BG105855A - 2-aminopyridines containing fused ring substituents - Google Patents

2-aminopyridines containing fused ring substituents

Info

Publication number: BG105855A
Authority: BG; Bulgaria
Prior art keywords: group; alkyl; ring; aryl; aralkyl
Prior art date: 1999-02-25

Application number

BG105855A

Other languages

Bulgarian (bg)

English (en)

Inventor

John Adams Lowe

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-25

Filing date

2001-08-30

Publication date

2002-04-30

2001-08-30 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2002-04-30 Publication of BG105855A publication Critical patent/BG105855A/xx

Links

150000003930 2-aminopyridines Chemical class 0.000 title abstract 2
125000003118 aryl group Chemical group 0.000 abstract 5
125000003710 aryl alkyl group Chemical group 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 2
108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
-1 nitro, cyano, amino Chemical group 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Emergency Medicine (AREA)

BG105855A 1999-02-25 2001-08-30 2-aminopyridines containing fused ring substituents BG105855A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12159799P	1999-02-25	1999-02-25
PCT/IB2000/000109 WO2000050400A1 (en)	1999-02-25	2000-02-02	2-aminopyridines containing fused ring substituents

Publications (1)

Publication Number	Publication Date
BG105855A true BG105855A (en)	2002-04-30

Family

ID=22397690

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105855A BG105855A (en)	1999-02-25	2001-08-30	2-aminopyridines containing fused ring substituents

Country Status (44)

Country	Link
US (2)	US6211208B1 (de)
EP (1)	EP1155000B1 (de)
JP (1)	JP3825636B2 (de)
KR (1)	KR20010114213A (de)
CN (1)	CN1341099A (de)
AP (1)	AP2001002251A0 (de)
AR (1)	AR018979A1 (de)
AT (1)	ATE245143T1 (de)
AU (1)	AU767593B2 (de)
BG (1)	BG105855A (de)
BR (1)	BR0008569A (de)
CA (1)	CA2364719C (de)
CO (1)	CO5160241A1 (de)
CR (1)	CR6438A (de)
CZ (1)	CZ20013036A3 (de)
DE (1)	DE60003893T2 (de)
DK (1)	DK1155000T3 (de)
DZ (1)	DZ3017A1 (de)
EA (1)	EA003941B1 (de)
EE (1)	EE200100454A (de)
ES (1)	ES2200813T3 (de)
GT (1)	GT200000021A (de)
HN (1)	HN2000000016A (de)
HR (1)	HRP20010597A2 (de)
HU (1)	HUP0200163A3 (de)
ID (1)	ID29892A (de)
IL (1)	IL144308A0 (de)
IS (1)	IS6005A (de)
MA (1)	MA26721A1 (de)
MX (1)	MXPA01008671A (de)
NO (1)	NO20014095L (de)
NZ (1)	NZ512912A (de)
OA (1)	OA11841A (de)
PA (1)	PA8490901A1 (de)
PE (1)	PE20001482A1 (de)
PL (1)	PL350219A1 (de)
PT (1)	PT1155000E (de)
SK (1)	SK12022001A3 (de)
SV (1)	SV2002000026A (de)
TN (1)	TNSN00034A1 (de)
TR (1)	TR200102481T2 (de)
WO (1)	WO2000050400A1 (de)
YU (1)	YU58301A (de)
ZA (1)	ZA200106974B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20010049379A1 (en) *	1997-08-27	2001-12-06	Lowe John Adams	2-aminopyridines containing fused ring substituents
CN1341099A (zh) *	1999-02-25	2002-03-20	辉瑞产品公司	含有稠合环取代基的2－氨基吡啶
NZ521870A (en)	2000-03-31	2004-08-27	Euro Celtique S	Aminopyridines and their use as anticonvulsants and sodium channel blockers
US20040092741A1 (en) *	2002-11-08	2004-05-13	Pfizer Inc	Substituted pyridines via boronic acid coupling
EP1567497B1 (de) *	2002-12-06	2009-09-23	Purdue Research Foundation	Pyridine zur behandlung von verletztemsäugetiernervengewebe
US8729107B2 (en) *	2002-12-06	2014-05-20	Purdue Research Foundation	Pyridines for treating injured mammalian nerve tissue
US20050192321A1 (en) *	2003-09-15	2005-09-01	Meythaler Jay M.	Treatment of neuropathy with rapid release aminopyridine
WO2014138460A1 (en) *	2013-03-07	2014-09-12	Northwestern University	2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
EP3215497A4 (de)	2014-11-04	2018-11-07	Northwestern University	Säugetier- und bakterielle stickoxid-synthaseinhibitoren
US10759791B2 (en)	2014-11-04	2020-09-01	Northwestern University	Mammalian and bacterial nitric oxide synthase inhibitors
US9585867B2 (en)	2015-08-06	2017-03-07	Charles Everett Ankner	Cannabinod formulation for the sedation of a human or animal
US12213973B2 (en)	2021-10-18	2025-02-04	Northwestern University	Bacterial nitric oxide synthase inhibitors

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AU4515696A (en) *	1994-12-12	1996-07-03	Merck & Co., Inc.	Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
JPH101435A (ja) *	1995-09-14	1998-01-06	Nippon Kayaku Co Ltd	２−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤
UA49006C2 (uk) *	1996-03-29	2002-09-16	Файзер Інк.	Похідні 6-фенілпіридил-2-аміну, фармацевтична композиція, спосіб інгібування синтази оксиду нітрогену у ссавців та спосіб лікування
HN1997000027A (es)	1996-12-06	1997-06-05	Pfizer Prod Inc	Derivados de 6-fenil piridil - 2 amina
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CN1341099A (zh) *	1999-02-25	2002-03-20	辉瑞产品公司	含有稠合环取代基的2－氨基吡啶

2000
- 2000-02-02 CN CN00804126A patent/CN1341099A/zh active Pending
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- 2000-02-02 SK SK1202-2001A patent/SK12022001A3/sk unknown
- 2000-02-02 EP EP00901285A patent/EP1155000B1/de not_active Expired - Lifetime
- 2000-02-02 WO PCT/IB2000/000109 patent/WO2000050400A1/en not_active Ceased
- 2000-02-02 BR BR0008569-3A patent/BR0008569A/pt not_active IP Right Cessation
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- 2000-02-02 DK DK00901285T patent/DK1155000T3/da active
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- 2000-02-02 JP JP2000600983A patent/JP3825636B2/ja not_active Expired - Fee Related
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- 2000-02-02 AU AU21243/00A patent/AU767593B2/en not_active Ceased
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- 2000-02-23 DZ DZ000036A patent/DZ3017A1/xx active
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2001
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Also Published As

Publication number	Publication date
WO2000050400A1 (en)	2000-08-31
NZ512912A (en)	2003-07-25
TNSN00034A1 (fr)	2005-11-10
AU2124300A (en)	2000-09-14
PL350219A1 (en)	2002-11-18
YU58301A (sh)	2004-05-12
SK12022001A3 (sk)	2002-07-02
NO20014095L (no)	2001-10-24
DE60003893T2 (de)	2004-02-05
OA11841A (en)	2005-08-22
ATE245143T1 (de)	2003-08-15
ID29892A (id)	2001-10-18
MXPA01008671A (es)	2002-03-14
EP1155000A1 (de)	2001-11-21
CZ20013036A3 (cs)	2002-03-13
US6211208B1 (en)	2001-04-03
IS6005A (is)	2001-07-13
SV2002000026A (es)	2002-02-05
KR20010114213A (ko)	2001-12-31
EE200100454A (et)	2002-12-16
PE20001482A1 (es)	2001-01-03
AU767593B2 (en)	2003-11-20
CO5160241A1 (es)	2002-05-30
CN1341099A (zh)	2002-03-20
DE60003893D1 (de)	2003-08-21
IL144308A0 (en)	2002-05-23
MA26721A1 (fr)	2004-12-20
US20010014689A1 (en)	2001-08-16
BR0008569A (pt)	2002-01-22
HUP0200163A2 (en)	2002-06-29
AR018979A1 (es)	2001-12-12
ZA200106974B (en)	2002-10-14
NO20014095D0 (no)	2001-08-23
DK1155000T3 (da)	2003-10-13
CA2364719A1 (en)	2000-08-31
DZ3017A1 (fr)	2004-03-20
AP2001002251A0 (en)	2001-09-30
HUP0200163A3 (en)	2002-11-28
HN2000000016A (es)	2001-02-02
TR200102481T2 (tr)	2002-01-21
EA200100816A1 (ru)	2001-12-24
GT200000021A (es)	2001-08-17
PT1155000E (pt)	2003-10-31
CR6438A (es)	2004-02-23
HRP20010597A2 (en)	2002-08-31
EP1155000B1 (de)	2003-07-16
JP3825636B2 (ja)	2006-09-27
US6372768B2 (en)	2002-04-16
CA2364719C (en)	2006-07-04
PA8490901A1 (es)	2001-04-30
ES2200813T3 (es)	2004-03-16
JP2002537381A (ja)	2002-11-05
EA003941B1 (ru)	2003-10-30

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