EE200400022A - Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised - Google Patents

Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised

Info

Publication number
EE200400022A
EE200400022A EEP200400022A EEP200400022A EE200400022A EE 200400022 A EE200400022 A EE 200400022A EE P200400022 A EEP200400022 A EE P200400022A EE P200400022 A EEP200400022 A EE P200400022A EE 200400022 A EE200400022 A EE 200400022A
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
thiadiazole derivatives
pyrrolidine oxadiazole
Prior art date
Application number
EEP200400022A
Other languages
English (en)
Estonian (et)
Inventor
Schwarz Matthias
Quattropani Anna
Page Patrick
J. Russell Thomas
Pomel Vincent
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200400022A publication Critical patent/EE200400022A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EEP200400022A 2001-06-18 2002-06-14 Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised EE200400022A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01113632 2001-06-18
PCT/EP2002/006629 WO2002102799A2 (en) 2001-06-18 2002-06-14 Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists

Publications (1)

Publication Number Publication Date
EE200400022A true EE200400022A (et) 2004-04-15

Family

ID=8177641

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200400022A EE200400022A (et) 2001-06-18 2002-06-14 Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised

Country Status (26)

Country Link
US (2) US7115639B2 (sr)
EP (1) EP1444225B1 (sr)
JP (1) JP4426284B2 (sr)
KR (1) KR20040030678A (sr)
CN (1) CN100564378C (sr)
AR (1) AR036108A1 (sr)
AU (1) AU2002319237B2 (sr)
BG (1) BG108424A (sr)
BR (1) BR0211030A (sr)
CA (1) CA2449578C (sr)
CZ (1) CZ20033475A3 (sr)
EA (1) EA006212B1 (sr)
EE (1) EE200400022A (sr)
ES (1) ES2397305T3 (sr)
HR (1) HRP20031017A2 (sr)
HU (1) HUP0400238A2 (sr)
IL (1) IL159219A0 (sr)
MX (1) MXPA03011441A (sr)
MY (1) MY128890A (sr)
NO (1) NO20035399L (sr)
PL (1) PL367275A1 (sr)
RS (1) RS99503A (sr)
SK (1) SK15552003A3 (sr)
UA (1) UA75145C2 (sr)
WO (1) WO2002102799A2 (sr)
ZA (1) ZA200309402B (sr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040030678A (ko) 2001-06-18 2004-04-09 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 피롤리딘 옥사디아졸 및 티아디아졸 유도체
DE602004024170D1 (de) * 2003-02-27 2009-12-31 Merck Serono Sa Coinsins Pyrrolidin-derivate als oxytocin antagonisten
DE602005003803T2 (de) * 2004-02-26 2008-12-24 Laboratoires Serono S.A., Coinsins Verfahren zur herstellung von pyrrolidinoximen
PL1879573T3 (pl) 2005-05-10 2013-05-31 Incyte Holdings Corp Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
US8450351B2 (en) 2005-12-20 2013-05-28 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
WO2008036642A2 (en) * 2006-09-19 2008-03-27 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
JP5465720B2 (ja) 2008-07-08 2014-04-09 インサイト・コーポレイション インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール
EP2845850A1 (en) * 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
ES2799582T3 (es) 2013-11-08 2020-12-18 Incyte Holdings Corp Proceso para la síntesis de un inhibidor de indoleamina 2,3-dioxigenasa
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
EP3753921A1 (en) 2014-07-02 2020-12-23 ObsEva S.A. Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime useful in methods of treating conditions related to the ot-r activity
TW202435864A (zh) 2023-02-09 2024-09-16 大陸商上海葆正醫藥科技有限公司 亞胺化合物及其製備方法和應用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722190B1 (fr) * 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
CA2210138A1 (en) 1995-01-24 1996-08-01 Peter D. Williams Tocolytic oxytocin receptor antagonists
US5756497A (en) 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
EP1176959B1 (en) * 1999-05-05 2006-03-08 Merck & Co., Inc. Novel prolines as antimicrobial agents
DK1268419T3 (da) 2000-03-27 2006-10-02 Applied Research Systems Farmaceutisk aktive pyrrolidinderivater som BAX-inhibitorer
DE60120661T2 (de) * 2000-03-27 2007-07-05 Applied Research Systems Ars Holding N.V. Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren
AU1401902A (en) * 2000-10-17 2002-04-29 Applied Research Systems Pharmaceutically active sulfanilide derivatives
EP1829861A3 (en) * 2001-03-20 2009-01-21 Laboratoires Serono SA Pyrrolidine ester derivatives active as oxytocin antagonists
KR20040030678A (ko) 2001-06-18 2004-04-09 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 피롤리딘 옥사디아졸 및 티아디아졸 유도체
ES2249636T3 (es) * 2001-12-20 2006-04-01 Applied Research Systems Ars Holding N.V. Triazoles como antagonistas de la oxitocina.
UA78058C2 (en) * 2002-07-05 2007-02-15 Applied Research Systems Pyrrolidine derivative as oxitocin antagonists

Also Published As

Publication number Publication date
US20060229343A1 (en) 2006-10-12
KR20040030678A (ko) 2004-04-09
JP4426284B2 (ja) 2010-03-03
NO20035399D0 (no) 2003-12-04
CN1639155A (zh) 2005-07-13
WO2002102799A3 (en) 2003-04-03
NO20035399L (no) 2004-02-17
HRP20031017A2 (en) 2004-04-30
US20040220238A1 (en) 2004-11-04
US7115639B2 (en) 2006-10-03
EP1444225A2 (en) 2004-08-11
UA75145C2 (en) 2006-03-15
JP2004534804A (ja) 2004-11-18
BG108424A (en) 2005-03-31
BR0211030A (pt) 2004-06-22
HK1074204A1 (zh) 2005-11-04
IL159219A0 (en) 2004-06-01
CZ20033475A3 (en) 2004-05-12
AU2002319237B2 (en) 2008-01-03
CA2449578A1 (en) 2002-12-27
SK15552003A3 (sk) 2004-05-04
EA200400049A1 (ru) 2004-08-26
EA006212B1 (ru) 2005-10-27
CA2449578C (en) 2011-12-13
HUP0400238A2 (hu) 2004-07-28
RS99503A (sr) 2006-12-15
AR036108A1 (es) 2004-08-11
ZA200309402B (en) 2004-12-03
CN100564378C (zh) 2009-12-02
PL367275A1 (en) 2005-02-21
WO2002102799A2 (en) 2002-12-27
ES2397305T3 (es) 2013-03-06
MXPA03011441A (es) 2004-07-01
MY128890A (en) 2007-02-28
EP1444225B1 (en) 2012-10-10

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