BG106883A - Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl - Google Patents

Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl

Info

Publication number: BG106883A
Authority: BG; Bulgaria
Prior art keywords: dimethylaminomethyl; hydroxycyclohexyl; hydroxybenzoate; phenyl; novel esters
Prior art date: 1999-12-30

Application number

BG106883A

Other languages

Bulgarian (bg)

English (en)

Inventor

Mancini Marisabel Mourelle

Ramon Amat Elisabet De

Juan HUGUET

Original Assignee

Laboratorios Vita,S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-30

Filing date

2002-06-28

Publication date

2003-05-30

2002-06-28 Application filed by Laboratorios Vita,S.A. filed Critical Laboratorios Vita,S.A.

2003-05-30 Publication of BG106883A publication Critical patent/BG106883A/xx

Links

-1 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl Chemical group 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
230000000202 analgesic effect Effects 0.000 abstract 2
TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960004380 tramadol Drugs 0.000 abstract 1
TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

BG106883A 1999-12-30 2002-06-28 Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl BG106883A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200000060A ES2160534B1 (es)	1999-12-30	1999-12-30	Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
PCT/ES2000/000486 WO2001049650A1 (es)	1999-12-30	2000-12-26	Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil)fenilo

Publications (1)

Publication Number	Publication Date
BG106883A true BG106883A (en)	2003-05-30

Family

ID=8491916

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG106883A BG106883A (en)	1999-12-30	2002-06-28	Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl

Country Status (30)

Country	Link
US (1)	US6894076B2 (pl)
EP (1)	EP1251120B1 (pl)
JP (1)	JP2003519208A (pl)
KR (1)	KR20020063281A (pl)
CN (1)	CN1414946A (pl)
AP (1)	AP1234A (pl)
AT (1)	ATE284380T1 (pl)
AU (1)	AU775918B2 (pl)
BG (1)	BG106883A (pl)
BR (1)	BR0016882A (pl)
CA (1)	CA2395976A1 (pl)
CZ (1)	CZ20022189A3 (pl)
DE (1)	DE60016631D1 (pl)
EA (1)	EA004770B1 (pl)
EE (1)	EE200200365A (pl)
ES (1)	ES2160534B1 (pl)
HR (1)	HRP20020559A2 (pl)
HU (1)	HUP0204147A3 (pl)
IL (1)	IL150392A0 (pl)
IS (1)	IS6440A (pl)
MA (1)	MA26862A1 (pl)
MX (1)	MXPA02006514A (pl)
NO (1)	NO20023098L (pl)
NZ (1)	NZ520263A (pl)
OA (1)	OA12132A (pl)
PL (1)	PL356056A1 (pl)
SK (1)	SK9252002A3 (pl)
WO (1)	WO2001049650A1 (pl)
YU (1)	YU50902A (pl)
ZA (1)	ZA200205193B (pl)

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US7776314B2 (en)	2002-06-17	2010-08-17	Grunenthal Gmbh	Abuse-proofed dosage system
DE102004032051A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de)	2003-08-06	2005-03-24	Grünenthal GmbH	Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de)	2003-12-24	2005-09-29	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en)	2003-08-06	2011-12-13	Gruenenthal Gmbh	Abuse-proofed dosage form
US20070048228A1 (en)	2003-08-06	2007-03-01	Elisabeth Arkenau-Maric	Abuse-proofed dosage form
DE102004032049A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de)	2007-03-07	2008-09-11	Grünenthal GmbH	Darreichungsform mit erschwertem Missbrauch
KR101616246B1 (ko)	2008-01-25	2016-05-02	그뤼넨탈 게엠베하	약제학적 투여형
AU2009243681B2 (en)	2008-05-09	2013-12-19	Grunenthal Gmbh	Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
US8058469B2 (en) *	2008-11-03	2011-11-15	Sabic Innovative Plastics Ip B.V.	Method for making carbamates, ureas and isocyanates
WO2011009602A1 (en)	2009-07-22	2011-01-27	Grünenthal GmbH	Hot-melt extruded controlled release dosage form
TWI473628B (zh)	2009-07-22	2015-02-21		用於對氧化敏感之類鴉片藥劑之抗破壞劑型
EP2383255A1 (en)	2010-04-28	2011-11-02	Lacer, S.A.	New compounds, synthesis and use thereof in the treatment of pain
WO2012028318A1 (en)	2010-09-02	2012-03-08	Grünenthal GmbH	Tamper resistant dosage form comprising an anionic polymer
CA2808219C (en)	2010-09-02	2019-05-14	Gruenenthal Gmbh	Tamper resistant dosage form comprising inorganic salt
EP2530072A1 (en)	2011-06-03	2012-12-05	Lacer, S.A.	New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en)	2011-07-09	2020-07-07	Syntrix Biosystems Inc.	Compositions and methods for overcoming resistance to tramadol
ES2648129T3 (es)	2011-07-29	2017-12-28	Grünenthal GmbH	Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
AU2012289764B2 (en)	2011-07-29	2017-03-02	Grünenthal GmbH	Tamper-resistant tablet providing immediate drug release
US20130225697A1 (en)	2012-02-28	2013-08-29	Grunenthal Gmbh	Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
PL2838512T3 (pl)	2012-04-18	2018-12-31	Grünenthal GmbH	Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
US10064945B2 (en)	2012-05-11	2018-09-04	Gruenenthal Gmbh	Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AU2014273227B2 (en)	2013-05-29	2019-08-15	Grunenthal Gmbh	Tamper-resistant dosage form containing one or more particles
JP6466417B2 (ja)	2013-05-29	2019-02-06	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
JP6449871B2 (ja)	2013-07-12	2019-01-09	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	エチレン−酢酸ビニルポリマーを含有する改変防止剤形
EP3073994A1 (en)	2013-11-26	2016-10-05	Grünenthal GmbH	Preparation of a powdery pharmaceutical composition by means of cryo-milling
EP3142646A1 (en)	2014-05-12	2017-03-22	Grünenthal GmbH	Tamper resistant immediate release capsule formulation comprising tapentadol
BR112017021475A2 (pt)	2015-04-24	2018-07-10	Gruenenthal Gmbh	forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
WO2017042325A1 (en)	2015-09-10	2017-03-16	Grünenthal GmbH	Protecting oral overdose with abuse deterrent immediate release formulations
HUE048032T2 (hu)	2015-10-15	2020-05-28	Jiangsu Hengrui Medicine Co	Oxaspiro-származék, elõállítási eljárása és alkalmazásai gyógyszerekben

Family Cites Families (8)

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DE1199764B (de) *	1963-04-02	1965-09-02	Gruenenthal Chemie	Verfahren zur Herstellung von basisch substituierten Phenolaethern
DE1518663A1 (de)	1965-08-02	1969-12-18	Gruenenthal Chemie	Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) *	1967-07-27	1972-03-28	Gruenenthal Chemie	1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3562589A (en) *	1968-09-09	1971-02-09	Ite Imperial Corp	Electrically resetting undervoltage trip for circuit breakers
US5470885A (en) *	1993-09-29	1995-11-28	The Research Foundation Of The State University Of New York	Fluorocarbons as anti-inflammatory agents
DE19525137C2 (de)	1995-07-11	2003-02-27	Gruenenthal Gmbh	6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
ES2141688B1 (es) *	1998-11-06	2001-02-01	Vita Invest Sa	Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
GB9924604D0 (en) *	1999-10-18	1999-12-22	European Molecular Biology Lab Embl	Genetic switch

1999
- 1999-12-30 ES ES200000060A patent/ES2160534B1/es not_active Expired - Fee Related
2000
- 2000-12-26 AU AU20126/01A patent/AU775918B2/en not_active Ceased
- 2000-12-26 EA EA200200614A patent/EA004770B1/ru not_active IP Right Cessation
- 2000-12-26 PL PL00356056A patent/PL356056A1/pl unknown
- 2000-12-26 CA CA002395976A patent/CA2395976A1/en not_active Abandoned
- 2000-12-26 BR BR0016882-3A patent/BR0016882A/pt not_active IP Right Cessation
- 2000-12-26 AT AT00983358T patent/ATE284380T1/de not_active IP Right Cessation
- 2000-12-26 WO PCT/ES2000/000486 patent/WO2001049650A1/es not_active Ceased
- 2000-12-26 IL IL15039200A patent/IL150392A0/xx unknown
- 2000-12-26 EP EP00983358A patent/EP1251120B1/en not_active Expired - Lifetime
- 2000-12-26 KR KR1020027008500A patent/KR20020063281A/ko not_active Withdrawn
- 2000-12-26 AP APAP/P/2002/002571A patent/AP1234A/en active
- 2000-12-26 SK SK925-2002A patent/SK9252002A3/sk unknown
- 2000-12-26 OA OA1200200201A patent/OA12132A/en unknown
- 2000-12-26 HU HU0204147A patent/HUP0204147A3/hu unknown
- 2000-12-26 JP JP2001550190A patent/JP2003519208A/ja active Pending
- 2000-12-26 MX MXPA02006514A patent/MXPA02006514A/es unknown
- 2000-12-26 DE DE60016631T patent/DE60016631D1/de not_active Expired - Fee Related
- 2000-12-26 CZ CZ20022189A patent/CZ20022189A3/cs unknown
- 2000-12-26 NZ NZ520263A patent/NZ520263A/en unknown
- 2000-12-26 HR HR20020559A patent/HRP20020559A2/hr not_active Application Discontinuation
- 2000-12-26 CN CN00817916A patent/CN1414946A/zh active Pending
- 2000-12-26 US US10/169,177 patent/US6894076B2/en not_active Expired - Fee Related
- 2000-12-26 YU YU50902A patent/YU50902A/sh unknown
- 2000-12-26 EE EEP200200365A patent/EE200200365A/xx unknown
2002
- 2002-06-24 MA MA26710A patent/MA26862A1/fr unknown
- 2002-06-25 IS IS6440A patent/IS6440A/is unknown
- 2002-06-26 NO NO20023098A patent/NO20023098L/no not_active Application Discontinuation
- 2002-06-27 ZA ZA200205193A patent/ZA200205193B/xx unknown
- 2002-06-28 BG BG106883A patent/BG106883A/xx unknown

Also Published As

Publication number	Publication date
EP1251120A1 (en)	2002-10-23
EE200200365A (et)	2003-10-15
MA26862A1 (fr)	2004-12-20
CZ20022189A3 (cs)	2003-03-12
ES2160534B1 (es)	2002-04-16
EA004770B1 (ru)	2004-08-26
US6894076B2 (en)	2005-05-17
EP1251120B1 (en)	2004-12-08
NO20023098D0 (no)	2002-06-26
HUP0204147A3 (en)	2003-10-28
ZA200205193B (en)	2003-06-27
IL150392A0 (en)	2002-12-01
PL356056A1 (pl)	2004-06-14
US20030100598A1 (en)	2003-05-29
ES2160534A1 (es)	2001-11-01
IS6440A (is)	2002-06-25
HUP0204147A2 (hu)	2003-04-28
EA200200614A1 (ru)	2002-12-26
SK9252002A3 (en)	2003-04-01
MXPA02006514A (es)	2004-07-30
BR0016882A (pt)	2002-11-05
CN1414946A (zh)	2003-04-30
HRP20020559A2 (en)	2004-02-29
OA12132A (en)	2006-05-05
ATE284380T1 (de)	2004-12-15
AU2012601A (en)	2001-07-16
YU50902A (sh)	2006-01-16
JP2003519208A (ja)	2003-06-17
AP1234A (en)	2003-12-28
CA2395976A1 (en)	2001-07-12
WO2001049650A1 (es)	2001-07-12
AP2002002571A0 (en)	2002-09-30
DE60016631D1 (de)	2005-01-13
NO20023098L (no)	2002-06-26
AU775918B2 (en)	2004-08-19
NZ520263A (en)	2004-07-30
KR20020063281A (ko)	2002-08-01

Publication	Publication Date	Title
BG106883A (en)	2003-05-30	Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
PL371414A1 (pl)	2005-06-13	Dipodstawione tiazolilokarboksyanilidy oraz ich zastosowanie jako środków mikrobójczych
BG106340A (en)	2002-10-31	Substituted oxoazaheterocyclyl compounds
ES2141688A1 (es)	2000-05-16	Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
EP1466898A4 (en)	2005-12-07	INHIBITORS OF THE PRODUCTION / SEPARATION OF BETA-AMYLOIDS PROTEINS
MY136269A (en)	2008-09-30	Novel diphenylazetidinone, process for its preparation, medicaments comprising this compound and their use
IL153561A0 (en)	2003-07-06	4-alkoxy cyclohexane-1-amino carboxylic acid esters and method for the production thereof
MXPA04000847A (es)	2004-03-26	Procedimiento para la obtencion de beraprost y sus sales.
BG106939A (en)	2003-03-31	Method for the preparation of citalopram
ATE373042T1 (de)	2007-09-15	Polycarbonatformmassen
ATE251124T1 (de)	2003-10-15	Flammwidrige cyanatester
MXPA05013012A (es)	2006-03-02	Formulaciones blanqueadoras fluorescentes estables al almacenamiento.
IL153830A0 (en)	2003-07-31	A PROCESS FOR THE PREPARATION OF alpha' CHLOROKETONES
EP1390343A4 (en)	2005-06-22	NOVEL RETINOID DERIVATIVES, METHODS FOR PREPARING THESE COMPOUNDS, AND ANTI-CANCER PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
MXPA01011104A (es)	2004-08-12	Procedimiento de sintesis de derivados n-(mercaptoail)-aminoacidos a partir de acidos acrilicos alfa substituidos.
DE60000402D1 (de)	2002-10-10	Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
AU3590801A (en)	2001-09-17	One-pot synthesis of alkyl 3-cyclopropylamino-2-(2,4-dibromo-3-(difluoromethoxy)benzoyl -2-propenoate as a useful intermediate for antibacterial quinolone medicaments
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IL158926A0 (en)	2004-05-12	Method for the production of biperidin
WO2005080329A3 (en)	2006-09-28	Process for manufacture of racemic carvedilol
MXPA05003881A (es)	2005-10-05	Preparacion de compuestos triazospiro.
MXPA02012052A (es)	2005-08-16	Procedimiento para la obtencion de ciclohexiloxiacetatos de alquilo.
ZA200204594B (en)	2003-10-29	Vitamin D precursors, method and intermediates.
MY120806A (en)	2005-11-30	Improved process for preparing pharmaceutically valuable norbenzomorphane derivatives.
MXPA04001951A (es)	2004-06-07	Coniosulfuros y sus derivados, procesos para prepararlos, y su uso como farmaceuticos.