BG105804A - 16-hydroxyestratrienes as selective acting estrogens - Google Patents

16-hydroxyestratrienes as selective acting estrogens

Info

Publication number: BG105804A
Authority: BG; Bulgaria
Prior art keywords: estrogens; 5ht2a; hydroxyestratrienes; uterus; effect
Prior art date: 1999-02-09

Application number

BG105804A

Other languages

Bulgarian (bg)

English (en)

Inventor

Hermann Kunzer

Rudolf Knauthe

Monika Lessl

Karl-Heinrich Fritzemeier

Christa Hegele-Hartung

Ulf Bomer

Gerd Muller

Dirk Kosemund

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-09

Filing date

2001-08-09

Publication date

2002-03-29

2001-08-09 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

2002-03-29 Publication of BG105804A publication Critical patent/BG105804A/xx

Links

229940011871 estrogen Drugs 0.000 title abstract 2
239000000262 estrogen Substances 0.000 title abstract 2
PYTMPVZFYYVDQO-UIRRPCRCSA-N (9r,10s,13r)-13-methyl-1,2,3,4,5,6,9,10,11,12-decahydrocyclopenta[a]phenanthren-16-ol Chemical class C([C@@H]12)CCCC1CC=C1[C@@H]2CC[C@@]2(C)C1=CC(O)=C2 PYTMPVZFYYVDQO-UIRRPCRCSA-N 0.000 title 1
241000700159 Rattus Species 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
210000004291 uterus Anatomy 0.000 abstract 2
102000049773 5-HT2A Serotonin Receptor Human genes 0.000 abstract 1
108010072564 5-HT2A Serotonin Receptor Proteins 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
230000001700 effect on tissue Effects 0.000 abstract 1
102000015694 estrogen receptors Human genes 0.000 abstract 1
108010038795 estrogen receptors Proteins 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
210000002307 prostate Anatomy 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0055—Estrane derivatives not substituted in position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG105804A 1999-02-09 2001-08-09 16-hydroxyestratrienes as selective acting estrogens BG105804A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19906159A DE19906159A1 (de)	1999-02-09	1999-02-09	16-Hydroxyestratriene als selektiv wirksame Estrogene
PCT/EP2000/001073 WO2000047603A2 (fr)	1999-02-09	2000-02-09	16-hydroxyestratrienes servant d'oestrogenes agissant de maniere selective

Publications (1)

Publication Number	Publication Date
BG105804A true BG105804A (en)	2002-03-29

Family

ID=7897485

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105804A BG105804A (en)	1999-02-09	2001-08-09	16-hydroxyestratrienes as selective acting estrogens

Country Status (30)

Country	Link
EP (2)	EP1144431B1 (fr)
JP (1)	JP2002536455A (fr)
KR (1)	KR20010101822A (fr)
CN (1)	CN1346364A (fr)
AR (1)	AR034392A1 (fr)
AT (1)	ATE313553T1 (fr)
AU (1)	AU2909500A (fr)
BG (1)	BG105804A (fr)
BR (1)	BR0008076A (fr)
CA (1)	CA2359660A1 (fr)
CO (1)	CO5150223A1 (fr)
CZ (1)	CZ20012843A3 (fr)
DE (2)	DE19906159A1 (fr)
DK (1)	DK1144431T3 (fr)
EA (1)	EA200100828A1 (fr)
EE (1)	EE200100412A (fr)
ES (1)	ES2255983T3 (fr)
HK (1)	HK1046145A1 (fr)
HU (1)	HUP0200055A3 (fr)
IL (1)	IL144455A0 (fr)
MX (1)	MXPA01008065A (fr)
NO (1)	NO20013860L (fr)
NZ (1)	NZ513409A (fr)
PE (1)	PE20001461A1 (fr)
PL (1)	PL350360A1 (fr)
PT (1)	PT1144431E (fr)
SK (1)	SK11302001A3 (fr)
WO (1)	WO2000047603A2 (fr)
YU (1)	YU57201A (fr)
ZA (1)	ZA200107388B (fr)

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DE10039199A1 (de) *	2000-08-10	2002-02-21	Schering Ag	Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
DE10048634A1 (de) *	2000-09-27	2002-04-18	Jenapharm Gmbh	19-Nor-17alpha-pregna-1,3,5(10)-trien-17beta-ole mit einem 21, 16alpha-Laktonring
DE10151365A1 (de)	2001-10-17	2003-04-30	Schering Ag	17-Chlor-D-Homosteroide als selektive Estrogenrezeptorantagonisten
DE10151114A1 (de) *	2001-10-15	2003-04-17	Schering Ag	8ß-Substituierte-11ß-aryl-estra-2,3,5(10)-trienderivate
DE10151363A1 (de) *	2001-10-17	2003-05-08	Schering Ag	Somatotrope Therapie
DE10226326A1 (de) *	2002-06-11	2004-01-15	Schering Ag	9-alpha-substiuierte Estratriene als selektiv wirksame Estrogene
US7414043B2 (en)	2002-06-11	2008-08-19	Schering Ag	9-α-substituted estratrienes as selectively active estrogens
TWI392682B (zh) *	2006-04-13	2013-04-11	Sigma Tau Ind Farmaceuti	作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物
TWI389917B (zh) *	2006-04-13	2013-03-21	Sigma Tau Ind Farmaceuti	作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物
SE536263C2 (sv) *	2011-12-21	2013-07-23	Airqone Building Scandinavia Ab	Reningsanordning för gasmedium innefattande medel för kontrollerad tillförsel av joniserad luft
EP3500265B1 (fr) *	2016-08-22	2023-10-04	Or-Genix Therapeutics, Inc.	Ligands sélectifs du récepteur bêta des oestrogènes
WO2019041078A1 (fr) *	2017-08-28	2019-03-07	Zhejiang Jiachi Pharmaceutical Development Ltd.	Synthèse asymétrique et utilisations de composés dans des traitements de maladies
JP2021535183A (ja)	2018-09-07	2021-12-16	トラスティーズ・オヴ・ダートマス・カレッジ	Ｃ１９骨格およびステロイドならびにそれらの使用および製造方法
US11512107B2 (en)	2018-09-07	2022-11-29	Trustees Of Dartmouth College	Methods for assembly of tetracyclic compounds by stereoselective C9-C10 bond formation
CN115154474A (zh) *	2021-04-01	2022-10-11	中国人民解放军总医院	一种环菠萝蜜烷型三萜皂苷化合物在制备t细胞免疫抑制剂中的应用
CN121129864B (zh) *	2025-11-17	2026-03-27	浙江大学	麦角甾醇在制备治疗肺动脉高压药物中的应用

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DE4322186A1 (de) *	1993-07-03	1995-01-12	Jenapharm Gmbh	Oral estrogen wirksame Ester des 14alpha, 15alpha-Methylen-estradiols
DE4326240A1 (de) *	1993-08-02	1995-02-09	Schering Ag	15,15-Dialkyl-substituierte Derivate des Estradiols
US5554603A (en) *	1993-09-17	1996-09-10	The United States Of America As Represented By The Department Of Health And Human Services	Orally active derivatives of 1,3,5(10)-estratriene
DE4338314C1 (de) *	1993-11-10	1995-03-30	Jenapharm Gmbh	Pharmazeutische Präparate zur Prophylaxe und Therapie radikalvermittelter Zellschädigungen
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DE19635525A1 (de) *	1996-08-20	1998-02-26	Schering Ag	7alpha-(xi-Aminoalkyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha(xi-Aminoalkyl-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
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1999
- 1999-02-09 DE DE19906159A patent/DE19906159A1/de not_active Withdrawn
2000
- 2000-02-08 CO CO00007990A patent/CO5150223A1/es unknown
- 2000-02-08 PE PE2000000093A patent/PE20001461A1/es not_active Application Discontinuation
- 2000-02-09 SK SK1130-2001A patent/SK11302001A3/sk unknown
- 2000-02-09 EP EP00907539A patent/EP1144431B1/fr not_active Expired - Lifetime
- 2000-02-09 MX MXPA01008065A patent/MXPA01008065A/es unknown
- 2000-02-09 HU HU0200055A patent/HUP0200055A3/hu unknown
- 2000-02-09 WO PCT/EP2000/001073 patent/WO2000047603A2/fr not_active Ceased
- 2000-02-09 AT AT00907539T patent/ATE313553T1/de not_active IP Right Cessation
- 2000-02-09 HK HK02107553.2A patent/HK1046145A1/zh unknown
- 2000-02-09 NZ NZ513409A patent/NZ513409A/xx unknown
- 2000-02-09 AU AU29095/00A patent/AU2909500A/en not_active Abandoned
- 2000-02-09 PL PL00350360A patent/PL350360A1/xx not_active Application Discontinuation
- 2000-02-09 KR KR1020017009989A patent/KR20010101822A/ko not_active Withdrawn
- 2000-02-09 EA EA200100828A patent/EA200100828A1/ru unknown
- 2000-02-09 PT PT00907539T patent/PT1144431E/pt unknown
- 2000-02-09 JP JP2000598520A patent/JP2002536455A/ja active Pending
- 2000-02-09 YU YU57201A patent/YU57201A/sh unknown
- 2000-02-09 ES ES00907539T patent/ES2255983T3/es not_active Expired - Lifetime
- 2000-02-09 IL IL14445500A patent/IL144455A0/xx unknown
- 2000-02-09 CA CA002359660A patent/CA2359660A1/fr not_active Abandoned
- 2000-02-09 EE EEP200100412A patent/EE200100412A/xx unknown
- 2000-02-09 DK DK00907539T patent/DK1144431T3/da active
- 2000-02-09 AR ARP000100553A patent/AR034392A1/es not_active Application Discontinuation
- 2000-02-09 BR BR0008076-4A patent/BR0008076A/pt not_active IP Right Cessation
- 2000-02-09 DE DE50011908T patent/DE50011908D1/de not_active Expired - Fee Related
- 2000-02-09 EP EP05075149A patent/EP1580192A2/fr not_active Withdrawn
- 2000-02-09 CN CN00803613A patent/CN1346364A/zh active Pending
- 2000-02-09 CZ CZ20012843A patent/CZ20012843A3/cs unknown
2001
- 2001-08-08 NO NO20013860A patent/NO20013860L/no not_active Application Discontinuation
- 2001-08-09 BG BG105804A patent/BG105804A/xx unknown
- 2001-09-06 ZA ZA200107388A patent/ZA200107388B/en unknown

Also Published As

Publication number	Publication date
DE50011908D1 (de)	2006-01-26
JP2002536455A (ja)	2002-10-29
BR0008076A (pt)	2002-02-05
PT1144431E (pt)	2006-05-31
EP1144431B1 (fr)	2005-12-21
DE19906159A1 (de)	2000-08-10
HUP0200055A3 (en)	2002-10-28
CN1346364A (zh)	2002-04-24
CO5150223A1 (es)	2002-04-29
AU2909500A (en)	2000-08-29
CA2359660A1 (fr)	2000-08-17
WO2000047603A3 (fr)	2001-08-02
SK11302001A3 (sk)	2002-01-07
EA200100828A1 (ru)	2002-04-25
ATE313553T1 (de)	2006-01-15
NZ513409A (en)	2004-02-27
ES2255983T3 (es)	2006-07-16
NO20013860D0 (no)	2001-08-08
NO20013860L (no)	2001-10-08
KR20010101822A (ko)	2001-11-14
ZA200107388B (en)	2005-01-25
PL350360A1 (en)	2002-12-02
EP1144431A3 (fr)	2002-06-12
HUP0200055A2 (hu)	2002-05-29
EP1144431A2 (fr)	2001-10-17
AR034392A1 (es)	2004-02-25
WO2000047603A9 (fr)	2001-09-07
PE20001461A1 (es)	2000-12-18
EE200100412A (et)	2002-12-16
HK1046145A1 (zh)	2002-12-27
CZ20012843A3 (cs)	2002-01-16
MXPA01008065A (es)	2002-04-24
IL144455A0 (en)	2002-05-23
YU57201A (sh)	2005-06-10
WO2000047603A2 (fr)	2000-08-17
DK1144431T3 (da)	2006-05-08
EP1580192A2 (fr)	2005-09-28

Publication	Publication Date	Title
NO20024907L (no)	2002-12-05	8<beta>-substituerte-11<beta>-pentyl- og 11<beta>-heksyl- östra-1,3,5(10)-trienderivater
ES2233998T3 (es)	2005-06-16	Compuestos que comprenden un grupo sulfamato.
YU57201A (sh)	2005-06-10	16-hidroksiestratrieni kao selektivno aktivni estrogeni
ZA200107631B (en)	2002-05-14	Indoline derivatives as progesterone antagonists.
CA2281844A1 (fr)	1999-07-08	Nouveaux steroides anti-oestrogenes, compositions pharmaceutiques associees et leur mode d'utilisation
HUP0101693A3 (en)	2002-08-28	Use of steroidal sapogenins and their derivatives for producing pharmaceutical compositions for the treatment of alzheimeirs disease
TW240215B (fr)	1995-02-11
HUP9902121A2 (hu)	1999-10-28	Gonadotropin-leadó hormon antagonista hatású indolszármazékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
PT836506E (pt)	2003-04-30	Penso transdermico para administracao de 17-desacetil norgestimato so ou em combinacao com um estrogenio
HUP0102913A3 (en)	2002-03-28	Use of biogenic estrogen sulfamates for producing pharmaceutical compositions for hormone replacement therapy
AU2284001A (en)	2001-07-09	Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone
AU1855201A (en)	2001-05-14	18-nor-steroids as selectively active estrogens
IL147123A0 (en)	2002-08-14	Compositions containing soluble forms of hla-g for treating inflammatory skin pathologies
MY136407A (en)	2008-09-30	Polymorph b of a known thiophenecarboxylic dodecahydrocyclopenta [a]phenanthrenyl ester
YU77302A (sh)	2005-11-28	8beta-hidrokarbil-supstituisani estratrieni kao selektivno delotvorni estrogeni
PT1196428E (pt)	2005-02-28	Esteroides substituidos com 11 beta-aril-17, 17-espirotiolano
AU9399898A (en)	1999-04-27	Benzothiophenes
AU4289600A (en)	2000-10-23	14,15-.alpha.-methylene equilenine derivatives, methods for producing the same and medicaments containing them
KR20080072087A (ko)	2008-08-05	Ｅｒ-베타 선택적 물질의 전구약물, 그의 제조 방법 및그것을 포함하는 제약 조성물