BG105547A - Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof - Google Patents

Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof

Info

Publication number: BG105547A
Authority: BG; Bulgaria
Prior art keywords: azithromycin; pharmaceutical compositions; ethanolate; manufacture; disclosed
Prior art date: 1998-11-30

Application number

BG105547A

Other languages

Bulgarian (bg)

English (en)

Inventor

Claude Singer

Judith Aronhime

Original Assignee

Teva Pharmaceutical Industries Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-30

Filing date

2001-05-29

Publication date

2001-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22332273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG105547(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-05-29 Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.

2001-12-31 Publication of BG105547A publication Critical patent/BG105547A/xx

Links

MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 4
229960004099 azithromycin Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

BG105547A 1998-11-30 2001-05-29 Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof BG105547A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11029898P	1998-11-30	1998-11-30
PCT/US1999/028368 WO2000032203A1 (en)	1998-11-30	1999-11-30	Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof

Publications (1)

Publication Number	Publication Date
BG105547A true BG105547A (en)	2001-12-31

Family

ID=22332273

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105547A BG105547A (en)	1998-11-30	2001-05-29	Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof

Country Status (26)

Country	Link
US (1)	US6365574B2 (pl)
EP (2)	EP1152765B1 (pl)
JP (1)	JP2002531409A (pl)
KR (1)	KR100603226B1 (pl)
CN (2)	CN100339384C (pl)
AP (1)	AP1709A (pl)
AT (1)	ATE279200T1 (pl)
AU (1)	AU768219B2 (pl)
BG (1)	BG105547A (pl)
CA (1)	CA2352562A1 (pl)
CZ (1)	CZ20011886A3 (pl)
DE (1)	DE69921192T2 (pl)
DK (1)	DK1152765T3 (pl)
ES (1)	ES2229804T3 (pl)
HK (1)	HK1043725B (pl)
HU (1)	HUP0104241A3 (pl)
IL (1)	IL143376A0 (pl)
LV (1)	LV12735B (pl)
NZ (1)	NZ512496A (pl)
PL (1)	PL197894B1 (pl)
PT (1)	PT1152765E (pl)
RO (1)	RO121408B1 (pl)
RU (1)	RU2240124C2 (pl)
SI (1)	SI20639A (pl)
WO (1)	WO2000032203A1 (pl)
ZA (1)	ZA200104312B (pl)

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HRP20020231A2 (en) *	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
TW546302B (en) *	1998-05-08	2003-08-11	Biochemie Sa	Improvements in macrolide production
US6245903B1 (en)	1998-08-21	2001-06-12	Apotex, Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
AU768219B2 (en) *	1998-11-30	2003-12-04	Teva Pharmaceutical Industries Ltd.	Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
CN100341886C (zh) *	2000-11-27	2007-10-10	桑多斯股份公司	大环内酯类化合物的溶剂化物
EE05200B1 (et) *	2000-11-27	2009-08-17	Biochemie S.A.	Asitromtsiin monohdraadina, selle valmistamismeetod ja selle kasutamine ravimkoostises
KR100431431B1 (ko) *	2001-04-25	2004-05-14	한미약품 주식회사	아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
DK1390377T3 (da) *	2001-05-22	2006-06-19	Pfizer Prod Inc	Ny krystalform af azithromycin
EP1652851A1 (en)	2001-05-22	2006-05-03	Pfizer Products Inc.	New crystal form of Azithromycin
US6861413B2 (en) *	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
EP1541134A3 (en) *	2001-10-18	2007-06-06	Teva Pharmaceutical Industries Limited	Stabilized azithromycin compositions
US20080149521A9 (en) *	2001-10-18	2008-06-26	Michael Pesachovich	Methods of stabilizing azithromycin
EP1446010B1 (en) *	2001-10-18	2009-04-15	Teva Pharmaceutical Industries Ltd.	Stabilized azithromycin compositions
PL371259A1 (pl) *	2001-12-21	2005-06-13	Pfizer Products Inc.	Bezpośrednio sprasowywalne preparaty azytromycyny
AU2002353316A1 (en) *	2001-12-21	2003-07-09	Pfizer Products Inc.	Methods for wet granulating azithromycin
BR0307331A (pt) *	2002-02-01	2004-12-07	Pfizer Prod Inc	Formulações granuladas a seco de azitromicina
HRP20020614A2 (en)	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US20050013835A1 (en) *	2003-07-15	2005-01-20	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
US20050101547A1 (en) *	2003-11-06	2005-05-12	Sadatrezaei Mohsen	Stabilized azithromycin composition
BRPI0416534A (pt) *	2003-12-04	2007-01-09	Pfizer Prod Inc	composições multiparticuladas com estabilidade melhorada
WO2005053639A2 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Controlled release multiparticulates formed with dissolution enhancers
US6984403B2 (en) *	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
ATE399536T1 (de) *	2003-12-04	2008-07-15	Pfizer Prod Inc	Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
EP1694304A2 (en) *	2003-12-04	2006-08-30	Pfizer Products Inc.	Azithromycin multiparticulate dosage forms by liquid-based processes
WO2005053652A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
CA2549225A1 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
US7943585B2 (en)	2003-12-22	2011-05-17	Sandoz, Inc.	Extended release antibiotic composition
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7683162B2 (en) *	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
US20100048498A1 (en) *	2004-12-21	2010-02-25	Johnson Barbara A	Stable non-dihydrate azithromycin oral suspensions
US20060198895A1 (en) *	2005-03-07	2006-09-07	Kotliar Eleonora M	Azithromycin powder for oral suspension compositions
US20090318375A1 (en) *	2005-06-08	2009-12-24	Hanmi Pharm Co., Ltd	Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same
CA2754604A1 (en)	2009-03-13	2010-09-16	Da Volterra	Compositions and methods for elimination of gram-negative bacteria
WO2010121187A2 (en) *	2009-04-17	2010-10-21	Micell Techologies, Inc.	Stents having controlled elution
WO2013088274A1 (en)	2011-12-14	2013-06-20	Wockhardt Limited	Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN103983730B (zh) *	2014-06-11	2015-09-30	北京市药品检验所	阿奇霉素或其制剂中的杂质检查方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI8110592A8 (en)	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
RO107257B1 (ro) *	1987-07-09	1993-10-30	Pfizer	Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
WO1989002271A1 (en) *	1987-09-10	1989-03-23	Pfizer	Azithromycin and derivatives as antiprotozoal agents
CN1093370A (zh) *	1993-12-10	1994-10-12	北京市集才药物研究所	一种新的阿齐红霉素结晶及其制备方法
CN1161971A (zh) *	1997-01-03	1997-10-15	石家庄制药集团有限公司	一种阿齐霉素结晶及其制备方法
US6245903B1 (en) *	1998-08-21	2001-06-12	Apotex, Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
AU768219B2 (en) *	1998-11-30	2003-12-04	Teva Pharmaceutical Industries Ltd.	Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
KR100491183B1 (ko) *	2001-03-21	2005-05-25	한미약품 주식회사	아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
DK1390377T3 (da) *	2001-05-22	2006-06-19	Pfizer Prod Inc	Ny krystalform af azithromycin

1999
- 1999-11-30 AU AU31065/00A patent/AU768219B2/en not_active Ceased
- 1999-11-30 CN CNB2005100785525A patent/CN100339384C/zh not_active Expired - Fee Related
- 1999-11-30 HK HK02102775.5A patent/HK1043725B/en not_active IP Right Cessation
- 1999-11-30 DK DK99965069T patent/DK1152765T3/da active
- 1999-11-30 RO ROA200100573A patent/RO121408B1/ro unknown
- 1999-11-30 JP JP2000584898A patent/JP2002531409A/ja active Pending
- 1999-11-30 NZ NZ512496A patent/NZ512496A/xx unknown
- 1999-11-30 AP APAP/P/2001/002183A patent/AP1709A/en active
- 1999-11-30 EP EP99965069A patent/EP1152765B1/en not_active Expired - Lifetime
- 1999-11-30 DE DE69921192T patent/DE69921192T2/de not_active Expired - Fee Related
- 1999-11-30 CN CNB998158542A patent/CN1273142C/zh not_active Expired - Fee Related
- 1999-11-30 US US09/451,738 patent/US6365574B2/en not_active Expired - Lifetime
- 1999-11-30 SI SI9920086A patent/SI20639A/sl not_active IP Right Cessation
- 1999-11-30 IL IL14337699A patent/IL143376A0/xx unknown
- 1999-11-30 AT AT99965069T patent/ATE279200T1/de not_active IP Right Cessation
- 1999-11-30 KR KR1020017006669A patent/KR100603226B1/ko not_active Expired - Fee Related
- 1999-11-30 ES ES99965069T patent/ES2229804T3/es not_active Expired - Lifetime
- 1999-11-30 EP EP04014455A patent/EP1484062A1/en not_active Withdrawn
- 1999-11-30 PT PT99965069T patent/PT1152765E/pt unknown
- 1999-11-30 HU HU0104241A patent/HUP0104241A3/hu unknown
- 1999-11-30 WO PCT/US1999/028368 patent/WO2000032203A1/en not_active Ceased
- 1999-11-30 CZ CZ20011886A patent/CZ20011886A3/cs unknown
- 1999-11-30 PL PL347971A patent/PL197894B1/pl not_active IP Right Cessation
- 1999-11-30 CA CA002352562A patent/CA2352562A1/en not_active Abandoned
- 1999-11-30 RU RU2001118035/15A patent/RU2240124C2/ru not_active IP Right Cessation
2001
- 2001-05-25 ZA ZA200104312A patent/ZA200104312B/en unknown
- 2001-05-29 BG BG105547A patent/BG105547A/xx unknown
- 2001-06-22 LV LVP-01-79A patent/LV12735B/en unknown

Also Published As

Publication number	Publication date
HUP0104241A3 (en)	2003-12-29
CN1737008A (zh)	2006-02-22
WO2000032203A1 (en)	2000-06-08
JP2002531409A (ja)	2002-09-24
CN1273142C (zh)	2006-09-06
PT1152765E (pt)	2004-12-31
KR20010099806A (ko)	2001-11-09
EP1152765A4 (en)	2002-07-17
US20020007049A1 (en)	2002-01-17
NZ512496A (en)	2003-02-28
EP1484062A1 (en)	2004-12-08
HK1043725A1 (en)	2002-09-27
SI20639A (sl)	2002-02-28
CN1334735A (zh)	2002-02-06
IL143376A0 (en)	2002-04-21
US6365574B2 (en)	2002-04-02
AP2001002183A0 (en)	2001-06-30
PL347971A1 (en)	2002-05-06
CA2352562A1 (en)	2000-06-08
AU3106500A (en)	2000-06-19
CN100339384C (zh)	2007-09-26
LV12735B (en)	2002-03-20
ATE279200T1 (de)	2004-10-15
EP1152765A1 (en)	2001-11-14
DK1152765T3 (da)	2005-01-31
KR100603226B1 (ko)	2006-08-28
ZA200104312B (en)	2001-11-28
DE69921192D1 (de)	2004-11-18
LV12735A (en)	2001-10-20
RU2240124C2 (ru)	2004-11-20
HK1043725B (en)	2005-05-06
HUP0104241A2 (hu)	2002-03-28
CZ20011886A3 (cs)	2001-10-17
EP1152765B1 (en)	2004-10-13
AU768219B2 (en)	2003-12-04
PL197894B1 (pl)	2008-05-30
DE69921192T2 (de)	2006-02-16
AP1709A (en)	2007-02-27
RO121408B1 (ro)	2007-05-30
ES2229804T3 (es)	2005-04-16

Publication	Publication Date	Title
BG105547A (en)	2001-12-31	Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
BG104159A (en)	2000-08-31	Polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and method for their preparation
MX9707706A (es)	1997-12-31	Compuestos intermediarios novedosos y proceso para la manufactura de derivados de la camptotecina (cpt-11) y compuestos relacionados.
CA2295515A1 (en)	1999-02-04	Method for large-scale production of di(uridine 5'-tetraphosphate) and salts thereof
BG101900A (en)	1999-03-31	Crystalline forms of 2-methyl-thieno-benzodiazepine and method for their preparation
NZ237132A (en)	1993-04-28	Preparation of substituted oxetanones from beta-hydroxy-omega-lactones; various beta-hydroxy and beta-keto-omega-lactones
ATE302786T1 (de)	2005-09-15	Verfahren zur herstllung von clarithromycin polymorphen und polymorph iv
PL345215A1 (en)	2001-12-03	Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same
FR2847594B1 (fr)	2004-12-24	Preparation de blocs d'halogenure de terre rare
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MY107160A (en)	1995-09-30	N-aryl-3-aryl-4-substituted-4,5-dihydro-1h-pyrazole-1- carboxamides and processes for their production.
NZ509561A (en)	2002-10-25	Crystalline forms of osanetant
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NO20031137L (no)	2003-05-05	Foreliggende oppfinnelse angår en fremgangsmåte for fremstilling av kiraleforbindelser under betingelsene for en 1,4-Michael-addisjon.Oppfinnelsen angårogså de tilsvarende forbindelser
BG108151A (en)	2004-09-30	Caloporoside derivatives, methods for the production thereof and their use
YU38901A (sh)	2004-07-15	Etanolat azitromicina, procesi proizvodnje i njegov farmaceutski sastav
BG104964A (bg)	2001-07-31	Подобрен метод за получаване на фармацевтично ценни норбензоморфанови производни
EP0414913A4 (en)	1992-08-05	P-aminophenol derivative and production and application thereof
MY141464A (en)	2010-04-30	Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
JPS5419985A (en)	1979-02-15	Production of hydroxycarbostyril derivative
JPS53112868A (en)	1978-10-02	Production of thienylacetic acid derivative
CO4410182A1 (es)	1997-01-09	Proceso para mejorar la pureza enantiomerica de aldehidos