PL399009A1 - Sposób wytwarzania tricyklicznego ketonu do syntezy analogów kamptotecyny i sposób wytwarzania kamptotecyny - Google Patents

Sposób wytwarzania tricyklicznego ketonu do syntezy analogów kamptotecyny i sposób wytwarzania kamptotecyny

Info

Publication number: PL399009A1
Authority: PL; Poland
Prior art keywords: camptothecin; producing; synthesis; tricyclic ketone; cpt
Prior art date: 2001-02-21

Application number

PL399009A

Other languages

English (en)

Other versions

PL217238B1 (pl

Inventor

Takanori Ogawa

Hiroyuki Nishiyama

Miyuki Uchida

Seigo Sawada

Original Assignee

Kabushiki Kaisha Yakult Honsha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-21

Filing date

2002-02-21

Publication date

2012-09-10

2002-02-21 Application filed by Kabushiki Kaisha Yakult Honsha filed Critical Kabushiki Kaisha Yakult Honsha

2012-09-10 Publication of PL399009A1 publication Critical patent/PL399009A1/pl

2014-06-30 Publication of PL217238B1 publication Critical patent/PL217238B1/pl

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 5
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 title abstract 3
229940127093 camptothecin Drugs 0.000 title abstract 3
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 title abstract 3
150000002576 ketones Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
FBDOJYYTMIHHDH-OZBJMMHXSA-N (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-2,4,6,8,10,14,20-heptaen-18-one Chemical group CC[C@@]1(O)C(=O)OCC2=CN3Cc4cc5ccccc5nc4C3C=C12 FBDOJYYTMIHHDH-OZBJMMHXSA-N 0.000 abstract 1
HHCZNCHGYNRIBP-UHFFFAOYSA-N 1-(2-amino-5-hydroxyphenyl)propan-1-one Chemical compound CCC(=O)C1=CC(O)=CC=C1N HHCZNCHGYNRIBP-UHFFFAOYSA-N 0.000 abstract 1
229960000779 irinotecan hydrochloride Drugs 0.000 abstract 1
GURKHSYORGJETM-WAQYZQTGSA-N irinotecan hydrochloride (anhydrous) Chemical compound Cl.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 GURKHSYORGJETM-WAQYZQTGSA-N 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
238000006257 total synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
- C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PL399009A 2001-02-21 2002-02-21 Sposób wytwarzania tricyklicznego ketonu do syntezy analogów kamptotecyny oraz sposób wytwarzania analogów kamptotecyny PL217238B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2001045430		2001-02-21
JP2001309322		2001-10-05

Publications (2)

Publication Number	Publication Date
PL399009A1 true PL399009A1 (pl)	2012-09-10
PL217238B1 PL217238B1 (pl)	2014-06-30

Family

ID=26609837

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL399009A PL217238B1 (pl)	2001-02-21	2002-02-21	Sposób wytwarzania tricyklicznego ketonu do syntezy analogów kamptotecyny oraz sposób wytwarzania analogów kamptotecyny
PL363440A PL218065B1 (pl)	2001-02-21	2002-02-21	Sposób wytwarzania 2'-amino-5'-hydroksypropiofenonu do syntezy analogów kamptotecyny, sposoby wytwarzania analogów kamptotecyny oraz półprodukty

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL363440A PL218065B1 (pl)	2001-02-21	2002-02-21	Sposób wytwarzania 2'-amino-5'-hydroksypropiofenonu do syntezy analogów kamptotecyny, sposoby wytwarzania analogów kamptotecyny oraz półprodukty

Country Status (23)

Country	Link
US (2)	US7126000B2 (pl)
EP (1)	EP1378505B1 (pl)
JP (2)	JP4210119B2 (pl)
KR (2)	KR100864692B1 (pl)
CN (1)	CN100408550C (pl)
AR (2)	AR035684A1 (pl)
AU (1)	AU2002237527B2 (pl)
BG (2)	BG108031A (pl)
BR (1)	BR0207470A (pl)
CA (2)	CA2437702C (pl)
CZ (1)	CZ20032470A3 (pl)
EE (1)	EE05361B1 (pl)
HU (1)	HUP0302755A3 (pl)
IL (2)	IL156949A0 (pl)
MX (1)	MXPA03007528A (pl)
NO (2)	NO328628B1 (pl)
NZ (2)	NZ527615A (pl)
PL (2)	PL217238B1 (pl)
RO (2)	RO122639B9 (pl)
RU (1)	RU2308447C2 (pl)
SK (2)	SK288073B6 (pl)
TW (1)	TWI245768B (pl)
WO (1)	WO2002066416A1 (pl)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ299329B6 (cs) *	2003-08-26	2008-06-18	Pliva-Lachema A.S.	Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) *	2003-12-16	2008-09-10	Pliva-Lachema A. S.	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
WO2006016203A1 (en) *	2004-08-09	2006-02-16	Shilpa Medicare Limited	An improved process for the preparation of irinotecan hydrochloride trihydrate
ES2391775T3 (es) *	2004-11-05	2012-11-29	Samyang Biopharmaceuticals Corporation	Formulación farmacéutica para aumentar la solubilidad de compuestos de 10-hidroxicamptotecina en disolventes polares no acuosos
DE602006009901D1 (de) *	2005-02-07	2009-12-03	Fermion Oy	Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin
CA2591074C (en)	2005-02-08	2015-01-20	Fermion Oy	Preparation method
CA2591071C (en)	2005-02-08	2014-04-29	Fermion Oy	Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof
US8112154B2 (en) *	2005-04-13	2012-02-07	The Cleveland Clinic Foundation	Systems and methods for neuromodulation using pre-recorded waveforms
TWI375678B (en) *	2005-06-09	2012-11-01	Yakult Honsha Kk	A method of preparation of a tricyclic ketone
WO2007015259A2 (en) *	2005-08-03	2007-02-08	Avra Laboratories Pvt. Ltd.	Method of synthesizing key intermediates for the production of camptothecin derivatives
EP1803725A1 (en) *	2005-12-13	2007-07-04	W.C. Heraeus GmbH	Methods for preparing irinotecan
US9220889B2 (en)	2008-02-11	2015-12-29	Intelect Medical, Inc.	Directional electrode devices with locating features
CN101824038B (zh) *	2009-03-06	2013-08-21	复旦大学	喜树碱及其类似物的制备方法
WO2011025865A1 (en)	2009-08-27	2011-03-03	The Cleveland Clinic Foundation	System and method to estimate region of tissue activation
JP5599094B2 (ja) *	2010-05-20	2014-10-01	国立大学法人千葉大学	ニトリル化合物の製造方法
WO2011159688A2 (en)	2010-06-14	2011-12-22	Boston Scientific Neuromodulation Corporation	Programming interface for spinal cord neuromodulation
WO2013023085A2 (en)	2011-08-09	2013-02-14	Boston Scientific Neuromodulation Corporation	Systems and methods for stimulation-related volume analysis, creation, and sharing
WO2014036079A2 (en)	2012-08-28	2014-03-06	Boston Scientific Neuromodulation Corporation	Parameter visualization, selection, and annotation interface
US9792412B2 (en)	2012-11-01	2017-10-17	Boston Scientific Neuromodulation Corporation	Systems and methods for VOA model generation and use
US8722886B1 (en) *	2012-11-13	2014-05-13	Bionumerik Pharmaceuticals, Inc.	Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin
US9959388B2 (en)	2014-07-24	2018-05-01	Boston Scientific Neuromodulation Corporation	Systems, devices, and methods for providing electrical stimulation therapy feedback
US10265528B2 (en)	2014-07-30	2019-04-23	Boston Scientific Neuromodulation Corporation	Systems and methods for electrical stimulation-related patient population volume analysis and use
US10272247B2 (en)	2014-07-30	2019-04-30	Boston Scientific Neuromodulation Corporation	Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming
US9974959B2 (en)	2014-10-07	2018-05-22	Boston Scientific Neuromodulation Corporation	Systems, devices, and methods for electrical stimulation using feedback to adjust stimulation parameters
US9447126B2 (en)	2014-10-22	2016-09-20	Arno Therapeutics, Inc.	Methods and systems for camptothecin analog synthesis
WO2016191436A1 (en)	2015-05-26	2016-12-01	Boston Scientific Neuromodulation Corporation	Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
US10780283B2 (en)	2015-05-26	2020-09-22	Boston Scientific Neuromodulation Corporation	Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
WO2017003946A1 (en)	2015-06-29	2017-01-05	Boston Scientific Neuromodulation Corporation	Systems and methods for selecting stimulation parameters based on stimulation target region, effects, or side effects
US10441800B2 (en)	2015-06-29	2019-10-15	Boston Scientific Neuromodulation Corporation	Systems and methods for selecting stimulation parameters by targeting and steering
US10071249B2 (en)	2015-10-09	2018-09-11	Boston Scientific Neuromodulation Corporation	System and methods for clinical effects mapping for directional stimulation leads
US10716942B2 (en)	2016-04-25	2020-07-21	Boston Scientific Neuromodulation Corporation	System and methods for directional steering of electrical stimulation
AU2017281934B2 (en)	2016-06-24	2019-11-14	Boston Scientific Neuromodulation Corporation	Systems and methods for visual analytics of clinical effects
WO2018044881A1 (en)	2016-09-02	2018-03-08	Boston Scientific Neuromodulation Corporation	Systems and methods for visualizing and directing stimulation of neural elements
US10780282B2 (en)	2016-09-20	2020-09-22	Boston Scientific Neuromodulation Corporation	Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters
EP3493876B1 (en)	2016-10-14	2021-03-17	Boston Scientific Neuromodulation Corporation	Systems for closed-loop determination of stimulation parameter settings for an electrical simulation system
ES2871008T3 (es)	2017-01-03	2021-10-28	Boston Scient Neuromodulation Corp	Sistemas y procedimientos para seleccionar parámetros de estimulación compatibles con IRM
WO2018132334A1 (en)	2017-01-10	2018-07-19	Boston Scientific Neuromodulation Corporation	Systems and methods for creating stimulation programs based on user-defined areas or volumes
US10625082B2 (en)	2017-03-15	2020-04-21	Boston Scientific Neuromodulation Corporation	Visualization of deep brain stimulation efficacy
WO2018187090A1 (en)	2017-04-03	2018-10-11	Boston Scientific Neuromodulation Corporation	Systems and methods for estimating a volume of activation using a compressed database of threshold values
AU2018301355B2 (en)	2017-07-14	2020-10-01	Boston Scientific Neuromodulation Corporation	Systems and methods for estimating clinical effects of electrical stimulation
WO2019036180A1 (en)	2017-08-15	2019-02-21	Boston Scientific Neuromodulation Corporation	SYSTEMS AND METHODS FOR CONTROLLING ELECTRICAL STIMULATION USING MULTIPLE STIMULATION FIELDS
WO2019210214A1 (en)	2018-04-27	2019-10-31	Boston Scientific Neuromodulation Corporation	Systems for visualizing and programming electrical stimulation
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ES2951064T3 (es) *	2019-01-15	2023-10-17	Laurus Labs Ltd	Procedimiento de preparación de 2-amino-5-hidroxipropiofenona
EP4291294A1 (en)	2021-04-27	2023-12-20	Boston Scientific Neuromodulation Corporation	Systems and methods for automated programming of electrical stimulation
US12403313B2 (en)	2021-06-15	2025-09-02	Boston Scientific Neuromodulation Corporation	Methods and systems for estimating neural activation by stimulation using a stimulation system
CA3239636A1 (en)	2021-12-09	2023-06-15	Boston Scientific Neuromodulation Corporation	Methods and systems for monitoring or assessing movement disorders or other physiological parameters using a stimulation system
EP4415809B1 (en)	2021-12-10	2026-01-28	Boston Scientific Neuromodulation Corporation	Systems and methods for generating and using response maps for electrical stimulation
WO2023167872A1 (en)	2022-03-02	2023-09-07	Boston Scientific Neuromodulation Corporation	Systems and methods for monitoring stimulation drift in an electrical stimulation system
CN118108705A (zh) *	2024-01-29	2024-05-31	浙江工业大学	一种富马酸沃诺拉赞的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2061678C1 (ru) *	1992-05-14	1996-06-10	Валерий Павлович Севодин	Способ получения 2-амино-5-нитробензофенона
US5391745A (en) *	1992-07-23	1995-02-21	Sloan-Kettering Institute For Cancer Research	Methods of preparation of camptothecin analogs
JPH07101956A (ja) *	1993-10-05	1995-04-18	Tanabe Seiyaku Co Ltd	ヒドロキシカンプトテシン化合物の製法
KR960029336A (ko) *	1995-01-09	1996-08-17	김충환	캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
JPH08225482A (ja) *	1995-02-22	1996-09-03	Dai Ichi Seiyaku Co Ltd	テトラロン関連化合物及びその製法
TW438775B (en)	1995-04-07	2001-06-07	Pharmacia & Upjohn Co Llc	Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
SG50747A1 (en) *	1995-08-02	1998-07-20	Tanabe Seiyaku Co	Comptothecin derivatives
ATE301659T1 (de)	1995-11-02	2005-08-15	Osi Pharm Inc	Verfahren zur herstellung von campothecinderivate
SG104284A1 (en) *	1996-10-30	2004-06-21	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof

2002
- 2002-02-20 TW TW091102967A patent/TWI245768B/zh not_active IP Right Cessation
- 2002-02-20 AR ARP020100579A patent/AR035684A1/es active IP Right Grant
- 2002-02-21 EE EEP200300373A patent/EE05361B1/xx not_active IP Right Cessation
- 2002-02-21 MX MXPA03007528A patent/MXPA03007528A/es active IP Right Grant
- 2002-02-21 CA CA2437702A patent/CA2437702C/en not_active Expired - Fee Related
- 2002-02-21 WO PCT/JP2002/001538 patent/WO2002066416A1/ja not_active Ceased
- 2002-02-21 US US10/467,987 patent/US7126000B2/en not_active Expired - Lifetime
- 2002-02-21 IL IL15694902A patent/IL156949A0/xx unknown
- 2002-02-21 HU HU0302755A patent/HUP0302755A3/hu unknown
- 2002-02-21 BR BRPI0207470-2A patent/BR0207470A/pt not_active IP Right Cessation
- 2002-02-21 JP JP2002565934A patent/JP4210119B2/ja not_active Expired - Fee Related
- 2002-02-21 KR KR1020077030609A patent/KR100864692B1/ko not_active Expired - Fee Related
- 2002-02-21 CZ CZ20032470A patent/CZ20032470A3/cs unknown
- 2002-02-21 NZ NZ52761502A patent/NZ527615A/xx not_active IP Right Cessation
- 2002-02-21 CA CA2683768A patent/CA2683768C/en not_active Expired - Fee Related
- 2002-02-21 EP EP02703874.4A patent/EP1378505B1/en not_active Expired - Lifetime
- 2002-02-21 RO ROA200300695A patent/RO122639B9/ro unknown
- 2002-02-21 PL PL399009A patent/PL217238B1/pl unknown
- 2002-02-21 CN CNB028053230A patent/CN100408550C/zh not_active Expired - Fee Related
- 2002-02-21 SK SK1147-2003A patent/SK288073B6/sk not_active IP Right Cessation
- 2002-02-21 AU AU2002237527A patent/AU2002237527B2/en not_active Ceased
- 2002-02-21 KR KR1020037010841A patent/KR100858972B1/ko not_active Expired - Fee Related
- 2002-02-21 SK SK5001-2011A patent/SK288149B6/sk not_active IP Right Cessation
- 2002-02-21 RU RU2003128530/04A patent/RU2308447C2/ru not_active IP Right Cessation
- 2002-02-21 RO ROA200900165A patent/RO125158A2/ro unknown
- 2002-02-21 PL PL363440A patent/PL218065B1/pl unknown
2003
- 2003-07-15 IL IL156949A patent/IL156949A/en not_active IP Right Cessation
- 2003-07-25 BG BG108031A patent/BG108031A/bg unknown
- 2003-08-13 NO NO20033579A patent/NO328628B1/no not_active IP Right Cessation
- 2003-08-14 NZ NZ534374A patent/NZ534374A/xx not_active IP Right Cessation
2006
- 2006-09-08 US US11/517,621 patent/US7378555B2/en not_active Expired - Lifetime
2008
- 2008-03-28 JP JP2008085358A patent/JP4805967B2/ja not_active Expired - Lifetime
2009
- 2009-11-24 NO NO20093402A patent/NO331656B1/no not_active IP Right Cessation
2011
- 2011-08-11 AR ARP110102927A patent/AR082663A2/es not_active Application Discontinuation
2013
- 2013-04-23 BG BG10111453A patent/BG111453A/en unknown

Also Published As

Publication number	Publication date
HUP0302755A2 (hu)	2003-12-29
EP1378505A4 (en)	2006-09-27
HUP0302755A3 (en)	2008-03-28
CA2437702C (en)	2010-04-06
CZ20032470A3 (cs)	2004-02-18
US7126000B2 (en)	2006-10-24
RO125158A2 (ro)	2010-01-29
IL156949A (en)	2009-09-01
PL363440A1 (pl)	2004-11-15
SK288149B6 (sk)	2013-12-02
EP1378505A1 (en)	2004-01-07
CA2683768C (en)	2013-05-28
CN1492851A (zh)	2004-04-28
RO122639B1 (ro)	2009-10-30
JP4210119B2 (ja)	2009-01-14
NO328628B1 (no)	2010-04-12
SK11472003A3 (sk)	2004-03-02
EE200300373A (et)	2003-10-15
PL218065B1 (pl)	2014-10-31
JPWO2002066416A1 (ja)	2004-09-24
KR20030077631A (ko)	2003-10-01
US20070010674A1 (en)	2007-01-11
NZ527615A (en)	2004-12-24
NO331656B1 (no)	2012-02-13
KR100858972B1 (ko)	2008-09-17
EE05361B1 (et)	2010-12-15
BG111453A (en)	2013-09-30
IL156949A0 (en)	2004-02-08
BR0207470A (pt)	2008-04-08
US20040106830A1 (en)	2004-06-03
RU2003128530A (ru)	2005-03-27
RO122639B9 (ro)	2014-03-28
US7378555B2 (en)	2008-05-27
NO20033579L (no)	2003-10-10
PL217238B1 (pl)	2014-06-30
TWI245768B (en)	2005-12-21
NZ534374A (en)	2004-12-24
SK288073B6 (sk)	2013-05-03
RU2308447C2 (ru)	2007-10-20
AR035684A1 (es)	2004-06-23
NO20033579D0 (no)	2003-08-13
CA2683768A1 (en)	2002-08-29
WO2002066416A1 (fr)	2002-08-29
MXPA03007528A (es)	2003-12-11
AR082663A2 (es)	2012-12-26
EP1378505B1 (en)	2014-11-05
JP4805967B2 (ja)	2011-11-02
JP2008273952A (ja)	2008-11-13
BG108031A (bg)	2005-04-30
CN100408550C (zh)	2008-08-06
AU2002237527B2 (en)	2007-01-04
NO20093402L (no)	2003-10-10
KR20080012383A (ko)	2008-02-11
KR100864692B1 (ko)	2008-10-23
CA2437702A1 (en)	2002-08-29

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