BG108031A - Метод за синтез на аналози на камптотецин - Google Patents

Метод за синтез на аналози на камптотецин Download PDF

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Publication number
BG108031A
BG108031A BG108031A BG10803103A BG108031A BG 108031 A BG108031 A BG 108031A BG 108031 A BG108031 A BG 108031A BG 10803103 A BG10803103 A BG 10803103A BG 108031 A BG108031 A BG 108031A
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BG
Bulgaria
Prior art keywords
compound
group
mixture
solvent
preparing
Prior art date
Application number
BG108031A
Other languages
Bulgarian (bg)
English (en)
Inventor
Takanori Ogawa
Hiroyuki Nishiyama
Miyuki Uchida
Seigo Sawada
Original Assignee
Kabushiki Kaisha Yakult Honsha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabushiki Kaisha Yakult Honsha filed Critical Kabushiki Kaisha Yakult Honsha
Publication of BG108031A publication Critical patent/BG108031A/bg
Priority to BG10111453A priority Critical patent/BG111453A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BG108031A 2001-02-21 2003-07-25 Метод за синтез на аналози на камптотецин BG108031A (bg)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG10111453A BG111453A (en) 2001-02-21 2013-04-23 METHOD FOR PREPARING A THRACTICAL CETTON

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001045430 2001-02-21
JP2001309322 2001-10-05

Publications (1)

Publication Number Publication Date
BG108031A true BG108031A (bg) 2005-04-30

Family

ID=26609837

Family Applications (2)

Application Number Title Priority Date Filing Date
BG108031A BG108031A (bg) 2001-02-21 2003-07-25 Метод за синтез на аналози на камптотецин
BG10111453A BG111453A (en) 2001-02-21 2013-04-23 METHOD FOR PREPARING A THRACTICAL CETTON

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG10111453A BG111453A (en) 2001-02-21 2013-04-23 METHOD FOR PREPARING A THRACTICAL CETTON

Country Status (23)

Country Link
US (2) US7126000B2 (cs)
EP (1) EP1378505B1 (cs)
JP (2) JP4210119B2 (cs)
KR (2) KR100864692B1 (cs)
CN (1) CN100408550C (cs)
AR (2) AR035684A1 (cs)
AU (1) AU2002237527B2 (cs)
BG (2) BG108031A (cs)
BR (1) BR0207470A (cs)
CA (2) CA2437702C (cs)
CZ (1) CZ20032470A3 (cs)
EE (1) EE05361B1 (cs)
HU (1) HUP0302755A3 (cs)
IL (2) IL156949A0 (cs)
MX (1) MXPA03007528A (cs)
NO (2) NO328628B1 (cs)
NZ (2) NZ527615A (cs)
PL (2) PL217238B1 (cs)
RO (2) RO125158A2 (cs)
RU (1) RU2308447C2 (cs)
SK (2) SK288073B6 (cs)
TW (1) TWI245768B (cs)
WO (1) WO2002066416A1 (cs)

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ATE446299T1 (de) 2005-02-07 2009-11-15 Fermion Oy Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin
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JP5599094B2 (ja) * 2010-05-20 2014-10-01 国立大学法人 千葉大学 ニトリル化合物の製造方法
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US10780283B2 (en) 2015-05-26 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
ES2940303T3 (es) 2015-06-29 2023-05-05 Boston Scient Neuromodulation Corp Sistemas de selección de parámetros de estimulación por uso de dianas y direccionamiento
US20160375248A1 (en) 2015-06-29 2016-12-29 Boston Scientific Neuromodulation Corporation Systems and methods for selecting stimulation parameters based on stimulation target region, effects, or side effects
US10071249B2 (en) 2015-10-09 2018-09-11 Boston Scientific Neuromodulation Corporation System and methods for clinical effects mapping for directional stimulation leads
US10716942B2 (en) 2016-04-25 2020-07-21 Boston Scientific Neuromodulation Corporation System and methods for directional steering of electrical stimulation
JP6905541B2 (ja) 2016-06-24 2021-07-21 ボストン サイエンティフィック ニューロモデュレイション コーポレイション 臨床効果の視覚分析のためのシステム及び方法
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JP6828149B2 (ja) 2016-10-14 2021-02-10 ボストン サイエンティフィック ニューロモデュレイション コーポレイション 電気刺激システムに対する刺激パラメータ設定の閉ループ決定のためのシステム及び方法
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US10625082B2 (en) 2017-03-15 2020-04-21 Boston Scientific Neuromodulation Corporation Visualization of deep brain stimulation efficacy
US11357986B2 (en) 2017-04-03 2022-06-14 Boston Scientific Neuromodulation Corporation Systems and methods for estimating a volume of activation using a compressed database of threshold values
EP3651849B1 (en) 2017-07-14 2023-05-31 Boston Scientific Neuromodulation Corporation Estimating clinical effects of electrical stimulation
US10960214B2 (en) 2017-08-15 2021-03-30 Boston Scientific Neuromodulation Corporation Systems and methods for controlling electrical stimulation using multiple stimulation fields
WO2019210202A1 (en) 2018-04-27 2019-10-31 Boston Scientific Neuromodulation Corporation Multi-mode electrical stimulation systems and methods of making and using
US11285329B2 (en) 2018-04-27 2022-03-29 Boston Scientific Neuromodulation Corporation Systems and methods for visualizing and programming electrical stimulation
EP3911660B1 (en) * 2019-01-15 2023-05-10 Laurus Labs Limited Process for preparation of 2-amino-5-hydroxy propiophenone
EP4291294A1 (en) 2021-04-27 2023-12-20 Boston Scientific Neuromodulation Corporation Systems and methods for automated programming of electrical stimulation
US12403313B2 (en) 2021-06-15 2025-09-02 Boston Scientific Neuromodulation Corporation Methods and systems for estimating neural activation by stimulation using a stimulation system
CN118251257A (zh) 2021-12-09 2024-06-25 波士顿科学神经调制公司 用于使用刺激系统监测或评估运动障碍或其他生理参数的方法和系统
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US12471831B2 (en) 2021-12-10 2025-11-18 Boston Scientific Neuromodulation Corporation Systems and methods for generating and using response maps for electrical stimulation
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Also Published As

Publication number Publication date
RU2308447C2 (ru) 2007-10-20
BG111453A (en) 2013-09-30
US7126000B2 (en) 2006-10-24
NZ527615A (en) 2004-12-24
HUP0302755A2 (hu) 2003-12-29
RO122639B9 (ro) 2014-03-28
NO20033579D0 (no) 2003-08-13
SK288149B6 (sk) 2013-12-02
NO328628B1 (no) 2010-04-12
AU2002237527B2 (en) 2007-01-04
JPWO2002066416A1 (ja) 2004-09-24
KR100864692B1 (ko) 2008-10-23
CA2437702C (en) 2010-04-06
CZ20032470A3 (cs) 2004-02-18
EP1378505A4 (en) 2006-09-27
KR100858972B1 (ko) 2008-09-17
PL399009A1 (pl) 2012-09-10
SK11472003A3 (sk) 2004-03-02
IL156949A (en) 2009-09-01
US20070010674A1 (en) 2007-01-11
IL156949A0 (en) 2004-02-08
SK288073B6 (sk) 2013-05-03
CN100408550C (zh) 2008-08-06
JP2008273952A (ja) 2008-11-13
JP4805967B2 (ja) 2011-11-02
AR082663A2 (es) 2012-12-26
EE05361B1 (et) 2010-12-15
CA2683768A1 (en) 2002-08-29
BR0207470A (pt) 2008-04-08
WO2002066416A1 (fr) 2002-08-29
NO20093402L (no) 2003-10-10
RU2003128530A (ru) 2005-03-27
CN1492851A (zh) 2004-04-28
MXPA03007528A (es) 2003-12-11
KR20030077631A (ko) 2003-10-01
CA2437702A1 (en) 2002-08-29
PL363440A1 (en) 2004-11-15
JP4210119B2 (ja) 2009-01-14
NO331656B1 (no) 2012-02-13
PL217238B1 (pl) 2014-06-30
TWI245768B (en) 2005-12-21
RO125158A2 (ro) 2010-01-29
NO20033579L (no) 2003-10-10
HUP0302755A3 (en) 2008-03-28
US20040106830A1 (en) 2004-06-03
EP1378505B1 (en) 2014-11-05
NZ534374A (en) 2004-12-24
US7378555B2 (en) 2008-05-27
PL218065B1 (pl) 2014-10-31
EE200300373A (et) 2003-10-15
KR20080012383A (ko) 2008-02-11
EP1378505A1 (en) 2004-01-07
RO122639B1 (ro) 2009-10-30
CA2683768C (en) 2013-05-28
AR035684A1 (es) 2004-06-23

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