BG104340A - 3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity - Google Patents

3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity

Info

Publication number: BG104340A
Authority: BG; Bulgaria
Prior art keywords: modified; antibacterial activity; substituted erythromycin; erythromycin ketolide; ketolide derivatives
Prior art date: 1997-09-30

Application number

BG104340A

Other languages

Bulgarian (bg)

English (en)

Inventor

Yat S. Or

Zhenkun Ma

Daniel T. Chu

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-30

Filing date

2000-04-14

Publication date

2001-01-31

2000-04-14 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

2001-01-31 Publication of BG104340A publication Critical patent/BG104340A/xx

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 4
230000000844 anti-bacterial effect Effects 0.000 title abstract 2
229960003276 erythromycin Drugs 0.000 title abstract 2
239000003835 ketolide antibiotic agent Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
208000035143 Bacterial infection Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

BG104340A 1997-09-30 2000-04-14 3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity BG104340A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US94087197A	1997-09-30	1997-09-30
US13312198A	1998-08-12	1998-08-12
PCT/US1998/019311 WO1999016779A1 (en)	1997-09-30	1998-09-16	3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity

Publications (1)

Publication Number	Publication Date
BG104340A true BG104340A (en)	2001-01-31

Family

ID=26831064

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104340A BG104340A (en)	1997-09-30	2000-04-14	3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity

Country Status (22)

Country	Link
EP (1)	EP1025114B1 (de)
JP (1)	JP2001518476A (de)
KR (1)	KR20010030807A (de)
CN (1)	CN1271363A (de)
AR (1)	AR015727A1 (de)
AT (1)	ATE260293T1 (de)
AU (1)	AU737310B2 (de)
BG (1)	BG104340A (de)
BR (1)	BR9812577A (de)
CA (1)	CA2303930A1 (de)
CO (1)	CO4990958A1 (de)
DE (1)	DE69821964T2 (de)
DK (1)	DK1025114T3 (de)
ES (1)	ES2217579T3 (de)
HU (1)	HUP0004579A3 (de)
IL (1)	IL134608A0 (de)
NO (1)	NO20001439L (de)
PL (1)	PL339575A1 (de)
PT (1)	PT1025114E (de)
SK (1)	SK4562000A3 (de)
TR (1)	TR200000805T2 (de)
WO (1)	WO1999016779A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4573925B2 (ja) *	1998-07-09	2010-11-04	アベンティス・ファーマ・ソシエテ・アノニム	新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
ATE340183T1 (de) *	1999-04-16	2006-10-15	Kosan Biosciences Inc	Antiinfektiöse makrolidderivate
US6355620B1 (en) *	1999-05-14	2002-03-12	Abbott Laboratories	C-2 modified erythromycin derivatives
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
WO2002014339A1 (en) *	2000-08-14	2002-02-21	Taisho Pharmaceutical Co., Ltd.	Process for producing erythromycin derivative
US20020111317A1 (en) *	2000-09-25	2002-08-15	Leonard Katz	Sixteen-membered macrolide compounds
ITMI20021726A1 (it)	2002-08-01	2004-02-02	Zambon Spa	Macrolidi ad attivita' antiinfiammatoria.
TW200420573A (en)	2002-09-26	2004-10-16	Rib X Pharmaceuticals Inc	Bifunctional heterocyclic compounds and methods of making and using same
CN108101948A (zh) *	2004-02-27	2018-06-01	瑞伯-X医药品有限公司	大环化合物以及其制作和使用方法
EP1723159B1 (de) *	2004-02-27	2019-06-12	Melinta Therapeutics, Inc.	Makrozyklische verbindungen, deren herstellung und verwendung
US20080287376A1 (en) *	2004-07-28	2008-11-20	Mohammad Salman	Ketolide Derivatives as Antibacterial Agents
US20090170790A1 (en) *	2004-10-25	2009-07-02	Biswajit Das	Ketolide derivatives as antibacterial agents
WO2006129257A2 (en) *	2005-05-30	2006-12-07	Ranbaxy Laboratories Limited	Ketolide derivatives as antibacterial agents
EP1934237A2 (de)	2005-08-24	2008-06-25	Rib-X Pharmaceuticals, Inc.	Triazolverbindungen und verfahren zu deren herstellung und anwendung
EP3290427A1 (de)	2005-08-24	2018-03-07	Melinta Therapeutics, Inc.	Triazolverbindungen und verfahren zur herstellung und verwendung davon
US20090005325A1 (en) *	2005-11-23	2009-01-01	Biswajit Bas	Ketolide Derivatives as Antibacterial Agents
RU2455308C2 (ru) *	2006-05-01	2012-07-10	Тайсо Фармасьютикал Ко., Лтд.	Макролидные производные
WO2008099368A1 (en) *	2007-02-15	2008-08-21	Ranbaxy Laboratories Limited	Macrolide derivatives as antibacterial agents
WO2008111020A2 (en) *	2007-03-14	2008-09-18	Ranbaxy Laboratories Limited	Macrolide derivatives as antibacterial agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
ATE259823T1 (de) *	1995-11-08	2004-03-15	Abbott Lab	Tricyclische erythromycinderivate

1998
- 1998-09-16 BR BR9812577-0A patent/BR9812577A/pt not_active IP Right Cessation
- 1998-09-16 CN CN98809567A patent/CN1271363A/zh active Pending
- 1998-09-16 KR KR1020007003408A patent/KR20010030807A/ko not_active Withdrawn
- 1998-09-16 AT AT98946087T patent/ATE260293T1/de not_active IP Right Cessation
- 1998-09-16 DK DK98946087T patent/DK1025114T3/da active
- 1998-09-16 ES ES98946087T patent/ES2217579T3/es not_active Expired - Lifetime
- 1998-09-16 TR TR2000/00805T patent/TR200000805T2/xx unknown
- 1998-09-16 PL PL98339575A patent/PL339575A1/xx unknown
- 1998-09-16 EP EP98946087A patent/EP1025114B1/de not_active Expired - Lifetime
- 1998-09-16 PT PT98946087T patent/PT1025114E/pt unknown
- 1998-09-16 IL IL13460898A patent/IL134608A0/xx unknown
- 1998-09-16 CA CA002303930A patent/CA2303930A1/en not_active Abandoned
- 1998-09-16 SK SK456-2000A patent/SK4562000A3/sk unknown
- 1998-09-16 JP JP2000513861A patent/JP2001518476A/ja not_active Withdrawn
- 1998-09-16 HU HU0004579A patent/HUP0004579A3/hu unknown
- 1998-09-16 DE DE69821964T patent/DE69821964T2/de not_active Expired - Fee Related
- 1998-09-16 AU AU93176/98A patent/AU737310B2/en not_active Ceased
- 1998-09-16 WO PCT/US1998/019311 patent/WO1999016779A1/en not_active Ceased
- 1998-09-28 CO CO98056259A patent/CO4990958A1/es unknown
- 1998-09-29 AR ARP980104856A patent/AR015727A1/es unknown
2000
- 2000-03-20 NO NO20001439A patent/NO20001439L/no not_active Application Discontinuation
- 2000-04-14 BG BG104340A patent/BG104340A/xx unknown

Also Published As

Publication number	Publication date
CN1271363A (zh)	2000-10-25
IL134608A0 (en)	2001-04-30
AU9317698A (en)	1999-04-23
TR200000805T2 (tr)	2000-10-23
DE69821964T2 (de)	2004-12-30
PT1025114E (pt)	2004-07-30
ATE260293T1 (de)	2004-03-15
AR015727A1 (es)	2001-05-16
NO20001439L (no)	2000-05-29
HUP0004579A2 (hu)	2001-05-28
EP1025114A1 (de)	2000-08-09
CA2303930A1 (en)	1999-04-08
CO4990958A1 (es)	2000-12-26
DE69821964D1 (de)	2004-04-01
NO20001439D0 (no)	2000-03-20
WO1999016779A1 (en)	1999-04-08
ES2217579T3 (es)	2004-11-01
EP1025114B1 (de)	2004-02-25
BR9812577A (pt)	2000-10-17
KR20010030807A (ko)	2001-04-16
JP2001518476A (ja)	2001-10-16
HUP0004579A3 (en)	2001-11-28
AU737310B2 (en)	2001-08-16
PL339575A1 (en)	2000-12-18
DK1025114T3 (da)	2004-07-05
SK4562000A3 (en)	2000-09-12

Publication	Publication Date	Title
BG104340A (en)	2001-01-31	3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity
BG104434A (en)	2001-01-31	2-halo-6-o-substituted ketolide derivatives
CA2263972A1 (en)	1998-03-12	6-o-substituted ketolides having antibacterial activity
CA2316919A1 (en)	1999-07-15	Novel macrolides
AP9801253A0 (en)	1999-12-04	9-Oxime erythromycin derivatives.
BG103969A (en)	2000-07-31	C-4"-substituted macrolide derivatives
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
TR200001140T2 (tr)	2001-05-21	6, 11-Köprülü eritromisin türevleri.
BR9812148A (pt)	2000-07-18	Derivados de eritromicina 6,9-ligados em ponte
CA2351429A1 (en)	2000-06-02	13-membered azalides and their use as antibiotic agents
CA2108903A1 (en)	1992-11-04	Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
WO2004011477A3 (en)	2004-03-18	6,11-4-carbon bridged ketolides
IL123551A0 (en)	1998-10-30	Tricyclic erythromycin derivatives
TW427906B (en)	2001-04-01	Antifungal compositions
BR9708929A (pt)	1999-08-03	Composto composição farmacêutica e processos para controlar uma infecção bacteriana em um mamífero e para preparar compostos de macrólidos
WO1999011651A3 (en)	1999-05-06	3-descladinose 6-o-substituded erythromycin derivatives
WO2003089446A3 (en)	2003-12-18	23-o-substituted 5-o-mycaminosyltylonide derivatives
CA2380455A1 (en)	2001-03-01	9a-azalides with antibacterial activity
WO2000010998A3 (en)	2000-05-18	Pyridone antibiotic with improved safety profile
CA2290421A1 (en)	1998-12-03	Multicyclic erythromycin derivatives
AP9801235A0 (en)	1999-11-07	Erythromycin derivatives.
CA2564020A1 (en)	1998-03-12	6-o-substituted ketolides having antibacterial activity