BG106263A - Pyrazinone thrombin inhibitors - Google Patents

Pyrazinone thrombin inhibitors

Info

Publication number: BG106263A
Authority: BG; Bulgaria
Prior art keywords: thrombin inhibitors; alkyl; pyrazinone; pyrazinone thrombin; fuhvc
Prior art date: 1999-06-04

Application number

BG106263A

Other languages

Bulgarian (bg)

English (en)

Inventor

Christopher Burgey

Kyle ROBINSON

Peter Williams

Craig Coburn

Terry Lyle

Philip SANDERSON

Original Assignee

Merck & Co. Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-04

Filing date

2001-12-21

Publication date

2002-06-28

2001-12-21 Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.

2002-06-28 Publication of BG106263A publication Critical patent/BG106263A/xx

Links

HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical compound OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 title 1
229940122388 Thrombin inhibitor Drugs 0.000 title 1
239000003868 thrombin inhibitor Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
108090000190 Thrombin Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000004963 sulfonylalkyl group Chemical group 0.000 abstract 1
229960004072 thrombin Drugs 0.000 abstract 1
230000001732 thrombotic effect Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG106263A 1999-06-04 2001-12-21 Pyrazinone thrombin inhibitors BG106263A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13753899P	1999-06-04	1999-06-04
US14429199P	1999-07-16	1999-07-16
PCT/US2000/015140 WO2000075134A1 (en)	1999-06-04	2000-06-01	Pyrazinone thrombin inhibitors

Publications (1)

Publication Number	Publication Date
BG106263A true BG106263A (en)	2002-06-28

Family

ID=26835338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG106263A BG106263A (en)	1999-06-04	2001-12-21	Pyrazinone thrombin inhibitors

Country Status (31)

Country	Link
US (1)	US6455532B1 (uk)
EP (1)	EP1189899B1 (uk)
JP (2)	JP4495377B2 (uk)
KR (1)	KR20020029653A (uk)
CN (1)	CN1353705A (uk)
AT (1)	ATE232527T1 (uk)
AU (1)	AU761982B2 (uk)
BG (1)	BG106263A (uk)
BR (1)	BR0011260A (uk)
CA (1)	CA2373999C (uk)
CZ (1)	CZ20014343A3 (uk)
DE (1)	DE60001414T2 (uk)
DK (1)	DK1189899T3 (uk)
DZ (1)	DZ3264A1 (uk)
EA (1)	EA004372B1 (uk)
EE (1)	EE200100641A (uk)
ES (1)	ES2190417T3 (uk)
HK (1)	HK1047277A1 (uk)
HR (1)	HRP20010903A2 (uk)
HU (1)	HUP0202366A3 (uk)
IL (1)	IL146393A0 (uk)
IS (1)	IS6158A (uk)
MX (1)	MXPA01012505A (uk)
NO (1)	NO20015887L (uk)
NZ (1)	NZ515454A (uk)
PL (1)	PL352558A1 (uk)
SK (1)	SK17532001A3 (uk)
TR (1)	TR200103491T2 (uk)
UA (1)	UA58636C2 (uk)
WO (1)	WO2000075134A1 (uk)
YU (1)	YU84301A (uk)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001092234A1 (en)	2000-06-01	2001-12-06	Merck & Co., Inc.	Pyrazinone thrombin inhibitors
FR2818277B1 (fr) *	2000-12-14	2003-01-24	Servier Lab	Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6528503B2 (en)	2000-12-18	2003-03-04	Merck & Co., Inc.	Thrombin inhibitors
JP2004516286A (ja)	2000-12-18	2004-06-03	メルクエンドカムパニーインコーポレーテッド	ベンジルアミン誘導体およびそれのトロンビン阻害薬としての使用
CA2436176A1 (en)	2001-02-09	2002-08-22	Merck & Co., Inc.	Thrombin inhibitors
WO2003048127A1 (en)	2001-12-04	2003-06-12	Corvas International, Inc.	Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation
FR2867780B1 (fr) *	2004-03-19	2006-05-19	Servier Lab	Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE102004022897A1 (de) *	2004-05-10	2005-12-08	Bayer Cropscience Ag	Azinyl-imidazoazine
GB0507577D0 (en)	2005-04-14	2005-05-18	Novartis Ag	Organic compounds
DE102008041214A1 (de)	2008-08-13	2010-02-18	Bayer Cropscience Ag	N-substituierte Azinylakyl-azincarboxamide und deren Analoge
MX2012005165A (es) *	2009-11-03	2012-08-08	Diakron Pharmaceuticals Inc	Proceso para la preparacion de inhibidor de pirazinona trombina y sus intermediarios.
US10016417B2 (en)	2011-11-07	2018-07-10	Diakron Pharmaceuticals, Inc.	Extended release formulation of a direct thrombin inhibitor
CN115677511B (zh) *	2022-10-26	2024-06-21	南通华祥医药科技有限公司	一种2,2-二氟丙胺盐酸盐的合成方法

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ES2037738T3 (es)	1986-09-26	1993-07-01	Ciba-Geigy Ag	Procedimiento para la obtencion de aminopirazinonas y aminotriazinonas.
TW201303B (uk)	1990-07-05	1993-03-01	Hoffmann La Roche
GB9207145D0 (en)	1991-04-18	1992-05-13	Ici Plc	Heterocyclic amides
JP2599665B2 (ja)	1991-05-01	1997-04-09	大塚製薬株式会社	ピラジン誘導体
DE4127404A1 (de)	1991-08-19	1993-02-25	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
TW223629B (uk)	1992-03-06	1994-05-11	Hoffmann La Roche
US5672582A (en)	1993-04-30	1997-09-30	Merck & Co., Inc.	Thrombin inhibitors
EP0699074B1 (en)	1993-04-30	2002-11-13	Merck & Co. Inc.	Thrombin inhibitors
US5510369A (en)	1994-07-22	1996-04-23	Merck & Co., Inc.	Pyrrolidine thrombin inhibitors
WO1996031504A1 (en)	1995-04-04	1996-10-10	Merck & Co., Inc.	Thrombin inhibitors
US5629324A (en)	1995-04-10	1997-05-13	Merck & Co., Inc.	Thrombin inhibitors
JPH11508558A (ja)	1995-06-27	1999-07-27	メルクエンドカンパニーインコーポレーテッド	ピリジノントロンビン阻害剤
PL329441A1 (en) *	1996-04-23	1999-03-29	Merck & Co Inc	Pyrasinone-type thrombin inhibitors
US5668289A (en)	1996-06-24	1997-09-16	Merck & Co., Inc.	Pyridinone thrombin inhibitors
US5981546A (en)	1996-08-29	1999-11-09	Merck & Co., Inc.	Integrin antagonists
CA2277929A1 (en)	1997-01-22	1998-07-23	Merck & Co., Inc.	Thrombin inhibitors
AU728006B2 (en) *	1997-03-24	2001-01-04	Merck & Co., Inc.	Thrombin inhibitors
US5866573A (en)	1997-04-21	1999-02-02	Merck & Co., Inc.	Pyrazinone thrombin inhibitors
EP1017393A4 (en)	1997-09-05	2002-01-23	Merck & Co Inc	PYRAZINONE THROMBINE INHIBITORS
CA2329914A1 (en) *	1998-05-19	1999-11-25	Merck & Co., Inc.	Pyrazinone thrombin inhibitors
HUP0202191A3 (en)	1999-05-19	2003-02-28	Pharmacia Corp Chicago	Substituted polycyclic aryl and heteroaryl pirazinones useful for selective inhibition of the coagulation cascade and pharmaceutical compositions containing them

2000
- 2000-01-06 UA UA2002010007A patent/UA58636C2/uk unknown
- 2000-06-01 DK DK00939492T patent/DK1189899T3/da active
- 2000-06-01 JP JP2001502417A patent/JP4495377B2/ja not_active Expired - Fee Related
- 2000-06-01 CN CN00808497A patent/CN1353705A/zh active Pending
- 2000-06-01 KR KR1020017015562A patent/KR20020029653A/ko not_active Ceased
- 2000-06-01 SK SK1753-2001A patent/SK17532001A3/sk unknown
- 2000-06-01 EP EP00939492A patent/EP1189899B1/en not_active Expired - Lifetime
- 2000-06-01 TR TR2001/03491T patent/TR200103491T2/xx unknown
- 2000-06-01 CZ CZ20014343A patent/CZ20014343A3/cs unknown
- 2000-06-01 US US09/585,112 patent/US6455532B1/en not_active Expired - Lifetime
- 2000-06-01 WO PCT/US2000/015140 patent/WO2000075134A1/en not_active Ceased
- 2000-06-01 CA CA002373999A patent/CA2373999C/en not_active Expired - Lifetime
- 2000-06-01 DZ DZ003264A patent/DZ3264A1/fr active
- 2000-06-01 BR BR0011260-7A patent/BR0011260A/pt not_active IP Right Cessation
- 2000-06-01 AU AU54571/00A patent/AU761982B2/en not_active Expired
- 2000-06-01 MX MXPA01012505A patent/MXPA01012505A/es unknown
- 2000-06-01 IL IL14639300A patent/IL146393A0/xx unknown
- 2000-06-01 YU YU84301A patent/YU84301A/sh unknown
- 2000-06-01 NZ NZ515454A patent/NZ515454A/xx not_active Application Discontinuation
- 2000-06-01 ES ES00939492T patent/ES2190417T3/es not_active Expired - Lifetime
- 2000-06-01 DE DE60001414T patent/DE60001414T2/de not_active Expired - Lifetime
- 2000-06-01 HK HK02108849.4A patent/HK1047277A1/zh unknown
- 2000-06-01 AT AT00939492T patent/ATE232527T1/de active
- 2000-06-01 HU HU0202366A patent/HUP0202366A3/hu unknown
- 2000-06-01 EE EEP200100641A patent/EE200100641A/xx unknown
- 2000-06-01 PL PL00352558A patent/PL352558A1/xx not_active Application Discontinuation
- 2000-06-01 HR HR20010903A patent/HRP20010903A2/hr not_active Application Discontinuation
- 2000-06-01 EA EA200200005A patent/EA004372B1/ru not_active IP Right Cessation
2001
- 2001-11-13 IS IS6158A patent/IS6158A/is unknown
- 2001-12-03 NO NO20015887A patent/NO20015887L/no not_active Application Discontinuation
- 2001-12-21 BG BG106263A patent/BG106263A/xx unknown
2010
- 2010-02-24 JP JP2010038280A patent/JP2010150275A/ja active Pending

Also Published As

Publication number	Publication date
DE60001414D1 (en)	2003-03-20
JP2003501426A (ja)	2003-01-14
IS6158A (is)	2001-11-13
BR0011260A (pt)	2002-03-19
IL146393A0 (en)	2002-07-25
JP4495377B2 (ja)	2010-07-07
CZ20014343A3 (cs)	2002-03-13
UA58636C2 (uk)	2003-08-15
NO20015887L (no)	2002-01-23
NZ515454A (en)	2004-02-27
HRP20010903A2 (en)	2003-04-30
TR200103491T2 (tr)	2002-12-23
ES2190417T3 (es)	2003-08-01
EP1189899A1 (en)	2002-03-27
EP1189899B1 (en)	2003-02-12
US6455532B1 (en)	2002-09-24
HK1047277A1 (zh)	2003-02-14
EA004372B1 (ru)	2004-04-29
WO2000075134A1 (en)	2000-12-14
MXPA01012505A (es)	2002-07-02
CA2373999C (en)	2007-01-02
CA2373999A1 (en)	2000-12-14
DZ3264A1 (fr)	2000-12-14
SK17532001A3 (sk)	2002-05-09
KR20020029653A (ko)	2002-04-19
DE60001414T2 (de)	2003-11-06
JP2010150275A (ja)	2010-07-08
ATE232527T1 (de)	2003-02-15
YU84301A (sh)	2004-07-15
EA200200005A1 (ru)	2002-06-27
EE200100641A (et)	2003-02-17
NO20015887D0 (no)	2001-12-03
CN1353705A (zh)	2002-06-12
HUP0202366A2 (en)	2002-10-28
AU5457100A (en)	2000-12-28
AU761982B2 (en)	2003-06-12
HUP0202366A3 (en)	2005-07-28
DK1189899T3 (da)	2003-03-10
PL352558A1 (en)	2003-08-25

Publication	Publication Date	Title
CA2373999A1 (en)	2000-12-14	Pyrazinone thrombin inhibitors
IS4853A (is)	1998-09-25	Pýrazínón þrombín latar
PL346344A1 (en)	2002-02-11	Arylpiperazines and their use as metalloproteinase inhibiting agents (mmp)
MY135732A (en)	2008-06-30	5,6-trimethylenepyrimidin - 4 - one compounds
ATE337775T1 (de)	2006-09-15	Strukturen und zusammensetzungen zur erhöhung der stabilität von aktiven peroxiden
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AU2001266575A1 (en)	2002-01-08	Chemical compounds
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AU2001264081A1 (en)	2001-12-24	Serine protease inhibitors
TW324021B (en)	1998-01-01	Mono-azo dyestuff
AU2001296515A1 (en)	2002-04-15	Cyclic sulfonyl compounds as inhibitors of metalloproteases
CO5241356A1 (es)	2003-01-31	Compuestos
MXPA02012472A (es)	2004-01-26	Compuestos quimicos.
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WO2002100847A3 (en)	2003-08-21	Factor xa inhibitor
YU79602A (en)	2006-05-25	Sodium-hydrogen exchanger type 1 inhibitor (nhe-1)