BG105299A - Substituted amidazo[1,2a]azines as selective inhibitors of cox-2 - Google Patents

Substituted amidazo[1,2a]azines as selective inhibitors of cox-2

Info

Publication number: BG105299A
Authority: BG; Bulgaria
Prior art keywords: substituted; cox; amidazo; azines; selective inhibitors
Prior art date: 1998-08-03

Application number

BG105299A

Other languages

Bulgarian (bg)

English (en)

Inventor

Gallemi Carles Farrerons

BONO Ignacio - Jose MIQUEL

Serrat Ana Maria Fernandez

Vidal Carlos Monserrat

Arnal Carmen Lagunas

Guasch Ferran Gimenez

Garcia Andres Fernandez

Original Assignee

Laboratorios S.A.L.V.A.T., S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-03

Filing date

2001-02-28

Publication date

2001-11-30

2001-02-28 Application filed by Laboratorios S.A.L.V.A.T., S.A. filed Critical Laboratorios S.A.L.V.A.T., S.A.

2001-11-30 Publication of BG105299A publication Critical patent/BG105299A/xx

Links

101150071146 COX2 gene Proteins 0.000 title 1
101100114534 Caenorhabditis elegans ctc-2 gene Proteins 0.000 title 1
101150000187 PTGS2 gene Proteins 0.000 title 1
229940124639 Selective inhibitor Drugs 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 abstract 1
108050003243 Prostaglandin G/H synthase 1 Proteins 0.000 abstract 1
102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 1
108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
-1 trifluoromethoxyl Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
230000001562 ulcerogenic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BG105299A 1998-08-03 2001-02-28 Substituted amidazo[1,2a]azines as selective inhibitors of cox-2 BG105299A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009801652A ES2140354B1 (es)	1998-08-03	1998-08-03	Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2.
PCT/ES1999/000235 WO2000008024A1 (es)	1998-08-03	1999-07-23	IMIDAZO[1,2a]AZINAS SUSTITUIDAS COMO INHIBIDORES SELECTIVOS DE LA COX-2

Publications (1)

Publication Number	Publication Date
BG105299A true BG105299A (en)	2001-11-30

Family

ID=8304755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105299A BG105299A (en)	1998-08-03	2001-02-28	Substituted amidazo[1,2a]azines as selective inhibitors of cox-2

Country Status (30)

Country	Link
US (1)	US6670365B1 (da)
EP (1)	EP1104762B1 (da)
JP (1)	JP2002522438A (da)
KR (1)	KR20010079602A (da)
CN (1)	CN1131865C (da)
AP (1)	AP2001002082A0 (da)
AT (1)	ATE224391T1 (da)
AU (1)	AU749770B2 (da)
BG (1)	BG105299A (da)
BR (1)	BR9912968A (da)
CA (1)	CA2339187A1 (da)
CZ (1)	CZ291783B6 (da)
DE (1)	DE69903046T2 (da)
DK (1)	DK1104762T3 (da)
EA (1)	EA003399B1 (da)
ES (2)	ES2140354B1 (da)
HU (1)	HUP0103004A3 (da)
ID (1)	ID28539A (da)
IL (1)	IL141242A0 (da)
MX (1)	MXPA01001332A (da)
NO (1)	NO20010568L (da)
NZ (1)	NZ510196A (da)
OA (1)	OA11592A (da)
PL (1)	PL345804A1 (da)
PT (1)	PT1104762E (da)
SK (1)	SK1662001A3 (da)
TR (1)	TR200100359T2 (da)
WO (1)	WO2000008024A1 (da)
YU (1)	YU7401A (da)
ZA (1)	ZA200101632B (da)

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KR100793668B1 (ko)	1999-12-08	2008-01-10	파마시아 코포레이션	강화된 생체이용률을 지닌 고체상 형태의 셀레콕시브
US8241622B2 (en) *	2001-07-13	2012-08-14	University Of Iowa Research Foundation	Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences
US20030100594A1 (en) *	2001-08-10	2003-05-29	Pharmacia Corporation	Carbonic anhydrase inhibitor
DE10247271A1 (de) *	2002-10-10	2004-08-26	Grünenthal GmbH	Substituierte C-Imidazo[1,2-a]pyridin-3-yle
DE10256881A1 (de) *	2002-12-05	2004-06-24	Beiersdorf Ag	Neue topische Verwendung von Bis-Arylimidazo[1,2-a]thiolanderivaten
ES2275218T3 (es)	2003-05-07	2007-06-01	Osteologix A/S	Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
ES2298798T3 (es) *	2003-07-30	2008-05-16	Laboratorios S.A.L.V.A.T., S.A.	Imidazopirimidinas sustituidas para la prevencion y el tratamiento del cancer.
WO2007034278A2 (en) *	2005-09-19	2007-03-29	Pfizer Products Inc.	Fused imidazole derivatives as c3a receptor antagonists
CA2634670A1 (en) *	2005-12-30	2007-07-12	University Of Iowa Research Foundation	Method of identifying compounds useful to treat neuronal degenerative diseases
WO2007096764A2 (en) *	2006-02-27	2007-08-30	Glenmark Pharmaceuticals S.A.	Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
CN101861316B (zh) *	2007-11-14	2013-08-21	奥梅-杨森制药有限公司	咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
AU2009300318A1 (en) *	2008-10-01	2010-04-08	Synta Pharmaceuticals Corp.	Compounds for inflammation and immune-related uses
GB201321732D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
WO2017139381A1 (en)	2016-02-08	2017-08-17	University Of Iowa Research Foundation	Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
CA3016985C (en)	2016-03-07	2023-07-04	University Of Iowa Research Foundation	Aav-mediated expression using a synthetic promoter and enhancer
WO2017205739A1 (en)	2016-05-26	2017-11-30	University Of Iowa Research Foundation	cis AND trans REQUIREMENTS FOR TERMINAL RESOLUTION OF HUMAN BOCAVIRUS 1
US11142775B2 (en)	2017-01-13	2021-10-12	University Of Iowa Research Foundation	Bocaparvovirus small noncoding RNA and uses thereof
IL305573A (en)	2021-03-15	2023-10-01	Saul Yedgar	HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2785133A (en) *	1954-03-26	1957-03-12	Gen Aniline & Film Corp	Compositions for a method of whitening fine fabrics
US3455924A (en) *	1967-02-08	1969-07-15	Upjohn Co	Dianisylimidazoles
AU9137591A (en)	1990-12-13	1992-07-08	Smithkline Beecham Corporation	Novel csaids
WO1993019066A1 (fr) *	1992-03-17	1993-09-30	Nippon Shinyaku Co., Ltd.	Derive de l'imidazopyridine et medicament
US5620999A (en) *	1994-07-28	1997-04-15	Weier; Richard M.	Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
CN1186492A (zh) *	1995-04-04	1998-07-01	葛兰素集团有限公司	咪唑并[1,2－α]吡啶衍生物
UA57002C2 (uk) *	1995-10-13	2003-06-16	Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі.	Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування

1998
- 1998-08-03 ES ES009801652A patent/ES2140354B1/es not_active Expired - Lifetime
1999
- 1999-07-23 ID IDW20010517A patent/ID28539A/id unknown
- 1999-07-23 KR KR1020017001453A patent/KR20010079602A/ko not_active Ceased
- 1999-07-23 AU AU47824/99A patent/AU749770B2/en not_active Ceased
- 1999-07-23 HU HU0103004A patent/HUP0103004A3/hu unknown
- 1999-07-23 SK SK166-2001A patent/SK1662001A3/sk unknown
- 1999-07-23 JP JP2000563657A patent/JP2002522438A/ja active Pending
- 1999-07-23 ES ES99931266T patent/ES2182546T3/es not_active Expired - Lifetime
- 1999-07-23 EA EA200100212A patent/EA003399B1/ru not_active IP Right Cessation
- 1999-07-23 CZ CZ2001433A patent/CZ291783B6/cs not_active IP Right Cessation
- 1999-07-23 NZ NZ510196A patent/NZ510196A/xx unknown
- 1999-07-23 BR BR9912968-0A patent/BR9912968A/pt not_active IP Right Cessation
- 1999-07-23 DE DE69903046T patent/DE69903046T2/de not_active Expired - Fee Related
- 1999-07-23 MX MXPA01001332A patent/MXPA01001332A/es unknown
- 1999-07-23 AT AT99931266T patent/ATE224391T1/de not_active IP Right Cessation
- 1999-07-23 CA CA002339187A patent/CA2339187A1/en not_active Abandoned
- 1999-07-23 YU YU7401A patent/YU7401A/sh unknown
- 1999-07-23 IL IL14124299A patent/IL141242A0/xx unknown
- 1999-07-23 DK DK99931266T patent/DK1104762T3/da active
- 1999-07-23 EP EP99931266A patent/EP1104762B1/en not_active Expired - Lifetime
- 1999-07-23 CN CN998116750A patent/CN1131865C/zh not_active Expired - Fee Related
- 1999-07-23 TR TR2001/00359T patent/TR200100359T2/xx unknown
- 1999-07-23 US US09/762,146 patent/US6670365B1/en not_active Expired - Fee Related
- 1999-07-23 OA OA1200100033A patent/OA11592A/en unknown
- 1999-07-23 PT PT99931266T patent/PT1104762E/pt unknown
- 1999-07-23 WO PCT/ES1999/000235 patent/WO2000008024A1/es not_active Ceased
- 1999-07-23 AP APAP/P/2001/002082A patent/AP2001002082A0/en unknown
- 1999-07-23 PL PL99345804A patent/PL345804A1/xx not_active IP Right Cessation
2001
- 2001-02-02 NO NO20010568A patent/NO20010568L/no not_active Application Discontinuation
- 2001-02-27 ZA ZA200101632A patent/ZA200101632B/en unknown
- 2001-02-28 BG BG105299A patent/BG105299A/xx unknown

Also Published As

Publication number	Publication date
MXPA01001332A (es)	2002-11-29
PL345804A1 (en)	2002-01-02
PT1104762E (pt)	2002-11-29
IL141242A0 (en)	2002-03-10
ZA200101632B (en)	2001-08-30
US6670365B1 (en)	2003-12-30
SK1662001A3 (en)	2001-08-06
DK1104762T3 (da)	2002-10-21
BR9912968A (pt)	2001-05-08
ES2140354A1 (es)	2000-02-16
CN1321157A (zh)	2001-11-07
EA003399B1 (ru)	2003-04-24
CA2339187A1 (en)	2000-02-17
NZ510196A (en)	2002-09-27
DE69903046D1 (de)	2002-10-24
HK1037629A1 (en)	2002-02-15
WO2000008024A1 (es)	2000-02-17
ID28539A (id)	2001-05-31
OA11592A (en)	2004-07-30
EP1104762B1 (en)	2002-09-18
DE69903046T2 (de)	2003-05-22
HUP0103004A3 (en)	2003-03-28
YU7401A (sh)	2003-10-31
CN1131865C (zh)	2003-12-24
EP1104762A1 (en)	2001-06-06
NO20010568D0 (no)	2001-02-02
CZ2001433A3 (cs)	2001-08-15
ATE224391T1 (de)	2002-10-15
ES2140354B1 (es)	2000-11-01
NO20010568L (no)	2001-04-02
EA200100212A1 (ru)	2001-08-27
AP2001002082A0 (en)	2001-03-31
JP2002522438A (ja)	2002-07-23
KR20010079602A (ko)	2001-08-22
ES2182546T3 (es)	2003-03-01
TR200100359T2 (tr)	2001-06-21
AU4782499A (en)	2000-02-28
CZ291783B6 (cs)	2003-05-14
HUP0103004A2 (hu)	2002-01-28
AU749770B2 (en)	2002-07-04

Publication	Publication Date	Title
BG105299A (en)	2001-11-30	Substituted amidazo[1,2a]azines as selective inhibitors of cox-2
DK1070056T3 (da)	2004-11-08	Phthalazinon-PDE III/IV-inhibitorer
BG106771A (en)	2003-03-31	Heterocyclic substituted pyrazolones
DE69725171D1 (de)	2003-10-30	Substituierte pyrrolylverbindungen zur behandlung von entzündungen
WO2002017914A8 (en)	2002-07-11	Fused pyrrolocarbazoles against inflammation
NO20032254D0 (no)	2003-05-19	Forbindelser for inhibering av ekspresjon av VACM-I
IL135536A0 (en)	2001-05-20	Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same
WO2004106293A3 (en)	2005-03-24	Oxazolyl - and thiazolyl - purine based tricyclic compounds.
EA200300105A1 (ru)	2003-06-26	Нестероидные ингибиторы воспалений
TR200302268T4 (tr)	2004-01-21	NOS inhibitörleri olarak yararlı N-heterosiklik türevler.
ATE444065T1 (de)	2009-10-15	4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidon-deriva e als pde-4-hemmer zur behandlung von neurologischen syndromen
DE60324544D1 (de)	2008-12-18	Muskarin antagonisten
MA26767A1 (fr)	2004-12-20	Hydroxamates de sulfonamide
SE9804212D0 (sv)	1998-12-04	Compounds
WO2005035537A3 (en)	2005-06-09	Substituted tricyclic heterocycles and their uses
WO2004075846A3 (en)	2005-05-19	Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
EA200000204A1 (ru)	2000-10-30	Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов
HK1046404A1 (zh)	2003-01-10	用作nmda受体拮抗剂的取代的吡咯烷-2，3，4-三酮-3-肟衍生物
WO2005011609A3 (en)	2005-06-09	Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
BR0002508B1 (pt)	2010-07-27	cetonas alfa, beta insaturadas, mistura e composição adorìfera.
WO2002051848A3 (de)	2002-10-24	Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer
ATE286050T1 (de)	2005-01-15	Heterozyclische oder benzol derivate von liponsäure, deren herstellung und deren verwendung als heilmittel
NO983511D0 (no)	1998-07-30	Difenylstilbener som pro-legemidler for COX-2-inhibitorer
NZ336091A (en)	2000-12-22	Aqueous disinfecting cleaning composition
AU2001230180A1 (en)	2001-07-24	Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof