BG106321A - Novel carboxylic acid derivatives with 5,6- substituted pyrimidine ring, the production and utilization thereof as endothelin receptor antagonists - Google Patents

Novel carboxylic acid derivatives with 5,6- substituted pyrimidine ring, the production and utilization thereof as endothelin receptor antagonists

Info

Publication number: BG106321A
Authority: BG; Bulgaria
Prior art keywords: utilization; production; carboxylic acid; acid derivatives; receptor antagonists
Prior art date: 1999-07-20

Application number

BG106321A

Other languages

Bulgarian (bg)

English (en)

Inventor

Wilhelm Amberg

Georg Kettschau

Original Assignee

Abbott Gmbh & Co. Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-20

Filing date

2002-01-18

Publication date

2002-08-30

2002-01-18 Application filed by Abbott Gmbh & Co. Kg filed Critical Abbott Gmbh & Co. Kg

2002-08-30 Publication of BG106321A publication Critical patent/BG106321A/xx

Links

229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
239000002308 endothelin receptor antagonist Substances 0.000 title 1
125000000714 pyrimidinyl group Chemical group 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

BG106321A 1999-07-20 2002-01-18 Novel carboxylic acid derivatives with 5,6- substituted pyrimidine ring, the production and utilization thereof as endothelin receptor antagonists BG106321A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19933164A DE19933164A1 (de)	1999-07-20	1999-07-20	Neue Carbonsäurederivate mit 5,6 substituiertem Pyrimidinring, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten
PCT/EP2000/006293 WO2001005771A1 (de)	1999-07-20	2000-07-05	Neue carbonsäurederivate mit 5,6 substituiertem pyrimidinring, ihre herstellung und verwendung als endothelin rezeptorantagonisten

Publications (1)

Publication Number	Publication Date
BG106321A true BG106321A (en)	2002-08-30

Family

ID=7914884

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG106321A BG106321A (en)	1999-07-20	2002-01-18	Novel carboxylic acid derivatives with 5,6- substituted pyrimidine ring, the production and utilization thereof as endothelin receptor antagonists

Country Status (21)

Country	Link
EP (1)	EP1196394A1 (cs)
JP (1)	JP2003505377A (cs)
KR (1)	KR20020019550A (cs)
CN (1)	CN1367778A (cs)
AR (1)	AR030026A1 (cs)
AU (1)	AU6561500A (cs)
BG (1)	BG106321A (cs)
BR (1)	BR0012592A (cs)
CA (1)	CA2379545A1 (cs)
CZ (1)	CZ2002190A3 (cs)
DE (1)	DE19933164A1 (cs)
HU (1)	HUP0202646A3 (cs)
IL (1)	IL147666A0 (cs)
MX (1)	MXPA02000616A (cs)
NO (1)	NO20020254L (cs)
PL (1)	PL353165A1 (cs)
SK (1)	SK772002A3 (cs)
TR (1)	TR200200622T2 (cs)
TW (1)	TW555749B (cs)
WO (1)	WO2001005771A1 (cs)
ZA (1)	ZA200200333B (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2462065T3 (es) *	2009-07-10	2014-05-22	Cadila Healthcare Limited	Proceso mejorado para la preparación de Ambrisentán e intermedios novedosos de este
CA2792473A1 (en)	2010-03-15	2011-09-22	Natco Pharma Limited	A process for the preparation of highly pure ambrisentan

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19636046A1 (de) *	1996-09-05	1998-03-12	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten
PL340871A1 (en) *	1997-10-31	2001-03-12	Basf Ag	Novel derivatives of carboxylic with admidic side chains, method of obtaining them and application of such novel derivatives as antagonists of endothelin rceptors

1999
- 1999-07-20 DE DE19933164A patent/DE19933164A1/de not_active Withdrawn
2000
- 2000-07-05 IL IL14766600A patent/IL147666A0/xx unknown
- 2000-07-05 JP JP2001511432A patent/JP2003505377A/ja not_active Abandoned
- 2000-07-05 PL PL00353165A patent/PL353165A1/xx not_active Application Discontinuation
- 2000-07-05 EP EP00953009A patent/EP1196394A1/de not_active Withdrawn
- 2000-07-05 HU HU0202646A patent/HUP0202646A3/hu unknown
- 2000-07-05 CZ CZ2002190A patent/CZ2002190A3/cs unknown
- 2000-07-05 WO PCT/EP2000/006293 patent/WO2001005771A1/de not_active Ceased
- 2000-07-05 MX MXPA02000616A patent/MXPA02000616A/es unknown
- 2000-07-05 CA CA002379545A patent/CA2379545A1/en not_active Abandoned
- 2000-07-05 AU AU65615/00A patent/AU6561500A/en not_active Abandoned
- 2000-07-05 KR KR1020027000815A patent/KR20020019550A/ko not_active Ceased
- 2000-07-05 CN CN00810533A patent/CN1367778A/zh active Pending
- 2000-07-05 BR BR0012592-0A patent/BR0012592A/pt not_active IP Right Cessation
- 2000-07-05 SK SK77-2002A patent/SK772002A3/sk unknown
- 2000-07-05 TR TR2002/00622T patent/TR200200622T2/xx unknown
- 2000-07-13 TW TW089113992A patent/TW555749B/zh active
- 2000-07-17 AR ARP000103661A patent/AR030026A1/es unknown
2002
- 2002-01-15 ZA ZA200200333A patent/ZA200200333B/en unknown
- 2002-01-17 NO NO20020254A patent/NO20020254L/no not_active Application Discontinuation
- 2002-01-18 BG BG106321A patent/BG106321A/xx unknown

Also Published As

Publication number	Publication date
AU6561500A (en)	2001-02-05
TR200200622T2 (cs)	2002-06-21
HUP0202646A3 (en)	2003-03-28
CZ2002190A3 (cs)	2003-08-13
JP2003505377A (ja)	2003-02-12
IL147666A0 (en)	2002-08-14
HUP0202646A2 (hu)	2003-02-28
NO20020254L (no)	2002-02-20
ZA200200333B (en)	2003-04-30
CA2379545A1 (en)	2001-01-25
EP1196394A1 (de)	2002-04-17
BR0012592A (pt)	2002-05-28
DE19933164A1 (de)	2001-01-25
CN1367778A (zh)	2002-09-04
AR030026A1 (es)	2003-08-13
MXPA02000616A (es)	2002-08-30
TW555749B (en)	2003-10-01
KR20020019550A (ko)	2002-03-12
NO20020254D0 (no)	2002-01-17
PL353165A1 (en)	2003-10-20
WO2001005771A1 (de)	2001-01-25
SK772002A3 (en)	2003-01-09

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CA2379026A1 (en)	2001-01-25	Substituted thiene-3-yl-sulphonylamino(thio)carbonyl-triazolin(thi)ones
AP2002002637A0 (en)	2002-09-30	Novel piperazine
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SE9702773D0 (sv)	1997-07-22	Novel compounds
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