BG104192A - Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands - Google Patents

Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands

Info

Publication number: BG104192A
Authority: BG; Bulgaria
Prior art keywords: substituted; carboxamides; naphthyridine; oxo; agonists
Prior art date: 1997-08-25

Application number

BG104192A

Other languages

Bulgarian (bg)

English (en)

Inventor

Pamela Albaugh

Robert Desimone

Gang Liu

Original Assignee

Neurogen Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-25

Filing date

2000-02-25

Publication date

2001-05-31

2000-02-25 Application filed by Neurogen Corporation filed Critical Neurogen Corporation

2001-05-31 Publication of BG104192A publication Critical patent/BG104192A/xx

Links

210000004556 brain Anatomy 0.000 title abstract 3
UFCOHPJEZNHBRJ-UHFFFAOYSA-N 4-oxo-3h-1,8-naphthyridine-3-carboxamide Chemical class C1=CC=C2C(=O)C(C(=O)N)C=NC2=N1 UFCOHPJEZNHBRJ-UHFFFAOYSA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1
239000000556 agonist Substances 0.000 abstract 4
239000005557 antagonist Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
201000010374 Down Syndrome Diseases 0.000 abstract 1
230000036626 alertness Effects 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229940049706 benzodiazepine Drugs 0.000 abstract 1
208000010877 cognitive disease Diseases 0.000 abstract 1
230000001149 cognitive effect Effects 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1
125000005415 substituted alkoxy group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BG104192A 1997-08-25 2000-02-25 Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands BG104192A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US91818097A	1997-08-25	1997-08-25
PCT/US1998/017513 WO1999010347A1 (en)	1997-08-25	1998-08-24	Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Publications (1)

Publication Number	Publication Date
BG104192A true BG104192A (en)	2001-05-31

Family

ID=25439933

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104192A BG104192A (en)	1997-08-25	2000-02-25	Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands

Country Status (24)

Country	Link
EP (1)	EP1007526A1 (is)
JP (1)	JP2001514181A (is)
KR (1)	KR20010023313A (is)
CN (1)	CN1268136A (is)
AP (1)	AP2000001742A0 (is)
AU (1)	AU753800B2 (is)
BG (1)	BG104192A (is)
BR (1)	BR9811362A (is)
CA (1)	CA2301599C (is)
EG (1)	EG21717A (is)
HU (1)	HUP0003258A3 (is)
IL (1)	IL134291A0 (is)
IS (1)	IS5382A (is)
LV (1)	LV12539B (is)
NO (1)	NO20000822L (is)
NZ (1)	NZ502548A (is)
OA (1)	OA11293A (is)
PE (1)	PE130999A1 (is)
PL (1)	PL338783A1 (is)
SI (1)	SI20270A (is)
SK (1)	SK2162000A3 (is)
TW (1)	TW574221B (is)
WO (1)	WO1999010347A1 (is)
YU (1)	YU10500A (is)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0010308A (pt) *	1999-05-06	2002-01-08	Neurogen Corp	Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma doença ou distúrbio associados com o agonismo patogênico, agonismo inverso ou antagonismo do receptor de gabaa, para localizar receptores de gabaa em uma amostra de tecido, para inibir a ligação de um composto de benzodiazepina a um receptor de gabaa e para alterar a atividade da transdução de sinal dos receptores de gabaa, e, composição farmacêutica embalada
AU5289600A (en)	1999-05-25	2000-12-12	Neurogen Corporation	4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
US6730682B2 (en)	2000-07-12	2004-05-04	Pharmacia & Upjohn Company	Heterocycle carboxamides as antiviral agents
US6562822B2 (en)	2000-07-12	2003-05-13	Pharmacia & Upjohn Company	Heterocyle carboxamides as antiviral agents
US6559145B2 (en)	2000-07-12	2003-05-06	Pharmacia & Upjohn Company	Heterocycle carboxamides as antiviral agents
CA2425440C (en)	2000-10-12	2010-04-13	Merck & Co., Inc.	Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
JP2004517860A (ja)	2000-10-12	2004-06-17	メルク　エンド　カムパニー　インコーポレーテッド	Ｈｉｖインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類
US6919351B2 (en)	2000-10-12	2005-07-19	Merck & Co., Inc.	Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors
US20020151591A1 (en) *	2000-10-17	2002-10-17	Anabella Villalobos	Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
WO2002069948A1 (en) *	2001-03-01	2002-09-12	Pfizer Products Inc.	Use of gabaa inverse agonists in combination with nicotine receptor partial agonists, estrogen, selective estrogen modulators, or vitamin e for the treatment of cognitive disorders
AR036256A1 (es)	2001-08-17	2004-08-25	Merck & Co Inc	Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
EP1467970B1 (en)	2002-01-17	2007-08-22	Merck & Co., Inc.	Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
WO2003077857A2 (en)	2002-03-15	2003-09-25	Merck & Co., Inc.	N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2004106336A1 (en) *	2003-05-27	2004-12-09	Pfizer Products Inc.	Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) *	2003-05-28	2004-12-09	Pfizer Products Inc.	Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
JP5373613B2 (ja) *	2006-10-16	2013-12-18	バイオノミクスリミテッド	新規な抗不安薬化合物
ES2610508T3 (es) *	2006-11-22	2017-04-27	Clinical Research Associates, Llc	Métodos para tratar el síndrome de Down, el síndrome del cromosoma X frágil y el autismo

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR204813A1 (es) *	1972-05-08	1976-03-05	Yamanouchi Pharma Co Ltd	Proceso para la preparacion de derivados de ampilicina
GB1433774A (en) *	1973-02-26	1976-04-28	Allen & Hanburys Ltd	Heterocyclic compounds apparatus for conveying articles
US4374138A (en) *	1981-11-13	1983-02-15	Warner-Lambert Company	Antibacterial amide compounds, compositions, and methods of use
DD279887A1 (de) *	1987-07-03	1990-06-20	Inst Pharmakologische Forschun	Verfahren zur herstellung von d-alpha-(4(1h)-1,5-naphthyridon-3-carboxamido)-benzylpenicillin und anderen beta-lactamantibiotika
DD279875A1 (de) *	1987-07-03	1990-06-20	Inst Pharmakologische Forschun	Verfahren zur herstellung von aktivierten carbonsaeureestern
DD295360A5 (de) *	1987-07-03	1991-10-31	Akad Wissenschaften	Verfahren zur Herstellung von aktivierten Carbonsäureestern
JPS6461461A (en) *	1987-09-01	1989-03-08	Otsuka Pharma Co Ltd	Benzohetero ring derivative

1998
- 1998-08-24 PL PL98338783A patent/PL338783A1/xx unknown
- 1998-08-24 YU YU10500A patent/YU10500A/sh unknown
- 1998-08-24 IL IL13429198A patent/IL134291A0/xx unknown
- 1998-08-24 SI SI9820055A patent/SI20270A/sl unknown
- 1998-08-24 CN CN98808578A patent/CN1268136A/zh active Pending
- 1998-08-24 JP JP2000507675A patent/JP2001514181A/ja active Pending
- 1998-08-24 HU HU0003258A patent/HUP0003258A3/hu unknown
- 1998-08-24 CA CA002301599A patent/CA2301599C/en not_active Expired - Fee Related
- 1998-08-24 SK SK216-2000A patent/SK2162000A3/sk unknown
- 1998-08-24 WO PCT/US1998/017513 patent/WO1999010347A1/en not_active Ceased
- 1998-08-24 BR BR9811362-3A patent/BR9811362A/pt not_active Application Discontinuation
- 1998-08-24 EP EP98943352A patent/EP1007526A1/en not_active Withdrawn
- 1998-08-24 KR KR1020007001948A patent/KR20010023313A/ko not_active Withdrawn
- 1998-08-24 NZ NZ502548A patent/NZ502548A/en unknown
- 1998-08-24 AU AU91173/98A patent/AU753800B2/en not_active Ceased
- 1998-09-29 EG EG118098A patent/EG21717A/xx active
- 1998-10-23 TW TW87117597A patent/TW574221B/zh active
- 1998-11-13 PE PE1998001100A patent/PE130999A1/es not_active Application Discontinuation
2000
- 2000-02-01 AP APAP/P/2000/001742A patent/AP2000001742A0/en unknown
- 2000-02-18 OA OA1200000044A patent/OA11293A/en unknown
- 2000-02-18 NO NO20000822A patent/NO20000822L/no not_active Application Discontinuation
- 2000-02-22 IS IS5382A patent/IS5382A/is unknown
- 2000-02-25 BG BG104192A patent/BG104192A/xx unknown
- 2000-03-16 LV LVP-00-29A patent/LV12539B/en unknown

Also Published As

Publication number	Publication date
HUP0003258A2 (en)	2001-03-28
LV12539B (en)	2001-01-20
WO1999010347A1 (en)	1999-03-04
EP1007526A1 (en)	2000-06-14
HUP0003258A3 (en)	2001-05-28
AU9117398A (en)	1999-03-16
PL338783A1 (en)	2000-11-20
BR9811362A (pt)	2000-08-22
TW574221B (en)	2004-02-01
NZ502548A (en)	2002-06-28
AU753800B2 (en)	2002-10-31
CN1268136A (zh)	2000-09-27
IS5382A (is)	2000-02-22
OA11293A (en)	2002-11-19
IL134291A0 (en)	2001-04-30
CA2301599A1 (en)	1999-03-04
NO20000822D0 (no)	2000-02-18
SI20270A (sl)	2000-12-31
JP2001514181A (ja)	2001-09-11
PE130999A1 (es)	1999-12-16
CA2301599C (en)	2003-03-25
LV12539A (en)	2000-10-20
SK2162000A3 (en)	2001-03-12
KR20010023313A (ko)	2001-03-26
YU10500A (sh)	2002-10-18
EG21717A (en)	2002-02-27
NO20000822L (no)	2000-04-13
AP2000001742A0 (en)	2000-02-24

Publication	Publication Date	Title
BG104192A (en)	2001-05-31	Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands
OA09579A (en)	1993-01-31	Certain imidazoquinoxalines a new class of gaba brain receptor ligands
CA2175204A1 (en)	1995-05-11	Certain Fused Pyrrolecarboxanilides; a New Class of GABA Brain Receptor Ligands
NZ330861A (en)	2000-03-27	Fused pyrrolecarboxamides and use as a new class of GABA brain receptor ligands
AU4818000A (en)	2000-11-21	Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands
DE60014339T8 (de)	2006-04-27	Aryl- und heteroaryl-kondensierte aminoalkyl-imidazol-derivate: selektive modulatoren der gabaa-rezeptoren
NO20013001L (no)	2001-06-15	2,3,4,4A-tetrahydro-1H-pyrazino(1,2-A)kinoksalin-5(6H)on- derivater som er 5HT2C-agonister
DE60106641D1 (de)	2004-11-25	Cyclopenta[b][1,4] diazepino[6,7,1-hi]indole als 5ht2c antagonisten
TW200510324A (en)	2005-03-16	6-(2,2,2-trifluoroethylamino)-7-chiloro-2, 3, 4, 5-tetrahydro-1h-benzo[d]azepine as a 5-ht2c receptor agonist
CA2091986A1 (en)	1992-04-10	Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
PT1666462E (pt)	2009-05-07	Derivados de n-[1h-indol-5-il]-naftaleno-1-sulfonamida e compostos associados enquanto antagonistas do receptor 5- ht6 de serotonina para o tratamento de distúrbios do sistema nervoso central
WO2002000623A3 (en)	2002-07-18	Aryl fused substituted 4-oxy-pyridines
WO1999043661A3 (en)	2000-01-06	Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands
AU2321597A (en)	1997-10-01	Novel imidazo{1,5-c}quinazolines; a new class of gaba brain receptor ligands
AP2002002420A0 (en)	2002-03-31	Fused pyrrolecarboxamides: gaba brain receptor ligands.
ATE300539T1 (de)	2005-08-15	Oxo-pyridoimidazol-carboxamide: gaba-rezeptor- liganden im gehirn
CA2249562A1 (en)	1997-09-25	Certain fused pyrrolecarboxamides as gaba brain receptor ligands
MY107732A (en)	1996-05-30	Certain imidazoquinoxalines; a new class of gaba brain receptor ligands.
DE69907448D1 (de)	2003-06-05	Pyrido[2,3-b]indolizinderivate und aza analoge: crf1 spezifische liganden
MX9709771A (es)	1998-03-31	Nuevas aril y cicloalquil imidazolonas substituidas, una clase de ligandos receptores de acido gamma-aminobutirico del cerebro.
AR007742A1 (es)	1999-11-10	Pirrolcarboxanilidas fusionadas; una nueva clase de ligandos receptores gaba del cerebro.