BG105778A - Микробиален метод за получаване на правастатин - Google Patents

Микробиален метод за получаване на правастатин Download PDF

Info

Publication number
BG105778A
BG105778A BG105778A BG10577801A BG105778A BG 105778 A BG105778 A BG 105778A BG 105778 A BG105778 A BG 105778A BG 10577801 A BG10577801 A BG 10577801A BG 105778 A BG105778 A BG 105778A
Authority
BG
Bulgaria
Prior art keywords
compound
formula
pravastatin
broth
strain
Prior art date
Application number
BG105778A
Other languages
Bulgarian (bg)
English (en)
Inventor
Antonia Jekkel
Attila Konya
Istvan Barta
Eva Ilkoy
Gyorgy Somogyi
Gabor Ambrus
Gyula Horvath
Karoly Albrecht
Istvan Szabo
Juliana SUTO
Janos Salat
Attila Andor
Laszlo Birincsik
Sandor Boros
Ildiko Lang
Nee Igloy Margit Bidlo
Original Assignee
Institute For Drug Research Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute For Drug Research Ltd. filed Critical Institute For Drug Research Ltd.
Publication of BG105778A publication Critical patent/BG105778A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG105778A 1999-02-03 2001-08-03 Микробиален метод за получаване на правастатин BG105778A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US13475999P 1999-05-18 1999-05-18
PCT/US2000/002993 WO2000046175A1 (fr) 1999-02-03 2000-02-03 Procede microbien pour la preparation de la pravastatine

Publications (1)

Publication Number Publication Date
BG105778A true BG105778A (bg) 2002-05-31

Family

ID=26816384

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105778A BG105778A (bg) 1999-02-03 2001-08-03 Микробиален метод за получаване на правастатин

Country Status (27)

Country Link
EP (1) EP1154979B1 (fr)
JP (2) JP3645491B2 (fr)
KR (2) KR100648541B1 (fr)
CN (3) CN1260344C (fr)
AR (2) AR023368A1 (fr)
AT (1) ATE294771T1 (fr)
AU (2) AU774438B2 (fr)
BG (1) BG105778A (fr)
BR (1) BR0009180A (fr)
CA (1) CA2361701C (fr)
CZ (1) CZ20012761A3 (fr)
DE (1) DE60019898T2 (fr)
ES (1) ES2240072T3 (fr)
HK (1) HK1042686B (fr)
HR (1) HRP20010577B1 (fr)
HU (1) HUP0200650A3 (fr)
IL (1) IL144697A0 (fr)
IS (1) IS6036A (fr)
MX (1) MXPA01007807A (fr)
NO (1) NO20013818L (fr)
PL (1) PL350317A1 (fr)
PT (1) PT1154979E (fr)
RU (1) RU2004127981A (fr)
SK (1) SK10932001A3 (fr)
TR (2) TR200103127T2 (fr)
WO (1) WO2000046175A1 (fr)
YU (1) YU55701A (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
RU2002114072A (ru) 1999-11-30 2004-07-20 Биогал Джиоджисзерджиар РТ (HU) Способ выделения соединений статина из ферментационного бульона
EP1798214A3 (fr) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Processus de récupération des composés à base de statine dans un bouillon de fermentation
CA2394200C (fr) 1999-12-14 2006-10-03 Biogal Gyogyszergyar Rt. Nouvelles formes de pravastatine sodique
IL155194A0 (en) * 2000-10-05 2003-11-23 Biogal Pharmaceutical Co Ltd Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
JP3463875B2 (ja) 2001-08-06 2003-11-05 三共株式会社 プラバスタチンを精製する方法
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (fr) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Procédé d'isolation et purification de pravastatine sodique
EP1619190B1 (fr) * 2003-04-25 2010-12-29 Nippon Chemiphar Co., Ltd. Sels de l'acide (2s,3s)-3- [[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl] oxirane-2-carboxylique
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
DE202004020671U1 (de) 2003-11-24 2005-12-08 Teva Gyogyszergyar Reszvenytarsasag Pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
US20110130450A1 (en) * 2008-04-02 2011-06-02 Aad Johannes Bouman Pravastatin extraction
EP3714959A1 (fr) * 2019-03-29 2020-09-30 Basf Se Isolation de petites molécules à partir d'un bouillon de fermentation d'un micro-organisme eucaryote
CN117164541B (zh) * 2022-05-27 2025-09-30 黑龙江华瑞生物科技有限公司 一种从美伐他汀母液中分离纯化美伐他汀的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69724782T3 (de) * 1996-03-28 2015-12-24 Dsm Ip Assets B.V. Verfahren zur Herstellung von granulärer mikrobieller Biomasse und Gewinnung wertvoller Komponenten aus mikrobieller Biomasse

Also Published As

Publication number Publication date
AR061765A2 (es) 2008-09-17
EP1154979B1 (fr) 2005-05-04
NO20013818D0 (no) 2001-08-03
CN1260344C (zh) 2006-06-21
CZ20012761A3 (cs) 2002-05-15
JP3645491B2 (ja) 2005-05-11
PL350317A1 (en) 2002-12-02
AU2004214559A1 (en) 2004-10-21
AU3356700A (en) 2000-08-25
JP2002535977A (ja) 2002-10-29
RU2004127981A (ru) 2006-03-10
CN1537935A (zh) 2004-10-20
EP1154979A4 (fr) 2004-05-26
DE60019898T2 (de) 2006-08-10
HRP20010577B1 (en) 2005-12-31
CA2361701A1 (fr) 2000-08-10
JP4197312B2 (ja) 2008-12-17
AU774438B2 (en) 2004-06-24
HRP20010577A2 (en) 2002-12-31
HUP0200650A3 (en) 2008-03-28
TR200600009T2 (tr) 2006-08-21
KR100648541B1 (ko) 2006-11-24
EP1154979A1 (fr) 2001-11-21
DE60019898D1 (de) 2005-06-09
KR20010112257A (ko) 2001-12-20
ATE294771T1 (de) 2005-05-15
IS6036A (is) 2001-08-02
SK10932001A3 (sk) 2002-06-04
YU55701A (sh) 2004-07-15
HK1042686B (en) 2005-10-14
NO20013818L (no) 2001-10-03
CN1590363A (zh) 2005-03-09
PT1154979E (pt) 2005-08-31
AR023368A1 (es) 2002-09-04
IL144697A0 (en) 2002-06-30
TR200103127T2 (tr) 2002-04-22
BR0009180A (pt) 2002-03-26
MXPA01007807A (es) 2003-06-04
CN1177793C (zh) 2004-12-01
HK1042686A1 (en) 2002-08-23
JP2005047924A (ja) 2005-02-24
ES2240072T3 (es) 2005-10-16
CN1347400A (zh) 2002-05-01
WO2000046175A1 (fr) 2000-08-10
KR20060061406A (ko) 2006-06-07
HUP0200650A2 (en) 2002-08-28
CA2361701C (fr) 2007-04-10

Similar Documents

Publication Publication Date Title
US6682913B1 (en) Microbial process for preparing pravastatin
EP1154979B1 (fr) Procede microbien pour la preparation de la pravastatine
RU2235780C2 (ru) Гидроксилирование компактина до правастатина с помощью micromonospora
JP2003528576A5 (fr)
RU2252258C2 (ru) Микробный способ получения правастатина
EP1491522A1 (fr) Procédé microbien pour la préparation de la pravastatine
CA2572473A1 (fr) Sel sodique cristallin de la pravastatine
HK1072050A (en) Microbial process for preparing pravastatin
AU2004218684A1 (en) Microbial process for preparing pravastatin
JP2004196680A (ja) 新規ｆｋｉ−０９２９物質およびその製造法