BG108830A - Метод за получаване на 4' - трифлуорометилбифенил-2-карбоксамидо-(1,2,3,4-тетрахидроизохинолин-6-ил) и негови соли - Google Patents

Метод за получаване на 4' - трифлуорометилбифенил-2-карбоксамидо-(1,2,3,4-тетрахидроизохинолин-6-ил) и негови соли Download PDF

Info

Publication number: BG108830A
Authority: BG; Bulgaria
Prior art keywords: give; compound; added; structural formula; mmol
Prior art date: 1996-11-27

Application number

BG108830A

Other languages

Bulgarian (bg)

English (en)

Inventor

George Chang

George Quallich

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-27

Filing date

1999-05-26

Publication date

2005-10-31

1999-05-26 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2005-10-31 Publication of BG108830A publication Critical patent/BG108830A/bg

Links

150000003839 salts Chemical class 0.000 title claims abstract 6
-1 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXAMIDO-(1,2,3,4-TETRAHYDROISOQUINOLINE-6-YL) Chemical class 0.000 title claims abstract 4
238000000034 method Methods 0.000 title claims abstract 4
150000001408 amides Chemical class 0.000 claims abstract 8
239000002253 acid Substances 0.000 claims abstract 5
150000001875 compounds Chemical class 0.000 claims abstract 4
WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 claims 2
239000012458 free base Substances 0.000 claims 2
150000001412 amines Chemical class 0.000 claims 1
238000010511 deprotection reaction Methods 0.000 claims 1
125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
210000001589 microsome Anatomy 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Other In-Based Heterocyclic Compounds (AREA)

BG108830A 1996-11-27 1999-05-26 Метод за получаване на 4' - трифлуорометилбифенил-2-карбоксамидо-(1,2,3,4-тетрахидроизохинолин-6-ил) и негови соли BG108830A (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3230796P	1996-11-27	1996-11-27

Publications (1)

Publication Number	Publication Date
BG108830A true BG108830A (bg)	2005-10-31

Family

ID=21864233

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BG108830A BG108830A (bg)	1996-11-27	1999-05-26	Метод за получаване на 4' - трифлуорометилбифенил-2-карбоксамидо-(1,2,3,4-тетрахидроизохинолин-6-ил) и негови соли
BG103434A BG103434A (en)	1996-11-27	1999-05-26	Apo b-secretion/mtp inhibiting amides

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BG103434A BG103434A (en)	1996-11-27	1999-05-26	Apo b-secretion/mtp inhibiting amides

Country Status (34)

Country	Link
US (1)	US6121283A (fr)
EP (1)	EP0944602A1 (fr)
JP (1)	JP3270764B2 (fr)
KR (1)	KR100334567B1 (fr)
CN (2)	CN1238764A (fr)
AP (1)	AP804A (fr)
AR (1)	AR010309A1 (fr)
AU (1)	AU716151B2 (fr)
BG (2)	BG108830A (fr)
BR (1)	BR9714364A (fr)
CA (1)	CA2272719C (fr)
CZ (1)	CZ292160B6 (fr)
DZ (1)	DZ2358A1 (fr)
EA (1)	EA001539B1 (fr)
GT (1)	GT199700122A (fr)
HN (1)	HN1997000144A (fr)
HR (1)	HRP970642A2 (fr)
ID (1)	ID18995A (fr)
IL (1)	IL129744A0 (fr)
IS (1)	IS5040A (fr)
MA (1)	MA26451A1 (fr)
NO (1)	NO312760B1 (fr)
NZ (1)	NZ335162A (fr)
OA (1)	OA11050A (fr)
PA (1)	PA8441601A1 (fr)
PE (1)	PE17199A1 (fr)
SK (1)	SK65499A3 (fr)
TN (1)	TNSN97193A1 (fr)
TR (1)	TR199901180T2 (fr)
TW (1)	TW502023B (fr)
UY (1)	UY24789A1 (fr)
WO (1)	WO1998023593A1 (fr)
YU (1)	YU23499A (fr)
ZA (1)	ZA9710641B (fr)

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1997
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- 1997-11-03 EP EP97945048A patent/EP0944602A1/fr not_active Withdrawn
- 1997-11-03 KR KR1019997004662A patent/KR100334567B1/ko not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
US6121283A (en)	2000-09-19
AR010309A1 (es)	2000-06-07
AU716151B2 (en)	2000-02-17
AP9701145A0 (en)	1998-01-31
MA26451A1 (fr)	2004-12-20
TW502023B (en)	2002-09-11
AP804A (en)	2000-01-28
NO992525D0 (no)	1999-05-26
NZ335162A (en)	2000-01-28
BR9714364A (pt)	2000-03-21
CZ292160B6 (cs)	2003-08-13
NO992525L (no)	1999-05-26
HRP970642A2 (en)	1998-10-31
EP0944602A1 (fr)	1999-09-29
ID18995A (id)	1998-05-28
KR20000057269A (ko)	2000-09-15
EA001539B1 (ru)	2001-04-23
PE17199A1 (es)	1999-02-19
TR199901180T2 (xx)	1999-08-23
AU4634797A (en)	1998-06-22
HN1997000144A (es)	1997-12-16
OA11050A (en)	2002-03-07
ZA9710641B (en)	1999-05-26
DZ2358A1 (fr)	2002-12-28
CA2272719A1 (fr)	1998-06-04
NO312760B1 (no)	2002-07-01
SK65499A3 (en)	2001-05-10
UY24789A1 (es)	2000-09-29
YU23499A (sh)	2001-07-10
PA8441601A1 (es)	2000-05-24
IS5040A (is)	1999-04-30
GT199700122A (es)	1999-05-19
EA199900416A1 (ru)	1999-12-29
TNSN97193A1 (fr)	2005-03-15
BG103434A (en)	2000-07-31
IL129744A0 (en)	2000-02-29
KR100334567B1 (ko)	2002-05-03
CN1380289A (zh)	2002-11-20
WO1998023593A1 (fr)	1998-06-04
JP2000505810A (ja)	2000-05-16
CN1238764A (zh)	1999-12-15
CA2272719C (fr)	2002-10-01
JP3270764B2 (ja)	2002-04-02

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