BG108444A - Pediatric formulation of gatifloxacin - Google Patents

Pediatric formulation of gatifloxacin

Info

Publication number: BG108444A
Authority: BG; Bulgaria
Prior art keywords: gatifloxacin; taste; found; masked; crystalline
Prior art date: 2001-06-20

Application number

BG108444A

Other languages

Bulgarian (bg)

English (en)

Inventor

Krishnaswamy S. Raghavan

Sunanda A. Ranadive

Kenneth S. Bembeneck

Loutfy Benkerrour

Veronique Trognon

Richard G. Corrao

Luigi Esposito

Original Assignee

Bristol-Myers Squibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-20

Filing date

2003-12-12

Publication date

2004-08-31

2003-12-12 Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company

2004-08-31 Publication of BG108444A publication Critical patent/BG108444A/xx

Links

XUBOMFCQGDBHNK-JTQLQIEISA-N (S)-gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCN[C@@H](C)C1 XUBOMFCQGDBHNK-JTQLQIEISA-N 0.000 title abstract 6
229960003923 gatifloxacin Drugs 0.000 title abstract 6
238000009472 formulation Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 abstract 2
239000002244 precipitate Substances 0.000 abstract 2
235000021314 Palmitic acid Nutrition 0.000 abstract 1
235000021355 Stearic acid Nutrition 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000007900 aqueous suspension Substances 0.000 abstract 1
235000019658 bitter taste Nutrition 0.000 abstract 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 abstract 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 1
229940072132 quinolone antibacterials Drugs 0.000 abstract 1
239000008117 stearic acid Substances 0.000 abstract 1
210000002784 stomach Anatomy 0.000 abstract 1
235000019640 taste Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Seasonings (AREA)

BG108444A 2001-06-20 2003-12-12 Pediatric formulation of gatifloxacin BG108444A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29962501P	2001-06-20	2001-06-20
PCT/US2002/014596 WO2003000175A2 (en)	2001-06-20	2002-05-10	Pediatric formulation of gatifloxacin

Publications (1)

Publication Number	Publication Date
BG108444A true BG108444A (en)	2004-08-31

Family

ID=23155586

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG108444A BG108444A (en)	2001-06-20	2003-12-12	Pediatric formulation of gatifloxacin

Country Status (29)

Country	Link
US (1)	US6589955B2 (is)
EP (1)	EP1406572A4 (is)
JP (1)	JP4617475B2 (is)
KR (1)	KR100888519B1 (is)
CN (1)	CN1264514C (is)
AR (1)	AR034483A1 (is)
AU (1)	AU2002345534B2 (is)
BG (1)	BG108444A (is)
BR (1)	BR0209692A (is)
CA (1)	CA2450742A1 (is)
CZ (1)	CZ20033487A3 (is)
EE (1)	EE200400018A (is)
GE (1)	GEP20053610B (is)
HR (1)	HRP20031027A2 (is)
HU (1)	HUP0401497A2 (is)
IL (1)	IL158863A0 (is)
IS (1)	IS7048A (is)
MX (1)	MXPA03011451A (is)
NO (1)	NO20035605D0 (is)
NZ (1)	NZ529611A (is)
PE (1)	PE20030126A1 (is)
PL (1)	PL366559A1 (is)
RU (1)	RU2288218C2 (is)
SK (1)	SK14152003A3 (is)
TW (1)	TWI224004B (is)
UA (1)	UA75656C2 (is)
WO (1)	WO2003000175A2 (is)
YU (1)	YU100303A (is)
ZA (1)	ZA200309173B (is)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8383154B2 (en)	2004-05-11	2013-02-26	Egalet A/S	Swellable dosage form comprising gellan gum
US7838532B2 (en) *	2005-05-18	2010-11-23	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
US8546423B2 (en) *	2005-05-18	2013-10-01	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
US20070051418A1 (en) *	2005-09-02	2007-03-08	Rowles Brian A	Multilayer tubes
TW201010708A (en) *	2008-06-02	2010-03-16	Intervet Int Bv	Composition comprising an antibiotic and a corticosteroid
CN102325532B (zh) *	2008-10-07	2015-06-17	Mpex医药有限公司	用于减轻肺部炎症的左氧氟沙星吸入剂
AU2009302478B2 (en) *	2008-10-07	2015-09-03	Horizon Orphan Llc	Aerosol fluoroquinolone formulations for improved pharmacokinetics
LT2473170T (lt)	2009-09-04	2019-10-10	Horizon Orphan Llc	Aerozolizuoto levofloksacino panaudojimas cistinės fibrozės gydymui
CN102397546A (zh) *	2010-09-10	2012-04-04	广州自远生物科技有限公司	一种用于嗅觉或味觉敏感型动物的药物给药方法
CN102397552B (zh) *	2010-09-10	2016-06-08	广州自远生物科技有限公司	一种含喹诺酮类的药物复合制剂及其制备方法和应用
WO2014152332A1 (en)	2013-03-15	2014-09-25	Melinta Therapeutics, Inc.	Methods of treating infections in overweight and obese patients using antibiotics
WO2018129079A1 (en) *	2017-01-03	2018-07-12	Thermolife International, Llc	Method of isolating theacrine and composition comprising theacrine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RO88836A2 (ro)	1983-10-11	1986-03-31	Institutul Pentru Controlul De Stat Al Medicamentului Si Cercetari Farmaceutice,Ro	Procedeu de obtinere a comprimatelor cu eritromicina propionat de uz pediatric
JPH089597B2 (ja)	1986-01-21	1996-01-31	杏林製薬株式会社	選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
NL193682C (nl)	1987-05-14	2000-07-04	Glaxo Group Ltd	Beklede cefuroximaxetilsamenstelling.
US5405617A (en)	1991-11-07	1995-04-11	Mcneil-Ppc, Inc.	Aliphatic or fatty acid esters as a solventless carrier for pharmaceuticals
IT1255792B (it)	1992-08-05	1995-11-16	Bayer Italia Spa	Composizioni farmaceutiche per la somministrazione orale di diidropiridine in forma di bevanda
US5407921A (en)	1993-07-01	1995-04-18	Kao Corporation	Method for suppressing bitter taste
JP3449658B2 (ja)	1994-12-21	2003-09-22	杏林製薬株式会社	安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
DE19633480A1 (de)	1996-08-20	1998-02-26	Bayer Ag	Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
US5891469A (en)	1997-04-02	1999-04-06	Pharmos Corporation	Solid Coprecipitates for enhanced bioavailability of lipophilic substances
CA2227314A1 (en)	1997-01-24	1998-07-24	Hoechst Aktiengesellschaft	Preparation of concealed taste preparations of antibacterially active quinolone derivatives
GB9702799D0 (en)	1997-02-12	1997-04-02	Scherer Corp R P	Process for preparing solid pharmaceutical dosage forms
DE19820801A1 (de) *	1998-05-09	1999-11-25	Gruenenthal Gmbh	Orale Arzneiformen mit reproduzierbarer Wirkstofffreisetzung von Gatifloxacin oder pharmazeutisch verwendbaren Salzen oder Hydraten
DK1200129T3 (da)	1999-07-14	2009-01-12	Schering Plough Ltd	Smagsmaskering af orale, flydende quinolonfremstillinger ved anvendelse af ionbytterharpikser

2002
- 2002-05-09 US US10/143,487 patent/US6589955B2/en not_active Expired - Lifetime
- 2002-05-10 EE EEP200400018A patent/EE200400018A/xx unknown
- 2002-05-10 JP JP2003506621A patent/JP4617475B2/ja not_active Expired - Fee Related
- 2002-05-10 MX MXPA03011451A patent/MXPA03011451A/es active IP Right Grant
- 2002-05-10 CA CA002450742A patent/CA2450742A1/en not_active Abandoned
- 2002-05-10 PL PL02366559A patent/PL366559A1/xx not_active Application Discontinuation
- 2002-05-10 WO PCT/US2002/014596 patent/WO2003000175A2/en not_active Ceased
- 2002-05-10 AU AU2002345534A patent/AU2002345534B2/en not_active Ceased
- 2002-05-10 EP EP02744141A patent/EP1406572A4/en not_active Withdrawn
- 2002-05-10 CZ CZ20033487A patent/CZ20033487A3/cs unknown
- 2002-05-10 CN CNB02812409XA patent/CN1264514C/zh not_active Expired - Fee Related
- 2002-05-10 RU RU2003136068/04A patent/RU2288218C2/ru not_active IP Right Cessation
- 2002-05-10 YU YU100303A patent/YU100303A/sh unknown
- 2002-05-10 BR BR0209692-7A patent/BR0209692A/pt not_active IP Right Cessation
- 2002-05-10 HR HR20031027A patent/HRP20031027A2/hr not_active Application Discontinuation
- 2002-05-10 NZ NZ529611A patent/NZ529611A/en unknown
- 2002-05-10 GE GE5383A patent/GEP20053610B/en unknown
- 2002-05-10 SK SK1415-2003A patent/SK14152003A3/sk unknown
- 2002-05-10 HU HU0401497A patent/HUP0401497A2/hu unknown
- 2002-05-10 KR KR1020037016647A patent/KR100888519B1/ko not_active Expired - Fee Related
- 2002-05-10 IL IL15886302A patent/IL158863A0/xx unknown
- 2002-06-13 AR ARP020102227A patent/AR034483A1/es not_active Application Discontinuation
- 2002-06-14 TW TW091113074A patent/TWI224004B/zh not_active IP Right Cessation
- 2002-06-18 PE PE2002000518A patent/PE20030126A1/es not_active Application Discontinuation
- 2002-10-05 UA UA20031211971A patent/UA75656C2/uk unknown
2003
- 2003-11-20 IS IS7048A patent/IS7048A/is unknown
- 2003-11-25 ZA ZA200309173A patent/ZA200309173B/en unknown
- 2003-12-12 BG BG108444A patent/BG108444A/xx unknown
- 2003-12-16 NO NO20035605A patent/NO20035605D0/no unknown

Also Published As

Publication number	Publication date
EP1406572A4 (en)	2005-05-25
PL366559A1 (en)	2005-02-07
UA75656C2 (en)	2006-05-15
CZ20033487A3 (cs)	2004-05-12
HRP20031027A2 (en)	2005-10-31
EP1406572A2 (en)	2004-04-14
IS7048A (is)	2003-11-20
KR20040011543A (ko)	2004-02-05
PE20030126A1 (es)	2003-02-08
HUP0401497A2 (hu)	2004-12-28
CN1264514C (zh)	2006-07-19
EE200400018A (et)	2004-04-15
MXPA03011451A (es)	2004-04-05
WO2003000175A3 (en)	2003-04-10
AR034483A1 (es)	2004-02-25
IL158863A0 (en)	2004-05-12
RU2003136068A (ru)	2005-02-10
GEP20053610B (en)	2005-09-12
JP2005500306A (ja)	2005-01-06
US6589955B2 (en)	2003-07-08
WO2003000175A2 (en)	2003-01-03
BR0209692A (pt)	2004-04-20
NO20035605D0 (no)	2003-12-16
SK14152003A3 (sk)	2004-06-08
TWI224004B (en)	2004-11-21
JP4617475B2 (ja)	2011-01-26
ZA200309173B (en)	2005-02-25
YU100303A (sh)	2006-08-17
KR100888519B1 (ko)	2009-03-11
US20030028025A1 (en)	2003-02-06
NZ529611A (en)	2006-02-24
CN1518449A (zh)	2004-08-04
CA2450742A1 (en)	2003-01-03
AU2002345534B2 (en)	2007-07-12
RU2288218C2 (ru)	2006-11-27

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