BG105470A - Means and method for the treament of tumours - Google Patents

Means and method for the treament of tumours

Info

Publication number: BG105470A
Authority: BG; Bulgaria
Prior art keywords: treament; tumours; acetyldinaline; capecitabine; gemcitabine
Prior art date: 1998-09-25

Application number

BG105470A

Other languages

Bulgarian (bg)

English (en)

Inventor

William GROVE

Wayne KLOHS

Ronald MERRIMAN

Original Assignee

Warner-Lambert Company Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-25

Filing date

2001-04-25

Publication date

2001-12-29

2001-04-25 Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc

2001-12-29 Publication of BG105470A publication Critical patent/BG105470A/xx

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 abstract 1
GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
229960004117 capecitabine Drugs 0.000 abstract 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
229960004316 cisplatin Drugs 0.000 abstract 1
229960005277 gemcitabine Drugs 0.000 abstract 1
SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000002195 synergetic effect Effects 0.000 abstract 1
VAZAPHZUAVEOMC-UHFFFAOYSA-N tacedinaline Chemical compound C1=CC(NC(=O)C)=CC=C1C(=O)NC1=CC=CC=C1N VAZAPHZUAVEOMC-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Inorganic Chemistry (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

BG105470A 1998-09-25 2001-04-25 Means and method for the treament of tumours BG105470A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10180998P	1998-09-25	1998-09-25
PCT/US1999/015386 WO2000018393A1 (en)	1998-09-25	1999-07-08	Chemotherapy of cancer with acetyldinaline in combination with gemcitabine, capecitabine or cisplatin

Publications (1)

Publication Number	Publication Date
BG105470A true BG105470A (en)	2001-12-29

Family

ID=22286531

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105470A BG105470A (en)	1998-09-25	2001-04-25	Means and method for the treament of tumours

Country Status (34)

Country	Link
US (3)	US6469058B1 (tr)
EP (1)	EP1115391B1 (tr)
JP (1)	JP2002525320A (tr)
KR (1)	KR20010075348A (tr)
CN (1)	CN1319009A (tr)
AP (1)	AP2001002109A0 (tr)
AT (1)	ATE225655T1 (tr)
AU (1)	AU762079B2 (tr)
BG (1)	BG105470A (tr)
BR (1)	BR9913952A (tr)
CA (1)	CA2342981A1 (tr)
CZ (1)	CZ2001905A3 (tr)
DE (1)	DE69903458T2 (tr)
DK (1)	DK1115391T3 (tr)
EA (1)	EA200100369A1 (tr)
EE (1)	EE200100187A (tr)
ES (1)	ES2185378T3 (tr)
GE (1)	GEP20043199B (tr)
HK (1)	HK1040190A1 (tr)
HR (1)	HRP20010225B1 (tr)
HU (1)	HUP0103640A3 (tr)
ID (1)	ID30046A (tr)
IL (1)	IL141951A0 (tr)
IS (1)	IS5888A (tr)
NO (1)	NO20011493L (tr)
NZ (1)	NZ510504A (tr)
OA (1)	OA11659A (tr)
PL (1)	PL348673A1 (tr)
PT (1)	PT1115391E (tr)
SK (1)	SK3602001A3 (tr)
TR (1)	TR200100859T2 (tr)
WO (1)	WO2000018393A1 (tr)
YU (1)	YU22401A (tr)
ZA (1)	ZA200102233B (tr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE225655T1 (de) *	1998-09-25	2002-10-15	Warner Lambert Co	Chemotherapie des krebses mit acetyldinalin in verbindung mit gemcitabin, capecitabin oder cisplatin
CZ20022216A3 (cs) *	2001-07-02	2003-05-14	Warner-Lambert Company	Kombinační chemoterapie
US20080075762A1 (en) *	2001-10-03	2008-03-27	Paul Tardi	Compositions for delivery of drug combinations
CA2383259A1 (en)	2002-04-23	2003-10-23	Celator Technologies Inc.	Synergistic compositions
US7850990B2 (en) *	2001-10-03	2010-12-14	Celator Pharmaceuticals, Inc.	Compositions for delivery of drug combinations
CN101259120B (zh) *	2002-03-04	2012-07-04	Hdac默克研究有限责任公司	辛二酰苯胺异羟肟酸或其可药用盐在制备诱导末期分化的药物的用途
US7456219B2 (en)	2002-03-04	2008-11-25	Merck Hdac Research, Llc	Polymorphs of suberoylanilide hydroxamic acid
US20040132825A1 (en) *	2002-03-04	2004-07-08	Bacopoulos Nicholas G.	Methods of treating cancer with HDAC inhibitors
AU2003226408B2 (en) *	2002-04-15	2007-06-14	Sloan-Kettering Institute For Cancer Research	Combination therapy for the treatment of cancer
US20070032422A1 (en)	2002-10-24	2007-02-08	Spectrum Pharmaceuticals, Inc.	Methods, compositions and articles of manufacture for contributing to the treatment of cancers
US8026216B2 (en)	2002-10-24	2011-09-27	Spectrum Pharmaceuticals, Inc.	Methods and compositions for contributing to the treatment of cancers
GB0226434D0 (en) *	2002-11-13	2002-12-18	Astrazeneca Ab	Combination product
MXPA05003431A (es) *	2002-11-15	2005-07-05	Warner Lambert Co	Quimioterapia de combinacion.
RU2240117C1 (ru) *	2003-04-01	2004-11-20	Алтайский государственный медицинский университет	Способ лечения больных с местнораспространенными формами плоскоклеточного рака с локализацией в области слизистой оболочки полости рта и ротового отдела глотки
EP1643971A2 (en) *	2003-05-22	2006-04-12	Neopharm, Inc.	Liposomal formulations comprising a combination of two or more active agents
PE20050206A1 (es) *	2003-05-26	2005-03-26	Schering Ag	Composicion farmaceutica que contiene un inhibidor de histona deacetilasa
CN100431606C (zh) *	2004-11-22	2008-11-12	山东蓝金生物工程有限公司	一种抗癌药物组合物
US7957507B2 (en)	2005-02-28	2011-06-07	Cadman Patrick F	Method and apparatus for modulating a radiation beam
CN100443081C (zh) *	2005-04-05	2008-12-17	吴一心	木犀草素与一种铂类化疗药物联合用于制备抗肿瘤的药物
US8232535B2 (en)	2005-05-10	2012-07-31	Tomotherapy Incorporated	System and method of treating a patient with radiation therapy
CN101268467B (zh) *	2005-07-22	2012-07-18	断层放疗公司	用于评估治疗计划的实施中的质量保证标准的方法和系统
AU2006272742A1 (en)	2005-07-22	2007-02-01	Tomotherapy Incorporated	System and method of delivering radiation therapy to a moving region of interest
JP2009514559A (ja)	2005-07-22	2009-04-09	トモセラピー・インコーポレーテッド	線量体積ヒストグラムを用いて輪郭構造を生成するシステムおよび方法
US7639853B2 (en)	2005-07-22	2009-12-29	Tomotherapy Incorporated	Method of and system for predicting dose delivery
CA2616301A1 (en) *	2005-07-22	2007-02-01	Tomotherapy Incorporated	Method and system for evaluating delivered dose
JP5060476B2 (ja)	2005-07-22	2012-10-31	トモセラピー・インコーポレーテッド	放射線療法を受けている患者の呼吸位相を検出するシステムおよび方法
US7567694B2 (en)	2005-07-22	2009-07-28	Tomotherapy Incorporated	Method of placing constraints on a deformation map and system for implementing same
EP1907065B1 (en)	2005-07-22	2012-11-07	TomoTherapy, Inc.	Method and system for adapting a radiation therapy treatment plan based on a biological model
US8442287B2 (en)	2005-07-22	2013-05-14	Tomotherapy Incorporated	Method and system for evaluating quality assurance criteria in delivery of a treatment plan
EP1906827A4 (en)	2005-07-22	2009-10-21	Tomotherapy Inc	SYSTEM AND METHOD FOR EVALUATING A DOSE ADMINISTERED BY A RADIATION THERAPY SYSTEM
CA2616306A1 (en)	2005-07-22	2007-02-01	Tomotherapy Incorporated	Method and system for processing data relating to a radiation therapy treatment plan
EP3175886B1 (en)	2005-07-23	2018-06-27	TomoTherapy, Inc.	Radiation therapy imaging and delivery utilizing coordinated motion of gantry and couch
BRPI0722292A2 (pt)	2006-08-31	2014-04-15	Spectrum Pharmaceuticals Inc	Sensibilização de células de tumor à terapia com radiação pela administração de agonistas de endotelina
KR101560339B1 (ko) *	2008-01-28	2015-10-14	나노캐리어 가부시키가이샤	의약 조성물 또는 조합제
FR2937867B1 (fr) *	2008-11-03	2011-03-04	Biorebus	Association pharmaceutique contenant l acide lipoique et l acide hydroxycitrique a titre de principes actifs.
AU2010234637B2 (en)	2009-04-06	2016-05-12	Taiho Pharmaceutical Co., Ltd.	(2 ' -deoxy-ribofuranosyl) -1,3,4, 7-tetrahydro- (1,3) iazepin-2-0ne derivatives for treating cancer
WO2012003413A1 (en) *	2010-06-30	2012-01-05	The Broad Institute, Inc.	Novel solid forms of tacedinaline
US8691875B2 (en)	2011-07-01	2014-04-08	Broad Institute, Inc.	Solid forms of tacedinaline
US9308235B2 (en)	2012-05-09	2016-04-12	Spectrum Pharmaceuticals, Inc.	Treatment of primary and metastatic carcinoma
EP2711007A1 (en)	2012-09-19	2014-03-26	Institut Univ. de Ciència i Tecnologia, S.A.	4-Aminopyrazolo[3,4-d]pyrimidine for use in treating or preventing primary and metastatic breast and prostate cancer
EP2711008A1 (en)	2012-09-19	2014-03-26	Institut Univ. de Ciència i Tecnologia, S.A.	N6,N6-dimethyladenosine for use in treating or preventing primary and metastatic breast cancer
EP2711009A1 (en)	2012-09-19	2014-03-26	Institut Univ. de Ciència i Tecnologia, S.A.	Compounds for use in treating or preventing primary and metastatic breast and prostate cancer
EP2962309B1 (en)	2013-02-26	2022-02-16	Accuray, Inc.	Electromagnetically actuated multi-leaf collimator
US10189797B2 (en) *	2015-12-30	2019-01-29	Duke University	Chemical modulators of immune checkpoints and therapeutic use
WO2020028392A1 (en)	2018-07-30	2020-02-06	Duke University	Niclosamide analogues and therapeutic use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5562925A (en) *	1970-04-20	1996-10-08	Research Corporation Tech. Inc.	Anti-tumor method
NZ219974A (en) *	1986-04-22	1989-08-29	Goedecke Ag	N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
AU671491B2 (en) *	1992-12-18	1996-08-29	F. Hoffmann-La Roche Ag	N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
AU6878198A (en)	1997-04-24	1998-11-13	Warner-Lambert Company	Use of acetyldinaline for the manufacture of a medicament for the treatment of renal cell carcinoma
US5972986A (en) *	1997-10-14	1999-10-26	G.D. Searle & Co.	Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
ATE225655T1 (de) *	1998-09-25	2002-10-15	Warner Lambert Co	Chemotherapie des krebses mit acetyldinalin in verbindung mit gemcitabin, capecitabin oder cisplatin

1999
- 1999-07-08 AT AT99935442T patent/ATE225655T1/de not_active IP Right Cessation
- 1999-07-08 ID IDW20010901A patent/ID30046A/id unknown
- 1999-07-08 IL IL14195199A patent/IL141951A0/xx unknown
- 1999-07-08 DK DK99935442T patent/DK1115391T3/da active
- 1999-07-08 BR BR9913952-9A patent/BR9913952A/pt not_active IP Right Cessation
- 1999-07-08 HK HK02101589.3A patent/HK1040190A1/zh unknown
- 1999-07-08 JP JP2000571912A patent/JP2002525320A/ja active Pending
- 1999-07-08 GE GEAP19995872A patent/GEP20043199B/en unknown
- 1999-07-08 PT PT99935442T patent/PT1115391E/pt unknown
- 1999-07-08 HU HU0103640A patent/HUP0103640A3/hu unknown
- 1999-07-08 CA CA002342981A patent/CA2342981A1/en not_active Abandoned
- 1999-07-08 CN CN99811320A patent/CN1319009A/zh active Pending
- 1999-07-08 DE DE69903458T patent/DE69903458T2/de not_active Expired - Fee Related
- 1999-07-08 PL PL99348673A patent/PL348673A1/xx not_active Application Discontinuation
- 1999-07-08 EP EP99935442A patent/EP1115391B1/en not_active Expired - Lifetime
- 1999-07-08 KR KR1020017003794A patent/KR20010075348A/ko not_active Withdrawn
- 1999-07-08 EE EEP200100187A patent/EE200100187A/xx unknown
- 1999-07-08 EA EA200100369A patent/EA200100369A1/ru unknown
- 1999-07-08 NZ NZ510504A patent/NZ510504A/en unknown
- 1999-07-08 WO PCT/US1999/015386 patent/WO2000018393A1/en not_active Ceased
- 1999-07-08 HR HR20010225A patent/HRP20010225B1/xx not_active Application Discontinuation
- 1999-07-08 ES ES99935442T patent/ES2185378T3/es not_active Expired - Lifetime
- 1999-07-08 CZ CZ2001905A patent/CZ2001905A3/cs unknown
- 1999-07-08 AP APAP/P/2001/002109A patent/AP2001002109A0/en unknown
- 1999-07-08 YU YU22401A patent/YU22401A/sh unknown
- 1999-07-08 TR TR2001/00859T patent/TR200100859T2/tr unknown
- 1999-07-08 OA OA1200100078A patent/OA11659A/en unknown
- 1999-07-08 AU AU50921/99A patent/AU762079B2/en not_active Ceased
- 1999-07-08 SK SK360-2001A patent/SK3602001A3/sk unknown
- 1999-07-08 US US09/744,130 patent/US6469058B1/en not_active Expired - Fee Related
2001
- 2001-03-14 IS IS5888A patent/IS5888A/is unknown
- 2001-03-16 ZA ZA200102233A patent/ZA200102233B/en unknown
- 2001-03-23 NO NO20011493A patent/NO20011493L/no not_active Application Discontinuation
- 2001-04-25 BG BG105470A patent/BG105470A/xx unknown
2002
- 2002-10-08 US US10/184,309 patent/US20030170300A1/en not_active Abandoned
- 2002-10-09 US US10/185,221 patent/US20030086965A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69903458D1 (de)	2002-11-14
JP2002525320A (ja)	2002-08-13
SK3602001A3 (en)	2002-07-02
PL348673A1 (en)	2002-06-03
AU5092199A (en)	2000-04-17
EP1115391A1 (en)	2001-07-18
ATE225655T1 (de)	2002-10-15
ID30046A (id)	2001-11-01
OA11659A (en)	2004-12-08
ZA200102233B (en)	2002-06-18
ES2185378T3 (es)	2003-04-16
CA2342981A1 (en)	2000-04-06
PT1115391E (pt)	2003-02-28
NZ510504A (en)	2003-09-26
US20030086965A1 (en)	2003-05-08
HUP0103640A2 (en)	2002-06-29
DE69903458T2 (de)	2003-07-10
GEP20043199B (en)	2004-03-25
HRP20010225B1 (en)	2004-10-31
AU762079B2 (en)	2003-06-19
US6469058B1 (en)	2002-10-22
HK1040190A1 (zh)	2002-05-31
US20030170300A1 (en)	2003-09-11
HRP20010225A2 (en)	2002-04-30
DK1115391T3 (da)	2003-02-10
KR20010075348A (ko)	2001-08-09
NO20011493D0 (no)	2001-03-23
BR9913952A (pt)	2001-06-12
HUP0103640A3 (en)	2003-01-28
IL141951A0 (en)	2002-03-10
CZ2001905A3 (cs)	2001-08-15
WO2000018393A1 (en)	2000-04-06
IS5888A (is)	2001-03-14
AP2001002109A0 (en)	2001-03-31
EP1115391B1 (en)	2002-10-09
EE200100187A (et)	2002-08-15
TR200100859T2 (tr)	2001-08-21
EA200100369A1 (ru)	2001-10-22
YU22401A (sh)	2004-03-12
NO20011493L (no)	2001-05-23
CN1319009A (zh)	2001-10-24

Publication	Publication Date	Title
BG105470A (en)	2001-12-29	Means and method for the treament of tumours
ZA921911B (en)	1993-08-19	2,4-diaminoquinazoline derivatives for enhancing anti-tumor activity.
MXPA01004648A (es)	2002-05-06	Tratamientro de enfermedades hematologicas malignas asociadas con celulas tumorales de la circulacion usando el anticuerpo quimerico anti-cd20.
AU2592600A (en)	2000-07-31	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
HU9301314D0 (en)	1993-09-28	Quinazoline derivatves for improving anto-tumouric activity
PT2322187E (pt)	2014-07-24	Utilização de uridina em combinação com colina para o tratamento de disfunções de memória
MX9700118A (es)	1997-06-28	Metodo para inhibir metastasis de cancer mediante administracion oral de pectina citrica modificada soluble.
PL330496A1 (en)	1999-07-05	Methods of and compositions for treating and preventing tumours, disorders associated with tumours as well as cachexy
IL134445A0 (en)	2001-04-30	A method of preventing or treating estrogen-dependent diseases and disorders
BR0108728A (pt)	2003-12-30	Combinação farmacêutica terapêutica, e, método para tratar um c ncer.
MY137303A (en)	2009-01-30	Methods for treating proliferative diseases
MXPA03011306A (es)	2004-03-19	Metodos para la preparacion y uso de 1a,24 (s) - hidroxivitamina d2.
HU9503625D0 (en)	1996-02-28	Use of p antagonist for producing pharmaceutical compositions for treating acne, rosacea and/or pubic arythema
DE3685484D1 (tr)	1992-07-02
HU9701060D0 (en)	1997-08-28	Pharmaceutical composition for treating cognitive disturbs
IL131478A0 (en)	2001-01-28	Methods for treatment of scar tissue
HUP0200717A3 (en)	2004-11-29	Radioactive cisplatin in the treatment of cancer
IL139303A0 (en)	2001-11-25	Treatment of arthritis and other similar conditions
DE69909395D1 (de)	2003-08-14	Zusammensetzung mit ketanserin und carnitin zur behandlung von crps
ATE179987T1 (de)	1999-05-15	Vitamin b 12-haltige sanddornkonzentrate oder - extrakte
UA26946C2 (uk)	1999-12-29	Аhтигістаміhhий лікарський препарат
CA2259997A1 (en)	1998-01-15	Remedies and preventives for stomatitis
RU96107442A (ru)	1998-07-27	Способ лечения вегетативной дистонии с парасимпатическими пароксизмами
SI1115391T1 (en)	2003-02-28	Chemotherapy of cancer with acetyldinaline in combination with gemcitabine, capecitabine or cisplatin
MX9703460A (es)	1997-07-31	Composicion de cisplatino en combinacion con 2,2'ditio-bis (etanosulfonato) (dimesna).