BG108549A - Методи, определящи лекарства на база структура, за идентифициране на d-ala-d-ala лигазни инхибитори като антибактериални лекарства - Google Patents

Методи, определящи лекарства на база структура, за идентифициране на d-ala-d-ala лигазни инхибитори като антибактериални лекарства Download PDF

Info

Publication number: BG108549A
Authority: BG; Bulgaria
Prior art keywords: ala; ligase; inhibitor; potential inhibitor; potential
Prior art date: 2001-06-28

Application number

BG108549A

Other languages

Bulgarian (bg)

English (en)

Inventor

Manuel Navia

Paul Ala

James GRIFFITH

Janid Ali

Carlos FAERMAN

Scott Moe

Andrew MAGEE

Patrick Connelly

Emanuele Perola

Original Assignee

Pliva D.D.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-28

Filing date

2004-01-28

Publication date

2005-02-28

2004-01-28 Application filed by Pliva D.D. filed Critical Pliva D.D.

2005-02-28 Publication of BG108549A publication Critical patent/BG108549A/bg

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)

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Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Enzymes And Modification Thereof (AREA)

BG108549A 2001-06-28 2004-01-28 Методи, определящи лекарства на база структура, за идентифициране на d-ala-d-ala лигазни инхибитори като антибактериални лекарства BG108549A (bg)

Applications Claiming Priority (1)

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US30167601P	2001-06-28	2001-06-28

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BG108549A true BG108549A (bg)	2005-02-28

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BG108549A BG108549A (bg)	2001-06-28	2004-01-28	Методи, определящи лекарства на база структура, за идентифициране на d-ala-d-ala лигазни инхибитори като антибактериални лекарства

Country Status (16)

Country	Link
US (2)	US20030119061A1 (cs)
EP (1)	EP1412516A4 (cs)
CN (1)	CN1268765C (cs)
BG (1)	BG108549A (cs)
BR (1)	BR0211312A (cs)
CA (1)	CA2451837A1 (cs)
CZ (1)	CZ200441A3 (cs)
EA (1)	EA007612B1 (cs)
EE (1)	EE200400044A (cs)
HU (1)	HUP0600158A2 (cs)
IL (1)	IL159539A0 (cs)
MX (1)	MXPA04000157A (cs)
PL (1)	PL367484A1 (cs)
SK (1)	SK282004A3 (cs)
WO (1)	WO2003002063A2 (cs)
YU (1)	YU102403A (cs)

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US8329060B2 (en) *	2008-10-22	2012-12-11	General Electric Company	Blue-green and green phosphors for lighting applications
US20170314007A1 (en) *	2014-09-30	2017-11-02	China Three Gorges University	Medicament design pocket of ornithine decarboxylase and application of medicament design pocket
CN108504647B (zh) *	2018-03-09	2021-11-05	中山大学	一种dna促旋酶的药物结合口袋及其应用

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US6251620B1 (en) *	1995-08-30	2001-06-26	Ariad Pharmaceuticals, Inc.	Three dimensional structure of a ZAP tyrosine protein kinase fragment and modeling methods
US6037117A (en) *	1997-01-31	2000-03-14	Smithkline Beecham Corporation	Methods using the Staphylococcus aureus glycyl tRNA synthetase crystalline structure
US6183121B1 (en) *	1997-08-14	2001-02-06	Vertex Pharmaceuticals Inc.	Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets

2002
- 2002-06-28 US US10/186,886 patent/US20030119061A1/en not_active Abandoned
- 2002-06-28 HU HU0600158A patent/HUP0600158A2/hu unknown
- 2002-06-28 SK SK28-2004A patent/SK282004A3/sk not_active Application Discontinuation
- 2002-06-28 CN CNB028152700A patent/CN1268765C/zh not_active Expired - Fee Related
- 2002-06-28 BR BR0211312-0A patent/BR0211312A/pt not_active IP Right Cessation
- 2002-06-28 EA EA200400093A patent/EA007612B1/ru unknown
- 2002-06-28 EP EP02749688A patent/EP1412516A4/en not_active Withdrawn
- 2002-06-28 CA CA002451837A patent/CA2451837A1/en not_active Abandoned
- 2002-06-28 PL PL02367484A patent/PL367484A1/xx not_active Application Discontinuation
- 2002-06-28 YU YU102403A patent/YU102403A/sh unknown
- 2002-06-28 MX MXPA04000157A patent/MXPA04000157A/es unknown
- 2002-06-28 EE EEP200400044A patent/EE200400044A/xx unknown
- 2002-06-28 IL IL15953902A patent/IL159539A0/xx unknown
- 2002-06-28 WO PCT/US2002/020465 patent/WO2003002063A2/en not_active Ceased
- 2002-06-28 CZ CZ200441A patent/CZ200441A3/cs unknown
2004
- 2004-01-28 BG BG108549A patent/BG108549A/bg unknown
2006
- 2006-08-01 US US11/461,678 patent/US20070207512A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HUP0600158A2 (en)	2006-05-29
SK282004A3 (sk)	2005-06-02
US20070207512A1 (en)	2007-09-06
US20030119061A1 (en)	2003-06-26
EE200400044A (et)	2004-10-15
EP1412516A4 (en)	2004-09-08
EP1412516A2 (en)	2004-04-28
WO2003002063A3 (en)	2003-02-20
YU102403A (sh)	2006-08-17
EA200400093A1 (ru)	2005-06-30
BR0211312A (pt)	2004-07-13
CZ200441A3 (cs)	2004-08-18
EA007612B1 (ru)	2006-12-29
MXPA04000157A (es)	2005-06-06
CN1268765C (zh)	2006-08-09
PL367484A1 (en)	2005-02-21
CN1539020A (zh)	2004-10-20
IL159539A0 (en)	2004-06-01
CA2451837A1 (en)	2003-01-09
WO2003002063A2 (en)	2003-01-09

Publication	Publication Date	Title
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Du et al.	2008	Crystal structure and enantiomer selection by D-alanyl carrier protein ligase DltA from Bacillus cereus
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Scaglione et al.	2017	Structure of the adenylation domain Thr1 involved in the biosynthesis of 4‐chlorothreonine in Streptomyces sp. OH‐5093—protein flexibility and molecular bases of substrate specificity
Chen et al.	2006	Structure and kinetics of phosphonopyruvate hydrolase from Voriovorax sp. Pal2: New insight into the divergence of catalysis within the pep mutase/isocitrate lyase superfamily
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Ramos‐Figueroa et al.	2022	Phosphoenolpyruvate Mutase‐Catalyzed C− P Bond Formation: Mechanistic Ambiguities and Opportunities
Wubben et al.	2010	Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis
US20030119061A1 (en)	2003-06-26	Structure-based drug design methods for identifying D-Ala-D-Ala ligase inhibitors as antibacterial drugs
Matoba et al.	2020	Cyclization mechanism catalyzed by an ATP‐grasp enzyme essential for d‐cycloserine biosynthesis
Micaloni et al.	2003	Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences
AU2002320184A1 (en)	2003-03-03	Structure-based drug design methods for identifying d-ala-d-ala ligase inhibitors as antibacterial drugs
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Daniel-Ivad et al.	2023	Structure of the oxygen, pyridoxal phosphate-dependent capuramycin biosynthetic protein Cap15
US7747395B2 (en)	2010-06-29	Method of inhibitor design and identification using a 3-D structure of human peptide deformylase
WO2001009154A2 (en)	2001-02-08	USE OF THE CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ISOLEUCYL-tRNA SYNTHETASE IN ANTIBIOTIC DESIGN
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