/001275 WO1998038186A1 (en)	1997-02-27	1998-02-24	Quinoxalinediones

Publications (1)

Publication Number	Publication Date
BG103685A true BG103685A (bg)	2000-06-30

Family

ID=26070194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103685A BG103685A (bg)	1997-02-27	1999-08-24	Хиноксалиндиони

Country Status (16)

Country	Link
EP (1)	EP0973766B1 (de)
JP (2)	JP3588363B2 (de)
CN (2)	CN1121403C (de)
AT (1)	ATE282608T1 (de)
BG (1)	BG103685A (de)
BR (1)	BR9808126A (de)
CA (1)	CA2281580C (de)
DE (1)	DE69827614T2 (de)
ES (1)	ES2230685T3 (de)
HR (1)	HRP980104A2 (de)
HU (1)	HUP0003612A3 (de)
NO (1)	NO994135L (de)
NZ (1)	NZ336842A (de)
SK (1)	SK113399A3 (de)
TR (1)	TR199902055T2 (de)
WO (1)	WO1998038186A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9605027D0 (en) *	1996-03-09	1996-05-08	Pfizer Ltd	Quinoxalinediones
GB0310881D0 (en) *	2003-05-12	2003-06-18	Merck Sharp & Dohme	Pharmaceutical formulation
MY145368A (en)	2004-01-13	2012-01-31	Nissan Chemical Ind Ltd	Aminoquinoxaline compounds and polyaminoquinoxaline compounds, and use thereof
EP1713101B1 (de)	2004-02-06	2012-10-31	Yamaguchi University	Elektrode für eine energiespeichereinrichtung und herstellungsprozess dafür
EP2044066A2 (de) *	2006-06-06	2009-04-08	Bristol-Myers Squibb Company	Kristalline formen von n-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidincarbonsäureamid
CN101679383B (zh)	2007-05-17	2014-10-29	株式会社半导体能源研究所	三唑衍生物，和使用三唑衍生物的发光元件、发光器件和电子器件
WO2011051478A1 (en) *	2009-10-30	2011-05-05	Domain Therapeutics	Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE194985T1 (de) *	1990-11-06	2000-08-15	Yamanouchi Pharma Co Ltd	Kondensiertes pyrazinderivat
DE4217952A1 (de) *	1992-05-30	1993-12-02	Basf Ag	Chinoxalin-2,3(1H,4H)-dione
GB9605027D0 (en) *	1996-03-09	1996-05-08	Pfizer Ltd	Quinoxalinediones

1998
- 1998-02-24 CN CN98802879A patent/CN1121403C/zh not_active Expired - Fee Related
- 1998-02-24 SK SK1133-99A patent/SK113399A3/sk unknown
- 1998-02-24 ES ES98913660T patent/ES2230685T3/es not_active Expired - Lifetime
- 1998-02-24 EP EP98913660A patent/EP0973766B1/de not_active Expired - Lifetime
- 1998-02-24 DE DE69827614T patent/DE69827614T2/de not_active Expired - Fee Related
- 1998-02-24 NZ NZ336842A patent/NZ336842A/xx unknown
- 1998-02-24 TR TR1999/02055T patent/TR199902055T2/xx unknown
- 1998-02-24 CA CA002281580A patent/CA2281580C/en not_active Expired - Fee Related
- 1998-02-24 AT AT98913660T patent/ATE282608T1/de not_active IP Right Cessation
- 1998-02-24 WO PCT/EP1998/001275 patent/WO1998038186A1/en not_active Ceased
- 1998-02-24 HU HU0003612A patent/HUP0003612A3/hu unknown
- 1998-02-24 JP JP53732798A patent/JP3588363B2/ja not_active Expired - Fee Related
- 1998-02-24 BR BR9808126-8A patent/BR9808126A/pt not_active Application Discontinuation
- 1998-02-26 HR HR9715783.8A patent/HRP980104A2/hr not_active Application Discontinuation
1999
- 1999-08-24 BG BG103685A patent/BG103685A/bg unknown
- 1999-08-26 NO NO994135A patent/NO994135L/no unknown
2003
- 2003-03-20 CN CN03107362A patent/CN1443763A/zh active Pending
2004
- 2004-07-02 JP JP2004196277A patent/JP2004269547A/ja active Pending

Also Published As

Publication number	Publication date
HUP0003612A3 (en)	2003-04-28
JP2000509730A (ja)	2000-08-02
TR199902055T2 (xx)	2000-07-21
BR9808126A (pt)	2000-03-08
CN1443763A (zh)	2003-09-24
NO994135D0 (no)	1999-08-26
CA2281580C (en)	2003-04-22
HRP980104A2 (en)	1999-02-28
EP0973766B1 (de)	2004-11-17
DE69827614T2 (de)	2005-11-10
ATE282608T1 (de)	2004-12-15
WO1998038186A1 (en)	1998-09-03
JP3588363B2 (ja)	2004-11-10
DE69827614D1 (de)	2004-12-23
SK113399A3 (en)	2001-04-09
CN1121403C (zh)	2003-09-17
CN1248971A (zh)	2000-03-29
NO994135L (no)	1999-10-22
NZ336842A (en)	2000-05-26
HUP0003612A2 (hu)	2001-10-28
EP0973766A1 (de)	2000-01-26
ES2230685T3 (es)	2005-05-01
CA2281580A1 (en)	1998-09-03
JP2004269547A (ja)	2004-09-30

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MX2010011358A (es)	2010-11-10	Indoles como moduladores del receptor nicotinico de acetilcolina subtipo alfa-71.
JPH05279357A (ja)	1993-10-26	アザヘテロサイクリルメチル−クロマン類
KR102150739B1 (ko)	2020-09-02	카르바메이트/우레아 유도체
HU196792B (en)	1989-01-30	Process for producing 3,3-disubstituted indolin derivatives and pharmaceutical compositions containing them
WO2008041090A1 (en)	2008-04-10	Malanin concentrating hormone receptor-1 antagonist pyridinones
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