BG108424A - Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives - Google Patents

Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives

Info

Publication number: BG108424A
Authority: BG; Bulgaria
Prior art keywords: compounds; well; derivatives; relates; pyrrolidinethiadiazole
Prior art date: 2001-06-18

Application number

BG108424A

Other languages

Bulgarian (bg)

English (en)

Inventor

Matthias Schwarz

Anna Quattropani

Patrick Page

Russell Thomas

Vincent Pomel

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-18

Filing date

2003-12-08

Publication date

2005-03-31

2003-12-08 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

2005-03-31 Publication of BG108424A publication Critical patent/BG108424A/xx

Links

150000001875 compounds Chemical class 0.000 abstract 4
150000003235 pyrrolidines Chemical class 0.000 abstract 2
UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical group C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 abstract 1
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
101800000989 Oxytocin Proteins 0.000 abstract 1
102000004279 Oxytocin receptors Human genes 0.000 abstract 1
108090000876 Oxytocin receptors Proteins 0.000 abstract 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
208000005107 Premature Birth Diseases 0.000 abstract 1
208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
206010036590 Premature baby Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000006806 disease prevention Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical group C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
229960001723 oxytocin Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
-1 preterm labor Chemical compound 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BG108424A 2001-06-18 2003-12-08 Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives BG108424A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01113632		2001-06-18

Publications (1)

Publication Number	Publication Date
BG108424A true BG108424A (en)	2005-03-31

Family

ID=8177641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG108424A BG108424A (en)	2001-06-18	2003-12-08	Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives

Country Status (26)

Country	Link
US (2)	US7115639B2 (sr)
EP (1)	EP1444225B1 (sr)
JP (1)	JP4426284B2 (sr)
KR (1)	KR20040030678A (sr)
CN (1)	CN100564378C (sr)
AR (1)	AR036108A1 (sr)
AU (1)	AU2002319237B2 (sr)
BG (1)	BG108424A (sr)
BR (1)	BR0211030A (sr)
CA (1)	CA2449578C (sr)
CZ (1)	CZ20033475A3 (sr)
EA (1)	EA006212B1 (sr)
EE (1)	EE200400022A (sr)
ES (1)	ES2397305T3 (sr)
HR (1)	HRP20031017A2 (sr)
HU (1)	HUP0400238A2 (sr)
IL (1)	IL159219A0 (sr)
MX (1)	MXPA03011441A (sr)
MY (1)	MY128890A (sr)
NO (1)	NO20035399L (sr)
PL (1)	PL367275A1 (sr)
RS (1)	RS99503A (sr)
SK (1)	SK15552003A3 (sr)
UA (1)	UA75145C2 (sr)
WO (1)	WO2002102799A2 (sr)
ZA (1)	ZA200309402B (sr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA75145C2 (en)	2001-06-18	2006-03-15	Applied Research Systems	Pyrrolidine oxadiazole and thiadiazole derivatives, pharmaceutical composition based thereon, a method for producing thereof (variants)
JP4773335B2 (ja) *	2003-02-27	2011-09-14	メルクセローノソシエテアノニム	オキシトシンアンタゴニストとしてのピロリジン誘導体
DK1725526T3 (da) *	2004-02-26	2008-03-03	Serono Lab	Fremgangsmåde til fremstilling af pyrrolidinoximer
PL1879573T3 (pl)	2005-05-10	2013-05-31	Incyte Holdings Corp	Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
CA2634198C (en)	2005-12-20	2014-06-03	Incyte Corporation	N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
ES2444574T3 (es)	2006-09-19	2014-02-25	Incyte Corporation	N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa
CL2007002650A1 (es)	2006-09-19	2008-02-08	Incyte Corp	Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
PL2315756T3 (pl)	2008-07-08	2015-02-27	Incyte Holdings Corp	1,2,5-oksadiazole jako inhibitory 2,3-dioksygenazy indoloaminy
EP2845850A1 (en)	2013-09-10	2015-03-11	ObsEva S.A.	Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
DK3066085T3 (da)	2013-11-08	2020-06-02	Incyte Holdings Corp	Fremgangsmåde til syntesen af en indolamin-2,3-dioxygenaseinhibitor
EP2886107A1 (en)	2013-12-17	2015-06-24	ObsEva S.A.	Oral formulations of pyrrolydine derivatives
AU2015283133B2 (en)	2014-07-02	2019-05-16	ObsEva SA	Crystalline (3Z,5S)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methyloxime useful in methods of treating conditions related to the OT-R activity
TW202435864A (zh)	2023-02-09	2024-09-16	大陸商上海葆正醫藥科技有限公司	亞胺化合物及其製備方法和應用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2722190B1 (fr)	1994-07-05	1996-10-04	Sanofi Sa	Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
CA2210138A1 (en)	1995-01-24	1996-08-01	Peter D. Williams	Tocolytic oxytocin receptor antagonists
US5756497A (en)	1996-03-01	1998-05-26	Merck & Co., Inc.	Tocolytic oxytocin receptor antagonists
FR2757157B1 (fr) *	1996-12-13	1999-12-31	Sanofi Sa	Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
US6333344B1 (en) *	1999-05-05	2001-12-25	Merck & Co.	Prolines as antimicrobial agents
ATE329899T1 (de) *	2000-03-27	2006-07-15	Applied Research Systems	Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren
AU2001256209B2 (en)	2000-03-27	2006-02-16	Merck Serono Sa	Pharmaceutically active pyrrolidine derivatives
EP1335901B1 (en) *	2000-10-17	2010-04-14	Merck Serono SA	Pharmaceutically active sulfanilide derivatives
EP1829861A3 (en) *	2001-03-20	2009-01-21	Laboratoires Serono SA	Pyrrolidine ester derivatives active as oxytocin antagonists
UA75145C2 (en)	2001-06-18	2006-03-15	Applied Research Systems	Pyrrolidine oxadiazole and thiadiazole derivatives, pharmaceutical composition based thereon, a method for producing thereof (variants)
US7468385B2 (en) *	2001-12-20	2008-12-23	Laboratoires Serono Sa	Triazoles as oxytocin antagonists
UA78058C2 (en) *	2002-07-05	2007-02-15	Applied Research Systems	Pyrrolidine derivative as oxitocin antagonists

2002
- 2002-06-14 UA UA20031211897A patent/UA75145C2/uk unknown
- 2002-06-14 EP EP02748785A patent/EP1444225B1/en not_active Expired - Lifetime
- 2002-06-14 HU HU0400238A patent/HUP0400238A2/hu unknown
- 2002-06-14 SK SK1555-2003A patent/SK15552003A3/sk not_active Application Discontinuation
- 2002-06-14 CZ CZ20033475A patent/CZ20033475A3/cs unknown
- 2002-06-14 ES ES02748785T patent/ES2397305T3/es not_active Expired - Lifetime
- 2002-06-14 RS YU99503A patent/RS99503A/sr unknown
- 2002-06-14 KR KR10-2003-7016485A patent/KR20040030678A/ko not_active Ceased
- 2002-06-14 EE EEP200400022A patent/EE200400022A/xx unknown
- 2002-06-14 BR BR0211030-0A patent/BR0211030A/pt not_active IP Right Cessation
- 2002-06-14 CA CA2449578A patent/CA2449578C/en not_active Expired - Fee Related
- 2002-06-14 HR HR20031017A patent/HRP20031017A2/xx not_active Application Discontinuation
- 2002-06-14 MX MXPA03011441A patent/MXPA03011441A/es active IP Right Grant
- 2002-06-14 IL IL15921902A patent/IL159219A0/xx unknown
- 2002-06-14 WO PCT/EP2002/006629 patent/WO2002102799A2/en not_active Ceased
- 2002-06-14 US US10/480,992 patent/US7115639B2/en not_active Expired - Fee Related
- 2002-06-14 CN CNB028159446A patent/CN100564378C/zh not_active Expired - Fee Related
- 2002-06-14 EA EA200400049A patent/EA006212B1/ru not_active IP Right Cessation
- 2002-06-14 JP JP2003506272A patent/JP4426284B2/ja not_active Expired - Fee Related
- 2002-06-14 AU AU2002319237A patent/AU2002319237B2/en not_active Ceased
- 2002-06-14 PL PL02367275A patent/PL367275A1/xx not_active Application Discontinuation
- 2002-06-18 MY MYPI20022260A patent/MY128890A/en unknown
- 2002-06-21 AR ARP020102353A patent/AR036108A1/es unknown
2003
- 2003-12-03 ZA ZA200309402A patent/ZA200309402B/en unknown
- 2003-12-04 NO NO20035399A patent/NO20035399L/no unknown
- 2003-12-08 BG BG108424A patent/BG108424A/xx unknown
2006
- 2006-06-09 US US11/449,802 patent/US20060229343A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2397305T3 (es)	2013-03-06
UA75145C2 (en)	2006-03-15
MY128890A (en)	2007-02-28
KR20040030678A (ko)	2004-04-09
US20040220238A1 (en)	2004-11-04
JP2004534804A (ja)	2004-11-18
SK15552003A3 (sk)	2004-05-04
US7115639B2 (en)	2006-10-03
NO20035399L (no)	2004-02-17
NO20035399D0 (no)	2003-12-04
CN100564378C (zh)	2009-12-02
HUP0400238A2 (hu)	2004-07-28
WO2002102799A2 (en)	2002-12-27
BR0211030A (pt)	2004-06-22
CN1639155A (zh)	2005-07-13
HK1074204A1 (zh)	2005-11-04
EA200400049A1 (ru)	2004-08-26
PL367275A1 (en)	2005-02-21
ZA200309402B (en)	2004-12-03
IL159219A0 (en)	2004-06-01
EE200400022A (et)	2004-04-15
CA2449578A1 (en)	2002-12-27
EP1444225A2 (en)	2004-08-11
MXPA03011441A (es)	2004-07-01
JP4426284B2 (ja)	2010-03-03
AR036108A1 (es)	2004-08-11
AU2002319237B2 (en)	2008-01-03
HRP20031017A2 (en)	2004-04-30
CA2449578C (en)	2011-12-13
CZ20033475A3 (en)	2004-05-12
EP1444225B1 (en)	2012-10-10
RS99503A (sr)	2006-12-15
EA006212B1 (ru)	2005-10-27
WO2002102799A3 (en)	2003-04-03
US20060229343A1 (en)	2006-10-12

Publication	Publication Date	Title
IL155333A0 (en)	2003-11-23	Sulfanilide derivatives for use in medicine, certain such new derivatives and their preparation
TW200745111A (en)	2007-12-16	New compounds
BG108424A (en)	2005-03-31	Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives
MXPA02007942A (es)	2004-09-10	Derivados de pirrolopirimidinona, procesos de preparacion y uso.
SE0104340D0 (sv)	2001-12-20	New compounds
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TW200800984A (en)	2008-01-01	New compounds
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Li et al.	2010	Studies on the structure–activity relationship of 1, 3, 3, 4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents
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